The laboratory rat 1 Biology and diseases
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| Sprache: | English |
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1979
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| Schriftenreihe: | American College of Laboratory Animal Medicine series
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| 245 | 1 | 0 | |a The laboratory rat |n 1 |p Biology and diseases |c ed. by Henry J. Baker, J(ames) Russell Lindsey, Steven H. Weisbroth |
| 264 | 1 | |a New York |b Acad. Pr. |c 1979 | |
| 300 | |a XIII, 435 S. |b Ill. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a American College of Laboratory Animal Medicine series | |
| 650 | 7 | |a Laboratory animals |2 cabt | |
| 650 | 7 | |a Rats |2 cabt | |
| 700 | 1 | |a Baker, Henry J. |e Sonstige |4 oth | |
| 700 | 1 | |a Lindsey, James Russell |e Sonstige |4 oth | |
| 700 | 1 | |a Weisbroth, Steven H. |e Sonstige |4 oth | |
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Datensatz im Suchindex
| DE-19_call_number | 0760/La (1979-36) |
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| DE-BY-UBM_katkey | 5781687 |
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| _version_ | 1823056843313774592 |
| adam_text | Titel: Bd. 1. The laboratory rat. Biology and diseases
Autor:
Jahr: 1979
The Laboratory Rat
Volume I
Biology and Diseases
EDITED BY
Henry J. Baker
Department of Comparative Medicine
Schools of Medicine and Dentistry
University of Alabama in Birmingham
Birmingham, Alabama
/. Russell Lindsey
Department of Comparative Medicine
Schools of Medicine and Dentistry
University of Alabama in Birmingham
and the Veterans Administration Hospital
Birmingham, Alabama
Steven H. Weisbroth
AnMed Laboratories, Inc.
New Hyde Park, New York
ACADEMIC PRESS 1979
A SUBSIDIARY OF HARCOURT BRACE JOVANOVICH, PUBLISHERS
New York London Toronto Sydney San Francisco
Contents
List of Contributors ix Chapter 4 Morphophysiology
W. Sheldon Bivin, M. Pat Crawford, and
Preface xi N. R. Brewer
I. Introduction 74
Contents Of Volume II XÜi D- General Appearance 74
Hl. The Digestive System 77
IV. Respiratory System 83
Chapter 1 Historical Foundations V. Cardiovascular System 86
J. Russell Lindsey VI. Urinary and Reproductive Systems 88
I. Origin of the Laboratory Rat 2 Vn. Endocrine System 93
II. The Wistar Institute 3 VIII. Nervous System 95
III. Nutrition and Biochemistry 11 IX. Special Sense Organs 98
IV. Endocrinology and Reproductive Physiology 16 References 100
V. Cancer Research Institutes 19
VI. Behavioral Research 23
Vn. Genetics 25
Other Stocks of Rats 29 Daniel H. Ringler and Lyubica Dabich
Chapter 5 Hematology and Clinical Biochemistry
VIII
IX. Genealogy of Major Rat Stocks and Strains 30
I. Introduction 105
X. Some Key Events after World War II 31 n Sources of Variation 105
XI. Information Requested 32 m Microtechniques 107
References 33 Iv- Quantities and Units 107
V. Hematology 108
_, _ _ , y-, VI. Clinical Biochemistry 113
Chapter 2 Taxonomy and Genetics References 118
Roy Robinson
I. Introduction 37
H. Taxonomy and Geographical Distribution 38 Chapter 6 Nutrition
DI. Adaptation to the Laboratory 38 Adrianne E. Rogers
IV. Genetics 39 I. Introduction 123
V. Chromosome Mapping 47 O. Dietary Considerations in Experimental Studies 124
VI. Cytogenetics 47 HI. Nutrient Requirements 128
VH. Inbred Strains 50 References 146
Reference£ 50
Chapter 7 Reproduction and Breeding
Chapter 3 Inbred Strains Dennis E j Baker
Michael F. W. Festing I. introduction 154
I. Introduction 55 II. Biotic Aspects 154
n. Nomenclature Rules 56 in. Nutrition 158
References 69 IV. Spatial Aspects 160
»• TABLE OF CONTENTS
V. Climatic Aspects 160 Chapter 13 Neoplastic Diseases
VI. Temporal Aspects 162 Norman H. Altman and DawnG. Goodman
VH. Management 163 _ Introduction 334
References 166 H. Integumentary System 336
m. Musculoskeletal System 340
Chapter 8 Housing to Control Research Variables IV- Respiratory System 341
Henry J. Baker, J. Russell Lindsey, and 1 Cardiovascular System 342
,. , . . VI. Digestive System 343
Steven H. Weisbroth vn Endocrine System 347
I. Introduction 169 ym Hematopoietic System 352
H. Physical Factors Affecting Biological Response 170 K ijrinary System 355
m. Chemical Factors Affecting Biologie Response 180 x^ Female Reproductive System 358
IV. Microbial Factors Affecting Biologie Response 183 XI Mammary Gland 361
V. Ethical and Legal Considerations 186 xn Male Reproductive System 362
Xm. Nervous System 365
References 371
References 186
Chapter 9 Bacterial and Mycotic Diseases
Steven H. Weisbroth Chapter 14 Lesions Associated with Aging
I. Introduction 193
II. Bacterial Diseases 194
HI. Mycotic Diseases 228
References 230
Miriam R. Anver and Bennett J. Cohen
I. Introduction 378
H. Major Age-Associated Lesions 378
HI. Influence of Diet on Longevity and Age-Associated
Lesions 384
Chapter 10 Mycoplasma! and Rickettsia! Diseases IV. other Age-Associated Lesions 387
Gail H. Cassell, J. Russell Lindsey, References 396
Henry J. Baker, and Jerry K. Davis
Chapter 15 Health Hazards for Man
I. Introduction 243
II. Mycoplasmal Diseases 243
UI. Rickettsial Diseases 259
References 265
Estelle Hecht Geller
I. Introduction 402
H. Allergy 402
HI. Bites 402
Chapter 11 Viral Diseases IV. Bacterial Diseases 402
Robert O. Jacoby, Pravin N. Bhatt, and V. Rickettsial Diseases 405
Albert M. Jonas VI. Viral Diseases 405
I. Introduction 272 VH. Protozoan Diseases 406
D. DNA Viruses 273 VBI. Helminth Infections 406
HI. RNA Viruses 284 K- Arthropod Infestations 407
IV. Unclassified Viruses or Viruslike Agents 297 x- Mycoses 407
V. Experimental Viral Infections 298 XI. Conclusion 407
VI. CollectionofSamples for Serological Tests and Virus References 407
Isolation 299
Vn. General Comments on the Detection, Diagnosis, and
Control of Viral Infections 300 Appendix 1 Selected Normative Data 411
References 302 Henry J. Baker, J. Russell Lindsey, and
Steven H. Weisbroth
Chapter 12 Parasitic Diseases
Chao-Kuang Hsu
I. Introduction 307 Appendix 2 Drugs and Dosages 413
II. Parasites of Parenteral Systems 308 Sam M. Kruckenberg
DI. Parasites of the Alimentary System 317
IV. Parasites of the Integument 326
References 328 Subject Index 423
The Laboratory Rat
Volume II
Research Applications
EDITED BY
Henry J. Baker
Department of Comparative Medicine
Schools of Medicine and Dentistry
University of Alabama in Birmingham
Birmingham, Alabama
/. Russell Lindsey
Department of Comparative Medicine
Schools of Medicine and Dentistry
University of Alabama in Birmingham
and the Veterans Administration Hospital
Birmingham, Alabama
Steven H. Weisbroth
An Med Laboratories, Inc.
New Hyde Park, New York
ACADEM1C PRESS 1980
A SUBSIDIARY OF HARCOURT BRACE JOVANOVICH, PUBLISHERS
New York London Toronto Sydney San Francisco
Contents
List of Contributors ix Chapter 4 Embryology and Teratology
Allan R. Beaudoin
Preface xi I- Introduction 75
n. Embryology 76
_ ,. , . •:; HI. Experimental Teratology 85
Contents of Volume I xm J*^ ^
Chapter 1 Research Methodology Chapter 5 Toxicology
Alan L. Kraus G Bmce Briggs and
I. Introduction 2
II. Handling and Restraint 2
III. Identification Methods 4
TV. _r______________
V. Substance Administration 19 m Toxicological Research ..... _ 104
VI
Frederick W. Oehme
I. Introduction 104
. ,,.. c II. General Considerations in Selecting Animals for
Specimen Couecüon - . °
A rtvt T hn ues 22 *• Considerations for Selecting the Laboratory Rat for
Toxicological Research 104
IV. Variables to Be Controlled 106
Vn. Euthanasia 24
Vm. Specialized Research Techniques 26 .,»,,,.,, . . . .^ .
.-,,._.. 10 V. Use of the Laboratory Rat in Pharmaceuücal Testing 108
IX. Necropsy Techniques 28 . ,..,..., . . ,
_ , 28 VI. Studies Usmg the Laboratory Rat in Evaluating the
Safety and Efficacy of New Drugs 111
Vn. Use of the Laboratory Rat for Safety and Efficacy
Chapter 2 Gnotobiology . Testing of Nondrug Chemicals 116
Henry L. Foster Vin. Good Laboratory Practices in Conducting Toxicity
I. Introduction 43 Studies 117
H. The Germfree and Gnotobiotic Laboratory Rat 44 IX. Conclusion 117
in. Research Applications of Gnotobiotic Rats 51 References 117
IV. Conclusions 52
References 54 Chapter 6 Experimental Oncology
John C. Peckham
Chapter 3 Dental Research I. introduction 119
Juan M. Navia and Annie Jo Narkates U. Rats as Research Animals in Oncology 120
I. Introduction 59 III. Rat Tumors as Models of Human Neoplastic Disease 122
H. Oral Characteristics of the Rat 60 IV. Use in Carcinogenesis 133
HI. The Rat as an Animal Model for the Study of Oral V. Use in Cancer Therapy 136
Disease 64 VI. Use in Cancer Prevention 136
IV. Conclusion 72 vn. Conclusions 137
References 72 References 137
v,7i CONTENTS
Chapter 7 Experimental Gerontology Chapter 10 Immunogenetics
Joe D. Burek and Carel F. Hollander Donald V. Cramer, Heinz W. Kunz,
I. Introduction 149 and Thomas J. GUI, HI
n. Some Factors That Influence Longevity and the I. Definitions 213
Interpretation of Results from Life Span Studies n. Cell Surface Alloantigens 214
Using Rats 150 rrj. Genetically Controlled Immune Responses 217
m. How Old Is an Old Rat? 154 iv. Allogeneic Reactions 220
IV. Cost of Old Rats 155 v. Immunogenetics of Wild Populations of Rats 221
V. Models of Aging Using the Rat 155 VI. Conclusions 221
VI. Sources of Old Rats 157 References 222
Vn. Summary 157
References 158
Chapter 11 Experimental Parasitology
Chapter 8 Cardiovascular Research Dickson D. Despommier
Sanford P. Bishop l- introduction 225
I. Introduction 162 H. Survey of Parasites Which Have Been Used
H. Macroscopic Anatomy 162 Experimentally in Rattus norvegicus 225
m. Microscopic Anatomy 164 DI. Rattus norvegicus as a Model for Human Parasitic
IV. Methods for in Vivo Evaluation of the Cardiovascular Diseases 235
System 165 References 240
V. Methods for in Vitro Study of Myocardium 166
VI. Spontaneous Models of Human Cardiovascular
Disease 168 Chapter 12 Wild Rats in Research
VH. Experimentally Induced Models for Cardiovascular Christine S. F. Williams
Research 172 I. Introduction 245
Vm. Use of the Rat for Miscellaneous Studies 174 n. Laboratory Management of Captive Wild Rats 246
IX. Special Considerations for Use of the Rat in m. Wild Rats Used in Research 247
Cardiovascular Research 175 References 253
X. Conclusions 175
References 176
Appendix 1 Selected Normative Data 257
Chapter 9 Immunology Henry J. Baker, J. Russell Lindsey,
Philip B. Carter and Herve Bazin and Steven H. Weisbroth
I. Introduction 181
n. Humoral Aspects 181
in. Celiular Aspects 192 Appendix 2 Drugs and Dosages 259
IV. Autoimmune Disease 204 Sam M. Kruckenberg
V. Infection and Tumor Immunity 204
VI. Conclusion 205
References 205 Subject Index 269
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| illustrated | Illustrated |
| indexdate | 2025-02-03T17:57:29Z |
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| isbn | 0120749017 |
| language | English |
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| physical | XIII, 435 S. Ill. |
| publishDate | 1979 |
| publishDateSearch | 1979 |
| publishDateSort | 1979 |
| publisher | Acad. Pr. |
| record_format | marc |
| series2 | American College of Laboratory Animal Medicine series |
| spellingShingle | The laboratory rat Laboratory animals cabt Rats cabt |
| title | The laboratory rat |
| title_auth | The laboratory rat |
| title_exact_search | The laboratory rat |
| title_full | The laboratory rat 1 Biology and diseases ed. by Henry J. Baker, J(ames) Russell Lindsey, Steven H. Weisbroth |
| title_fullStr | The laboratory rat 1 Biology and diseases ed. by Henry J. Baker, J(ames) Russell Lindsey, Steven H. Weisbroth |
| title_full_unstemmed | The laboratory rat 1 Biology and diseases ed. by Henry J. Baker, J(ames) Russell Lindsey, Steven H. Weisbroth |
| title_short | The laboratory rat |
| title_sort | the laboratory rat biology and diseases |
| topic | Laboratory animals cabt Rats cabt |
| topic_facet | Laboratory animals Rats |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=021597917&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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