Pediatric rheumatology
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Philadelphia, Pa.
Saunders
2012
|
| Schriftenreihe: | Pediatric clinics of North America
59,2 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
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| 245 | 1 | 0 | |a Pediatric rheumatology |c guest ed. Ronald M. Laxer ... |
| 264 | 1 | |a Philadelphia, Pa. |b Saunders |c 2012 | |
| 300 | |a XIV S., S. 225 - 531 |b zahlr. Ill., graph. Darst. | ||
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Datensatz im Suchindex
| _version_ | 1819735539111165952 |
|---|---|
| adam_text | Pediatrie
Rheumatology
Contents
Preface:
Pediatric
Rheumatology
xiii
Ronald M.
Laxer
and David D. Sherry
Principles of Inflammation for the Pediatrician
225
Alessia Omenetti,
Sabrina
Chiesa,
and Marco Gattorno
The immune system consists of
2
branches: innate and adaptive. The for¬
mer represents the first line of host defense during infection and plays
a key role in the early recognition and protection against invading patho¬
gens. The latter orchestrates elimination of pathogens in the late phase
of infection and leads to the generation of
immunologie
memory. Innate
and adaptive immunity should not be considered separate compartments.
Innate and adaptive immune responses represent an integrated system of
host defense. The authors review the mechanisms driving the induction
and perpetuation of the inflammatory responses observed during patho¬
gen-associated, autoimmune, and autoinflammatory diseases.
Approach to the Child with Joint Inflammation
245
Roberta Berard
Arthritis is manifested as a swollen joint having at least
2
of the following
conditions: limited range of motion, pain on movement, or warmth overly¬
ing the joint. This article discusses an approach to the evaluation of a child
with arthritis of one (mono) or several (poly) joints.
Laboratory Testing in
Pediatrie
Rheumatology
263
Jay Mehta
In children, laboratory evaluations can assist in the screening of patients
for inflammatory disorders, confirm diagnoses, allow for monitoring of dis¬
ease activity and response to therapy, and suggest prognoses and risk of
morbidities associated with rheumatic diseases. This review provides an
overview of the usefulness and interpretation of both the commonly or¬
dered tests ordered by the general pediatrician as well as those frequently
used in the
pediatric
rheumatology clinic for diagnosis and disease moni¬
toring. Studies discussed include the complete blood count, acute phase
reactants, autoantibodies, serum complement, urinalysis, streptococcal
antibody tests, and commonly used genetic studies.
Rheumatologic Emergencies in Newborns, Children, and Adolescents
285
Jonathan D. Akikusa
This article presents five clinical scenarios in which the initial manifesta¬
tions of
pediatric
rheumatic diseases constitute life-threatening medical
emergencies. It is intended as a problem-oriented guide for pediatricians
to assist in the recognition of rheumatologic differentials in children pre¬
senting with critical illness and provides an approach to their initial inves¬
tigation and management.
Contents
Juvenile
Idiopathic Arthritis 301
Peter J.
Gowdie and Shirley
M.L.
Tse
Juvenile idiopathic arthritis
(ЛА)
encompasses a complex group of disor¬
ders with arthritis as a common feature. This article provides the pediatrician
with a review of the epidemiology, classification, clinical manifestations, and
complications of JIA. It also provides an update on the current understand¬
ing of the cause of JIA and recent developments in management and a
recent review of the long-term outcome in JIA.
Making Sense of the Cytokine Storm: A Conceptual Framework for Understanding,
Diagnosing, and Treating Hemophagocytic Syndromes
329
Scott W.
Canna
and Edward M.
Behrens
Cytokine storm syndromes (CSS) are a group of disorders representing
a variety of inflammatory causes. The clinical presentations of all CSS
can be strikingly similar, creating diagnostic uncertainty. However, clini¬
cians should avoid the temptation to treat all CSS equally, because their
inciting inflammatory insults vary widely. Failure to identify and address
this underlying trigger results in delayed,
inoptimal,
or potentially harmful
consequences. This review places the hemophagocytic syndromes hemo¬
phagocytic lymphohistiocytosis and
macrophage
activation syndrome
within a conceptual model of CSS and provides a logical framework for
diagnosis and treatment of CSS of suspected rheumatic origin.
Systemic Lupus Erythematosus in Children and Adolescents
345
Deborah M. Levy and Sylvia
Kamphuis
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with
a wide range of disease manifestations that can involve any organ system,
and can lead to significant morbidity and even mortality. This article reviews
the epidemiology, common clinical features, and complications of the
disease, and briefly discusses the available treatment options. In addition,
important medical and
psychosocial
issues relevant to the pediatrician
caring for children and adolescents with SLE are discussed.
Idiopathic Inflammatory
Myopathies
in Childhood: Current Concepts
365
Adam M. Huber
The juvenile idiopathic inflammatory
myopathies
are a group of rare, chronic,
multisystem, autoimmune diseases associated with muscle weakness. This
article reviews practical issues of relevance to pediatricians, including
clinical presentation, differential diagnosis, investigation, therapy, and prog¬
nosis. The importance of early recognition and specialist involvement is
emphasized.
Pediatrie
Scleroderma:
Systemic and Localized Forms
381
Kathryn S.
Torok
Pediatrie scleroderma
includes
2
major groups of clinical entities, systemic
sclerosis (SSc) and localized
scleroderma (LS).
Although both share a com¬
mon pathophysiology, their clinical manifestations differ. LS is typically
confined to the skin and underlying subcutis, with up to a quarter of
Contents ix
patients
showing extracutaneous disease manifestations such as arthritis
and uveitis. Vascular, cutaneous, gastrointestinal, pulmonary, and muscu-
loskeletal involvement are most commonly seen in children with SSc.
Treatment of both forms targets the active inflammatory stage and halts
disease progression; however, progress needs to be made toward the
development of more effective antifibrotic therapy to help reverse disease
damage.
Pediatric Vasculitis
407
Pamela F. Weiss
Childhood vasculitis is a challenging and complex group of conditions that
are multisystem in nature and often require integrated care from multiple
subspecialties, including rheumatology, dermatology, cardiology, nephrol-
ogy, neurology, and gastroenterology. Vasculitis is defined as the presence
of inflammation in the blood vessel wall. The site of vessel involvement, size
of the affected vessels, extent of vascular injury, and underlying pathology
determine the disease phenotype and severity. This article explores the
classification and general features of
pediatric
vasculitis, as well as the clin¬
ical presentation, diagnostic evaluation, and therapeutic options for the
most common vasculitides.
Kawasaki Disease
425
Rosie
Scuccimarri
Kawasaki disease is a systemic vasculitis and the leading cause of ac¬
quired heart disease in North American and Japanese children. The epide¬
miology, cause, and clinical characteristics of this disease are reviewed.
The diagnostic challenge of Kawasaki disease and its implications for cor¬
onary artery outcomes are discussed, as are the recommended treatment,
ongoing treatment controversies, concerns associated with treatment
resistance, and the importance of ongoing follow up.
Autoinflammatory Syndromes
447
Philip J. Hashkes and
Ori Toker
There has been an expansion of the autoinflammatory syndromes due to the
discovery of new diseases related to mutations in genes regulating the innate
immune system and the knowledge gained from these diseases as applied
to more common nongenetic inflammatory conditions. Autoinflammatory
syndromes are characterized by unprovoked (or triggered by minor events)
recurrent episodes of systemic inflammation involving various body sys¬
tems, which are often accompanied by fever. Inflammation is mediated by
polymorphonuciear and
macrophage
cells through cytokines, particularly
interleukin-1
.
This article reviews the clinical approach to patients with sus¬
pected autoinflammatory syndromes, several of the main and new (mostly
genetics) syndromes, advances in treatment, and prognosis.
Approach to the Patient with Noninflammatory Musculoskeletal Pain
471
Peter
Weiser
Musculoskeletal pain is one of the most common presenting symptoms at
the pediatrician s office. Etiology ranges from benign conditions to serious
Contents
ones requiring prompt attention. This article addresses entities that pres¬
ent as musculoskeletal pain but are not associated with arthritis. The most
common nonarthritic conditions are benign limb pain of childhood (grow¬
ing pains), hypermobility, overuse syndromes with or without skeletal
abnormalities, malignancies, and pain amplification syndromes. The| initial
decision process, diagnosis, and treatment options for each of these con¬
ditions are discussed.
Immunodeficiency Diseases with Rheumatic Manifestations
493
Troy R. Torgerson
Most clinicians associate primary immunodeficiency disorders (PIDDs)
with susceptibility to frequent or severe infections. It is less commonly rec¬
ognized, however, that PIDDs are frequently associated with autoimmune
or rheumatologic manifestations. This review provides a synopsis of the
rheumatic manifestations associated with immunodeficiencies in each of
the major compartments of the immune system.
Index
509
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| illustrated | Illustrated |
| indexdate | 2024-12-24T02:43:56Z |
| institution | BVB |
| isbn | 9781455739097 |
| language | English |
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| publishDate | 2012 |
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| publisher | Saunders |
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| series | Pediatric clinics of North America |
| series2 | Pediatric clinics of North America |
| spellingShingle | Pediatric rheumatology Pediatric clinics of North America Kind (DE-588)4030550-8 gnd Rheumatismus (DE-588)4049836-0 gnd |
| subject_GND | (DE-588)4030550-8 (DE-588)4049836-0 (DE-588)4143413-4 |
| title | Pediatric rheumatology |
| title_auth | Pediatric rheumatology |
| title_exact_search | Pediatric rheumatology |
| title_full | Pediatric rheumatology guest ed. Ronald M. Laxer ... |
| title_fullStr | Pediatric rheumatology guest ed. Ronald M. Laxer ... |
| title_full_unstemmed | Pediatric rheumatology guest ed. Ronald M. Laxer ... |
| title_short | Pediatric rheumatology |
| title_sort | pediatric rheumatology |
| topic | Kind (DE-588)4030550-8 gnd Rheumatismus (DE-588)4049836-0 gnd |
| topic_facet | Kind Rheumatismus Aufsatzsammlung |
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