Molecular pathology the molecular basis of human disease
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| Sprache: | English |
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Elsevier, Acad. Press
2009
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| 020 | |a 9780123744197 |9 978-0-12-374419-7 | ||
| 020 | |a 0123744199 |9 0-12-374419-9 | ||
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| 245 | 1 | 0 | |a Molecular pathology |b the molecular basis of human disease |c ed. by William B. Coleman ... |
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier, Acad. Press |c 2009 | |
| 300 | |a XIX, 636 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 7 | |a pathology |2 cabt | |
| 650 | 7 | |a man |2 cabt | |
| 650 | 7 | |a molecular biology |2 cabt | |
| 650 | 7 | |a human diseases |2 cabt | |
| 650 | 4 | |a Cytogenetic Analysis |x methods | |
| 650 | 4 | |a Molecular Biology |x methods | |
| 650 | 4 | |a Molecular biology | |
| 650 | 4 | |a Pathology, Clinical |x methods | |
| 650 | 4 | |a Pathology, Molecular | |
| 650 | 0 | 7 | |a Molekularpathologie |0 (DE-588)4170396-0 |2 gnd |9 rswk-swf |
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| 700 | 1 | |a Coleman, William B. |e Sonstige |4 oth | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-017153030 | ||
Datensatz im Suchindex
| _version_ | 1804138668580929536 |
|---|---|
| adam_text | Contents
List of Contributors
xi
Preface
xv
Foreword
xvii
Acknowledgments
xix
Essential Pathology
-
Mechanisms of Disease
Chapter
1
Molecular Mechanisms of Cell Death
3
John J. Lemasters,
M.Ü.,
Ph.D.
Introduction
3
Modes of Cell Death
3
Structural Features of Necrosis and Apoptosis
3
Cellular and Molecular Mechanisms Underlying
Necrotic Cell Death
б
Pathways to Apoptosis
12
Mitochondria
15
Nucleus
18
Endoplasmic Reticulum
18
Lysosomes
18
Concluding Remark
19
Chapter
3
Infection and Host Response
41
Margret
D.
Oethinger, M.D.,
Ph.D., and Sheldon M.
Campbell, M.D., Ph.D.
Microbes and Hosts
—
Balance of Power?
41
The Structure of the Immune Response
41
Regulation of Immunity
43
Pathogen Strategies
43
The African Trypanosome and Antibody Diversity:
Dueling Genomes
43
Staphylococcus Aureus: the Extracellular
Battleground
48
Mycobaclerium Tuberculosis and the
Macrophage
52
Herpes Simplex Virus: Taking Over
55
HIV:
The Immune Guerilla
57
Perspectives
60
Chapter
4
Neoplasia
63
William B. Coleman, Ph.D., and
Tara C.
Rubinas, M.D.
Introduction
63
Cancer Statistics and Epidemiology
63
Classification of Neoplastic Diseases
70
Characteristics of Benign and Malignant
Neoplasms
78
Clinical Aspects of
Neoplasia
82
Chapter
2
Acute and Clironic Inflammation Induces
Di>sease Pathogenesis
25
Vladislav Dolgachev, PhJ)., and Nicholas W.
Lukacs, Ph.D.
Introduction
25
Leukocyte Adhesion, Migration, and Activation
25
Acute Inflammation and Disease Pathogenesis
28
Pattern Recognition Receptors and Inflammatory
Responses
29
Chronic Inflammation and Acquired Immune
Responses
32
Tissue Remodeling During Acute and Chronic
Inflammatory Disease
34
II Concepts in Molecular
Biology and Genetics
Chapter
5
Basic Concepts in Human Molecular
Genetics
89
Kara A. Mensink, M.S., C.G.C, and W. Edward
Highsmith, Ph.D.
Introduction
89
Contents
Molecular
Structure
of
DNi^,
DNA
Transcription,
and Protein Translation
89
Molecular Pathology and
DNA
Repair
Mechanisms
92
Modes of Inheritance
96
Central Dogma and Rationale for Genetic
Testing
101
Allelic Heterogeneity and Choice of Analytical
Methodolog) 104
Conclusion
107
Chapter
6
The Human Genome: Implications for the
Understanding of Human Disease
109
Ashley
G. Rivenbark,
Ph.D.
Introduction
109
Structure and Organization of the Human
Genome
109
Overview of the Human Genome Project 111
Impact of the Human Genome Project on the
Identification of Disease-Related Genes
113
Sources of Variation in the Human Genome
115
Types of Genetic Diseases
116
Genetic Diseases and Cancer
11*7
Perspectives
119
Chapter
7
The Human
Transcriptome:
Implications
for the Understanding of Human
Disease
123
Matthias E. Futschik, Ph.D., Wolfgang Kemmner, Ph.D.,
Reinhold Schäfer,
Ph.D., and Christine
Sers,
Ph.D.
Introduction
123
Gene Expression Profiling: The Search for Candidate
Genes Involved in Pathogenesis
123
Transcriptome
Analysis Based on Microarrays: Technical
Prerequisites
126
Microarrays: Bioinformatic Analysis
130
Microarrays: Applications in Basic Research and
Translational Medicine
137
Perspectives
146
Chapter
8
The Human Epigenome: Implications for the
Understanding of Human Disease
151
Maria Berdasco, Ph.D., and Manel Esteller, Ph.D.
Introduction
151
Epigenetic Regulation of the Genome
151
Genomic Imprinting
152
Cancer Epigenetics
154
Human Disorders Associated with Epigenetics
157
Environment and the Epigenome
160
Chapter
9
Clinical Proteomics and Molecular
Pathology
165
Lance A. Liotta, M.D., Ph.D., Virginia
Espina,
M.S., M.T.,
Claudia Fredolini, Ph.D., Weidong Zhou, M.D., Ph.D.,
and
Emanuel Petricoin,
Ph.D.
Understanding Cancer at the Molecular Level: An
Evolving Frontier
165
Microdissection
Technolog)-
Brings Molecular Analysis
to the Tissue Level
165
Serum Proteomics: An Emerging Landscape for Early
Stage Cancer Detection
174
Chapter
10
Integrative
Systems Biology: Implications for
the Understanding of Human Disease
185
M. Michael Barmada, Ph.D., and David C.
Whitcomb, M.D., Ph.D.
Introduction
185
Data Generation
186
Data Integration
188
Modeling Systems
189
Implications for Understanding Disease
190
Discussion
192
III Principles and Practice of
Molecular Pathology
Chapter
11
Pathology: The Clinical Description of
Human Disease
197
William K. Funkhouser, M.D., Ph.D.
Introduction
197
Terms, Definitions, and Concepts
197
A Brief History of Approaches to Disease
198
Current Practice of Pathology
203
The Future of Diagnostic Pathology
206
Conclusion
207
Chapter
12
Understanding Molecular Pathogenesis: The
Biological Basis of Human Disease and
Implications for Improved Treatment of
Human Disease
209
William B. Coleman, Ph.D., and Gregory J. Tsongalis, Ph.D.
Introduction
209
Hepatitis
С
Virus Infection
209
Acute Myeloid Leukemia
212
Cystic Fibrosis
213
Chapter
13
Integration of Molecular and Cellular
Pathogenesis: A Bioinformatics
Approach
219
Jason H. Moore, Ph.D., and
С
Harker
Rhodes, M.D.,
Ph.D.
Introduction
219
Overview of Bioinformatics
220
Database Resources
221
Data Analysis
222
The Future of Bioinformatics
223
Contents
IV
Molecular
Pathology of
Human Disease
Chapter
14
Molecular Basis of Cardiovascular Disease
227
Amber Chang Liu, and Avrum I. Gotlieb, M.D.C.M.
Introduction
227
General Molecular Principles of Cardiovascular
Diseases 22V
The Cells of Cardiovascular Organs
227
Atherosclerosis
232
Ischemie
Heart Disease
235
Aneurysms
235
Vasculitis
236
Valvular Heart Disease
236
Cardiomyopathies
238
Chapter
15
Molecular Basis of
Hemostatic
and
Thrombotic Diseases
247
Alice D.
Ma, M.D.,
and Nigel S. Key, M.D.
Introduction and Overview of Coagulation
247
Disorders of Soluble Clotting Factors
249
Disorders of Fibrinolysis
256
Disorders of Platelet Number or Function
256
Thrombophilia
260
Chapter
16
Molecular Basis of Lymphoid and Myeloid
Diseases
265
Joseph R. Biggs, Ph.D., and Dong-Er Zhang, Ph.D.
Development of the Blood and Lymphoid
Organs
265
Myeloid Disorders
271
Lymphocyte Disorders
279
Chapter
17
Molecular Basis of Diseases of
Immunity
291
David
O. Beenhouwer, M.D.
Introduction
291
Normal Immune System
291
Major Syndromes
296
Chapter
18
Molecular Basis of Pulmonary
Disease
305
Carol
F,
Farcer, M.D., and
Dani S,
Zander, M.D.
Introduction
305
Neoplastic Lung and
Pleural
Diseases
305
Non-neoplastic Lung Disease
323
Obstructive Lung Diseases
323
Interstitial Lung Diseases
331
Pulmonary Vascular Diseases
338
Pulmonary Infections
342
Pulmonary Histiocytic Diseases
352
Pulmonary Occupational Diseases
354
Developmental Abnormalities
356
Chapter
19
Molecular Basis of Diseases of the
Gastrointestinal Tract
365
Antonia
R.
Sepulveda, M.D., Ph.D., and
Dara L.
Aisner, M.D.,
Ph.D.
Introduction
365
Gastric Cancer
365
Colorectal Cancer
372
Chapter
20
Molecular Basis of Liver Disease
395
Satdarshan P. Singh
Monga, M.D.,
and Jaideep
Behari, M.D.,
Ph.D.
Introduction
395
Molecular Basis of Liver Development
395
Molecular Basis of I
¿ver
Regeneration
397
Adult Liver Stem Cells in Liver Health and
Disease
399
Molecular Basis of Hepatocyte Death
400
Molecular Basis of Nonalcoholic Fatty Liver
Disease
402
Molecular Basis of Alcoholic Liver Disease
406
Molecular Basis of Hepatic Fibrosis and
Cirrhosis
407
Molecular Basis of Hepatic Tumors
408
Chapter
21
Molecular Basis of Diseases of the
Exocrine
Pancreas
421
Matthias Sendler, Ph.D., Julia Mayerle, Ph.D., and
Markus
M.
Lerch, M.D.
Acute Pancreatitis
421
Chronic and Hereditary Pancreatitis
426
Summary
430
Chapter
22
Molecular Basis of Diseases of the Endocrine
System
435
Alan Lap-Ym Pang, Ph.D., Malcolm M. Martin, M.D.,
Arline L.A. Martin, M.D., and Wai-Yee Chan, Ph.D.
Introduction
435
The Pituitary Gland
435
The Thyroid Gland
439
The Parathyroid Gland
446
The Adrenal Gland
450
Puberty
454
Contents
Chapter
23
Molecular Basis of Gynecologic Diseases
465
Samuel
С. Мок,
Ph.D., Kwong-kwok Wong, Ph.D., Karen
Lu, M.D.,
Karl Munger,
Ph.D., and
Zoltán Nagymanyoki,
Ph.D.
Introduction
465
Benign and Malignant Tumors of the Female
Reproductive Tract
465
Disorders Related to Pregnancy
477
Chapter
24
Molecular Pathogenesis of Prostate Cancer:
Somatic, Epigenetic, and Genetic
Alterations
489
Carlise R. Bethel, Ph.D.,
Angelo
M.
De Marzo, M.D.,
Ph.D., and William
G.
Nelson, M.D., Ph.D.
Introduction
489
Hereditär)
Component of Prostate Cancer Risk
490
Somatic Alterations in Gene Expression
490
Epigenetics
493
Advances in Mouse Models of Prostate Cancer
494
Conclusion
496
Acknowledgments
496
Chapter
25
Molecular Biology of Breast Cancer
501
Natasa
Snoj, M.D., Phuong Dinh, M.D., Philippe Bedard,
M.D., and
Christos
Sotiriou, M.D.,
Ph.D.
Introduction
501
Traditional Breast Cancer Classification
501
Biomarkers
503
Gene Expression Profiling
509
Conclusion
513
Chapter
27
Molecular Pathology: Neuropathology
551
Joshua A.
Sonnen,
Ph.D.,
С
Dirk Keene, M.D., Ph.D.,
Robert F. Hevner, M.D., Ph.D., and Thomas J.
Montine, M.D.,
Ph.D.
Introduction
551
Anatomy of the Central Nervous System
551
Neurodevelopmental Disorders
554
Neurological Injury: Stroke, Neurodegeneration,
and Toxicants
564
Neoplasia
577
Disorders of
Myelin 583
Practice of Molecular
Medicine
V
Chapter
26
Molecular Basis of Skin Disease
519
Vesarat
Wessagowit, M.D., Ph.D., and
John A. McGrath, Ph.D.
Skin Diseases and Their Impact
519
Molecular Basis of Healthy Skin
519
Skin Development and Maintenance Provide New
Insight; into the Molecular Mechanisms of
Disease
522
Molecular Pathology of Mendelian Genetic Skin
Disorders
525
Molecular Pathology of Common Inflammatory Skin
Diseases
531
Skin Proteins as Targets for Inherited and Acquired
Disorders
535
Molecular Pathology of Skin Cancer
539
Molecular Diagnosis of Skin Disease
544
New Molecular Mechanisms and Novel
Therapies
545
Chapter
28
Molecular Diagnosis of Human Disease
591
Lawrence M.
Silverman,
Ph.D., and Grant C. Bullock,
M.D., Ph.D.
Introduction
591
History of Molecular Diagnostics
591
Molecular Laboratory Subspecialties
593
Future Applications
602
Chapter
29
Molecular Assessment of Human Disease in
the Clinical Laboratory
605
Joel A. Lefferts, Ph.D., and Gregory J. Tsongalis, Ph.D.
Introduction
605
The Current Molecular Infectious Disease
Paradigm
606
A New Paradigm for Molecular Diagnostic
Applications
607
BCR-ABL: A Model for the New Paradigm
610
Conclusion
612
Chapter
30
Pharmacogenomics and Personalized
Medicine in the Treatment of Human
Diseases
613
Hong Kee Lee, Ph.D., and Gregory J. Tsongalis, Ph.D.
Introduction
613
Conclusion
620
Index
623
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| id | DE-604.BV035348855 |
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| spelling | Molecular pathology the molecular basis of human disease ed. by William B. Coleman ... Amsterdam [u.a.] Elsevier, Acad. Press 2009 XIX, 636 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier pathology cabt man cabt molecular biology cabt human diseases cabt Cytogenetic Analysis methods Molecular Biology methods Molecular biology Pathology, Clinical methods Pathology, Molecular Molekularpathologie (DE-588)4170396-0 gnd rswk-swf Molekularpathologie (DE-588)4170396-0 s DE-604 Coleman, William B. Sonstige oth Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017153030&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Molecular pathology the molecular basis of human disease pathology cabt man cabt molecular biology cabt human diseases cabt Cytogenetic Analysis methods Molecular Biology methods Molecular biology Pathology, Clinical methods Pathology, Molecular Molekularpathologie (DE-588)4170396-0 gnd |
| subject_GND | (DE-588)4170396-0 |
| title | Molecular pathology the molecular basis of human disease |
| title_auth | Molecular pathology the molecular basis of human disease |
| title_exact_search | Molecular pathology the molecular basis of human disease |
| title_full | Molecular pathology the molecular basis of human disease ed. by William B. Coleman ... |
| title_fullStr | Molecular pathology the molecular basis of human disease ed. by William B. Coleman ... |
| title_full_unstemmed | Molecular pathology the molecular basis of human disease ed. by William B. Coleman ... |
| title_short | Molecular pathology |
| title_sort | molecular pathology the molecular basis of human disease |
| title_sub | the molecular basis of human disease |
| topic | pathology cabt man cabt molecular biology cabt human diseases cabt Cytogenetic Analysis methods Molecular Biology methods Molecular biology Pathology, Clinical methods Pathology, Molecular Molekularpathologie (DE-588)4170396-0 gnd |
| topic_facet | pathology man molecular biology human diseases Cytogenetic Analysis methods Molecular Biology methods Molecular biology Pathology, Clinical methods Pathology, Molecular Molekularpathologie |
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