Cytolytic immune lymphocytes in the armamentarium of the human host products of the evolving universal immune system
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Passau
Schenk [u.a.]
2008
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| Schriftenreihe: | Vis medicatrix naturae
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Datensatz im Suchindex
| _version_ | 1805091267972956160 |
|---|---|
| adam_text |
TABLE OF CONTENTS
TABLES VIII
FIGURES (PLATES) IX
KEYWORDS X
PREFACE INTRODUCTION XI
FOREWORD (KATALIN PALOCZI) XIII
PREFACE (H. DAVID KAY) XV
A PREFACE FROM A CLOSE COLLABORATOR
AND FRIEND (JOSEPH C. HORVATH) XXII
1. THE INNATE IMMUNE SYSTEM 1
1.1. The Universal Ancestor(s) 1
1.2. Chemokines and Toll-like Receptors Make Their Appearance 7
1.3. Nod 12
1.4. Viral Evolution 13
1.5. Interferons and Small Interfering RNAs 17
1.6. The Ascidian Haemocyte and Its Followers 24
1.7. Programmed Cell Death 25
1.8. Bactericidal Substances 39
1.9. Some Simple Interactions 39
1.10. Oncogenic Mutations 40
2. THE ADAPTIVE IMMUNE SYSTEM 43
2.1. Primordial Adaptive Elements 43
2.2. Retrotransposons 44
2.3. Host and Viral Genetic Refinements 45
2.4. The Placenta 63
2.5. TheThymus, Bursaof Fabricius and MALT 67
2.6. The Host Confronts Mutagenes and Pathogenes Attacking
Lymphoid Tissues 69
2.7. DC, NK, T, B, TRE(. Cells 73
2.8. Humoral and Cell-Mediated Immunity 75
VI Table of Contents
3. TUMOR IMMUNOLOGY AND IMMUNOTHERAPY 89
3.1. Cancer Vaccines 89
3.2. Natural and Artificial Hybridoma Formations by Cell Fusions 92
3.3. Lymphocytes Cytotoxic to Human Tumor Cells 115
3.4. Adoptive Immune Lymphocyte Therapy 128
4. AUTOIMMUNITYANDLYMPHOMAGENESIS 137
4.1. Hashimoto Thyroiditis 137
4.2. Systemic Lupus Erythematosus 140
4.3. Malignant Thymoma and Autoimmunity 144
5. CYTOTOXIC LYMPHOCYTES AGAINST CELLULAR
AND VIRAL INFECTIOUS AGENTS 149
5.1. Complex Eukaryotic Pathogens 149
5.1.1. Worms 149
5.1.2. Unicellular Parasites 151
5.1.3. Fungal Pathogens 156
5.2. Septic Shock 157
5.3. Interaction with Intracellular Bacteria and Mycobacteria 159
5.3.1. Bacteria 159
5.3.2. Mycobacteria 163
5.4. Anti-Oncoviral Immunity 170
5.4.1. Retroviruses 170
5.4.2. DNA Viruses 187
6. A CONCISE SYNOPSIS (2007-8) 215
6.1. From RNA Concentrates to Synthrophus and Upward 215
6.1.1. Another Ancient Microorganism 215
6.1.2. The RNA Prevails 216
6.1.3. Avian Retroviruses and Herpesviruses Compete
for the Malignant Transformation of Their Host Cells 218
6.1.4. Unicellular Eukaryotes Emerge and Evolve 219
6.1.5. Transposable Elements Sustain the Plasticity
of the Genomes 221
6.1.6. The Pluripotent Stem Cell 224
6.2. Innate Immune Faculties Regulate the Lymphocytes 225
6.2.1. Land Plants Derive from Green Algae and Develop
Defensive Reactions 225
6.2.2. Circulating Cells Arise in the Service
of Multicellular Hosts 226
6.2.3. Molecular Defensins Predating Antibodies 227
6.2.4. Subverted Cytokines of the Host Serve the Tumor 230
6.2.5. The Most Advanced Hosts Still Mobilize
Innate Defenses 231
i
: Table of Contents VII
6.3. Innate and Adaptive Interactions in Infections and
in Malignancies 233
6.3.1. CpG Islands 233
6.3.2. The Pathogens Strike Back. Treacherous Cytokines 234
6.3.3. The Immunosuppression of Pregnancy 236
6.3.4. Co-evolving Viruses Establish a "Criminal Collusion" 241
6.3.5. The Immunoevasive Skills of the Viral Genome
is Matched by Protozoa 256
6.4. Latest Events in Human Cancer Immunology
and Immunotherapy 257
6.4.1. Epigenetics 257
6.4.2. Ancient TLRs Knew How to Induce Apoptosis 258
6.4.3. Obstacles to Antitumor Immune Reactions of the Host 259
6.4.4. Cancer Vaccines Induce Antitumor Immune Reactions
but the Tumor Survives 261
6.4.5. Adoptive Immune Lymphocyte Therapy 262
SUMMARY 269
APPENDIX I. 281
APPENDIX II. (ADDED AT PROOF-READING) 285
AUTHOR'S POSTSCRIPT 293
REFERENCES 295
ACKNOWLEDGEMENTS 377
ABOUT THE AUTHOR 381
SUBJECT INDEX 383 |
| adam_txt |
TABLE OF CONTENTS
TABLES VIII
FIGURES (PLATES) IX
KEYWORDS X
PREFACE INTRODUCTION XI
FOREWORD (KATALIN PALOCZI) XIII
PREFACE (H. DAVID KAY) XV
A PREFACE FROM A CLOSE COLLABORATOR
AND FRIEND (JOSEPH C. HORVATH) XXII
1. THE INNATE IMMUNE SYSTEM 1
1.1. The Universal Ancestor(s) 1
1.2. Chemokines and Toll-like Receptors Make Their Appearance 7
1.3. Nod 12
1.4. Viral Evolution 13
1.5. Interferons and Small Interfering RNAs 17
1.6. The Ascidian Haemocyte and Its Followers 24
1.7. Programmed Cell Death 25
1.8. Bactericidal Substances 39
1.9. Some Simple Interactions 39
1.10. Oncogenic Mutations 40
2. THE ADAPTIVE IMMUNE SYSTEM 43
2.1. Primordial Adaptive Elements 43
2.2. Retrotransposons 44
2.3. Host and Viral Genetic Refinements 45
2.4. The Placenta 63
2.5. TheThymus, Bursaof Fabricius and MALT 67
2.6. The Host Confronts Mutagenes and Pathogenes Attacking
Lymphoid Tissues 69
2.7. DC, NK, T, B, TRE(. Cells 73
2.8. Humoral and Cell-Mediated Immunity 75
VI Table of Contents
3. TUMOR IMMUNOLOGY AND IMMUNOTHERAPY 89
3.1. Cancer Vaccines 89
3.2. Natural and Artificial Hybridoma Formations by Cell Fusions 92
3.3. Lymphocytes Cytotoxic to Human Tumor Cells 115
3.4. Adoptive Immune Lymphocyte Therapy 128
4. AUTOIMMUNITYANDLYMPHOMAGENESIS 137
4.1. Hashimoto Thyroiditis 137
4.2. Systemic Lupus Erythematosus 140
4.3. Malignant Thymoma and Autoimmunity 144
5. CYTOTOXIC LYMPHOCYTES AGAINST CELLULAR
AND VIRAL INFECTIOUS AGENTS 149
5.1. Complex Eukaryotic Pathogens 149
5.1.1. Worms 149
5.1.2. Unicellular Parasites 151
5.1.3. Fungal Pathogens 156
5.2. Septic Shock 157
5.3. Interaction with Intracellular Bacteria and Mycobacteria 159
5.3.1. Bacteria 159
5.3.2. Mycobacteria 163
5.4. Anti-Oncoviral Immunity 170
5.4.1. Retroviruses 170
5.4.2. DNA Viruses 187
6. A CONCISE SYNOPSIS (2007-8) 215
6.1. From RNA Concentrates to Synthrophus and Upward 215
6.1.1. Another Ancient Microorganism 215
6.1.2. The RNA Prevails 216
6.1.3. Avian Retroviruses and Herpesviruses Compete
for the Malignant Transformation of Their Host Cells 218
6.1.4. Unicellular Eukaryotes Emerge and Evolve 219
6.1.5. Transposable Elements Sustain the Plasticity
of the Genomes 221
6.1.6. The Pluripotent Stem Cell 224
6.2. Innate Immune Faculties Regulate the Lymphocytes 225
6.2.1. Land Plants Derive from Green Algae and Develop
Defensive Reactions 225
6.2.2. Circulating Cells Arise in the Service
of Multicellular Hosts 226
6.2.3. Molecular Defensins Predating Antibodies 227
6.2.4. Subverted Cytokines of the Host Serve the Tumor 230
6.2.5. The Most Advanced Hosts Still Mobilize
Innate Defenses 231
i
: Table of Contents VII
6.3. Innate and Adaptive Interactions in Infections and
in Malignancies 233
6.3.1. CpG Islands 233
6.3.2. The Pathogens Strike Back. Treacherous Cytokines 234
6.3.3. The Immunosuppression of Pregnancy 236
6.3.4. Co-evolving Viruses Establish a "Criminal Collusion" 241
6.3.5. The Immunoevasive Skills of the Viral Genome
is Matched by Protozoa 256
6.4. Latest Events in Human Cancer Immunology
and Immunotherapy 257
6.4.1. Epigenetics 257
6.4.2. Ancient TLRs Knew How to Induce Apoptosis 258
6.4.3. Obstacles to Antitumor Immune Reactions of the Host 259
6.4.4. Cancer Vaccines Induce Antitumor Immune Reactions
but the Tumor Survives 261
6.4.5. Adoptive Immune Lymphocyte Therapy 262
SUMMARY 269
APPENDIX I. 281
APPENDIX II. (ADDED AT PROOF-READING) 285
AUTHOR'S POSTSCRIPT 293
REFERENCES 295
ACKNOWLEDGEMENTS 377
ABOUT THE AUTHOR 381
SUBJECT INDEX 383 |
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| dewey-ones | 616 - Diseases |
| dewey-raw | 616.0797 |
| dewey-search | 616.0797 |
| dewey-sort | 3616.0797 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| discipline_str_mv | Medizin |
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| illustrated | Illustrated |
| index_date | 2024-07-02T22:17:10Z |
| indexdate | 2024-07-20T09:52:59Z |
| institution | BVB |
| isbn | 9783939337577 |
| language | English |
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| series2 | Vis medicatrix naturae |
| spelling | Sinkovics, Joseph G. 1924- Verfasser (DE-588)136402224 aut Cytolytic immune lymphocytes in the armamentarium of the human host products of the evolving universal immune system Joseph G. Sinkovics Passau Schenk [u.a.] 2008 XXIV, 391 S. zahlr. Ill., graph. Darst. 28 cm txt rdacontent n rdamedia nc rdacarrier Vis medicatrix naturae Immunreaktion (DE-588)4133841-8 gnd rswk-swf Lymphozyt (DE-588)4036762-9 gnd rswk-swf Tumorimmunologie (DE-588)4128018-0 gnd rswk-swf Lymphozyt (DE-588)4036762-9 s Immunreaktion (DE-588)4133841-8 s DE-604 Tumorimmunologie (DE-588)4128018-0 s text/html http://deposit.dnb.de/cgi-bin/dokserv?id=3116667&prov=M&dok_var=1&dok_ext=htm Inhaltstext HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016777968&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Sinkovics, Joseph G. 1924- Cytolytic immune lymphocytes in the armamentarium of the human host products of the evolving universal immune system Immunreaktion (DE-588)4133841-8 gnd Lymphozyt (DE-588)4036762-9 gnd Tumorimmunologie (DE-588)4128018-0 gnd |
| subject_GND | (DE-588)4133841-8 (DE-588)4036762-9 (DE-588)4128018-0 |
| title | Cytolytic immune lymphocytes in the armamentarium of the human host products of the evolving universal immune system |
| title_auth | Cytolytic immune lymphocytes in the armamentarium of the human host products of the evolving universal immune system |
| title_exact_search | Cytolytic immune lymphocytes in the armamentarium of the human host products of the evolving universal immune system |
| title_exact_search_txtP | Cytolytic immune lymphocytes in the armamentarium of the human host products of the evolving universal immune system |
| title_full | Cytolytic immune lymphocytes in the armamentarium of the human host products of the evolving universal immune system Joseph G. Sinkovics |
| title_fullStr | Cytolytic immune lymphocytes in the armamentarium of the human host products of the evolving universal immune system Joseph G. Sinkovics |
| title_full_unstemmed | Cytolytic immune lymphocytes in the armamentarium of the human host products of the evolving universal immune system Joseph G. Sinkovics |
| title_short | Cytolytic immune lymphocytes |
| title_sort | cytolytic immune lymphocytes in the armamentarium of the human host products of the evolving universal immune system |
| title_sub | in the armamentarium of the human host products of the evolving universal immune system |
| topic | Immunreaktion (DE-588)4133841-8 gnd Lymphozyt (DE-588)4036762-9 gnd Tumorimmunologie (DE-588)4128018-0 gnd |
| topic_facet | Immunreaktion Lymphozyt Tumorimmunologie |
| url | http://deposit.dnb.de/cgi-bin/dokserv?id=3116667&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016777968&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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