Innate immunity of plants, animals and humans
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| Format: | Buch |
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| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
2008
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| Schriftenreihe: | Nucleic acids and molecular biology
21 |
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| Online-Zugang: | Inhaltsverzeichnis |
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| 245 | 1 | 0 | |a Innate immunity of plants, animals and humans |c Holger Heine, Ed. |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 2008 | |
| 300 | |a XIV, 241 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Nucleic acids and molecular biology |v 21 | |
| 650 | 4 | |a Immunité naturelle | |
| 650 | 4 | |a Immune System | |
| 650 | 4 | |a Immunity, Cellular | |
| 650 | 4 | |a Immunity, Innate | |
| 650 | 4 | |a Natural immunity | |
| 650 | 0 | 7 | |a Immunbiologie |0 (DE-588)4072743-9 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a Immunbiologie |0 (DE-588)4072743-9 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Heine, Holger |d 1966- |e Sonstige |0 (DE-588)114169888 |4 oth | |
| 830 | 0 | |a Nucleic acids and molecular biology |v 21 |w (DE-604)BV000695008 |9 21 | |
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Datensatz im Suchindex
| _version_ | 1819583680140541952 |
|---|---|
| adam_text | Contents
1 Evolution of Resistance Genes in Plants 1
Shunyuan Xiao, Wenming Wang, and Xiaohua Yang
1 Evolution of the Plant R Gene System 2
2 Conservation and Diversity of Plant R Genes 3
3 NBS, LRR and TIR Domains of Defense 6
4 Proliferation and Diversification of NBS LRR Genes in Plants 9
5 Mechanisms of R Avr Recognition 10
5.1 Direct R Avr Interaction the Gene For Gene Hypothesis . 10
5.2 Indirect R Avr Interaction the Guard Hypothesis 11
6 Patterns of R Avr Coevolution 13
6.1 Diversifying Selection Results from Direct R Avr Recognition? 14
6.2 Balancing Selection Results from Indirect Recognition? 15
6.3 A General Model for Evolution of the Plant R Gene System .. 17
7 New Perspectives 19
References 20
2 The Path Less Explored: Innate Immune Reactions in Cnidarians.. 27
Thomas C.G. Bosch
1 Cnidaria Are Among the Earliest Multicellular Animals
in the Tree of Life 28
2 Immune Reactions in Invertebrates 30
3 Immune Reactions in Cnidaria 30
3.1 How to Fight for a Space to Live? Intraspecies
Competition in Sea Anemones 31
3.2 How to Detect Approaching Allogeneic Cells
as Foreign and to Eliminate Them? Allorecognition
and Cell Lineage Competition in Colonial Hydractinia 32
3.3 How to Detect and Disarm Microbial Attackers?
Antimicrobial Defense Reactions in the Freshwater
Polyp Hydra and the Jellyfish Amelia 34
vii
viii Contents
3.4 How to Distinguish Between Friends and Foes:
Symbiotic Relationships in Corals and Hydra 36
4 How to Explore the Path They Went? Why Cnidarians Matter 38
References 39
3 Bug Versus Bug: Humoral Immune Responses
in Drosophila melanogaster 43
Deniz Erturk Hasdemir, Nicholas Paquette, Kamna Aggarwal,
and Neal Silverman
1 Introduction 44
1.1 A Brief History 44
1.2 Overview of the Drosophila Immune Response 45
2 Microbial Recognition the Peptidoglycan Recognition Proteins . . 45
2.1 Peptidoglycan 47
2.2 NF kB Proteins 48
3 The Toll Pathway 49
4 The IMD Pathway 55
5 Down Regulation of the IMD Pathway by PGRP Amidases 60
6 JAK/STAT Pathway 61
7 Concluding Remarks 62
References 63
4 Cellular Immune Responses in Drosophila melanogaster 73
Adrienne Ivory, Katherine Randle, and Louisa Wu
1 Introduction 74
2 Encapsulation 75
2.1 Recognition Centers on Membrane Differences 76
2.2 Lamellocyte Proliferation: Necessary for Successful
Encapsulation Response 78
2.3 Adhesion Requires Integrins, Rac, and Rho 78
2.4 Encapsulation Terminates with the Formation
of Basement Membrane 82
3 Phagocytosis 83
3.1 Proteins Opsonize Invading Bacteria and Fungi
to Promote Phagocytosis 84
3.2 Transmembrane and Circulating Peptidoglycan Recognition
Proteins are Involved in the Recognition of Bacteria 85
3.3 Receptors with Scavenger Like Activity Recognize
a Variety of Microbes 86
3.4 Phagocytosis Requires Reorganization of the Actin
Cytoskeleton 88
3.5 Engulfed Pathogens are Degraded in Phagolysosomes 89
3.6 Interactions Between Cellular and Humoral
Immune Responses 90
References 91
Contents ix
5 Immune Reactions in the Vertebrates Closest Relatives,
the Urochordates 99
Konstantin Khalturin, Ulrich Kiirn, and Thomas C.G. Bosch
1 Introduction 100
2 Urochordates are at the Root of Vertebrate Evolution 100
3 Natural History and Ecology of Urochordates 101
4 Immunity in Urochordates 102
4.1 Antimicrobial Peptides from Urochordates 103
4.2 Allorecognition in Urochordates 104
4.3 Complement in Urochordates 106
4.4 Despite the Absence of MHC, Urochordate Blood
Contains NK Like Cells 107
5 Conclusion 108
References 108
6 Innate Immune System of the Zebrafish, Danio rerio 113
Con Sullivan and Carol H. Kim
1 Overview 114
2 Components of Innate Immunity 115
2.1 General Description 115
2.2 Drosophila Toll: Identification and Recognition
of a Dually Functioning Pathway 116
2.3 TLRs and TIR Bearing Adaptor Proteins 117
3 Zebrafish as a Model for Infectious Disease and Innate
Immune Responses 118
3.1 Overview 118
3.2 Forward and Reverse Genetics 119
3.3 An Infectious Disease and Innate Immunity Model 120
4 NK Like Cells 122
5 Additional Innate Immunity Receptors in Zebrafish 124
6 Zebrafish Phagocytes 126
7 Conclusion 126
References 127
7 Toll Like Receptors in the Mammalian Innate Immune System .... 135
Andrei E. Medvedev and Stefanie N. Vogel
1 Introduction 136
2 TLRs as Primary Sensors of Pathogenic PAMPS
and Endogenous Danger Molecules 137
3 TLR Signaling Pathways 141
3.1 Interaction of TLRs with PAMPs and Co Receptors
Initiates Signaling 141
3.2 Role of TIR Containing Adapter Molecules
in TLR Signaling 142
x Contents
3.3 TLR Specificity for PAMPs in the Ectodomain
and Adapters in the TIR Domain Underlie a Dual
Recognition/Response System 146
3.4 The IRAK Family: Key Regulators of TLR Signaling 147
4 Mutations in TLRs and IRAK 4: Implications for Disease 149
5 Conclusions 155
References 156
8 NLRs: a Cytosolic Armory of Microbial Sensors Linked
to Human Diseases 169
Mathias Chamaillard
1 Introduction 170
2 NLRs, a Conserved Cytosolic Arm of the Innate Immune System . . 171
3 Physiological Role of NLRs in Innate and Adaptive Immunity:
NLRs Join TLRs 174
3.1 Host Sensing of Non TLR PAMPs: Lessons from NOD 1
and NOD2 Studies 174
3.2 NLRs Promote Maturation of TLR Induced II 1 (3
and IL 18 Release 176
4 What Can we Learn from NLRs Linked to Human Diseases? 177
4.1 NODI and NOD2 Mutations Linked to Chronic
Inflammatory Diseases 178
4.2 Auto Inflammatory Diseases 179
4.3 Reproduction Diseases 179
5 Concluding Remarks: Towards the Development
of Magic Bullets 179
References 180
9 Antimicrobial Peptides as First Line Effector Molecules
of the Human Innate Immune System 187
Regine Glaser, Jiirgen Harder, and Jens Michael Schroder
1 Introduction 188
2 Epithelial Antimicrobial Peptides and Proteins 189
2.1 Lysozyme 189
2.2 Human Beta Defensins 189
2.3 Human Alpha Defensins 194
2.4 RNases 195
2.5 S100 Proteins: S100 A7 (Psoriasin) 196
2.6 Others 198
3 Phagocyte Antimicrobial Peptides 200
3.1 Human Alpha Defensins 200
3.2 Cathelicidins 200
3.3 S100 Proteins: S100 A8/9 (Calprotectin) and S100A12
(Calgranulin C) 201
3.4 Others 202
Contents xi
4 Putative Action of Antimicrobial Peptides in the Healthy Human . 202
5 Antimicrobial Peptides and Diseases 205
5.1 Skin Diseases 205
5.2 Wound Healing 206
5.3 Diseases of the Airway Epithelia: Cystic Fibrosis 207
5.4 Gastrointestinal Diseases: Inflammatory Bowel Diseases . . . 208
5.5 Diseases Associated with Phagocyte Dysfunction 209
6 General Conclusion and Future Aspects 210
References 210
10 The Complement System in Innate Immunity 219
K.R. Mayilyan, Y.H. Kang, A.W. Dodds, and R.B. Sim
1 The Complement System in Mammals 220
1.1 Classical Pathway 221
1.2 The Lectin Pathway 223
1.3 Alternative Pathway 225
1.4 Regulation of the Complement System 228
1.5 Complement Receptors 229
2 The Structure of Complement Proteins 230
3 Complement Across Species 232
References 233
Index 237
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| id | DE-604.BV023044047 |
| illustrated | Illustrated |
| indexdate | 2024-12-23T20:44:25Z |
| institution | BVB |
| isbn | 9783540739296 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016247529 |
| oclc_num | 181602383 |
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| physical | XIV, 241 S. Ill., graph. Darst. |
| publishDate | 2008 |
| publishDateSearch | 2008 |
| publishDateSort | 2008 |
| publisher | Springer |
| record_format | marc |
| series | Nucleic acids and molecular biology |
| series2 | Nucleic acids and molecular biology |
| spellingShingle | Innate immunity of plants, animals and humans Nucleic acids and molecular biology Immunité naturelle Immune System Immunity, Cellular Immunity, Innate Natural immunity Immunbiologie (DE-588)4072743-9 gnd |
| subject_GND | (DE-588)4072743-9 (DE-588)4143413-4 |
| title | Innate immunity of plants, animals and humans |
| title_auth | Innate immunity of plants, animals and humans |
| title_exact_search | Innate immunity of plants, animals and humans |
| title_full | Innate immunity of plants, animals and humans Holger Heine, Ed. |
| title_fullStr | Innate immunity of plants, animals and humans Holger Heine, Ed. |
| title_full_unstemmed | Innate immunity of plants, animals and humans Holger Heine, Ed. |
| title_short | Innate immunity of plants, animals and humans |
| title_sort | innate immunity of plants animals and humans |
| topic | Immunité naturelle Immune System Immunity, Cellular Immunity, Innate Natural immunity Immunbiologie (DE-588)4072743-9 gnd |
| topic_facet | Immunité naturelle Immune System Immunity, Cellular Immunity, Innate Natural immunity Immunbiologie Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016247529&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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| work_keys_str_mv | AT heineholger innateimmunityofplantsanimalsandhumans |