Insulin resistance and cancer epidemiology, cellular and molecular mechanisms and clinical implications
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| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY [u.a.]
Springer
2011
|
| Schriftenreihe: | Energy balance and cancer
1 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
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| 020 | |a 9781441999108 |9 978-1-4419-9910-8 | ||
| 035 | |a (OCoLC)745532675 | ||
| 035 | |a (DE-599)BVBBV039166428 | ||
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| 245 | 1 | 0 | |a Insulin resistance and cancer |b epidemiology, cellular and molecular mechanisms and clinical implications |c I. George Fantus, ed. |
| 264 | 1 | |a New York, NY [u.a.] |b Springer |c 2011 | |
| 300 | |a XI, 298 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Energy balance and cancer |v 1 | |
| 650 | 0 | 7 | |a Krebs |g Medizin |0 (DE-588)4073781-0 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Insulinresistenz |0 (DE-588)4234712-9 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Krebs |g Medizin |0 (DE-588)4073781-0 |D s |
| 689 | 0 | 1 | |a Insulinresistenz |0 (DE-588)4234712-9 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Fantus, I. George |e Sonstige |4 oth | |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe |z 978-1-4419-9911-5 |
| 830 | 0 | |a Energy balance and cancer |v 1 |w (DE-604)BV036593934 |9 1 | |
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| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-024183776 | |
Datensatz im Suchindex
| _version_ | 1819668184139038720 |
|---|---|
| adam_text | Contents
1 Insulin
and the Physiology of Carbohydrate Metabolism
................... 1
Sandra
Pereira
and
Adria
Giacca
2
Insulin/IGF-l Signaling Nodes and their Role in Carcinogenesis
...... 53
Cullen M. Taniguchi and
С
Ronald
Kahn
3
The Mechanisms and Impact of Obesity
and Insulin Resistance on Breast Cancer Incidence
............................ 77
Deborah J. Clegg
4
Obesity and Cancer: Epidemiology
....................................................... 101
Melinda L.
Irwin
5
Insulin, Insulin Resistance, and Cancer Associations
.......................... 111
Lorraine Lipscombe
6
Animal Models of Hyperinsulinemia,
Insulin Resistance, and Cancer
.............................................................. 141
Ruslan Novosyadlyy,
Archana
Vijayakumar, Yvonne
Fiere,
and Derek LeRoith
7
Potential Mechanisms Linking Insulin to Cancer
................................ 159
Yael Babichev, Sarah Khalid, and I. George Fantus
8
Actions of Insulin As a Survival and Growth
Factor:
Akt, mTOR,
and Regulation of Translation
........................... 181
Luc Furie, Mark
Livingstone, Ivan Topisirovic,
and Nahum
Sonenberg
9
AMP-Activated Protein Kinase and Cancer Cell Metabolism
........... 193
Bin Zheng and Lewis
С
Cantley
10
The Role of the IGF Axis in Human Malignancy:
Evidence from Epidemiological Studies and Tissue Analysis
............. 213
Julia V. Burnier, Shun Li, and Pnina Brodt
viii Contents
11
IGF-I
and Insulin Receptor Families in Cancer
.................................. 243
Antonino
Belfiore,
Ira D. Goldfine, and
Roberta Malaguarnera
12
Insulin
Resistance: Clinical Implications
for Cancer TVeatment and Prevention
.................................................. 269
Saroj Niraula and Pamela J. Goodwin
Index
................................................................................................................. 293
Energy Balance and
Cancer
1
Series
Editor: Nathan A. Berger
I.
George Fantus Editor
Insulin Resistance and
Cancer
Epidemiology, Cellular and Molecular Mechanisms and Clinical Implications
Ihis book reviews the epidemiological associations between insulin resistance and
cancer. This is followed by reviews ot animal models which support this relationship
and provide insight into potential mechanisms. Several chapters then provide detailed
examination of the cellular and molecular changes characterizing the insulin resist¬
ant state, such as hyperinsulinemia, abnormal metabolism and hormone signaling,
and how these interact with various tumor characteristics. For example some tumors
present increased quantities ot the tetal
torni ot
the insulin receptor, unique regula¬
tion ot oxidative
(Krebs
cycle) metabolism (Warburg effect), as well as mutations in
various relevant signaling pathways. Finally, the clinical implications of these data
are integrated with considerations of insulin sensitization and potential metabolic
interventions to prevent and treat cancer. It should be noted that while a number ot
cancers are associated with obesity the authors here have focused primarily on breast
cancer as a key and significant model.
|
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| id | DE-604.BV039166428 |
| illustrated | Illustrated |
| indexdate | 2024-12-24T02:11:50Z |
| institution | BVB |
| isbn | 9781441999108 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-024183776 |
| oclc_num | 745532675 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | XI, 298 S. graph. Darst. |
| publishDate | 2011 |
| publishDateSearch | 2011 |
| publishDateSort | 2011 |
| publisher | Springer |
| record_format | marc |
| series | Energy balance and cancer |
| series2 | Energy balance and cancer |
| spellingShingle | Insulin resistance and cancer epidemiology, cellular and molecular mechanisms and clinical implications Energy balance and cancer Krebs Medizin (DE-588)4073781-0 gnd Insulinresistenz (DE-588)4234712-9 gnd |
| subject_GND | (DE-588)4073781-0 (DE-588)4234712-9 |
| title | Insulin resistance and cancer epidemiology, cellular and molecular mechanisms and clinical implications |
| title_auth | Insulin resistance and cancer epidemiology, cellular and molecular mechanisms and clinical implications |
| title_exact_search | Insulin resistance and cancer epidemiology, cellular and molecular mechanisms and clinical implications |
| title_full | Insulin resistance and cancer epidemiology, cellular and molecular mechanisms and clinical implications I. George Fantus, ed. |
| title_fullStr | Insulin resistance and cancer epidemiology, cellular and molecular mechanisms and clinical implications I. George Fantus, ed. |
| title_full_unstemmed | Insulin resistance and cancer epidemiology, cellular and molecular mechanisms and clinical implications I. George Fantus, ed. |
| title_short | Insulin resistance and cancer |
| title_sort | insulin resistance and cancer epidemiology cellular and molecular mechanisms and clinical implications |
| title_sub | epidemiology, cellular and molecular mechanisms and clinical implications |
| topic | Krebs Medizin (DE-588)4073781-0 gnd Insulinresistenz (DE-588)4234712-9 gnd |
| topic_facet | Krebs Medizin Insulinresistenz |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024183776&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024183776&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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