Multidisciplinary approach to cancer care
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| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Philadelphia, PA
Saunders
2009
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| Schriftenreihe: | Surgical clinics of North America
89,1 |
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| Online-Zugang: | Inhaltsverzeichnis |
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| 245 | 1 | 0 | |a Multidisciplinary approach to cancer care |c guest ed. Kimberly M. Brown ; Margo Shoup |
| 264 | 1 | |a Philadelphia, PA |b Saunders |c 2009 | |
| 300 | |a XVI, 294 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 490 | 1 | |a Surgical clinics of North America |v 89,1 | |
| 650 | 4 | |a Cancer |x Surgery | |
| 650 | 4 | |a Cancer |x Treatment | |
| 650 | 4 | |a Neoplasms |x therapy | |
| 700 | 1 | |a Brown, Kimberly M. |e Sonstige |0 (DE-588)1060778955 |4 oth | |
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Datensatz im Suchindex
| DE-19_call_number | 0760/8 Med.GZ 268(89,1 |
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| adam_text | Titel: Multidisciplinary approach to cancer care
Autor: Brown, Kimberly M.
Jahr: 2009
Contents
Foreword xiii
Ronald F. Martin
Preface xv
Kimberly M. Brown and Margo Shoup
The Molecular Basis of Cancer and the Development of Targeted Therapy 1
Lee B. Riley and Darius C. Desai
The sequencing of the human genome and the ability to rapidly identify
genes and proteins, both normal and mutant, that are involved in tumori-
genesis and malignant phenotypes, have changed the ability to under¬
stand malignant cells. Understanding and applying this information to
the diagnosis and treatment of cancer are facilitated best with a multidisci-
plinary team. The cancer surgeon plays a pivotal role in this team. This ar¬
ticle briefly summarizes: (1) the clinically relevant applications of molecular
biology to the cancer surgeon, (2) the current understanding of the molec¬
ular basis for cancer, and (3) the current targeted agents and their clinical
applications.
Measuring Outcomes in Oncology Treatment: The Importance of Patient-Centered
Outcomes 17
Aundrea Oliver and Caprice C. Greenberg
An important component of quality healthcare is that it be patient-centered
with a focus on the patient, including his or her preferences, values, and be¬
liefs. The goal of this article is to provide a broad overview of patient-cen¬
tered outcomes in oncologic research. It starts with an introduction to the
different types of patient-centered measures including patient satisfaction,
decision regret, patient preference, and health-related quality of life. It then
offers an overview of survey instrument design and selection. Finally, it pro¬
vides examples of existing approaches to measurement and previously val¬
idated instruments for each type of patient-centered outcome.
Surgical Palliation: Getting Back to Our Roots 27
Alan A. Thomay, David P. Jacques, and Thomas J. Miner
This article provides an overview of the approach to patients who may
benefit from palliative care. While the article s details lend themselves
to the treatment of complications secondary to advanced malignancies,
the data herein can also be extrapolated to other chronic, terminal dis¬
eases. Guidelines for patient selection are discussed, using currently
available outcomes data as a platform for the critical decision making
process. Suggestions for a multidisciplinary team approach are offered,
using the palliative triangle as the ideal model of communication and co¬
operation. Finally, methods for measuring success are detailed, along
with proposals for how to better equip the surgeons of tomorrow with
the knowledge and experience needed to tackle these difficult and inti¬
mate problems.
Multimodal Treatment for Head and Neck Cancer 43
Miriam N. Lango
Head and neck cancers are relatively less common tumors, but with com¬
plex anatomic and physiologic relationships to the structures from which
they arise. Multimodal management is required for advanced stage dis¬
ease, while single modality treatment is usually sufficient for early lesions.
Treatment paradigms have shifted toward more functional preservation of
speech and swallowing, when possible. Increased use of radiation, sys¬
temic/targeted therapies and function-preserving surgical approaches
have allowed for organ preservation without compromising oncologic out¬
comes in properly selected patients.
The Role of Invasive Treatments in Surgical Oncology 53
Mark S. Choh and James A. Madura II
This article reviews the use of minimally invasive surgical and endo-
scopic techniques in the field of surgical oncology. It reviews the indica¬
tions and techniques of the use of minimally invasive surgery for several
oncologic indications in general surgery. In particular, it reviews the cur¬
rently published literature discussing the oncologic outcomes of these
techniques.
Multidisciplinary Approach to Esophageal and Gastric Cancer 79
Roderick M. Quiros and Courtney L. Bui
The incidence of esophageal and gastric malignancies has increased over
the last decade. Historically, surgery has been considered the best treat¬
ment for these cancers. However, long-term survival after surgery is fair at
best, because of the tendency of disease to recur locally and distantly.
Presently, the management of these cancers involves surgery, chemother¬
apy, and radiation therapy. This article discusses various treatment strat¬
egies that employ these modalities either alone or in combination, in an
attempt to improve survival rates for patients who have gastroesophageal
malignancies.
Liver-Directed Treatment Modalities for Primary and Secondary Hepatic Tumors 97
Brett Yamane and Sharon Weber
Colorectal cancer liver metastases and hepatocellular carcinoma remain
significant health problems in the United States and worldwide. Although
surgical resection is often the treatment of choice, patient comorbidities
or disease extent may preclude this option. Alternative approaches to pri¬
mary and secondary hepatic malignancies have been developed, and their
impact on disease control has been the subject of much recent study.
These therapies can be administered alone but can also be effective
when used in combination, or with other chemotherapeutic regimens.
This article reviews the different techniques of liver-directed therapy and
the available literature on short- and long-term outcomes.
Multidisciplinary Approach to Tumors of the Pancreas and Biliary Tree 115
Kimberly M. Brown
Tumors of the pancreas and biliary tree remain formidable challenges to
patients and clinicians. These tumors elude early detection, rapidly spread
locally and systemically, and frequently recur despite apparently complete
resection. Cystic tumors of the pancreas, however, may represent a subset
of patients who do not uniformly require aggressive resection, and
a thoughtful, evidence-based approach to work-up allows for the rational
application of surgical therapy. Increasing evidence supports treating pa¬
tients who have pancreaticobiliary disease in a multidisciplinary setting.
Multidisciplinary Care for Patients with Breast Cancer 133
Melissa C. Hulvat, Nora M. Hansen, and Jacqueline S. Jeruss
The care of patients with breast cancer has become increasingly complex
with advancements in diagnostic modalities, surgical approaches, and ad¬
juvant treatments. A multidisciplinary approach to breast cancer care is
essential to the successful integration of available therapies. This article
addresses the key components of multidisciplinary breast cancer care,
with a special emphasis on new and emerging approaches over the past
10 years in the fields of diagnostics, surgery, radiation, medical oncology,
and plastic surgery.
The Multidisciplinary Management of Rectal Cancer 177
Kenneth L. Meredith, Sarah E. Hoffe, and David Shibata
Advancements have been made in multiple aspects of diagnostic and ther¬
apeutic approaches to rectal cancer. These advances include clinical
staging such as endorectal ultrasound and pelvic MRI, surgical ap¬
proaches such as transanal excision, and adjuvant treatments such as
new chemotherapeutic agents and refined radiotherapy techniques. Opti¬
mal patient outcomes depend on multidisciplinary involvement for tailored
therapy. The successful management of rectal cancer requires a multidis¬
ciplinary approach, with treatment decisions based on precise patient
evaluations by a group of clinicians, including surgeons, gastroenterolo-
gists, medical and radiation oncologists, radiologists, and pathologists.
The accurate identification of patients who are candidates for combined
modality treatment is particularly essential to optimize outcomes. Techni¬
cal and technologic advances have led to the availability of a wide range of
surgical approaches for managing rectal cancer. Concomitantly, similar
critical developments and refinements have also occurred in the adminis¬
tration of radiation and chemotherapeutic agents. This article provides an
overview of the multimodal treatment of patients who have rectal cancer,
with a focus on staging, surgical techniques, and the application of che¬
motherapy or radiation in the adjuvant and neoadjuvant settings.
Multidisciplinary Treatment of Gastrointestinal Stromal Tumors 217
T. Peter Kingham and Ronald P. DeMatteo
Gastrointestinal stromal tumor (GIST) has been recognized as a unique tu¬
mor only in the last decade. Although rare as a clinical entity, there is much
interest in the pathology and treatment because the KIT protooncogene
mutation common to most GISTs can be inhibited by imatinib mesylate.
Diagnosing and treating GIST requires a multidisciplinary approach, given
the combination of pathologic and radiographic evaluation, surgical treat¬
ment, and oncologic care required to successfully treat patients with GIST.
Soft Tissue Sarcomas: Current Management and Future Directions 235
Robert J. Kenney, Richard Cheney, Margaret A. Stull, and William Kraybill
This article reviews the current state of diagnosis and treatment of soft tis¬
sue sarcomas. Etiology, staging, imaging, tissue sampling, and current
treatment are all reviewed using updated references. Current standards
for surgical treatment are emphasized and the future directions of treat¬
ment addressed.
The Surgical and Systemic Management of Neuroendocrine Tumors of the Pancreas 249
Gerard J. Abood, Aileen Go, Deepak Malhotra, and Margo Shoup
Neuroendocrine tumors of the pancreas comprise a class of rare tumors
that can be associated with symptoms of hormone overproduction. Five
distinct clinical endocrinopathies are associated with neuroendocrine tu¬
mors; however, most of these tumors remain asymptomatic and follow
an indolent course. Complete surgical resection offers the only hope for
cure, but understanding the basic biology of the tumors has advanced
the medical management in metastatic disease. Surgical resection of
hepatic metastases offers survival advantage and should be performed
when feasible. Although hepatic artery embolization is currently the pre¬
ferred mode of nonsurgical palliation for pain and hormonal symptoms,
other modalities may play a role in metastatic disease.
Multidisciplinary Treatment of Primary Melanoma 267
Katharine Yao, Glen Balch, and David J. Winchester
This article covers the multidisciplinary treatment of primary melanoma.
Excision margins and the need for sentinel lymphadenectomy are mainly
dictated by the Breslow thickness although exceptions to this dictum do
exist. Interferon is the only FDA approved adjuvant therapy for high risk
melanoma although its overall survival benefit is minimal. Trials examining
different doses or duration of interferon therapy have not demonstrated
any promising survival data so far. There have been several randomized
vaccine trials for melanoma but none have shown an overall survival ben¬
efit. Research into T-cell regulation continues and will hopefully bring
promise for the future of melanoma treatment.
Index 283
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| language | English |
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| physical | XVI, 294 S. Ill., graph. Darst. |
| publishDate | 2009 |
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| record_format | marc |
| series | Surgical clinics of North America |
| series2 | Surgical clinics of North America |
| spellingShingle | Multidisciplinary approach to cancer care Surgical clinics of North America Cancer Surgery Cancer Treatment Neoplasms therapy |
| title | Multidisciplinary approach to cancer care |
| title_auth | Multidisciplinary approach to cancer care |
| title_exact_search | Multidisciplinary approach to cancer care |
| title_full | Multidisciplinary approach to cancer care guest ed. Kimberly M. Brown ; Margo Shoup |
| title_fullStr | Multidisciplinary approach to cancer care guest ed. Kimberly M. Brown ; Margo Shoup |
| title_full_unstemmed | Multidisciplinary approach to cancer care guest ed. Kimberly M. Brown ; Margo Shoup |
| title_short | Multidisciplinary approach to cancer care |
| title_sort | multidisciplinary approach to cancer care |
| topic | Cancer Surgery Cancer Treatment Neoplasms therapy |
| topic_facet | Cancer Surgery Cancer Treatment Neoplasms therapy |
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