Mechanisms of DNA repair
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| Format: | Buch |
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| Sprache: | English |
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Amsterdam [u.a.]
Elsevier
2012
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| Schriftenreihe: | Progress in molecular biology and translational science
110 |
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| 020 | |a 9780123876652 |9 978-0-12-387665-2 | ||
| 035 | |a (OCoLC)809177822 | ||
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| 041 | 0 | |a eng | |
| 049 | |a DE-355 |a DE-12 | ||
| 082 | 0 | |a 572.86459 | |
| 245 | 1 | 0 | |a Mechanisms of DNA repair |c ed. by Paul W. Doetsch |
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier |c 2012 | |
| 300 | |a XII, 323 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Progress in molecular biology and translational science |v 110 | |
| 500 | |a Literaturangaben.- Einzelaufnahme eines Zeitschr.-Bd. | ||
| 700 | 1 | |a Doetsch, Paul W. |e Sonstige |4 oth | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025207539&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-025207539 | ||
Datensatz im Suchindex
| _version_ | 1804149391494217728 |
|---|---|
| adam_text | Titel: Mechanisms of DNA repair
Autor: Doetsch, Paul W
Jahr: 2012
Contents
Contributors..................................................................................... ix
Preface............................................................................................. xi
Dynamics of Lesion Processing by Bacterial
Nucleotide Excision Repair Proteins............... 1
Neil M. Kad and Bennett Van Houten
I. Structural Insights of Bacterial Nucleotide Excision Repair................... 2
II. So Few DNA Repair Proteins, So Much DNA: Defining the
Big Problem................................................................................ 4
III. Damage Searching by UvrA2 and UvrA2B2........................................ 14
IV. Future Directions......................................................................... 17
References.................................................................................. 19
Transcription-Coupled DNA Repair in Prokaryotes..... 25
Ann Ganesan, Graciela Spivak, and Philip C. Hanawalt
I. Introduction.............................................................................. 25
II. Background: Genomic Heterogeneity in NER and the
Discovery of TCR....................................................................... 26
III. The Role of RNA Polymerase in TCR............................................. 28
IV. The Role of Mfd in TCR.............................................................. 29
V. The Role of UvrA in TCR............................................................ 32
VI. The Role of UvrB in TCR............................................................ 33
VII. Other Examples of Transcription-Related DNA Damage
Processing in Bacteria.................................................................. 34
VIII. Conclusions............................................................................... 35
Acknowledgments....................................................................... 36
References................................................................................ 36
The Functions of MutL in Mismatch Repair:
The Power of Multitasking...................... 41
Alba Guarné
I. Overview of DNA Mismatch Repair................................................. 42
vi CONTENTS
II. MutL is a Multidomain Protein....................................................... 47
III. Architecture of the Endonuclease Domain........................................ 53
TV. Regulation of the Endonuclease Activity of MutL............................... 58
V. Concluding Remarks..................................................................... 62
References.................................................................................. 63
The Fpg/Nei Family of DNA Glycosylases: Substrates,
Structures, and Search for Damage............... 71
Aishwarya Prakash, Sylvie Doublié, and Susan S. Wallace
I. Introduction................................................................................ 71
II. Fpg/Nei Phylogeny....................................................................... 73
III. Fpg/Nei Structures....................................................................... 74
TV. Glycosylases Search for Lesions...................................................... 83
V. Concluding Remarks..................................................................... 85
Acknowledgments........................................................................ 85
References.................................................................................. 85
Regulation of Base Excision Repair in Eukaryotes
by Dynamic Localization Strategies............... 93
Daniel B. Swartzlander, Nicholas C. Bauer, Anita H. Corbett, and
Paul W. Doetsch
I. Base Excision Repair.................................................................... 94
II. Dynamic Localization of BER Proteins............................................ 102
III. Hypotheses on the Orchestration of Dynamic Localization................... 107
References.................................................................................. 109
Oxidized Base Damage and Single-Strand Break
Repair in Mammalian Genomes: Role of Disordered
Regions and Posttranslational Modifications in
Early Enzymes.............................. 123
Muralidhar L. Hegde, Tadahide Izumi, and Sankar Mitra
I. Oxidative DNA Damage and Its Repair in Mammalian Cells................ 124
II. Complexity and Sub-pathways of BER/SSBR..................................... 132
III. Nonconserved Terminal Extensions in Mammalian Early BER Proteins . 134
IV. Posttranslational Modifications in Early BER Proteins......................... 137
V. BER/SSBR Deficiency in Human Diseases....................................... 139
VI. Conclusions and Future Perspectives............................................... 142
Acknowledgments........................................................................ 143
References.................................................................................. 143
CONTENTS VU
Homologous Recombination in Eukaryotes.......... 155
Ravindra Amunugama and Richard Fishel
I. Meiosis..................................................................................... 156
II. DSB Repairin Somatic Cells........................................................ 158
III. RAD52 Epistasis Group............................................................... 163
rv. Recombination Mediators............................................................. 167
V. RAD51 Paralogs......................................................................... 172
VI. DSB Repair in Chromatin............................................................ 175
VII. Postsynaptic Removal of RAD51.................................................... 180
VIII. Second-End Capture................................................................... 181
IX. dHJ Dissolution.......................................................................... 181
X. Holliday Junction Resolution......................................................... 181
XI. Homeologous Recombination: The Interplay Between
Mismatch Repair and HR............................................................. 183
XII. Conclusion................................................................................ 184
References................................................................................ 184
Overview for the Histone Codes for DNA Repair...... 207
Elizabeth A. Williamson, Justin W. Wray, Pranshu Bansal,
and Robert Hromas
I. Histone Modifications of Homologous Recombination Repair............... 208
II. Histone Modifications of NHEJ....................................................... 215
III. Histone Modifications of Nucleotide Excision Repair.......................... 217
IV. Histone Modifications of Base Excision Repair................................... 219
V DNA Mismatch Repair and Histone Modifications.............................. 220
References.................................................................................. 222
The RSC and INO80 Chromatin-Remodeling
Complexes in DNA Double-Strand Break
Repair.................................... 229
Anna L. Chambers and Jessica A. Downs
I. Introduction................................................................................ 230
II. RSC........................................................................................... 232
III. INO80........................................................................................ 244
IV. Perspectives................................................................................. 253
Acknowledgments......................................................................... 254
References.................................................................................. 254
viii CONTENTS
Mechanistic Links Between ATM and Histone
Methylation Codes During DNA Repair............ 263
Ye Xu, Chang Xu, and Brendan D. Price
I. The DNA Damage Response.......................................................... 264
II. Ataxia telangiectasia and the ATM Kinase......................................... 265
III. The Tip60 Acetyltransferase........................................................... 269
IV. H3K9me3 and DDR..................................................................... 275
V Conclusions and Implications for Cancer Therapy.............................. 280
Acknowledgments........................................................................ 281
References.................................................................................. 281
Exploiting Synthetic Lethal Interactions Between
DNA Damage Signaling, Checkpoint Control,
and p53 for Targeted Cancer Therapy............. 289
Sandra Morandell and Michael B. Yaffe
I. Introduction................................................................................ 290
II. The Concept of Synthetic Lethality in Cancer Therapy....................... 295
III. Synthetic Lethality Between PARP1 and BRCA1/2 as a
Model for Enhancing DNA Damage-Induced Cell Death.................... 295
IV. Synthetic Lethality in the Context of p53 Mutations............................ 297
V. Potential for Future Therapies........................................................ 305
References.................................................................................. 307
Index......................................................................................... 315
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| indexdate | 2024-07-10T00:22:17Z |
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| isbn | 9780123876652 |
| language | English |
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| series2 | Progress in molecular biology and translational science |
| spelling | Mechanisms of DNA repair ed. by Paul W. Doetsch Amsterdam [u.a.] Elsevier 2012 XII, 323 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Progress in molecular biology and translational science 110 Literaturangaben.- Einzelaufnahme eines Zeitschr.-Bd. Doetsch, Paul W. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025207539&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Mechanisms of DNA repair |
| title | Mechanisms of DNA repair |
| title_auth | Mechanisms of DNA repair |
| title_exact_search | Mechanisms of DNA repair |
| title_full | Mechanisms of DNA repair ed. by Paul W. Doetsch |
| title_fullStr | Mechanisms of DNA repair ed. by Paul W. Doetsch |
| title_full_unstemmed | Mechanisms of DNA repair ed. by Paul W. Doetsch |
| title_short | Mechanisms of DNA repair |
| title_sort | mechanisms of dna repair |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025207539&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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