Accelerated partial breast irradiation techniques and clinical implementation
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| 245 | 1 | 0 | |a Accelerated partial breast irradiation |b techniques and clinical implementation |c David E. Wazer ... (eds.) |
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| adam_text | Titel: Accelerated partial breast irradiation
Autor: Wazer, David E.
Jahr: 2009
1 Accelerated Partial Breast Irradiation: History,
Rationale, and Controversies 1
Thomas A. Buchholz and Eric A. Strom
1.1 Introduction 1
1.2 History of APBI 4
1.3 Controversies Regarding the Use of APBI 7
1.3.1 What Volume of Breast Tissue Is at Risk for Residual
Disease After Breast-Conserving Surgery? 7
1.3.2 Which Patients May Be the Most Appropriate for APBI? 10
1.3.3 Does APBI Deliver an Adequate Radiation Dose? 11
1.3.4 Can APBI Increase Rates of Normal Tissue Injury? 12
1.3.5 Convenience Benefits of APBI 12
1.3.6 Will APBI Increase Access to Medical Facilities
and Reduce Costs? 13
1.4 Conclusions 13
References 14
2 Who Is a Candidate for APBI? 19
Douglas W. Arthur, Frank A. Vicini, and David E. Wazer
2.1 Introduction 19
2.2 Pathologic Data 21
2.3 Anatomic Patterns of In-Breast Failure
After Breast-Conserving Treatment 22
2.4 Proper Selection Criteria 23
References 30
3 Pathologic Anatomy of Early-Stage Breast Cancer
and Its Relevance to APBI: Defining the Target 35
Shruti Jolly, Larry L. Kestin, Neal S. Goldstein,
and Frank A. Vicini
3.1 Determining the Extent of Disease Beyond the Lumpectomy Cavity 35
3.1.1 Mastectomy Studies 35
v
vi Contents
3.1.2 Re-excision Pathologic Studies 37
3.1.3 Recurrence Patterns in PBI 39
3.1.4 Composite Disease Extension 41
3.2 Impact of Radiation on Local Recurrences 41
3.3 Conclusions 43
References 43
4 The Radiobiology of Accelerated Partial Breast Irradiation 47
Alexandra Stewart and Roger Dale
4.1 General Radiobiology Principles 48
4.2 The Radiobiology of Breast Cancer 49
4.3 IntraoperativeAPBI 50
4.4 External-Beam APBI 51
4.5 Interstitial Implant APBI 52
4.6 Conclusion 54
References 55
5 Surgical Considerations in Partial Breast Irradiation 59
Alan Stolier
5.1 Introduction 59
5.2 Patient Selection 60
5.3 Tumor Location 60
5.3.1 Subareola Tumors 61
5.3.2 Axillary Tail 61
5.3.3 Inframammary Fold and Other Peripheral Locations 62
5.4 Cavity Shape and Size 63
5.4.1 Surgical Approach with Wire Localization 65
5.5 Technical Considerations 67
5.5.1 Superficial Tumors 68
5.5.2 Deep Tumors 68
5.5.3 Balloon Symmetry 68
5.5.4 Conformance 70
5.6 Impact of Oncoplastic Techniques on the Use of APBI 71
References 72
6 Physics of Accelerated Partial Breast Irradiation 73
Rupak K. Das and Bruce Thomadsen
6.1 Introduction 73
6.2 Interstitial Brachytherapy 74
6.2.1 Low Dose Rate Implants 74
6.2.2 High Dose Rate Implants 75
6.3 Intracavitary Volume Implants 79
6.3.1 MammoSite (Hologic, Bedford, MA, USA) 79
6.3.2 Contura (SenoRX, Aliso Viejo, CA, USA) 85
Contents vii
6.3.3 ClearPath (NAS Medical, Chatsworth, CA, USA) 86
6.3.4 SAVI (Cianna Medical, Aliso Viejo, CA, USA) 87
6.3.5 Electronic Brachytherapy 88
6.4 External Beam 95
6.4.1 Target Definition for External-Beam Approaches 95
6.4.2 External-Beam Techniques 96
References 99
7 Quality Assurance for Accelerated Partial Breast Irradiation 101
Bruce Thomadsen and Rupak Das
7.1 Quality Management for Breast Brachytherapy 101
7.1.1 Quality Assurance During the Implantation Process 101
7.1.2 Quality Assurance During Localization and Reconstruction 104
7.1.3 Quality Assurance of the Treatment Plan 110
7.1.4 Post-treatment Verification 120
7.2 Quality Management for External-Beam Partial Breast Irradiation 120
7.2.1 Quality Control During Patient Positioning 120
7.2.2 Quality Control During Treatment Planning 121
7.2.3 Quality Management at the Time of Treatment 123
References 123
8 Overview of North American Trials 125
Rakesh R. Patel and Sushil Beriwal
8.1 Introduction 125
8.2 Patient Selection 126
8.3 Interstitial Technique 127
8.3.1 William Beaumont Hospital 130
8.4 Tufts/Brown/Rhode Island 131
8.4.1 The Ochsner Clinic 131
8.4.2 University of Wisconsin 132
8.4.3 Virginia Commonwealth University 134
8.4.4 Massachusetts General Hospital 134
8.5 MammoSite Balloon 135
8.5.1 FDA Study 136
8.5.2 American Society of Breast Surgeons MammoSite
Breast Brachytherapy Registry Trial 137
8.5.3 VCU Compilation 138
8.6 External-Beam APBI 142
8.6.1 William Beaumont Hospital 143
8.6.2 New York University 144
8.6.3 MGH 144
8.6.4 RTOG0319 145
8.7 Conclusion 146
References 147
viii Contents
9 An Overview of European Clinical Trials of APBI 151
Csaba Polgar, Tibor Major, Vratislav Strnad, Peter Niehoff,
Oliver J. Ott, Katalin Lovey, and Gyorgy Kovacs
9.1 Introduction 151
9.2 Early European APBI Trials 151
9.2.1 Christie Hospital s External-Beam APBI Trial 153
9.2.2 Uzsoki Hospital s Cobalt-Needle Study 154
9.2.3 Guy s Hospital Studies 155
9.2.4 Florence Series 155
9.2.5 Royal Devon/Exeter Hospital Series 156
9.3 Contemporary European APBI Trials 156
9.3.1 Ninewells Hospital s Study 156
9.3.2 Orebro Series 158
9.3.3 National Institute of Oncology (Hungary) Studies 158
9.3.4 German-Austrian Multicentric Trial 161
9.4 European MammoSite Brachytherapy Trials 163
9.5 European (GEC-ESTRO) Multicentric Randomized APBI Trial 167
9.6 Summary and Future Directions 169
References 170
10 The Phase III Trials: Obtaining Definitive Answers 173
Douglas W. Arthur
10.1 Patient Selection and Study Eligibility 179
10.2 Target Delineation 180
10.3 Technique and Dosimetry 184
10.4 Quality Assurance 185
10.5 Conclusion 186
References 186
11 The Virginia Commonwealth University Technique
of Interstitial Brachytherapy 189
Laurie W. Cuttino and Douglas W. Arthur
11.1 History 189
11.2 Implantation Technique 191
11.2.1 Preprocedure Evaluation 191
11.2.2 Patient Preparation 191
11.2.3 Catheter Placement 192
11.3 Dosimetric Guidelines 197
11.4 Results 199
11.5 Conclusion 200
References 201
Contents ix
12 Accelerated Partial Breast Irradiation: The William
Beaumont Hospital Technique of Interstitial Brachytherapy 203
Peter Y.Chen
12.1 History 203
12.2 Physics 204
12.2.1 LDRDosimetry 204
12.2.2 HDRDosimetry 204
12.3 Implantation Technique 205
12.3.1 Open Cavity Technique 206
12.3.2 Closed Cavity Technique 208
12.4 Clinical Results 212
12.5 Future Directions 215
References 216
13 Brachytherapy Techniques: The Arizona Approach 219
Robert R. Kuske
13.1 Introduction: A 17-Year Historical Perspective
on the Evolution of Accelerated Partial Breast Irradiation 219
13.2 A New Hypothesis and a Potential Paradigm Shift 222
13.3 The Target Volume 223
13.4 Irradiating the Target Volume 224
13.5 Brachytherapy Techniques 225
13.5.1 Open Freehand Interstitial Catheter Insertion 225
13.5.2 Ultrasound-Guided Supine Catheter Insertion 227
13.5.3 Image-Guided Prone Catheter Insertion
with a Special Breast Template 229
13.5.4 CT-Guided Supine Catheter Insertion
with a Special Breast Template 231
13.5.5 Balloon Intracavitary Catheter Insertion 240
13.5.6 SAVI or Contura Insertions 241
13.6 Judgment: Selecting the Optimal Technique
for a Particular Patient 242
13.7 Summary 244
References 245
14 The MammoSite Technique for Accelerated Partial
Breast Irradiation 247
Martin Keisch and Frank A. Vicini
14.1 History of the Applicator 247
14.2 MammoSite and the FDA Trial 248
14.3 Physics of the MammoSite 250
14.3.1 General 250
14.4 Single Dwell vs. Multidwell 251
14.5 Elliptical MammoSite 253
x Contents
14.6 Contrast Effect 253
14.7 Implantation Techniques 253
14.8 Other Considerations 255
14.9 Appropriateness for Treatment 256
14.10 Clinical Results 258
14.11 Conclusions 261
References 261
15 Permanent Breast Seed Implants 263
Jean-Philippe Pignol and Brian M. Keller
15.1 Introduction 263
15.2 PBSI Challenges and Solutions 264
15.2.1 Radioprotection 264
15.2.2 Accuracy of the Seed Implant 264
15.2.3 Seed Motion 266
15.3 PBSI Preimplant Planning 268
15.3.1 Planning and Target Volume Segmentation 268
15.3.2 Dose Prescription 268
15.3.3 Seed Dosimetry Protocol 269
15.4 PBSI Procedure 271
15.4.1 Anesthesia 271
15.4.2 Patient Preparation 271
15.4.3 Implantation 271
15.5 Results 272
15.5.1 Patient Cohort 272
15.5.2 Dosimetry Outcomes 272
15.5.3 Clinical Outcomes 273
15.6 Discussion and Conclusion 273
References 274
16 3D Conformai External-Beam Technique 277
Yasmin Hasan and Frank A. Vicini
16.1 History 279
16.1.1 Rationale for External-Beam APBI 279
16.1.2 Prospective Randomized Data Comparing APBI
and External-Beam APBI to Whole Breast
Radiation Therapy 279
16.2 Physics and Techniques 281
16.2.1 Prone 3D Conformai APBI 281
16.2.2 Dose Fractionation Scheme for Postoperative
Supine and Prone External-Beam APBI 281
16.2.3 Novel Treatment Delivery Techniques
for 3D Conformai APBI 283
Contents xi
16.3 Clinical Results 284
16.3.1 Pilot Phase I Dose-Escalation Trial 284
16.3.2 Phase I/II Trial of Prone 3D Conformal
APBI: New York University 286
16.3.3 The William Beaumont Hospital Experience:
3D Conformal APBI in the Supine Position 288
16.3.4 William Beaumont Hospital Experience 292
16.3.5 Two-and Three-Year Clinical Experience
(William Beaumont Hospital) 293
16.3.6 RTOG0319 293
16.3.7 Massachusetts General Hospital Experience 294
16.4 Challenges and Limiting Factors in the Application
of 3D Conformal APBI 294
16.5 Future Directions 296
References 298
17 External-Beam Partial Breast Irradiation:
The New York University Prone Technique 301
Silvia Formenti and Stella Lymberis
17.1 External-Beam Partial Breast Irradiation 301
17.2 Selection of a Dose Fractionation Scheme
for Postoperative Prone EB-PBI 301
17.3 Rationale for Patient Selection Criteria
for Postoperative Prone EB-PBI 302
17.4 Rationale for Prone Patient Positioning 304
17.5 Phase I Trial Using the Prone Position (University
of Southern California) 306
17.6 Results of the Subsequent Phase I/II Protocol NYU 00-23
(New York University) 306
17.7 Preliminary Results of PBI Using Cone-Beam Imaging: NYU
Protocol 07-582 307
17.7.1 NYU 07-582: Dose Specification and Planning 308
17.7.2 Cone-Beam Imaging for PBI 308
17.7.3 Preliminary Clinical Results of NYU Protocol
07-582: Image Guidance for Prone PBI 309
17.8 Conclusions 311
References 311
18 APBI 3D Conformal External Beam: The MGH Technique 315
Shannon M. MacDonald, David P. Gierga, Brian Napolitano,
and Alphonse G. Taghian
18.1 Introduction 315
18.2 MGH External-Beam Technique in APBI 316
xii Contents
18.3 Position Verification 319
18.4 Initial Results of the MGH Protocol 321
18.5 External-Beam APBI Dosimetric Comparison 322
18.6 APBI with Protons 322
18.7 Conclusions 325
References 325
19 APBI with 50 kV Photons: Targeted Intraoperative
Radiotherapy (TARGIT) 327
Jay ant S. Vaidya
19.1 Individualizing Local Treatment for Breast Cancer 327
19.2 Radiotherapy Has a Dual Benefit: On the Seed and On the Soil! 329
19.3 Radiobiology of Intraoperative Radiotherapy 331
19.4 Intraoperative Radiotherapy: An Elegant Method
of Partial Breast Irradiation 334
19.5 The Intrabeam Machine and Surgical Technique 335
19.6 Results of Clinical Trials with the Intrabeam System 337
19.7 Health Economics 339
References 340
20 APBI Intraoperative Technique with Electrons 345
Roberto Orecchia, Giovanni B. Ivaldi, and Maria C. Leonardi
20.1 Introduction 345
20.2 Rationale for the Use of IOERT in Breast Cancer 346
20.3 Radiobiology 347
20.4 Radiation Technique 349
20.5 ELIOT After Quadrantectomy 351
20.5.1 Tumor Removal 351
20.5.2 Breast Mobilization 352
20.5.3 Thoracic Wall Protection 352
20.5.4 Breast Gland Reconstruction 352
20.5.5 IORT Collimator Placement and Connection
to the Linear Accelerator 354
20.5.6 Radiation Treatment 354
20.6 EIO Experience 356
20.6.1 Phase I/II Study 356
20.6.2 Prospective Randomized Phase III Study of ELIOT 358
20.6.3 21 Gy as Sole Treatment at EIO 358
20.7 21 Gy as Sole Treatment at Santa Chiara Hospital 359
20.8 The Experience at the University of North Carolina 360
20.9 IORT as a Boost 360
20.9.1 EIO Experience 361
20.10 ELIOT After Nipple-Sparing Mastectomy 362
References 363
Contents xiii
21 Intraoperative Radiation Therapy During
Breast-Conserving Surgery; the Memorial
Sloan-Kettering Cancer Center Technique 367
Kathryn Beal, Gil ad N. Cohen, Beryl McCormick,
Virgilio Sacchini, and Michael Zelefsky
21.1 Background 367
21.2 Patient Selection 370
21.3 Technique 370
21.4 The Milan Electron Beam IORT Technique 370
21.5 The MSKCC High Dose Rate Remote Afterloading
IORT Technique 371
21.6 Patient Management 373
21.7 Cosmetic Results 374
21.8 Clinical Results 375
21.9 Complications 375
21.10 Discussion 375
References 376
22 Normal Tissue Toxicity After Accelerated Partial Breast Irradiation 377
David E. Wazer and Jaroslaw T. Hepel
22.1 Terminology, Techniques, and Radiation Biology 378
22.2 Interstitial Brachytherapy: Toxicity Reports from Select
Single- and Multi-institutional Studies 380
22.2.1 Interstitial Brachytherapy: Dosimetric Variables 382
22.2.2 Interstitial Brachytherapy for APBI: Toxicity
Avoidance Guidelines 384
22.3 Intracavity Brachytherapy 385
22.3.1 MammoSite Brachytherapy for APBI: Toxicity
Avoidance Guidelines 390
22.3.2 Is There an Adverse Interaction Between
Brachytherapy APBI and Chemotherapy? 391
22.4 3D Conformal External-Beam APBI 391
22.4.1 3D Conformal External-Beam APBI:
Toxicity Avoidance Guidelines 392
22.5 Intraoperative APBI 392
22.6 Conclusion 393
References 393
23 Emerging Technologies Part I: New Brachytherapy
Catheter Systems 397
Rakesh R. Patel and Adam Dickler
23.1 Introduction 397
23.2 Background: Multicatheter Interstitial Brachytherapy 398
xiv Contents
23.3 Background: MammoSite Balloon Brachytherapy 399
23.4 Hybrid Intracavitary Devices 400
23.4.1 Design Rationale 400
23.4.2 Treatment Planning 400
23.4.3 Surgical Technique 402
23.4.4 SenoRx Contura 403
23.4.5 Supporting Data 403
23.4.6 SAVI 404
23.4.7 Supporting Data 404
23.4.8 ClearPath 405
23.4.9 Supporting Data 406
23.5 Conclusion 406
References 407
24 Emerging Technologies Part II: Novel Sources and Delivery Systems 409
Jaroslaw T. Hepel, Shirin Sioshansi, Mark J. Rivard, and David E. Wazer
24.1 Introduction 409
24.2 Electronic Brachytherapy 410
24.2.1 XoftAxxent System 410
24.2.2 XoftAxxent Dosimetry 411
24.2.3 Radiobiological Considerations for the Xoft
Axxent System 414
24.2.4 Xoft Axxent EBT Source Anisotropy 416
24.2.5 The Future Potential of Xoft Axxent: Variable Energy,
Beam Directionality, and Depth-Dose Modulation 418
24.2.6 Clinical Experience with Xoft Axxent 418
24.3 AccuBoost 419
24.3.1 Why is Image-Guided Noninvasive Breast
Brachytherapy Therapy Desirable? 420
24.3.2 AccuBoost Applicators and Dosimetry 423
24.3.3 Indications/Patient Selection 425
24.3.4 Special Circumstances 425
24.3.5 Conclusion 427
24.4 Alternative Radionuclides 428
24.4.1 Intraoperative Avidination for Radionuclide
Therapy (IART) 428
24.5 Conclusion 429
References 429
Index 431
|
| any_adam_object | 1 |
| author2 | Wazer, David E. |
| author2_role | edt |
| author2_variant | d e w de dew |
| author_facet | Wazer, David E. |
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| bvnumber | BV035861469 |
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| ctrlnum | (OCoLC)496226507 (DE-599)DNB994282338 |
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| dewey-ones | 616 - Diseases |
| dewey-raw | 616.9940642 |
| dewey-search | 616.9940642 |
| dewey-sort | 3616.9940642 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| edition | 2. ed. |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV035861469 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T22:06:23Z |
| institution | BVB |
| isbn | 9783540880059 9783540880066 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-018719313 |
| oclc_num | 496226507 |
| open_access_boolean | |
| owner | DE-29 |
| owner_facet | DE-29 |
| physical | XVIII, 436 S. Ill., graph. Darst. 24 cm |
| publishDate | 2009 |
| publishDateSearch | 2009 |
| publishDateSort | 2009 |
| publisher | Springer |
| record_format | marc |
| spelling | Accelerated partial breast irradiation techniques and clinical implementation David E. Wazer ... (eds.) 2. ed. Dordrecht [u.a.] Springer 2009 XVIII, 436 S. Ill., graph. Darst. 24 cm txt rdacontent n rdamedia nc rdacarrier Literaturangaben Breast Neoplasms radiography Radiotherapy, Conformal methods Frühcarcinom (DE-588)4280820-0 gnd rswk-swf Brachytherapie (DE-588)4219194-4 gnd rswk-swf Strahlentherapie (DE-588)4057833-1 gnd rswk-swf Brustkrebs (DE-588)4008528-4 gnd rswk-swf Intraoperative Phase (DE-588)4515655-4 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Brustkrebs (DE-588)4008528-4 s Frühcarcinom (DE-588)4280820-0 s Brachytherapie (DE-588)4219194-4 s DE-604 Intraoperative Phase (DE-588)4515655-4 s Strahlentherapie (DE-588)4057833-1 s Wazer, David E. edt HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018719313&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Accelerated partial breast irradiation techniques and clinical implementation Breast Neoplasms radiography Radiotherapy, Conformal methods Frühcarcinom (DE-588)4280820-0 gnd Brachytherapie (DE-588)4219194-4 gnd Strahlentherapie (DE-588)4057833-1 gnd Brustkrebs (DE-588)4008528-4 gnd Intraoperative Phase (DE-588)4515655-4 gnd |
| subject_GND | (DE-588)4280820-0 (DE-588)4219194-4 (DE-588)4057833-1 (DE-588)4008528-4 (DE-588)4515655-4 (DE-588)4143413-4 |
| title | Accelerated partial breast irradiation techniques and clinical implementation |
| title_auth | Accelerated partial breast irradiation techniques and clinical implementation |
| title_exact_search | Accelerated partial breast irradiation techniques and clinical implementation |
| title_full | Accelerated partial breast irradiation techniques and clinical implementation David E. Wazer ... (eds.) |
| title_fullStr | Accelerated partial breast irradiation techniques and clinical implementation David E. Wazer ... (eds.) |
| title_full_unstemmed | Accelerated partial breast irradiation techniques and clinical implementation David E. Wazer ... (eds.) |
| title_short | Accelerated partial breast irradiation |
| title_sort | accelerated partial breast irradiation techniques and clinical implementation |
| title_sub | techniques and clinical implementation |
| topic | Breast Neoplasms radiography Radiotherapy, Conformal methods Frühcarcinom (DE-588)4280820-0 gnd Brachytherapie (DE-588)4219194-4 gnd Strahlentherapie (DE-588)4057833-1 gnd Brustkrebs (DE-588)4008528-4 gnd Intraoperative Phase (DE-588)4515655-4 gnd |
| topic_facet | Breast Neoplasms radiography Radiotherapy, Conformal methods Frühcarcinom Brachytherapie Strahlentherapie Brustkrebs Intraoperative Phase Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018719313&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT wazerdavide acceleratedpartialbreastirradiationtechniquesandclinicalimplementation |