Regenerative nephrology
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| Sprache: | English |
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Amsterdam [u.a.]
Elsevier, Acad. Press
2011
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| Ausgabe: | 1. ed. |
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| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV039955416 | ||
| 003 | DE-604 | ||
| 005 | 20120413 | ||
| 007 | t| | ||
| 008 | 120313s2011 xx ad|| |||| 00||| eng d | ||
| 016 | 7 | |a 015617990 |2 DE-101 | |
| 020 | |a 9780123809285 |c (hbk.) £79.00 |9 978-0-12-380928-5 | ||
| 020 | |a 0123809282 |c (hbk.) £79.00 |9 0-12-380928-2 | ||
| 035 | |a (OCoLC)785849799 | ||
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| 040 | |a DE-604 |b ger | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-355 | ||
| 084 | |a YK 7915 |0 (DE-625)153789:12921 |2 rvk | ||
| 245 | 1 | 0 | |a Regenerative nephrology |c ed. by Michael S. Goligorsky |
| 250 | |a 1. ed. | ||
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier, Acad. Press |c 2011 | |
| 300 | |a XV, 426 S., [16] Bl. |b Ill., graph. Darst. |c 28 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 0 | 7 | |a Nephrologie |0 (DE-588)4129395-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Regeneration |0 (DE-588)4048983-8 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Nephrologie |0 (DE-588)4129395-2 |D s |
| 689 | 0 | 1 | |a Regeneration |0 (DE-588)4048983-8 |D s |
| 689 | 0 | |C b |5 DE-604 | |
| 700 | 1 | |a Goligorsky, Michael S. |e Sonstige |4 oth | |
| 856 | 4 | 2 | |m Digitalisierung UB Regensburg |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024813266&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-024813266 | |
Datensatz im Suchindex
| DE-BY-UBR_call_number | 91/YK 7915 G626 |
|---|---|
| DE-BY-UBR_katkey | 4940074 |
| DE-BY-UBR_location | 91 |
| DE-BY-UBR_media_number | 069037770941 |
| _version_ | 1822704657606115328 |
| adam_text | Contents
Contributors
xi
Introduction
xiii
и
MEDIATORS OF REGENERATION
I
PHYLOGENY AND ONTOGENY
OF TISSUE REGENERATION
1.
Glomerulogenesis and
De Novo
Nephrogenesis
in Medaka Fish: An Evolutionary Approach
3
HISASHI HASHIMOTO AND YUKO WAKAMATSU
Introduction
3
Medaka as a Model Animal for Kidney Research
4
Kidney Development in Medaka
5
Kidney Regeneration in Medaka
11
Perspectives
15
Conclusion
16
2.
Renal Organogénesis:
Growing a Replacement
Kidney In Situ from Transplanted
Renal Primordia
19
MARC R. HAMMERMAN
Introduction
19
Methodology for
Organogénesis
20
Renal
Organogénesis
23
Alternatives to the Use of Embryonic Kidney Primordia
to Achieve
Organogénesis
29
Current Challenges in the Application of Renal
Organogénesis
Technology
31
Conclusion
33
3.
Use of Genetic Mouse Models to Study Kidney
Regeneration
37
AKIO KOBAYASHI AND JEREMY S. DUFFIELD
Introduction
38
Genetic Modification In Vivo
38
Development of the Nephron: How Genetic Tools have Enabled
Understanding of Nephron Formation
45
Adult Kidney Regeneration: How Genetic
Tools have Enabled Understanding of Nephron
Regeneration
47
Lessons from Generation of the Kidney: Can We
Use Recent Insights and Developmental Tools to
Regenerate the Kidney?
62
4.
Endogenous
Anti-
inflammatory and
Proresol
ving
Lipid
Mediators in Renal Disease
69
CHARLES
N.
SERHAN AND CATHERINE GODSON
Introduction
69
Lipid
Mediators: Chemical Autacoids in Inflammation and
Resolution
72
Lipoxins
72
Proresolving Pathways, Essential Fatty Acids and Resolution
Indices
74
Aspirin is Resolution Friendly
74
Statins and Anti-inflammatory
Lipid
Mediators
77
Lipoxins and
Heme Oxygenase-1
System
78
Resolvins are Novel Endogenous Mediators:
18R
Е
-Series
and 17R D-Series Resolvins
78
Resolvin and Protectin Biosynthesis
80
Resolvins and Protectins in Disease Models
81
Corneal
Damage: Epithelial Wound Healing
83
Renal Inflammation, Resolution and Fibrosis
84
Proresolving Therapeutics: Agonists of Resolution?
86
Conclusion
87
5.
Tissue Protection and Regeneration Aided
by Erythropoietin and Erythropoietin-derived
Peptides
93
DANILO
RISER
Introduction
93
Tissue Expression of Erythropoietin and the Erythropoietin
Receptor
93
Erythropoietin in the Vascular System
94
Erythropoietin and the Kidney
95
Conclusion
98
6.
Mast Cells in Kidney Regeneration
103
ERIC DAUGAS, WALID BEGHDADl AND
ULRICH
BLANK
Introduction
103
Basic Biology of Mast Cells
104
Model Systems to Study Mast Cell Functions
108
Beneficial Role of Mast Cells in Inflammation
109
Mast Cells as Regulators of Immune and Inflammatory
Reactions
110
Inflammation and Kidney Diseases: A Regenerative
Perspective 111
Mast Cells in Kidney Disease
112
VU
Vlil
CONTENTS
Positive
Actions
of Mast Cell Mediators in Kidney Disease
116
Conclusion
120
7.
Role of
Macrophages
in Renal Injury,
Repair and Regeneration
125
VINCENT LEE, Ql
CAO,
YIPING WANG AND DAVID C.H. HARRIS
Introduction
125
Injury, Repair and Regeneration of the Kidney
126
Macrophage Phenotype
127
Macrophages
in Different Disease Models
128
Alternative Methods for Stimulating
Macrophages
135
Alternative Sources of
Macrophages
135
Regenerative Potential of
Macrophages
in Kidney Disease
136
Current Limitations in the Use of
Macrophages as
Cellular Therapy
in Kidney Disease
136
Conclusion
137
8.
T-cell Contribution to Injury and Regenerative
Processes in Kidney Diseases: Focus on Regulatory
T
Cells
141
HYE RYOUN JANG AND
HAMID RABB
Overview of
T
Cells in Kidney Diseases
Glomerulonephritis
143
Acute Kidney Injury
144
Kidney Transplantation
147
Conclusion
147
141
III
STEM CELLS IN REGENERATIVE
PROCESSES
9.
Mesenchy
mal
Stem Cells
153
BENJAMIN D. HUMPHREYS AND JOSEPH V. BONVENTRE
Introduction
153
The Mesenchymal Stem Cell
154
Amniotic
Fluiďderived
Stem Cells
154
Bone Marrow Plasticity and Renal Repair
155
Mesenchymal Stem Cells Ameliorate Renal Injury
and Accelerate Repair
156
Efficacy of Mesenchymal Stem Cell Therapy in Chronic Kidney
Diseases
156
Do Exogenous Mesenchymal Stem Cells Directly Engraft
into Injured Tubules?
156
Homing of Exogenous Mesenchymal Stem Cells
158
Evidence that Mesenchymal Stem Cells Repair Kidney
by Paracrine and Endocrine Mechanisms
159
Paracrine Effects of Mesenchymal Stem Cells in Other Organs
160
Mesenchymal Stem Cell-derived Microvesicles and Acute Kidney
Injury
161
Recruitment of Endogenous Bone Marrow Mesenchymal
Stem Cells
161
Kidney Mesenchymal Stem Cells
161
Clinical Trials for Mesenchymal Stem Cells in Acute Kidney Injury,
Graft Tolerance and Lupus Nephritis
162
Conclusion
163
10.
Endothelial Progenitor Cells and the Kidney
167
MATTHIEU
MONGE,
ANTON JAN VAN
ZONNEVELD
AND TON J.
RABELINK
Introduction
167
The Concept of Endothelial Progenitor Cells
168
Endothelial Progenitor Cells as an Indicator of Cardiovascular
Disease
168
Microvascular Remodeling by Circulating Cells
170
11.
Potential of the Side Population in Regenerative
Nephrology
173
M.H. LITTLE AND G.A.
CHALLEN
What is the Side Population?
173
Role of ABC Transporters: Markers or Mediators of Stem Cells
174
Existence of Side Population from Other Organs and their
Association with Organ Regeneration
174
Does Dye Efflux Equal Stem Cell?
176
Fusion Versus
Transdifferentiation:
Does it Matter?
176
Origin of Non-Bone Marrow Side Population Cells
177
Heterogeneity Within Distinct Side Population Fractions
177
Identification of Side Population Cells Within the Embryonic
and Adult Kidney
178
Gene Expression Profile and Immunophenotype of Kidney Side
Population
178
Origin of and Cellular Heterogeneity Within the Kidney Side
Population
179
Renal Side Population Multipotentiality and Renal Regenerative
Potential
181
Potential Mechanism of Humoral Activity
182
Functional and Phenotypic Overlap between Kidney Side
Population and Other Putative Endogenous Renal Stem
Cells
183
Potential Regenerative Applications of Kidney Side
Population
184
Conclusion
185
12.
Very Small Embryonic-like Stem Cells and Their
Potential Relevance for Kidney Homeostasis
189
DONG-MYUNG SHIN,
RUI
LIU,
PRZEMYSŁAW NOWACKI,
JANINA RATAJCZAK,
MAGDA KUCIA
AND
MARIUSZ Z.
RATAJCZAK
Introduction
189
Developmental Overview on Stem Cell Compartment
191
Deposition of Developmentally Early Stem Cells in Adult
Tissues
191
Isolation of Very Small Embryonic-like Stem Cells
192
Regeneration Potential of Very Small Embryonic-like Stem
Cells
194
Developmental Origin of Very Small Embryonic-like Stem Cells
195
Germ Line as Origin and Scaffold System for Tissue-committed
Stem Cells in the Adult Body
195
CONTENTS
ЇХ
Molecular
Mechanisms Governing Quiescence of Very
Small Embryonic-like Stem Cells: Involvement
of Imprinted Genes
197
Molecular Signature of mRNA from Adult Bone Marrow-derived
Very Small Embryonic-like Stem Cells Supports Their
Developmental Epiblast/Germ-Line Origin
198
Potential Role of Very Small Embryonic-like Stem Cells in
Pathology: Potential Cancer Stem
Cellsľ
198
Applications to Other Areas of Health and Disease
199
13.
Induced Pluripotent Stem Ceils
203
KENJl OSAFUNE, SHINYA YAMANAKA
Introduction
203
Mechanisms of Kidney Development
204
Animal Cap in Fertilized Eggs of Amphibians
205
Embryonic Stem Cells
206
Creation of Induced Pluripotent Stem Cells
206
Cells and Animals to Use for the Generation of Induced Pluripotent
Stem Cells
207
Mechanistic Understanding of Reprogramming Processes
207
Improving Methods for Induced Pluripotent Stem Cell Induction
208
Increasing Efficiency of Induced Pluripotent Stem Cell
Induction
209
Complete Pluripotency
210
Disease Modeling with Patient-derived Induced Pluripotent Stem
Cells
210
Toxicology Screening Using Induced Pluripotent Stem Cells and
Embryonic Stem Cells
210
Future Directions in Induced Pluripotent Stem Cell Research and
Technology
211
Cues to Regenerate Kidney Lineage Cells from Induced Pluripotent
Stem Cells and Embryonic Stem Cells
211
Conclusion
212
14.
Methods of Isolation and Culture of Adult Stem
Cells
217
LINDOLFO
DA SILVA MEIRELLES
AND NANCE BEYER
NARDI
Introduction
217
Methods for the Isolation and Culture of Bone Marrow Stem
Cells
220
Isolation and Culture of Renal Progenitor Cells
223
Methods for the Isolation and Culture of Mesenchymal Stem
Cells
223
Isolation and Culture of Human Adipose Tissue-derived
Pericytes
226
IV
STEM CELLS
-
FROM THE NICHE
TO REPAIR
15.
Stem Cell Niche in the Kidney
233
LAURA LASAGNI, ELENA LAZZERI AND
PAOLA
ROMAGNANI
Introduction
233
Stem Cells in the Adult Kidney
233
Ontogenesis of the Renal Stem Cell Niche
235
The Adult Renal Stem Cell Niche
236
The Renal Niche in Aging
238
The Renal Niche in Glomerular Disorders
239
Conclusion
241
16.
Bioartificial Stem Cell Niches: Engineering
a Regenerative
Microenvironment 245
GLENN D. PRESTW1CH,
TAMMER
GHALY, PHILIP BRUDNICKI,
BRIAN RATLIFF AND MICHAEL S. GOLIGORSKY
Introduction
245
Design Criteria for Creating a Bioartificial Niche
246
Chemistry of Bioartificial Niches
246
Fabrication Techniques
248
Common Hydrogel Materials
250
Examples of Hydrogel Applications
251
Recruitment and Delivery of Stem and Progenitor Cells to
and from Artificial Niches
252
Extracellular Scaffold as a Mold for Kidney Regeneration
253
Hydrogel Encapsulation of Endothelial Progenitor Cells Protects
Cells from Cytotoxins and Improves Their Viability
253
17.
Imaging of Transplanted and Native Stem
Cells
257
XIANG-YANG ZHU, MARTIN RODRIGUEZ-PORCEL AND
LILÁCH
O. LERMAN
Introduction
257
Methodologies for Labeling Stem Cells
Imaging Modalities
258
Conclusion
268
258
V
CAUSES OF REGENERATIVE FAILURE
18.
Stem Cell Injury and Premature Senescence
275
MICHAEL S. GOLIGORSKY
Introduction
275
Molecular Mechanisms of Stem Cell Exhaustion
277
Impairment of Stem Cell Function
279
In Vivo and Ex Vivo Therapy of Stem and Endothelial Progenitor
Cells
283
Potential Mechanisms of Stem Cell-induced Organ
Repair
283
Use of Artificial Niches to Store and Deliver Endothelial Progenitor
Cells
284
19.
Regeneration and Aging: Regulation by Sirtuins
and the NAD+ Salvage Pathway
289
NICA
M.
BORRADAILE, ALANNA WATSON AND
J. GEOFFREY PICKERING
Introduction
289
Aging of the Kidney
290
Cellular Basis of Tissue Aging
291
Molecular Mechanisms Underlying Cellular Aging
292
CONTENTS
NAD 1 Biosynthesis and Cell Health
Conclusion
296
295
Clinical Trials on Renal Regeneration
346
Future Perspectives in Clinical Regenerative Nephrology
347
20.
Bone Marrow Mesenchymal Stem Cells
in Organ Repair and Strategies to Optimize
their Efficacy
299
CHRISTODOULOS X1NARIS, BARBARA
IMBERTI,
GIUSEPPE REMUZZI AND MARINA MORIGI
Introduction
299
Do Adult Bone Marrow-derived Stem Cells Participate in Kidney
Repair?
300
Bone Marrow Mesenchymal Stem Cell Therapy Contributes
to Renal Repair
300
Strategies to Enhance Stem Cell Effects
304
Conclusion
309
VI
EMERGING CLINICAL ASPECTS
OF STEM CELL THERAPY
21.
Treatment of Acute Kidney Injury with Allogeneic
Mesenchymal Stem Cells: Preclinical and Initial
Clinical Data
315
FLORIAN
E. TÖGEL
AND
CHRISTOF WESTENFELDER
Acute Kidney Injury: Clinical and Experimental Issues
316
Treatment of Acute Kidney Injury with Stem Cells: Preclinical
Studies
319
Phase I Clinical Trial
332
Prevention and Treatment of Postoperative Acute Kidney Injury
with Allogeneic Mesenchymal Stem Cells in Patients who
Require On-pump Cardiac Surgery
332
22.
Clinical Trials in Renal Regenerative
Medicine
341
MAARTEN
В.
ROOKMAAKER,
JAAP
A. JOLES
AND MARIANNE C.
VERHAAR
Introduction
341
Clinical Trials of Regenerative Medicine in Other Disciplines
342
23.
Potential Risks of Stem Cell Therapies
361
UTA KUNTER
AND
JÜRGEN FLOEGE
Introduction
361
Technical Caveats in Stem Cell Preparation and
Administration
364
Potential Clinical Problems of Stem Cell Therapies:
Tumor Formation,
Ectopie
Tissue and Other Unwanted
Effects
371
A Different Concept: Stimulation of Intrarenal Resident Stem Cell
Populations
379
The Human Risk Factor: Stem Cell Cures
379
Conclusion
379
24.
Tissue Engineering in Urology
389
ANTHONY ATALA
Introduction
389
Basic Components of Tissue Engineering
390
Tissue Engineering of Specific Genitourinary Organs
394
Conclusion
398
25.
Ethics in Regenerative Medicine
401
SVETLANA
GAVRILOV AND DONALD W.
LANDRY
Introduction
401
Alternative Methods
403
26.
Stem Cell Banking
409
VICENTE MIRABET AND
PILAR
SOLVES
Introduction
409
Basic Principles of Cell Banking
410
Donation
410
Collection
411
Processing
411
Storage
417
bdex
421
Color Plates
|
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| bvnumber | BV039955416 |
| classification_rvk | YK 7915 |
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| id | DE-604.BV039955416 |
| illustrated | Illustrated |
| indexdate | 2024-12-24T02:35:33Z |
| institution | BVB |
| isbn | 9780123809285 0123809282 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-024813266 |
| oclc_num | 785849799 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | XV, 426 S., [16] Bl. Ill., graph. Darst. 28 cm |
| publishDate | 2011 |
| publishDateSearch | 2011 |
| publishDateSort | 2011 |
| publisher | Elsevier, Acad. Press |
| record_format | marc |
| spellingShingle | Regenerative nephrology Nephrologie (DE-588)4129395-2 gnd Regeneration (DE-588)4048983-8 gnd |
| subject_GND | (DE-588)4129395-2 (DE-588)4048983-8 |
| title | Regenerative nephrology |
| title_auth | Regenerative nephrology |
| title_exact_search | Regenerative nephrology |
| title_full | Regenerative nephrology ed. by Michael S. Goligorsky |
| title_fullStr | Regenerative nephrology ed. by Michael S. Goligorsky |
| title_full_unstemmed | Regenerative nephrology ed. by Michael S. Goligorsky |
| title_short | Regenerative nephrology |
| title_sort | regenerative nephrology |
| topic | Nephrologie (DE-588)4129395-2 gnd Regeneration (DE-588)4048983-8 gnd |
| topic_facet | Nephrologie Regeneration |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024813266&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT goligorskymichaels regenerativenephrology |