Osteoporosis 1
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| 003 | DE-604 | ||
| 005 | 20090812 | ||
| 007 | t| | ||
| 008 | 080721s2008 xx ad|| |||| 00||| eng d | ||
| 020 | |a 9780123705457 |9 978-0-12-370545-7 | ||
| 035 | |a (OCoLC)836569732 | ||
| 035 | |a (DE-599)BVBBV023406240 | ||
| 040 | |a DE-604 |b ger |e rakwb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-355 |a DE-19 | ||
| 084 | |a WE 250 |2 nlm | ||
| 245 | 1 | 0 | |a Osteoporosis |n 1 |c ed. by Robert Marcus ... |
| 250 | |a 3. ed. | ||
| 264 | 1 | |a San Diego [u.a.] |b Acad. Press |c 2008 | |
| 300 | |a XXV, 972 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 700 | 1 | |a Marcus, Robert |d 1940- |e Sonstige |0 (DE-588)137928173 |4 oth | |
| 773 | 0 | 8 | |w (DE-604)BV013936906 |g 1 |
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| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-016588929 | |
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| DE-19_call_number | 0760/WE 250-2008 OA(1 |
|---|---|
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| DE-BY-UBM_media_number | 99994969049 |
| _version_ | 1823054396018130944 |
| adam_text |
Contents
VOLUME
I
Contributors
Preface
xix
xxv
Part I Introduction
Chapter
1
The Bone Organ System: Form
and Function
Elise F.
Morgan, George L. Barnes, and Thomas A.
Einhorn
I. Introduction
3
П.
Composition and Organization of Bone
3
III. Cellular Components of Bone
11
IV. Bone Homeostasis
14
V. Bone Mechanics
17
VI. Summary
22
Chapter
2
The Nature of Osteoporosis
Robert Marcus and Mary L. Bouxsein
I. Defining Osteoporosis
27
II. Material and Structural Basis of Skeletal
Fragility
28
III. Conclusions
33
Chapter
3
The Economics of Osteoporosis
Anna N.A. Tosteson and David J. Vanness
I. Introduction
37
II. Cost of Illness Studies: Characterizing the
Magnitude of the Health Problem
37
Ш.
Cost-Effectiveness Analyses: Identifying
Efficient Osteoporosis Care Strategies
40
IV. Future Research Directions
43
Chapter
4
Reflections on Osteoporosis
B. E. Christopher
Nordin
I. Introduction
47
II. Definition
47
III. Diagnosis
49
IV. Fragility Fractures
50
V. Bone Density and Fracture Risk
50
VI. Pathogenesis
51
VII.
Prevention
63
VIII.
Treatment
64
IX. Conclusions
65
Chapter
5
Skeletal Heterogeneity and the
Purposes of Bone Remodeling: Implications
for the Understanding of Osteoporosis
A. M.
Pariti i
I. Introduction
71
II. Skeletal Heterogeneity
72
III. The Purposes of Bone Remodeling
IV. Implications for Understanding
Osteoporosis
79
74
Part II Basic Science of Bone Biology
Chapter
6
Osteoblast Biology
Jane
B. Lian
and Gary S. Stein
I. Overview
93
II. Embryonic Development of the Osteoblast
Phenotype: Lessons for Bone Formation in the
Postnatal Skeleton
93
III. Development Sequence of Osteoblast Phenotype
Development
100
IV. Phenotype Properties of Osteogenic Lineage
Cells
106
Vi
CONTKNTS
V. Molecular Mechanisms Mediating
Progression of Osteoblast Growth and
Differentiation
116
VI. Conclusion
128
Chapter
7
Osteoclast Biology
Harry
с
Blair. Scott
Simonét,
David L. Lacey,
and
Mone Zaidi
I. Introduction
151
II. Key Osteoclast Differentiation
Pathways
151
III. The Fully Differentiated Osteoclast:
Mechanisms of Bone Degradation
154
IV. Bone
Resorption
Coordinated by Intermediate
Proteins
157
V. Osteoclast Death
158
VI. Mechanistic Approaches to Modification of
Osteoclastic Activity In Vivo
158
VII.
Regulation of Osteoclastic Differentiation and
Activity In Vivo
160
VIII.
Interaction of Hormonal and Local Signals with
Osteoclast Activity
161
IX. Diseases with Altered Bone
Resorption 162
Chapter
8
Osteocytes
Lynda
F. Bonewald
I. Introduction
169
II. Osteocyte Ontogeny
169
III. Osteoid-Osteocytes
170
IV. Osteocyte Selective Genes/Proteins and their
Potential Functions
171
V. Morphology of Osteocytes: Lacunocanalicular
System and
Dendrite
Formation
172
VI. Osteocyte Cell Models
174
VII.
Mechanisms and Response of Osteocytes to
Mechanical Forces
174
VIII.
Osteocyte Signals for Bone
Formation
177
IX. Osteocyte Signals for Bone
Resorption 178
X. Osteocyte Apoptosis
179
XI. Osteocyte Modification of their
Microenvironment 179
XII.
Osteocyte Density
180
XIII.
Role of Gap Junctions and Hemichannels in
Osteocyte Communication
180
XIV.
Osteocytes in the Embryonic and the Adult
Skeleton
181
XV. The Implications of Osteocyte Biology for
Bone Disease
182
XVI.
Conclusions
183
Chapter
9
The Regulatory Role of Matrix
Proteins in Mineralization of Bone
Wei Zhu. Pamela
Gehron
Robky,
and
Adele
L.
Boskey
I. Introduction
191
II. Collageneous Proteins
193
III. Intermediate Cartilage Matrix
195
IV. Bone-Enriched Matrix Proteins
201
V. The Mineralization of Bone Matrix
219
Chapter
10
Development of the Skeleton
Sylvain
Provot,
Ernestina
Schipani, Joy Wu, and Henry
Kronenberg
I. Introduction
241
II. Patterning the Skeleton
241
III. Endochondral Bone Formation
250
IV. Intramembranous Bone Formation
261
Chapter
11
Mouse Genetics as a Tool to
Study Bone Development and Physiology
Clifford J. Rosen and Wesley G. Beamer
I. Introduction: Historical Perspective and
Significance
271
II. Introduction To Mouse Skeletal
Physiology
272
III. Inbred Strains of Mice
273
IV.
Recombinant
Inbred strains
275
V.
Congenie
Strains
276
VI.
Recombinant
Congenie
Strains
279
VII.
Summary
280
Chapter
12
Parathyroid Hormone and
Parathyroid Hormone-Related Protein
Robert A. Nissenson
I. Introduction
283
II. Secretion of Parathyroid Hormone
283
III. Metabolism of Parathyroid Hormone
284
IV. Bone Resorbing Action of Parathyroid
Hormone
285
Contents
Vil
V. Effects of Parathyroid Hormone on Bone
Formation
286
VI. Renal Actions of Parathyroid
Hormone
288
VII.
Parathyroid Hormone-Related Protein as a
Mediator of Malignancy-Associated
Hypercalcemia
289
VIII.
Physiological Roles of Parathyroid Hormone-
Related Protein
289
IX. Mechanism of Action of Parathyroid
Hormone and Parathyroid Hormone-Related
Protein
294
Chapter
13
Vitamin D: Biology, Action, and
Clinical Implications
David Feldman, Peter S. Malloy, Aruna V. Krishnan, and Eva
Bálint
I. Introduction
317
II. Vitamin
D
Synthesis and Metabolism
318
III. Pathways of Activation and Inactivation of
Vitamin
D
326
IV. Mechanism of 1,25(OH)2D Action
331
V. Nongenomic Actions of Vitamin
D
341
VI. Physiology: Regulation of Serum
Calcium
342
VII.
Genetic Disorders
344
VIII.
1,25(OH)2D3
Analogs with Decreased Calcemic
Activity
346
IX. Actions of Vitamin
D
in Classical
Target Organs to Regulate Mineral
Homeostasis
348
X. Actions of 1,25(OH)2D in Nonclassical Target
Organs
354
XI. Vitamin
D
and Osteoporosis
360
Chapter
14
Regulation of Bone Cell
Function by Estrogens
Barry S.
Komm,
Boris Cheskis, and Peter V.N. Bodine
I. Introduction
383
II. What is an Estrogen?
383
III. Estrogen Receptors
383
IV. ERoc and
ERß
Knockout Mice
(ERKO
and
ßERKO) 392
V. Estrogens and Bone
392
VI. Estrogen Receptors in Bone Cells
393
VII.
Estrogenie
Responses in Bone Cells
398
VII.
Estrogen-Related
Receptor
-α
and Osteopontin
Gene Expression
410
IX. Nongenomic Actions of Estrogens in Bone
Cells
410
X. Conclusion
411
Chapter
15
Androgens and Skeletal
Biology: Basic Mechanisms
Kristine
M. Wiren
I. Introduction
425
II. Androgens and the Role of
Androgen
Metabolism
425
III. Cellular Biology of the
Androgen
Receptor in
the Skeleton
428
IV. The Consequences of
Androgen
Action in Bone
Cells
433
V. The Skeletal Effects of
Androgen:
Animal
Studies
437
VI. Animal Models of Altered
Androgen
Responsiveness
440
VII.
Effects on the Periosteum: The Role of
Androgen
Receptor versus Aromatization of
Testosterone
441
VIII.
Summary
442
Chapter
16
Phosphatonins
Peter J. Tebben, Theresa J.
Berndt,
and Rajiv Kumar
I. Introduction
451
II. Phosphorus Homeostasis
451
III. Phosphatonins
454
IV.
Fibroblast
Growth Factor
23 454
V. Secreted Frizzled-Related Protein
4 460
VI. Matrix Extracellular Phospho-
glycoprotein
460
VII. Fibroblast
Growth Factor
7 461
VIII.
Summary
462
Chapter
17
Wnt Signaling in Bone
Mark L. Johnson nd Robert R. Recker
I. Wnts
467
II. The
Wnt/ß-Catenin
Signaling
Pathway
468
III. Other Wnt Pathways
473
IV. Mutations in Wnt Pathway Components and
Altered Bone Mass
475
V. Wnt Signaling and Bone Cell
Function
477
VIU
Contents
VI. Wnt
Signaling and the Bone Response
to Mechanical Loading
480
VII.
Conclusions and Future Directions
481
Chapter
18
Cytokines and Bone Remodeling
Gregory R. Mundy. Babatunde Oyajobi, Gloria Gutierrez, Julie
Sterling. Susan Padalecki,
Florent Elefteriou,
and Ming Zhao
I. Introduction
491
II. Evidence for a Role of Cytokines in
Osteoclastic Bone
Resorption 492
III. The Osteoclast as a Cell Source of
Cytokines Involved in Osteoclastic
Resorption 493
IV. The Osteoblast as a Cell Source of
Cytokines Involved in Osteoclastic
Resorption 493
V. Rank Ligand and Its Signaling Receptor,
RANK
494
VI. Osteoprotegerin
497
VII.
Macrophage-Colony-Stimulating Factor and
Its Receptor, C-fms
498
VIII.
Vascular Endothelial Growth Factor
500
IX. Tumor Necrosis Factor
500
X. Interleukin-6 (IL-6)
501
XL Interleukin-15 (IL-15), Interleukin-17
(IL-
17),
and Interleukin-
18
(IL-
18) 502
XII.
Bone Morphogenetic Proteins
503
XIII.
Hedgehog (Hh) Signaling Molecules
509
XIV.
Sclerostin
511
XV. Parathyroid Hormone-Related
Peptide
(Pthrp)
511
XVI. Neuronal
Regulation of Bone
Remodeling
512
XVII.
Conclusion
515
Chapter
19
Skeletal Growth Factors
Ernesto Canalis
I. Introduction
529
II. Platelet-Derived Growth Factor
529
III. Vascular Endothelial Growth Factor
531
IV.
Fibroblast
Growth Factor
532
V. Transforming Growth Factor Beta
533
VI. Bone Morphogenetic Protein
534
VII. Insulin-Like
Growth Factor
535
VIII.
Insulin-Like Growth Factor Binding
Proteins
537
IX. Hepatocyte Growth Factor
538
Chapter
20
Intercellular Communication
during Bone Remodeling
T. John Martin and Gideon
A. Rodan
I. Introduction
547
II. Sequence of Cellular Events in Bone
Remodeling
548
III. Cell Interactions Early in
Remodeling
548
IV. Interaction of Osteoblast Lineage Cells with
Osteoclasts
549
V. Factors Proposed to Mediate the Coupling
of Bone Formation to
Resorption 550
VI. Osteoclast Products in the Coupling
Process
552
VII.
Similarities between Bone Remodeling and
Inflammation
553
VIII.
Bone Mass Homeostasis
554
IX. The Role of Mechanical Function (Strain)
in the Coupling of Bone
Resorption
to Bone
Formation
554
X. Integrated View of the Coupling of Bone
Resorption
and Bone Formation
555
Part III Structure and Biomechanics
Chapter
21
Skeletal Development:
Mechanical Consequences of Growth, Aging,
and Disease
Marjolein C.H.
van
der Meulen, Dennis R.
Carter, and Gary
S. Beaupré
I. Developmental Mechanics in
Skeletogenesis
563
П.
Mechanical Regulation of
Bone Biology
564
III. Mechanobiologic Self-Design of
Bones
566
IV. Adaptational Mechanics in Aging and
Disease
577
Chapter
22
Inhibition of Osteoporosis by
Biophysical Intervention
Clinton Rubin, Stefan Judex, Janet
Rubín,
and Yi-Xian Qin
I. Introduction
581
II. Bone's Sensitivity to Mechanical
Signals
582
Contents
ЇХ
III. Structural Demands on the Skeleton
582
IV. Regulation of Bone Morphology by
Biophysical Stimuli
585
V. Osteogenic Potential of Low-Magnitude,
High-Frequency Signals
589
VI. Regulating the Bone Cell Response to
Mechanical Signals
591
VII.
Biophysical Stimuli in the Clinic
593
VIII.
Summary
596
Chapter
23
Biomechanics of Age-Related
Fractures
Mary L. Boiixsein
I. Introduction
601
II. Biomechanics of Bone: Basic Concepts and
Age-Related Changes
602
III. Biomechanics of Hip Fractures
609
IV. Biomechanics of Vertebral Fractures
614
V. Summary and Clinical Implications
616
Chapter
24
Bone Quality
J. Christopher Friiton and
Mitchell
В.
Sciiaffikr
I. Introduction
625
II. Chapter Objective
627
III. The Brooklyn Bridge: A Paradigm for
Understanding Bone Quality
627
IV. Factors Impacting Bone Quality
629
V. Conclusions
635
Part IV Epidemiology and Risk
Factors
Chapter
25 Epidemiologie
Methods in
Studies of Osteoporosis
MaryFran Sowers and Carrie A. Karvqnfn-Gui ierrez
I. Introduction
645
II. Descriptive and Analytic Studies
645
III. Study Designs
646
IV. Some Useful
Epidemiologie
Concepts
654
V. Some Frequently Used Statistics
655
VI. Criteria for Deciding Whether an Association
is Causal
656
VII.
Sample Size Considerations
657
VIII.
Measurement Error
658
IX. Conclusions
663
Chapter
26
Race, Ethnicity and
Osteoporosis
Dorothy A. Nelson, John M. Pettifor, and Shane A. Norris
I. Introduction
667
II. Background and Definitions
667
III. Ethnoepidemiology of Osteoporosis
668
IV. Ethnic Influences on Risk for
Osteoporosis
672
V. Summary
680
Chapter
27
The Study of Osteoporotic
Fractures: Major Findings and Contributions
Jani;
A. Cauley.
Kristine
E.
Ensrud,
Teresa A.
Hillier, Marc4
HocHBERG. Katie
L. Stone,
Steven
R. Cummings
I. Overview
689
II. Summary of Key Findings
689
III. What is a Vertebral Fracture?
695
IV. Ethnic Differences in Osteoporosis
697
V. Sleep Disturbance and Risk of Falls
and Fractures
697
VI. Consequences of Fracture: Mortality
698
VII.
Breast Cancer
699
VIII.
Hip Osteoarthritis
699
IX.
SOF
Online
700
X. Summary
700
Chapter
28
Bone Mineral Acquisition
In
Utero
and during Infancy and Childhood
Jon M. Burnham and Mary B. Leonard
I. Introduction
705
II. Quantitative Assessment of Bone Health
in Infants and Children
705
HI. Bone Acquisition In
Utero
710
IV. Bone Acquisition in the Preterm
Infant
722
V. Bone Acquisition in Term Infants and
Children
723
Chapter
29
Bone Acquisition in Adolescence
Moira
А. Регіт,
Heather M. MacDonald. Hf.ather A. McKay,
and Tom Li.oyd
I. Introduction
743
II. Bone Development
743
III. Mechanical Factors
748
Contents
IV. Nonmechanical Factors
V. Summary
754
751
Chapter
30
Genetic Determinants
of Osteoporosis
André G.
Uitterlinden,
Fernando Rivadeneira, Hans
P. T. M.
van Leeuwen,
Joyce B. J. van
Meurs, and Huibert A. P.
Pols
I.
Introduction
759
II. Finding Risk Gene Variants for Complex
Traits
765
III. Osteoporosis Risk Gene Variants
781
IV. Applications and Prospects
791
Chapter
31
Nutrition and Risk for
Osteoporosis
Robert P. Heaimey
I. Introduction
799
II. Problems in the Investigation of Nutritional
Effects on Bone
802
Ш.
The Notion of a Nutrient Requirement
IV. The Natural Intake of Calcium and
805
Vitamin
D
805
V.
Calcium
807
VI.
Vitamin
D
821
VII.
Protein
823
VIII.
Vitamin
К
824
IX.
Other Essential Nutrients
X.
Conclusion
828
825
Chapter
32
Physical Activity in Prevention
of Osteoporosis and Associated Fractures
Kirsti Uusi-Rasi, Pekka Kannus,
Harri Sievänen
I. Introduction
837
II. Bone Adaptation to Physical Loading
837
III. Physical Activity and Bone
843
IV. Prevention of Falls and Fall-Related Fractures
by Physical Activity
850
V. Conclusions and Recommendations
852
Chapter
33
Premenopausal Reproductive
and Hormonal Characteristics and the Risk
for Osteoporosis
MaryFran Sowers
I. Introduction
861
II, Pregnancy
861
III. Age at First Pregnancy
IV. Parity and Nulliparity
864
864
V. Lactation
865
VI. Ovarian Activity or Menstrual Cycle
Characteristics and Bone Mass
VII.
Dysfunctional
Ovulation
870
VIII.
Oral Contraceptive Use
872
IX. Progestin-Injectable Contraceptives
X. Oophorectomy
876
XI. Summary and Implications
877
868
873
Chapter
34
Nonskeletal Risk Factors for
Osteoporosis and Fractures
Jeri W.
Nieves
887
I. Physical Characteristics
II.
Anthropométrie
Variables
III. Lifestyle Factors
892
Chapter
35
Falls as Risk Factors for
Fracture
Sarah D. Berry and Douglas P. Kiel
I. Introduction
911
II. Risk Factors for Falls
911
III. Risk Factors for Injurious Falls
IV. Falls Prevention Strategies
916
V. Summary and Implications
917
913
Chapter
36
Assessment of Fracture Risk
Nguyen Dinh Nguybn and Tuan V. Nguyen
I. Introduction
923
II. Definition of Osteoporotic Fracture
923
Ш.
Epidemiology of Osteoporotic Fracture
925
IV. Synthesis of Risk Factors and Risk Assessment
Models
944
V. Summary and Future Directions
948
Chapter
37
Outcomes of Osteoporotic
Fractures
Gail A. Greendale and Elizabeth Barrett-Connor
I. Introduction
959
II. Definitions of Functional Outcomes Related
to Fracture
959
III. Osteoporosis-Relevant Quality of Life
Assessments
959
IV. Outcomes of Wrist Fractures
960
V. Outcomes of Vertebral Fractures
961
VI. Outcomes of Hip Fractures
968
VII.
Conclusions
970 |
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| id | DE-604.BV023406240 |
| illustrated | Illustrated |
| indexdate | 2025-02-03T17:28:01Z |
| institution | BVB |
| isbn | 9780123705457 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016588929 |
| oclc_num | 836569732 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-19 DE-BY-UBM |
| owner_facet | DE-355 DE-BY-UBR DE-19 DE-BY-UBM |
| physical | XXV, 972 S. Ill., graph. Darst. |
| publishDate | 2008 |
| publishDateSearch | 2008 |
| publishDateSort | 2008 |
| publisher | Acad. Press |
| record_format | marc |
| spellingShingle | Osteoporosis |
| title | Osteoporosis |
| title_auth | Osteoporosis |
| title_exact_search | Osteoporosis |
| title_full | Osteoporosis 1 ed. by Robert Marcus ... |
| title_fullStr | Osteoporosis 1 ed. by Robert Marcus ... |
| title_full_unstemmed | Osteoporosis 1 ed. by Robert Marcus ... |
| title_short | Osteoporosis |
| title_sort | osteoporosis |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016588929&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV013936906 |
| work_keys_str_mv | AT marcusrobert osteoporosis1 |