Fluid and electrolyte regulation in spaceflight

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1. Verfasser: Leach Huntoon, Carolyn S. (VerfasserIn)
Format: Buch
Sprache:Undetermined
Veröffentlicht: San Diego, Calif. Univelt 1998
Ausgabe:1. print.
Schriftenreihe:Science and technology series 94
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adam_text AN /* MERICAN TRONAUTICAL IETY PUBLICATION FLUID AND ELECTROLYTE REGULATION IN SPACEFLIGHT BY CAROLYN S. LEACH HUNTOON ANATOLIY I. GRIGORIEV YURI V. NATOCHIN VOLUME 94 SCIENCE AND TECHNOLOGY SERIES A SUPPLEMENT TO ADVANCES IN THE ASTRONAUTICAL SCIENCES PUBLISHED FOR THE AMERICAN ASTRONAUTICAL SOCIETY BY UNIVELT, INCORPORATED, P.O. BOX 28130, SAN DIEGO, CALIFORNIA 92198 CONTENTS PAGE FOREWORD VII PREFACE IX INTRODUCTION XI CHAPTER 1: PHYSIOLOGICAL EFFECTS 1 I. EFFECTS OF WEIGHTLESSNESS 2 II. EFFECTS OF LANDING AND READAPTATION 5 III. SUMMARY 5 REFERENCES 6 CHAPTER 2: SHORT FLIGHTS 9 I. ASSESSMENT METHODS 9 II. EARLY EFFECTS ON FLUIDS AND ELECTROLYTES 15 A. BODY FLUID 15 B. BLOOD AND URINARY OSMOLALITY AND MONOVALENT IONS 18 C. BLOOD AND URINARY DIVALENT IONS 21 III. RENAL-STONE. RISK 21 IV. EARLY EFFECTS ON HORMONES REGULATING FLUID AND ELECTROLYTE METABOLISM . 22 A. ANTIDIURETIC HORMONE 22 B. ATRIAL NATRIURETIC PEPTIDE 24 C. RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM 24 D. CORTISOL AND ADRENOCORTICOTROPIN 27 E. CATECHOLAMINES 28 F. STRESS 28 V. HORMONES REGULATING CALCIUM OR BONE METABOLISM 29 VI. EARLY EFFECTS ON RENAL FUNCTION 29 VII. READAPTATION 31 VIII. CONCLUSIONS 34 REFERENCES 35 XV PAGE CHAPTER 3: LONG FLIGHTS 41 I. ASSESSMENT METHODS 41 II. FLUID AND ELECTROLYTE METABOLISM ON 2- TO 52-WEEK SPACEFLIGHTS: REVIEW OF FINDINGS 42 A. SKYLAB 42 1. BODY FLUID 42 2. ELECTROLYTES 43 3. HORMONES 44 B. SOVIET AND RUSSIAN FLIGHTS 47 1. BODY FLUID 47 2. BLOOD ELECTROLYTES 47 3. URINARY ELECTROLYTES 50 4. HORMONES 55 5. IN-FLIGHT MEASUREMENTS 57 III. PHYSIOLOGICAL RESPONSES TO LONG FLIGHTS: SUMMARY AND DISCUSSION 63 A. FLUID BALANCE, ELECTROLYTE BALANCE, AND FLUID REDISTRIBUTION . . . . 63 B. HORMONAL REGULATION OF FLUID AND ELECTROLYTE BALANCE 67 C. RENAL RESPONSES TO FLUID LOADS OR DEPRIVATION AFTER LONG FLIGHTS . . 69 IV. FLUID AND ELECTROLYTE STATUS AFTER LANDING 72 REFERENCES 74 CHAPTER 4: SPACEFLIGHT SIMULATIONS 81 I. SIMULATION MODELS: IMMERSION AND BED REST . 81 II. FLUID BALANCE 82 III. SODIUM AND POTASSIUM BALANCE 85 IV. PREDICTING FLUCTUATIONS IN FLUID BALANCE DURING BED REST 88 V. CALCIUM BALANCE 91 VI. RENAL OSMOREGULATORY RESPONSES TO IMMERSION AND BED REST 93 A. URINE-CONCENTRATING ABILITY/FLUID DEPRIVATION 96 B. URINE-DILUTING ABILITY/FLUID LOAD 97 VII. ELECTROLYTE LEVELS IN BLOOD 99 VIII. FLUID-COMPARTMENT VOLUMES 103 IX. POSSIBLE MECHANISMS FOR MAINTAINING FLUID-ELECTROLYTE HOMEOSTASIS . . 105 A. IMMERSION 105 1. BODY POSITION 106 2. TEMPERATURE 107 B. HEAD-DOWN BED REST 109 1. ENDOCRINE EFFECTS 110 2. CIRCADIAN INFLUENCES 115 3. PROSTAGLANDINS 116 4. GLUCOCORTICOID RECEPTORS 116 XVI PAGE 5. INSULIN SECRETION AND METABOLISM 117 6. CHANGES IN POTASSIUM AND CALCIUM STORAGE CAPACITIES . . . . 118 X. SUMMARY 123 REFERENCES 124 CHAPTER 5: ANIMAL EXPERIMENTS: THE KOSMOS BIOSATELLITES 133 I. FLUID AND ELECTROLYTE BALANCE 134 II. RENAL RESPONSE TO FLUID OR POTASSIUM-CHLORIDE LOADS 136 III. ELECTROLYTE CONTENT IN THE RAT KIDNEY CORTEX AND MEDULLA 140 IV. FLUID AND ELECTROLYTE CONTENT OF RAT REPRODUCTIVE ORGANS AND FETUSES 144 A. THE MALE REPRODUCTIVE SYSTEM 144 B. PREGNANCY AND REPRODUCTION 145 1. MATERNAL CHARACTERISTICS 145 2. FETAL DEVELOPMENT 146 3. NEONATAL DEVELOPMENT 148 REFERENCES 149 CHAPTER 6: COUNTERMEASURES 153 I. EXERCISE 154 A. GENERAL PRINCIPLES 154 B. IN-FLIGHT EXERCISE DEVICES 156 1. OTHER TRAINING DEVICES AND TECHNIQUES 156 C. EXERCISE PROTOCOLS DURING LONG FLIGHTS 157 1. PHASE I 157 2. PHASE II 158 3. PHASE III 159 D. SUMMARY 159 II. LOWER-BODY NEGATIVE PRESSURE 159 A. GENERAL PRINCIPLES FOR LBNP CONDITIONING 160 B. PROTOCOLS AND SCHEDULES FOR LBNP CONDITIONING IN SPACEFLIGHT . . 160 C. COMBINATIONS OF LBNP AND FLUID-SALT SUPPLEMENTS 161 III. OCCLUSION CUFFS AND POSITIVE PRESSURE GARMENTS 162 IV. PHARMACOLOGICAL PROPHYLAXIS 163 V. SUMMARY AND CONCLUSIONS 163 REFERENCES 164 CONCLUSIONS 171 I. FLUID AND ELECTROLYTE REGULATION ON EARTH 171 II. EFFECTS OF SPACEFLIGHT ON FLUID AND ELECTROLYTE HOMEOSTASIS 171 III. ADAPTATION 172 XVU PAGE IV. APPROACHES TO THE STUDY OF SPACEFLIGHT EFFECTS 173 A. INTEGRATING DIFFERENT LEVELS 173 B. LEVELS OF KNOWLEDGE ABOUT ANTIDIURETIC HORMONE 173 V. PHYSIOLOGICAL MECHANISMS OF SPACEFLIGHT EFFECTS 175 VI. FUTURE STUDIES 176 VII. IMPORTANCE OF FLUID AND ELECTROLYTE HOMEOSTASIS FOR SPACE MEDICINE . 177 VIII. EARTH BENEFITS FROM FLUID AND ELECTROLYTE STUDIES 177 REFERENCES 179 APPENDICES 183 APPENDIX A: SUMMARY OF HUMAN SPACEFLIGHT EXPERIENCE 184 APPENDIX B: PUBLICATIONS OF THE AMERICAN ASTRONAUTICAL SOCIETY . . . . 204 ADVANCES IN THE ASTRONAUTICAL SCIENCES 205 SCIENCE AND TECHNOLOGY SERIES 212 AAS HISTORY SERIES 218 XVIU
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spellingShingle Leach Huntoon, Carolyn S.
Fluid and electrolyte regulation in spaceflight
Science and technology series
title Fluid and electrolyte regulation in spaceflight
title_auth Fluid and electrolyte regulation in spaceflight
title_exact_search Fluid and electrolyte regulation in spaceflight
title_full Fluid and electrolyte regulation in spaceflight by Carolyn S. Leach Huntoon ; Anatoliy I. Grigoriev ; Yuri V. Natochin
title_fullStr Fluid and electrolyte regulation in spaceflight by Carolyn S. Leach Huntoon ; Anatoliy I. Grigoriev ; Yuri V. Natochin
title_full_unstemmed Fluid and electrolyte regulation in spaceflight by Carolyn S. Leach Huntoon ; Anatoliy I. Grigoriev ; Yuri V. Natochin
title_short Fluid and electrolyte regulation in spaceflight
title_sort fluid and electrolyte regulation in spaceflight
url http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018335862&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
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