Principles of evolutionary medicine
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| Format: | Buch |
| Sprache: | English |
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Oxford [u.a.]
Oxford Univ. Press
2009
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| Ausgabe: | 1. publ. |
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| 100 | 1 | |a Gluckman, Peter D. |d 1949- |e Verfasser |0 (DE-588)135774470 |4 aut | |
| 245 | 1 | 0 | |a Principles of evolutionary medicine |c Peter Gluckman ; Alan Beedle ; Mark Hanson |
| 250 | |a 1. publ. | ||
| 264 | 1 | |a Oxford [u.a.] |b Oxford Univ. Press |c 2009 | |
| 300 | |a XVI, 296 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
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| 650 | 4 | |a Medical anthropology | |
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| 700 | 1 | |a Hanson, Mark A. |d 1949- |e Verfasser |0 (DE-588)135774535 |4 aut | |
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| DE-BY-UBR_location | 91 |
| DE-BY-UBR_media_number | 069036343759 |
| _version_ | 1822724142144684032 |
| adam_text | Contents
Preface
xiii
PART
1
FUNDAMENTALS OF EVOLUTIONARY BIOLOGY
1
Introduction
3
1.1
What is disease?
4
1.2
What evolution is: fundamental principles
8
1.2.1
Selection
10
1.2.2
Variation and inheritance
10
1.2.3
Development and the life course
11
1.3
Time
13
1.4
Constraints
15
1.5
We are not alone
1 6
1.6
How evolutionary arguments fit alongside other
biological perspectives
17
1.7
Evolution and medicine
18
Key points
18
Further reading
18
2
Evolutionary theory
21
2.1
Introduction
21
2.2
What does evolutionary theory explain?
26
2.3
How does evolution work?
29
2.3.1
Variation
30
2.3.7.7
Mutation
31
2.3.1.2
Recombination
31
2.3.7.3
Constraints on variation
32
2.3.2
Selection
34
2.3.2.7
Artificial seleaion
34
2.3.2.2
Natural selection
34
2.3.2.3
Sexual selection
35
vi
CONTENTS
2.3.2.4
Levels of selection
36
2.3.2.5
Genes as units of selection
37
23.2.6
Extended phenotype
38
2.3.3
Inheritance
38
2.4
Areas of debate and the limitations of
adaptationist
argument
41
2.4.1
Does evolution have a direction?
41
2.4.2
Selection is not random
42
2.4.3
Is selection the only mechanism of evolution?
43
2.4.4
Is every feature of an organism an adaptation?
44
2.4.5
How do species evolve?
45
2.4.6
How fast is evolution?
47
2.4.7
How do we explain traits that appear to reduce fitness?
48
2.5
Conclusion
48
Key points
49
Further reading
49
3
The molecular basis of variation and inheritance
51
3.1
Introduction
51
3.2
Molecular basis of human genetic variation
52
3.2.1
What is a gene?
52
3.2.2
Mutation as a cause of sequence variation in the genome
53
3.2.3
SNPs
53
3.2.4
Indels
56
3.2.5
VNTRs
56
3.2.6
Transposable elements
56
3.2.7
Structural polymorphism
57
3.3
How different are any two individual genomes?
57
3.3.1
Recombination as a source of variation
58
3.3.2
Haplotypes and linkage
59
3.4
Factors affecting variation
60
3.4.1
How drift affects diversity
60
3.4.2
Molecular effects of selection
63
3.4.3
Signatures of selection
64
3.5
From genotype to phenotype
64
3.6
Why hasn t selection eliminated
monogenie
disease
from the population?
68
3.7
No single genes for common diseases
70
3.8
Non-genetic inheritance
71
3.9
Conclusion
74
Key points
74
Further reading
75
4
Evolution and development
77
4.1
Introduction
77
4.2
Development: pre-ordained or plastic?
79
CONTENTS
vii
4.3
Is development important?
80
4.4
Developmental plasticity
83
4.5
Responses to environmental cues during development
84
4.5.1
Developmental disruption
84
4.5.2
Adaptive responses in development
85
4.5.2.7
Immediately adaptive responses: coping
with the consequences
85
4.5.2.2
Predictive adaptive responses
86
4.6
Epigenetic mechanisms
88
4.7
Intergenerational effects
90
4.8
Learning and instinct
92
4.9
Evolution of novelty
92
4.10
Conclusion
94
Key points
96
Further reading
96
5
Evolution of life histories
97
5.1
Introduction
97
5.2
General overview of life history theory
98
5.2.1
Key trade-offs in life histories
98
5.2.7.7
Number versus quality of offspring
100
5.2.7.2
Current versus future reproduction
100
5.2.7.3
Age versus size at maturity
101
5.2.1.4
Fecundity versus lifespan
101
5.2.2
Extrinsic and intrinsic mortality
102
5.2.3
Extrinsic mortality and age at menarche
104
5.2.4
Lifespan and ageing
105
5.2.5
Evolutionary theories of senescence
106
5.3
Body size and shape
108
5.3.1
Allometry
109
5.3.2
Variation in growth and development
109
5.4
Growth in humans
112
5.4.1
Phases of growth
112
5.4.2
Puberty
114
5.5
Evolutionary analysis of the distinct features of human growth
116
5.5.1
The childhood phase
117
5.5.2
Pubertal
growth spurt
118
5.5.3
Reproductive decline and the menopause
119
5.6
Conclusion: interpreting the human life history
120
Key points
121
Further reading
121
б
Human evolution and the origins of human diversity
123
6.1
Introduction
123
6.2
The hominoid clade
123
viii
CONTENTS
б.З
Hominin
evolution
6.3.1
Timeline and species
6.3.2
Bipedalism
6.3.3
Body size
6.3.4
Face, jaw, and dentition
6.3.5
Gastrointestinal tract
6.3.6
The hairless ape
6.3.7
The hominin brain
6.3.8
Tool making
6.3.9
Language
6.3.10
Culture and society
6.3.11
Cultural evolution
6.4
Human adaptation to local selection pressures
6.4.1
Hominin origins and migrations: out of Africa again
6.4.2
Variation caused by migration
6.4.3
Variation caused by change in lifeways
6.5
Are humans still evolving?
6.6
Social implications of human diversity
6.7
Conclusion
Key points
Further reading
124
124
127
128
128
129
129
129
134
135
137
139
141
141
143
144
144
146
147
147
147
PART
2
UNDERSTANDING HUMAN DISEASE FROM AN EVOLUTIONARY
PERSPECTIVE
Reproduction
151
7.1
Introduction
7.2
Sexual reproduction
7.3
Why did sex evolve?
7.4
Sex determination
7.5
Reproductive strategies
7.6
Mate choice
7.7
Sexual differences in the human
7.8
Gender differences in morbidity and mortality
7.9
The human reproductive cycle
7.9.1
Puberty
7.9.2
The timing of puberty
7.9.3
Why menstruate?
7.9.4
Pregnancy
7.9.5
The placenta
7.9.6
Maternal-fetal interactions
7.9.7
Regulation of fetal growth
7.9.8
Conflict in development
7.9.9
Lactation and postnatal care
7.9.10
The menopause
151
152
152
155
155
156
160
161
162
162
163
166
166
167
168
170
172
172
173
CONTENTS ix
7.10
Conclusion: reproduction
and evolution
175
Key points
176
Further reading
177
8
Nutritional and metabolic adaptation
179
8.1
Introduction
179
8.2
Strategies for energy storage
179
8.3
Human diet: an evolutionary history
182
8.3.1
Pre-agricultural hominins
182
8.3.7.7
Anatomical evidence for diet quality
in early humans
183
8.3.1.2
Modern foraging populations: what do
they teach us?
184
8.3.2
The Neolithic Revolution
186
8.3.3
The modern nutrition transition
187
8.3.4
Well fed but poorly nourished
188
8.4
How can change in the environment increase disease risk?
192
8.4.1
A thrifty genotype?
192
8.4.7.7
Search for thrifty genes
192
8.4.7.2
Was there feast and famine?
194
8.4.7.3
Has post-agricultural famine
selected thrifty genes?
194
8.5
Does evolutionary novelty explain current patterns of
metabolic disease and obesity?
197
8.6
A developmental perspective: the missing link?
198
8.6.1
Maladaptive consequences of an adaptive process
201
8.6.2
Developmental plasticity in the setting of evolutionary novelty
203
8.6.3
Other possible developmental pathways
205
8.7
Conclusion
206
Key points
208
Further reading
208
9
Defence
211
9.1
Introduction
211
9.2
Prédation
and conspecific violence
211
9.2.1
Stress
212
9.2.2
Developmental changes in stress responses: adaptive prediction
213
9.3
Dealing with infection
216
9.3.1
Commensals
216
9.3.2
Pathogen emergence
217
9.3.3
Virulence
218
9.3.4
Antibiotic resistance
221
9.3.5
Microbiota and the human genome
221
9.3.6
Innate immunity
222
9.3.7
Adaptive immunity
224
χ
CONTENTS
9.3.8
Vaccination
226
9.3.9
Dysregulation
of the immune system
227
9.3.9.7
Autoimmune disease
227
93.9.2
Developmental regulation of immunity
227
9.3.93
Allergies and chronic inflammatory disorders
227
9.4
Other threats
228
9.5
Injury
229
9.6
Sleep and repair
230
9.7
Conclusion
230
Key points
231
Further reading
231
Stress responses
231
Defence
231
Detoxification
231
10
Social organization and behaviour
233
10.1
Introduction
233
10.2
Biological determinants of culture and behaviour
233
10.3
Evolution of human brain and behaviour
234
10.4
Evolution of social behaviour
236
10.4.1
Altruism
237
10.4.2
Selfishness and selfish genes
239
10.4.3
Emotions: Darwinian algorithms of the mind
242
10.4.4
Love, jealousy, marriage, and inheritance
242
10.4.5
Group behaviour and morality
244
10.4.6
Belief and religion
244
10.4.7
Learning
245
10.5
Evolutionary perspectives on psychology
246
10.6
Evolutionary psychiatry
248
10.6.1
Personality traits and disorders
248
10.6.2
Disorders of mood
249
70.6.2.7
Anxiety
249
70.6.22
Phobias
249
7 0.6.2.3
Depression and bipolar disorder
250
10.6.3
Psychoses
251
10.7
Conclusion
251
Key points
253
Further reading
253
PART
3
AN EVOLUTIONARY FRAMEWORK FOR HEALTH AND DISEASE
11
Evolutionary principles applied to medical practice
257
11.1
Introduction
257
11.2
Fundamental principles of evolutionary medicine
258
CONTENTS
xi
11.3
Why has evolution left our bodies vulnerable to disease?
259
11.4
An evolutionary classification of ultimate mechanisms
affecting disease risk
260
Π
.4.1
Pathway
1 :
an evolutionarily mismatched or novel environment
260
11.4.2
Pathway
2:
life history-associated factors
263
11.4.3
Pathway
3:
excessive and uncontrolled defence mechanisms
264
11.4.4
Pathway
4:
losing the evolutionary arms race
264
11.4.5
Pathway
5:
results of evolutionary constraints
265
11.4.6
Pathway
6:
an apparently harmful
alíele
is maintained
by balancing selection
266
11.4.7
Pathway
7:
sexual selection and competition
and their consequences
266
11.4.8
Pathway
8:
the outcomes of demographic history
267
11.5
Cultural evolution and disease
268
11.6
Evolutionary perspectives and cancer
268
11.6.1
Evolutionarily novel environments and cancer
269
11.6.2
Relationships to life history traits
270
11.6.3
Cancer and the evolutionary arms race
271
11.6.4
Demographic history
271
11.7
Understanding disease from an evolutionary perspective
272
11.7.1
The medical history
272
11.7.2
An evolutionary evaluation of clinical signs and symptoms
272
11.8
Implications for prevention and therapy
273
11.9
The challenges of an evolutionary perspective in medicine
274
11.10
Conclusion
275
Key points
275
Further reading
276
12
Coda: evolution, medicine, and society
277
12.1
Society and evolution
277
12.2
Religion and evolution
279
12.3
Social Darwinism, eugenics, and political thought
279
12.4
Research directions
281
12.5
The future of Homo sapiens
281
Further reading
282
Index
283
Evolutionary science is critical to an understanding of
integrated human biology and is increasingly recognised
as a core underpinning discipline by medical and public health
professionals. Advances in the fields of genomics, epigenetics,
developmental biology, and epidemiology have led to the grow¬
ing realisation that incorporating evolutionary thinking is
essential for medicine to achieve its full potential. This is the
first integrated and comprehensive textbook to explain
the principles of evolutionary biology from a medical
perspective and to focus on how medicine and public
health might utilise evolutionary biology. It is written
in a style which is accessible to a broad range of readers,
whether or not they have had formal exposure to
evolutionary science.
Principles of Evolutionary Medicine is divided into three
sections: the first provides a systematic approach to the principles
of evolutionary biology as they apply to human health and
disease, using examples specifically relevant to medicine.
It incorporates chapters on evolutionary processes, molecular
evolution, the evolution of humans, life history theory,
and evolutionary-developmental biology. The second
part illustrates the application of these principles to our
understanding of nutrition and metabolism, reproduction,
combatting infectious disease and stress, and human
behaviour. The final section provides a general frame¬
work to show in practical terms how the principles of
evolutionary medicine can be applied in medical practice
and public health.
This novel textbook provides the necessary toolkit
for doctors and other health professionals, medical
students and
biomedical
scientists, as well as
anthropologists interested in human health, to
gain a better understanding of the evolutionary
processes underlying human health and disease.
|
| any_adam_object | 1 |
| author | Gluckman, Peter D. 1949- Beedle, Alan Hanson, Mark A. 1949- |
| author_GND | (DE-588)135774470 (DE-588)135774535 |
| author_facet | Gluckman, Peter D. 1949- Beedle, Alan Hanson, Mark A. 1949- |
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| author_sort | Gluckman, Peter D. 1949- |
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| ctrlnum | (OCoLC)313664861 (DE-599)BVBBV035715099 |
| dewey-full | 610.1 616/.042 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 610 - Medicine and health 616 - Diseases |
| dewey-raw | 610.1 616/.042 |
| dewey-search | 610.1 616/.042 |
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| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| edition | 1. publ. |
| format | Book |
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| id | DE-604.BV035715099 |
| illustrated | Illustrated |
| indexdate | 2024-12-23T22:25:48Z |
| institution | BVB |
| isbn | 9780199236398 0199236399 9780199236381 0199236380 |
| language | English |
| lccn | 2009013842 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-017991967 |
| oclc_num | 313664861 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-11 |
| owner_facet | DE-355 DE-BY-UBR DE-11 |
| physical | XVI, 296 S. Ill., graph. Darst. |
| publishDate | 2009 |
| publishDateSearch | 2009 |
| publishDateSort | 2009 |
| publisher | Oxford Univ. Press |
| record_format | marc |
| spellingShingle | Gluckman, Peter D. 1949- Beedle, Alan Hanson, Mark A. 1949- Principles of evolutionary medicine Medical anthropology Human evolution Medical genetics Evolutionsmedizin (DE-588)7718082-3 gnd Anthropologie (DE-588)4002230-4 gnd Evolutionsbiologie (DE-588)4153283-1 gnd Genetik (DE-588)4071711-2 gnd |
| subject_GND | (DE-588)7718082-3 (DE-588)4002230-4 (DE-588)4153283-1 (DE-588)4071711-2 |
| title | Principles of evolutionary medicine |
| title_auth | Principles of evolutionary medicine |
| title_exact_search | Principles of evolutionary medicine |
| title_full | Principles of evolutionary medicine Peter Gluckman ; Alan Beedle ; Mark Hanson |
| title_fullStr | Principles of evolutionary medicine Peter Gluckman ; Alan Beedle ; Mark Hanson |
| title_full_unstemmed | Principles of evolutionary medicine Peter Gluckman ; Alan Beedle ; Mark Hanson |
| title_short | Principles of evolutionary medicine |
| title_sort | principles of evolutionary medicine |
| topic | Medical anthropology Human evolution Medical genetics Evolutionsmedizin (DE-588)7718082-3 gnd Anthropologie (DE-588)4002230-4 gnd Evolutionsbiologie (DE-588)4153283-1 gnd Genetik (DE-588)4071711-2 gnd |
| topic_facet | Medical anthropology Human evolution Medical genetics Evolutionsmedizin Anthropologie Evolutionsbiologie Genetik |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017991967&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017991967&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT gluckmanpeterd principlesofevolutionarymedicine AT beedlealan principlesofevolutionarymedicine AT hansonmarka principlesofevolutionarymedicine |