An introduction to clinical pharmaceutics
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
London [u.a.]
Pharmaceutical Press
2010
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| Ausgabe: | 1. publ. |
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| 245 | 1 | 0 | |a An introduction to clinical pharmaceutics |c Alexander T. Florence |
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| 300 | |a XIII, 179 S. |b Ill., graph. Darst. |c 24 cm | ||
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| adam_text | IMAGE 1
AN INTRODUCTION
TO CLINICAL PHARMACEUTICS
ALEXANDER T. FLORENCE EMERITUS PROFESSOR THE SCHOOL OF PHARMACY,
UNIVERSITY OF LONDON, UK
(PP)
LONDON * CHICAGO PHARMACEUTICAL PRESS
IMAGE 2
PREFACE IX
INTRODUCTION XI
BOOK OUTLINE XV
ABOUT THE AUTHOR XVII
1 WHAT IS CLINICAL PHARMACEUTICS? 1
INTRODUCTION 1
PHYSICAL CONCEPTS 2
THE NATURE OF THE DOSAGE FORM AND OUTCOMES 18
QUALITY OF EFFECT 19
INGREDIENTS IN DOSAGE FORMS AND THEIR INFLUENCE ON OUTCOMES 22
CONCLUSION 23
REFERENCES 24
2 EXCIPIENTS: NOT ALWAYS INERT 27
INTRODUCTION 27
USUALLY BUT NOT ALWAYS INERT 27
E-NUMBERS 31
CROSS-REACTIVITY 33
DYES USED IN LYMPH NODE IDENTIFICATION 33
NON-IONIC SURFACTANTS 33
POLYOXYETHYLENE GLYCOLS (PEGS) 35
ADJUVANTS AS THERAPEUTIC SUBSTANCES 35
TALE AS THERAPEUTIC AGENT AND EXCIPIENT 37
ACTIVE EXCIPIENTS IN MULTIPLE THERAPIES 39
CONCLUSIONS 39
REFERENCES 39
3 THINKING CHEMICALLY 41
INTRODUCTION 41
THE CHEMISTRY OF DRUGS AND CLINICAL PHARMACEUTICS 42
IMAGE 3
VI | CONTENTS
CHEMICAL NOMENCLATURE 47
SURFACE-ACTIVE DRUGS 49
ACIDS AND BASES 49
STRUCTURAL SIMILARITIES BETWEEN DRUGS 52
CROSS-REACTIVITY 52
BETA-IACTAM ANTIBIOTICS AND THE FORMATION OF OLIGOMERS 56 THE
BISPHOSPHONATES 57
HYDROPHOBIE AND HYDROPHILIC STATINS 58
PHOTOCHERNICAL REACTIONS AND PHOTOINDUCED REACTIONS 59
CHELATION AND TETRAEYCLINES 64
SUGAMMEDEX: A CYCLODEXTRIN DERIVATIVE 64
CONCLUSIONS 66
REFERENCES 67
4 LOOKING AT FORMULATIONS 69
INTRODUCTION 69
PROTEIN DRUGS AND FORMULATIONS 70
MONODONAL ANTIBODIES (MABS) 73
AMPHOTERICIN B FORMULATIONS 74
A DOXORUBICIN FORMULATION: DOXIL 78
A PROPOFOL FORMULATION: DIPRIVAN 78
LONG-ACTING DEPOT INJEETIONS 80
RAFT-PRODUCING ORAL FORMULATIONS 83
ETOPOSIDE (VEPESID, VP 16 AND ETOPOSIDE PHOSPHATE) 84 PACLITAXEL 86
EUTECTIC MIXTURES OF LOCAL ANAESTHETICS 87
CICLOSPORIN (CYCLOSPORIN) 87
LUPRON DEPOT; PROSTAP SR AND PROSTAP 3 90
ZOLADEX 90
FLUOROQUINOLONE EYE DROPS 91
LONSYS: LONTOPHORETIC TRANSDERMAL DEVICE FOR FENTANYL 93 PARENTERALS 93
CHLORAMPHENICOL 95
MATERIALS USED IN DRUG DELIVERY 95
CONCLUSIONS 97
REFERENCES 98
5 ADVERSE EVENTS AND FORMULATIONS AND DEVICES 101
INTRODUCTION 101
DOSAGE FORM TYPE 103
REACTIONS TO IMPURITIES 105
IMAGE 4
CONTENTS | VII
ABNORMAL BIOAVAILABILITY, HIGH OR IOW 114
TESTING FOR ADVERSE EFFECTS 114
NANOSYSTEMS 116
CONCLUSIONS 118
REFERENCES 119
6 PAEDIATRIC, GERIATRIC AND SPECIAL FORMULATIONS 121
INTRODUCTION 121
EXTEMPORANEOUS FORMULATIONS 122
EFFECT OF FORMULATION AND PRESENTATION: A CASE FROM THE LITERATURE 124
EXTEMPORANEOUS FORMULATIONS AND PERFORMANCE 126 THE ELDERLY AND THEIR
MEDICATION 126
ENTERAL FEEDING 128
DRUG INTERACTIONS WITH NUTRIENT FORMULATIONS 131
CONCLUSIONS 131
REFERENCES 131
7 GENERIC MEDICINES: CONVENTIONAL DRUGS AND BIOLOGICALS 133
INTRODUCTION 133
REGULATORY STATEMENTS ON GENERIC PRODUCTS 134
GENERICS: A QUESTION OF QUALITY 135
SPECIFIC CONDITIONS AND GENERICS 137
READING AND DECONSTRUCTING THE LITERATURE ON BIOEQUIVALENCE 139
ANTIRETROVIRAL DRUGS 139
BIOEQUIVALENCE OF OPHTHALMIC PRODUCTS 141
THE CASE OF SEVOFLURANE 141
GENERIC BIOLOGICALS (BIOLOGICS) 144
CONCLUSIONS 146
REFERENCES 148
8 THE FUTURE: DELIVERY SYSTEMS FOR MODERN THERAPEUTICS 151
INTRODUCTION 151
PERSONALISED MEDICINE AND MEDICINES 151
DRUG DELIVERY AND PERSONALISED MEDICINES 152
TECHNOLOGIES 155
NANOTECHNOLOGY 160
CELL-BASED THERAPIES 165
GENETHERAPY 168
CONCLUSIONS 169
REFERENCES 169
INDEX 173
|
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| id | DE-604.BV036694167 |
| illustrated | Illustrated |
| indexdate | 2025-02-03T17:28:01Z |
| institution | BVB |
| isbn | 9780853696919 0853696918 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-020612744 |
| oclc_num | 696022199 |
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| owner | DE-19 DE-BY-UBM |
| owner_facet | DE-19 DE-BY-UBM |
| physical | XIII, 179 S. Ill., graph. Darst. 24 cm |
| publishDate | 2010 |
| publishDateSearch | 2010 |
| publishDateSort | 2010 |
| publisher | Pharmaceutical Press |
| record_format | marc |
| spellingShingle | Florence, Alexander T. 1940- An introduction to clinical pharmaceutics Pharmakokinetik (DE-588)4115557-9 gnd |
| subject_GND | (DE-588)4115557-9 |
| title | An introduction to clinical pharmaceutics |
| title_auth | An introduction to clinical pharmaceutics |
| title_exact_search | An introduction to clinical pharmaceutics |
| title_full | An introduction to clinical pharmaceutics Alexander T. Florence |
| title_fullStr | An introduction to clinical pharmaceutics Alexander T. Florence |
| title_full_unstemmed | An introduction to clinical pharmaceutics Alexander T. Florence |
| title_short | An introduction to clinical pharmaceutics |
| title_sort | an introduction to clinical pharmaceutics |
| topic | Pharmakokinetik (DE-588)4115557-9 gnd |
| topic_facet | Pharmakokinetik |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020612744&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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