The enzymes 19 Mechanisms of catalysis
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| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY [u.a.]
Acad. Press
1990
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| Ausgabe: | 3. ed. |
| Online-Zugang: | Inhaltsverzeichnis |
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| 040 | |a DE-604 |b ger |e rakwb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-188 | ||
| 245 | 1 | 0 | |a The enzymes |n 19 |p Mechanisms of catalysis |c ed. by Paul D. Boyer ... |
| 250 | |a 3. ed. | ||
| 264 | 1 | |a New York, NY [u.a.] |b Acad. Press |c 1990 | |
| 300 | |a IX, 459 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 700 | 1 | |a Boyer, Paul D. |d 1918-2018 |e Sonstige |0 (DE-588)171986997 |4 oth | |
| 773 | 0 | 8 | |w (DE-604)BV026065578 |g 19 |
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| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-021330812 | |
Datensatz im Suchindex
| _version_ | 1819638961149050880 |
|---|---|
| adam_text | IMAGE 1
CONTENTS
PREFACE IX
1. BINDING ENERGY AND CATALYSIS
DAVID D. HACKNEY
I. INTRODUCTION I
II. RELATIONSHIP OF BINDING TO CATALYSIS IN UNINIOLECULAR REACTIONS 3
III. BEYOND UNINIOLECULAR REACTIONS: ENTROPY 14
IV. INDIRECT USES OF BINDING 27
V. PROSPECTS 34
REFERENCES 34
2. BIOLOGICAL ELECTRON TRANSFER
D O U G L AS C. R E ES A ND D A V ID F A R R E L LY
INTRODUCTION 38
1. THERMODYNAMICS OF ELECTRON TRANSFER REACTIONS 39
II. KINETICS OF ELECTRON TRANSFER REACTIONS 56
III. MICROSCOPIC THEORY OF ELECTRON TRANSFER 64
IV. EXAMPLES OF ELECTRON TRANSFER REACTIONS 75
V. FUTURE PROSPECTS 89
REFERENCES 92
3. STEADY-STATE KINETICS
W. W. CLELAND
I. INTRODUCTION 99
II. NOMENCLATURE AND NOTATION 100
III. BASIC THEORY 101
IV. DERIVATION OF RATE EQUATIONS 102
V. DETERMINATION OF KINETIC MECHANISM 104
VI. STICKINESS AND METHODS FOR MEASUREMENT 130
VII. DETERMINATION OF CHEMICAL MECHANISM 134
V
IMAGE 2
VI CONTENTS
VIII. CONCLUDING REMARKS 155
REFERENCES 155
4. ANALYSIS OF PROTEIN FUNCTION BY MUTAGENESIS
KENNETH A. JOHNSON AND STEPHEN J. BENKOVIC
INTRODUCTION 159
1. STRUCTURAL ASPECTS OF MUTANT ENZYMES 161
II. SUBSTRATE BINDING AND CATALYSIS 168
III. ENGINEERING NEW SPECILICITIES 194
IV. CONCLUSIONS 206
REFERENCES 207
5. MECHANISM-BASED (SUICIDE) ENZYME INACTIVATION
MARK A. ATOR AND PAUL R. ORTIZ DE MONTELLANO
I. INTRODUCTION 214
II. DEHYDRASES AND ISOMCRASES 220
III. PYRIDOXAL PHOSPHATE-DEPENDENT ENZYMES 221
IV. FLAVIN-DEPENDENT ENZYMES 229
V. HEMOPROTCIN ENZYMES 241
VI. NONHEMC METALLOENZYMES 253
VII. QUINOPROTEINS 260
VIII. HYDROLYTIC ENZYMES 262
IX. ENZYMES OF NUCLCOTIDC MODIFICATION 271
X. SUMMARY 276
REFERENCES 277
6. SITE-SPECIFIC MODIFICATION OF ENZYME SITES
ROBERTA F. COLMAN
I. INTRODUCTION 283
II. GENERAL CHARACTERISTICS OF SITE-SPECIFIC MODIFICATION 284
III. HALOKETONES 287
IV. ALDEHYDE AFFINITY LABELS 292
V. FLUOROSULFONYLBENZOYL NUCLEOSIDES 299
VI. PHOTOREACTIVE COMPOUNDS 306
VII. HALOACYL AND ALKYL HALIDE DERIVATIVES 310
VIII. MISCELLANEOUS AFFINITY LABELS 313
IX. CONCLUSIONS 313
REFERENCES 314
7. STEREOCHEMISTRY OF ENZYME-CATALYZED REACTIONS AT CARBON
DONALD J. CREIGHTON AND NUNNA S. R. K. MURTHY
I. INTRODUCTION 324
II. NICOTINAMIDC-DCPCNDCNT DEHYDROGENASES: HYDRIDE TRANSFER TO CARBON
331
IMAGE 3
CONTENTS VUE
III. FLAVIN-DEPENDENT OXIDOREDUCTASES: HYDRIDE TRANSFER TO NITROGEN 339
IV. ISOMERASES INVOLVING PROTON TRANSFER: IMPORTANCE OF SINGLE-BASE
MECHANISMS 344 V. ENZYME-CATALYZED ALDOL- AND CLAISEN-TYPE
CONDENSATIONS: /3-KETO ACID DECARBOX- YLASES: STEREOCHEMISTRY VERSUS
STABILITY OF REACTION INTERMEDIATES 356
VI. PYRIDOXAL PHOSPHATE- AND PYRUVYL-DEPENDENT ENZYMES: FLEXIBLE
RESPONSE TO DIFFER- ENT CHEMICAL CHALLENGES 3X2
VII. SS-ELIMINATION-ADDITION REACTIONS: E2 VERSUS ELCB MECHANISMS 397
VIII. METHYL GROUP TRANSFER REACTIONS: ONE- VERSUS TWO-STEP MECHANISMS
404 IX. CONCLUDING REMARKS 411
REFERENCES 412
AUTHOR INDEX 423
SUBJECT INDEX 453
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| ctrlnum | (OCoLC)311332964 (DE-599)BVBBV026987278 |
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| id | DE-604.BV026987278 |
| illustrated | Illustrated |
| indexdate | 2024-12-24T00:25:31Z |
| institution | BVB |
| isbn | 0121227197 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-021330812 |
| oclc_num | 311332964 |
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| owner | DE-188 |
| owner_facet | DE-188 |
| physical | IX, 459 S. graph. Darst. |
| publishDate | 1990 |
| publishDateSearch | 1990 |
| publishDateSort | 1990 |
| publisher | Acad. Press |
| record_format | marc |
| spellingShingle | The enzymes |
| title | The enzymes |
| title_auth | The enzymes |
| title_exact_search | The enzymes |
| title_full | The enzymes 19 Mechanisms of catalysis ed. by Paul D. Boyer ... |
| title_fullStr | The enzymes 19 Mechanisms of catalysis ed. by Paul D. Boyer ... |
| title_full_unstemmed | The enzymes 19 Mechanisms of catalysis ed. by Paul D. Boyer ... |
| title_short | The enzymes |
| title_sort | the enzymes mechanisms of catalysis |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=021330812&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV026065578 |
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