Immunogenomics and human disease
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2006
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| 245 | 1 | 0 | |a Immunogenomics and human disease |c [ed. by] András Falus |
| 264 | 1 | |a Chichester [u.a.] |b Wiley |c 2006 | |
| 300 | |a XXI, 526 p. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 7 | |a Genomica |2 gtt | |
| 650 | 7 | |a Immuniteit |2 gtt | |
| 650 | 7 | |a Immunogenetica |2 gtt | |
| 650 | 4 | |a Immunogénétique | |
| 650 | 7 | |a Methodologie |2 gtt | |
| 650 | 4 | |a Methode | |
| 650 | 4 | |a Immunogenetics | |
| 650 | 4 | |a Immunogenetics |x methods | |
| 650 | 4 | |a Genetic Techniques | |
| 650 | 4 | |a Genomics |x methods | |
| 650 | 4 | |a Immunity |x genetics | |
| 650 | 0 | 7 | |a Immungenetik |0 (DE-588)4130579-6 |2 gnd |9 rswk-swf |
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| 689 | 0 | |C b |5 DE-604 | |
| 700 | 1 | |a Falus, András |e Sonstige |4 oth | |
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| _version_ | 1804137184824918016 |
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| adam_text | One of the major features that distinguishes vertebrates from invertebrates is the presence
of a complex immune system. Over millions of years, many novel immune genes and gene
families have emerged and their products form sophisticated pathways conferring
protection against most pathogens. The Human Genome Project revealed that the
¡mmunoglobulin gene superfamily was one of the largest in the genome, containing more
than
2%
of all known human genes. High-throughput technologies for the study of
DNA,
mRNA and proteins, such as microarrays and real-time gene amplification technologies,
as well as biobank facilities, are enabling the investigation of these genes and pathways in
ever more detail. The parallel development of databases and bioinformatics tools to store
and interpret this information will also contribute to greater understanding of the function
of the immune system.
Genomics is finally changing from an academic discipline to one with real clinical
relevance. The study of immune regulation in response to pathogen invasion, to the
presence of malignant or allogeneic tissue and, in some cases, to normal autologous tissue
requires techniques that study the behaviour of whole systems in parallel. A genome-wide,
systems biology approach is needed to understand the genetic and environmental factors
that regulate the healthy immune system and its response to pathogens as well as to
malignant cells arising within the body. It will also facilitate determining what goes wrong
when the immune system attacks normal host cells, as in autoimmune diseases such as
Type
1
diabetes.
Finally, greater knowledge of the immune system will enable us to use it to promote health
and cure disease, through vaccine development
-
targeting both pathogens and tumour
cells
-
and by manipulation of cellular and humoral defences.
This book provides an overview of key conceptual and molecular technologies being
deployed in immunogenomics, followed by detailed evaluations of the impact of
genomics and systems biology on important areas such as cancer immunology,
autoimmunity, allergy and the response to infection. It will be of interest to all those
working in immunology, as well as to bioinformaticians and specialists such as
oncologists and microbiologists.
Contents
Preface xiii
List of Contributors xvii
1 Genotyping methods and disease gene identification 1
Ramon Kucharzak and Ivo Glynne Gut
1.1 Introduction 1
1.2 Genotyping of single-nucleotide polymorphisms 3
1.3 Methods for interrogating SNPs 4
1.4 Analysis formats 9
1.5 The current generation of methods for SNP genotyping 12
1.6 The next generation 13
1.7 Classical HLA typing 14
1.8 MHC haplotypes 15
1.9 Molecular haplotyping 16
1.10 Microhaplotyping 16
1.11 MHC and disease associations 16
1.12 Conclusions 17
Acknowledgements 17
References 17
2 Glycomics and the sugar code: primer to their structural
basis and functionality 23
Hans-Joachim Gabius
2.1 Introduction 23
2.2 Lectins as effectors in functional glycomics 26
2.3 Galectins: structural principles and intrafamily diversity 34
2.4 Ligand-dependent levels of affinity regulation 38
2.5 Perspectives for galectin-dependent medical applications 43
2.6 Conclusions 44
References 44
vi CONTENTS
3 Proteomics in clinical research: perspectives and expectations 53
Ivan Lefkovits, Thomas Grussenmeyer, Peter Matt,
Martin Grapow, Michael Lefkovits and Hans-Reinhard Zerkowski
3.1 Introduction 53
3.2 Proteomics: tools and projects 55
3.3 Discussion 62
3.4 Concluding remarks 65
Acknowledgements 65
References 65
4 Chemical genomics: bridging the gap between novel
targets and small molecule drug candidates.
Contribution to immunology 69
Gyo rgy Dormdn, Takenori Tomohiro,
Yasumaru Hatanaka and Ferenc Darvas
4.1 Introduction of chemical genomics: definitions 69
4.2 Chemical microarrays 75
4.3 Small molecule and peptide probes for studying binding interactions
through creating a covalent bond 78
4.4 Photochemical proteomics 79
4.5 General aspects of photoaffinity labelling 79
4.6 Photoreactive probes of biomolecules 82
4.7 Application to the immunobiology of living cells 84
4.8 Multifunctional photoprobes for rapid analysis and screening 85
4.9 Advanced application to functional proteomics 88
4.10 Summary 89
References 89
5 Genomic and proteomic analysis of activated human monocytes 95
Ameesha Batheja, George Ho, Xiaoyao Xiao, Xiwei Wang
and David Uhlinger
5.1 Primary human monocytes, as a model system 96
5.2 Transcriptional profiling of activated monocytes 97
5.3 Functional genomics 99
5.4 Proteomic analysis of activated human monocytes 102
References 105
6 Bioinformatics as a problem of knowledge representation:
applications to some aspects of immunoregulation 107
Sdndor Pongor and Andrds Falus
6.1 Introduction 107
6.2 Sequences and languages 111
6.3 Three-dimensional models 115
6.4 Genomes, proteomes, networks 116
6.5 Computational tools 119
CONTENTS vii
6.6 Information processing in the immune system 120
6.7 Concluding remarks 127
References 129
7 Immune responsiveness of human tumours 133
Ena Wang and Francesco M. Marincola
7.1 Introduction 134
7.2 Defining tumour immune responsiveness 135
7.3 Studying immune responsiveness in human tumours 136
7.4 Immune responsiveness in the context of therapy 138
7.5 The spatial dimension in the quest for the target 139
7.6 Studying the receiving end - tumour as an elusive target
for immune recognition 140
7.7 The role of the host in determining immune responsiveness 144
7.8 Concluding remarks 146
References 146
8 Chemokines regulate leukocyte trafficking
and organ-specific metastasis 153
Andor Pivarcsi, Anja Mueller and Bernhard Homey
8.1 Chemokines and chemokine receptors 153
8.2 Chemokine receptors in the organ-specific recruitment of tumour cells 157
8.3 Cancer therapy using chemokine receptor inhibitors 162
8.4 Conclusions 163
References 163
9 Towards a unified approach to new target discovery
in breast cancer: combining the power of genomics,
proteomics and immunology 167
Laszlo G. Radvanyi, Bryan Hennessy, Kurt Gish,
Gordon Mills and Neil Berinstein
9.1 Introduction 167
9.2 The use of CGH and DNA microarray-based transcriptional profiling
for new target discovery in breast cancer 170
9.3 The challenge of new tumour marker/target validation: traditional
techniques meet new proteomics tools 184
9.4 Immunological validation of new target genes in breast cancer:
the emerging concept of the cancer immunome 188
9.5 Future prospects: combining target discovery approaches
in unified publicly accessible databases 196
References 198
10 Genomics and functional differences of dendritic cell subsets 209
Peter Gogolak and Eva Rajnavolgyi
10.1 Introduction 209
10.2 Origin, differentiation and function of human dendritic cell subsets 210
Vlii CONTENTS
10.3 Tissue localization of dendritic cell subsets 213
10.4 Antigen uptake by dentritic cells 215
10.5 Antigen processing and presentation by dendritic cells 219
10.6 Activation and polarization of dendritic cells 223
10.7 Enhancement of inflammatory responses by NK cells 228
10.8 Suppression of inflammatory responses by natural regulatory T cells 229
10.9 The role of dendritic cells and T-lymphocytes in tumour-specific
immune responses 231
References 234
11 Systemic lupus erythematosus: new ideas
for diagnosis and treatment 249
Sandeep Krishnan and George C. Tsokos
11.1 Introduction 249
11.2 Strategies for identifying diagnostic markers 250
11.3 Strategies for gene therapy for SLE 258
11.4 Conclusion and future direction 265
References 266
12 Immunogenetics of experimentally induced arthritis 271
Tibor T. Giant and Vyacheslav A. Adarichev
12.1 Rheumatoid arthritis in humans and murine proteoglycan-induced arthritis:
introduction 271
12.2 Genetic linkage analysis of PGIA 274
12.3 Transcriptome picture of the disease: gene expression during the initiation
and progression of joint inflammation 284
12.4 Conclusions 290
References 291
13 Synovial activation in rheumatoid arthiritis 299
Lars C. Huber, Renate E. Gay and Steffen Gay
13.1 Introduction 299
13.2 Synovial activation in rheumatoid arthritis 301
13.3 Conclusions/perspectives 315
References 316
14 T cell epitope hierarchy in experimental autoimmune models 327
Edit Buzas
14.1 Introduction 327
14.2 Immunodominance and crypticity 328
14.3 Epitope spreading (endogenous self-priming) 328
14.4 Degenerate T cell epitope recognition 329
14.5 The self-reactive TCR repertoire 330
CONTENTS ix
14.6 Thymic antigen presentation 331
14.7 Peripheral antigen presentation 333
14.8 Epitope hierarchy in experimental autoimmune encephalomyelitis 336
14.9 Epitope hierarchy in aggrecan-induced murine arthritis 337
14.10 Summary 343
References 344
15 Gene-gene interaction in immunology as exemplified
by studies on autoantibodies against 60 kDa heat-shock protein 351
Zoltdn Prohdszka
15.1 Introduction 352
15.2 Basic features of gene-gene interactions 353
15.3 How to detect epistasis 356
15.4 Autoimmunity to heat-shock proteins 360
15.5 Epistatic effect in the regulation of anti-HSP6 autoantibody levels 362
15.6 Conclusions 363
Appendix 366
References 366
16 Histamine genomics and metabolomics 371
Andrds Falus, Hargita Hegyesi, Susan Darvas, Zoltan Pos
and Peter Igaz
16.1 Introduction 371
16.2 Chemistry 372
16.3 Biosynthesis and biotransformation 372
16.4 Histidine decarboxylase - gene and protein 374
16.5 Catabolic pathways of histamine 380
16.6 Histamine receptors 381
16.7 Histamine and cytokines, relation to the T cell polarization
of the immune response 387
16.8 Histamine and tumour growth 389
16.9 Histamine research: an insight into metabolomics, lessons
from HDC-deficient mice 389
16.10 Histamine genomics on databases 390
References 390
17 The histamine H4 receptor: drug discovery
in the post-genomic era 395
Mall O Donnell, Paul J. Dunford and Robin L Thurmond
17.1 Introduction 395
17.2 Cloning of H3R and H4R 396
17.3 Generation of H^R-specific antagonists 398
17.4 High-throughput screening 399
17.5 Functional studies 400
17.6 Future prospects 404
References 405
x CONTENTS
18 Application of microarray technology to bronchial asthma 407
Kenji Izuhara, Kazuhiko Arima, Sachiko Kanaji,
Kiyonari Masumoto and Taisuke Kanaji
18.1 Introduction 407
18.2 Lung tissue as source 410
18.3 Particular cell as source 411
18.4 Conclusions 414
Acknowledgements 415
References 415
19 Genomic investigation of asthma in human and animal models 419
Csaba Szalai
19.1 Introduction 419
19.2 Methods for localization of asthma susceptibility genes 421
19.3 Results of the association studies and genome-wide screens in humans 422
19.4 Animal models of asthma 434
19.5 Concluding remarks 438
References 438
20 Primary immunodeficiencies: genotype-phenotype correlations 443
Mauno Vihinen and Anne Durandy
20.1 Introduction 443
20.2 Immunodeficiency data services 445
20.3 Genotype-phenotype correlations 447
20.4 ADA deficiency 447
20.5 RAG1 and RAG2 deficiency 450
20.6 AID deficiency 451
20.7 WAS 452
20.8 XL A 454
20.9 Why GP correlations are not more common 456
References 457
21 Transcriptional profiling of dentritic cells
in response to pathogens 461
Maria Foti, Francesco Granucci, Mattia Pelizzola, Norman Pavelka,
Ottavio Beretta, Caterina Vizzardelli, Matteo Urbano,
Ivan Zanoni, Giusy Capuano, Francesco Mingozzi
and Paola Ricciardi-Castagnoli
21.1 Transcriptional profiling to study the complexity of the immune system 462
21.2 DC subsets and functional studies 463
21.3 DC at the intersection between innate and adaptive immunity 469
21.4 DC and infectious diseases 472
21.5 DC and bacteria interaction 472
21.6 DC and virus interaction 474
CONTENTS xi
21.7 DC and parasite interaction 475
21.8 Leishmania mexicana molecular signature 478
21.9 Conclusions 478
References 480
22 Parallel biology: a systematic approach to drug target and
biomarker discovery in chronic obstructive pulmonary disease 487
Laszlo Takacs
22.1 Introduction 487
22.2 Genome research is a specific application of parallel biology often
regarded as systems biology 489
22.3 Chronic obstructive pulmonary disease 489
22.4 Goals of the study 491
22.5 Methods 491
22.6 Results 494
Appendix 495
References 495
23 Mycobacterial granulomas: a genomic approach 497
Laura H. Hogan, Dominic O. Co and Matyas Sandor
23.1 Introduction 497
23.2 Initial infection of macrophage 499
23.3 Mycobacterial gene expression in the host 502
23.4 Host genes important to granuloma formation 508
23.5 Granulomatous inflammation as an ecological system 509
References 510
Index 515
|
| adam_txt |
One of the major features that distinguishes vertebrates from invertebrates is the presence
of a complex immune system. Over millions of years, many novel immune genes and gene
families have emerged and their products form sophisticated pathways conferring
protection against most pathogens. The Human Genome Project revealed that the
¡mmunoglobulin gene superfamily was one of the largest in the genome, containing more
than
2%
of all known human genes. High-throughput technologies for the study of
DNA,
mRNA and proteins, such as microarrays and real-time gene amplification technologies,
as well as biobank facilities, are enabling the investigation of these genes and pathways in
ever more detail. The parallel development of databases and bioinformatics tools to store
and interpret this information will also contribute to greater understanding of the function
of the immune system.
Genomics is finally changing from an academic discipline to one with real clinical
relevance. The study of immune regulation in response to pathogen invasion, to the
presence of malignant or allogeneic tissue and, in some cases, to normal autologous tissue
requires techniques that study the behaviour of whole systems in parallel. A genome-wide,
systems biology approach is needed to understand the genetic and environmental factors
that regulate the healthy immune system and its response to pathogens as well as to
malignant cells arising within the body. It will also facilitate determining what goes wrong
when the immune system attacks normal host cells, as in autoimmune diseases such as
Type
1
diabetes.
Finally, greater knowledge of the immune system will enable us to use it to promote health
and cure disease, through vaccine development
-
targeting both pathogens and tumour
cells
-
and by manipulation of cellular and humoral defences.
This book provides an overview of key conceptual and molecular technologies being
deployed in immunogenomics, followed by detailed evaluations of the impact of
genomics and systems biology on important areas such as cancer immunology,
autoimmunity, allergy and the response to infection. It will be of interest to all those
working in immunology, as well as to bioinformaticians and specialists such as
oncologists and microbiologists.
Contents
Preface xiii
List of Contributors xvii
1 Genotyping methods and disease gene identification 1
Ramon Kucharzak and Ivo Glynne Gut
1.1 Introduction 1
1.2 Genotyping of single-nucleotide polymorphisms 3
1.3 Methods for interrogating SNPs 4
1.4 Analysis formats 9
1.5 The current generation of methods for SNP genotyping 12
1.6 The next generation 13
1.7 Classical HLA typing 14
1.8 MHC haplotypes 15
1.9 Molecular haplotyping 16
1.10 Microhaplotyping 16
1.11 MHC and disease associations 16
1.12 Conclusions 17
Acknowledgements 17
References 17
2 Glycomics and the sugar code: primer to their structural
basis and functionality 23
Hans-Joachim Gabius
2.1 Introduction 23
2.2 Lectins as effectors in functional glycomics 26
2.3 Galectins: structural principles and intrafamily diversity 34
2.4 Ligand-dependent levels of affinity regulation 38
2.5 Perspectives for galectin-dependent medical applications 43
2.6 Conclusions 44
References 44
vi CONTENTS
3 Proteomics in clinical research: perspectives and expectations 53
Ivan Lefkovits, Thomas Grussenmeyer, Peter Matt,
Martin Grapow, Michael Lefkovits and Hans-Reinhard Zerkowski
3.1 Introduction 53
3.2 Proteomics: tools and projects 55
3.3 Discussion 62
3.4 Concluding remarks 65
Acknowledgements 65
References 65
4 Chemical genomics: bridging the gap between novel
targets and small molecule drug candidates.
Contribution to immunology 69
Gyo'rgy Dormdn, Takenori Tomohiro,
Yasumaru Hatanaka and Ferenc Darvas
4.1 Introduction of chemical genomics: definitions 69
4.2 Chemical microarrays 75
4.3 Small molecule and peptide probes for studying binding interactions
through creating a covalent bond 78
4.4 Photochemical proteomics 79
4.5 General aspects of photoaffinity labelling 79
4.6 Photoreactive probes of biomolecules 82
4.7 Application to the immunobiology of living cells 84
4.8 Multifunctional photoprobes for rapid analysis and screening 85
4.9 Advanced application to functional proteomics 88
4.10 Summary 89
References 89
5 Genomic and proteomic analysis of activated human monocytes 95
Ameesha Batheja, George Ho, Xiaoyao Xiao, Xiwei Wang
and David Uhlinger
5.1 Primary human monocytes, as a model system 96
5.2 Transcriptional profiling of activated monocytes 97
5.3 Functional genomics 99
5.4 Proteomic analysis of activated human monocytes 102
References 105
6 Bioinformatics as a problem of knowledge representation:
applications to some aspects of immunoregulation 107
Sdndor Pongor and Andrds Falus
6.1 Introduction 107
6.2 Sequences and languages 111
6.3 Three-dimensional models 115
6.4 Genomes, proteomes, networks 116
6.5 Computational tools 119
CONTENTS vii
6.6 Information processing in the immune system 120
6.7 Concluding remarks 127
References 129
7 Immune responsiveness of human tumours 133
Ena Wang and Francesco M. Marincola
7.1 Introduction 134
7.2 Defining tumour immune responsiveness 135
7.3 Studying immune responsiveness in human tumours 136
7.4 Immune responsiveness in the context of therapy 138
7.5 The spatial dimension in the quest for the target 139
7.6 Studying the receiving end - tumour as an elusive target
for immune recognition 140
7.7 The role of the host in determining immune responsiveness 144
7.8 Concluding remarks 146
References 146
8 Chemokines regulate leukocyte trafficking
and organ-specific metastasis 153
Andor Pivarcsi, Anja Mueller and Bernhard Homey
8.1 Chemokines and chemokine receptors 153
8.2 Chemokine receptors in the organ-specific recruitment of tumour cells 157
8.3 Cancer therapy using chemokine receptor inhibitors 162
8.4 Conclusions 163
References 163
9 Towards a unified approach to new target discovery
in breast cancer: combining the power of genomics,
proteomics and immunology 167
Laszlo G. Radvanyi, Bryan Hennessy, Kurt Gish,
Gordon Mills and Neil Berinstein
9.1 Introduction 167
9.2 The use of CGH and DNA microarray-based transcriptional profiling
for new target discovery in breast cancer 170
9.3 The challenge of new tumour marker/target validation: traditional
techniques meet new proteomics tools 184
9.4 Immunological validation of new target genes in breast cancer:
the emerging concept of the cancer 'immunome' 188
9.5 Future prospects: combining target discovery approaches
in unified publicly accessible databases 196
References 198
10 Genomics and functional differences of dendritic cell subsets 209
Peter Gogolak and Eva Rajnavolgyi
10.1 Introduction 209
10.2 Origin, differentiation and function of human dendritic cell subsets 210
Vlii CONTENTS
10.3 Tissue localization of dendritic cell subsets 213
10.4 Antigen uptake by dentritic cells 215
10.5 Antigen processing and presentation by dendritic cells 219
10.6 Activation and polarization of dendritic cells 223
10.7 Enhancement of inflammatory responses by NK cells 228
10.8 Suppression of inflammatory responses by natural regulatory T cells 229
10.9 The role of dendritic cells and T-lymphocytes in tumour-specific
immune responses 231
References 234
11 Systemic lupus erythematosus: new ideas
for diagnosis and treatment 249
Sandeep Krishnan and George C. Tsokos
11.1 Introduction 249
11.2 Strategies for identifying diagnostic markers 250
11.3 Strategies for gene therapy for SLE 258
11.4 Conclusion and future direction 265
References 266
12 Immunogenetics of experimentally induced arthritis 271
Tibor T. Giant and Vyacheslav A. Adarichev
12.1 Rheumatoid arthritis in humans and murine proteoglycan-induced arthritis:
introduction 271
12.2 Genetic linkage analysis of PGIA 274
12.3 Transcriptome picture of the disease: gene expression during the initiation
and progression of joint inflammation 284
12.4 Conclusions 290
References 291
13 Synovial activation in rheumatoid arthiritis 299
Lars C. Huber, Renate E. Gay and Steffen Gay
13.1 Introduction 299
13.2 Synovial activation in rheumatoid arthritis 301
13.3 Conclusions/perspectives 315
References 316
14 T cell epitope hierarchy in experimental autoimmune models 327
Edit Buzas
14.1 Introduction 327
14.2 Immunodominance and crypticity 328
14.3 Epitope spreading (endogenous self-priming) 328
14.4 Degenerate T cell epitope recognition 329
14.5 The self-reactive TCR repertoire 330
CONTENTS ix
14.6 Thymic antigen presentation 331
14.7 Peripheral antigen presentation 333
14.8 Epitope hierarchy in experimental autoimmune encephalomyelitis 336
14.9 Epitope hierarchy in aggrecan-induced murine arthritis 337
14.10 Summary 343
References 344
15 Gene-gene interaction in immunology as exemplified
by studies on autoantibodies against 60 kDa heat-shock protein 351
Zoltdn Prohdszka
15.1 Introduction 352
15.2 Basic features of gene-gene interactions 353
15.3 How to detect epistasis 356
15.4 Autoimmunity to heat-shock proteins 360
15.5 Epistatic effect in the regulation of anti-HSP6 autoantibody levels 362
15.6 Conclusions 363
Appendix 366
References 366
16 Histamine genomics and metabolomics 371
Andrds Falus, Hargita Hegyesi, Susan Darvas, Zoltan Pos
and Peter Igaz
16.1 Introduction 371
16.2 Chemistry 372
16.3 Biosynthesis and biotransformation 372
16.4 Histidine decarboxylase - gene and protein 374
16.5 Catabolic pathways of histamine 380
16.6 Histamine receptors 381
16.7 Histamine and cytokines, relation to the T cell polarization
of the immune response 387
16.8 Histamine and tumour growth 389
16.9 Histamine research: an insight into metabolomics, lessons
from HDC-deficient mice 389
16.10 Histamine genomics on databases 390
References 390
17 The histamine H4 receptor: drug discovery
in the post-genomic era 395
Mall O'Donnell, Paul J. Dunford and Robin L Thurmond
17.1 Introduction 395
17.2 Cloning of H3R and H4R 396
17.3 Generation of H^R-specific antagonists 398
17.4 High-throughput screening 399
17.5 Functional studies 400
17.6 Future prospects 404
References 405
x CONTENTS
18 Application of microarray technology to bronchial asthma 407
Kenji Izuhara, Kazuhiko Arima, Sachiko Kanaji,
Kiyonari Masumoto and Taisuke Kanaji
18.1 Introduction 407
18.2 Lung tissue as 'source' 410
18.3 Particular cell as'source' 411
18.4 Conclusions 414
Acknowledgements 415
References 415
19 Genomic investigation of asthma in human and animal models 419
Csaba Szalai
19.1 Introduction 419
19.2 Methods for localization of asthma susceptibility genes 421
19.3 Results of the association studies and genome-wide screens in humans 422
19.4 Animal models of asthma 434
19.5 Concluding remarks 438
References 438
20 Primary immunodeficiencies: genotype-phenotype correlations 443
Mauno Vihinen and Anne Durandy
20.1 Introduction 443
20.2 Immunodeficiency data services 445
20.3 Genotype-phenotype correlations 447
20.4 ADA deficiency 447
20.5 RAG1 and RAG2 deficiency 450
20.6 AID deficiency 451
20.7 WAS 452
20.8 XL A 454
20.9 Why GP correlations are not more common 456
References 457
21 Transcriptional profiling of dentritic cells
in response to pathogens 461
Maria Foti, Francesco Granucci, Mattia Pelizzola, Norman Pavelka,
Ottavio Beretta, Caterina Vizzardelli, Matteo Urbano,
Ivan Zanoni, Giusy Capuano, Francesco Mingozzi
and Paola Ricciardi-Castagnoli
21.1 Transcriptional profiling to study the complexity of the immune system 462
21.2 DC subsets and functional studies 463
21.3 DC at the intersection between innate and adaptive immunity 469
21.4 DC and infectious diseases 472
21.5 DC and bacteria interaction 472
21.6 DC and virus interaction 474
CONTENTS xi
21.7 DC and parasite interaction 475
21.8 Leishmania mexicana molecular signature 478
21.9 Conclusions 478
References 480
22 Parallel biology: a systematic approach to drug target and
biomarker discovery in chronic obstructive pulmonary disease 487
Laszlo Takacs
22.1 Introduction 487
22.2 Genome research is a specific application of parallel biology often
regarded as systems biology 489
22.3 Chronic obstructive pulmonary disease 489
22.4 Goals of the study 491
22.5 Methods 491
22.6 Results 494
Appendix 495
References 495
23 Mycobacterial granulomas: a genomic approach 497
Laura H. Hogan, Dominic O. Co and Matyas Sandor
23.1 Introduction 497
23.2 Initial infection of macrophage 499
23.3 Mycobacterial gene expression in the host 502
23.4 Host genes important to granuloma formation 508
23.5 Granulomatous inflammation as an ecological system 509
References 510
Index 515 |
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| classification_rvk | WF 9910 XD 3600 |
| ctrlnum | (OCoLC)62089790 (DE-599)DNB 2005027905 |
| dewey-full | 616.07/96 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.07/96 |
| dewey-search | 616.07/96 |
| dewey-sort | 3616.07 296 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| discipline_str_mv | Biologie Medizin |
| format | Book |
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| id | DE-604.BV022945062 |
| illustrated | Illustrated |
| index_date | 2024-07-02T18:59:27Z |
| indexdate | 2024-07-09T21:08:16Z |
| institution | BVB |
| isbn | 9780470015308 0470015306 |
| language | English |
| lccn | 2005027905 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016149644 |
| oclc_num | 62089790 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-578 |
| owner_facet | DE-355 DE-BY-UBR DE-578 |
| physical | XXI, 526 p. Ill., graph. Darst. |
| publishDate | 2006 |
| publishDateSearch | 2006 |
| publishDateSort | 2006 |
| publisher | Wiley |
| record_format | marc |
| spelling | Immunogenomics and human disease [ed. by] András Falus Chichester [u.a.] Wiley 2006 XXI, 526 p. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Genomica gtt Immuniteit gtt Immunogenetica gtt Immunogénétique Methodologie gtt Methode Immunogenetics Immunogenetics methods Genetic Techniques Genomics methods Immunity genetics Immungenetik (DE-588)4130579-6 gnd rswk-swf Immungenetik (DE-588)4130579-6 s b DE-604 Falus, András Sonstige oth http://www.loc.gov/catdir/toc/ecip061/2005027905.html Table of contents only http://www.loc.gov/catdir/enhancements/fy0623/2005027905-d.html Publisher description Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016149644&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Klappentext HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016149644&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Immunogenomics and human disease Genomica gtt Immuniteit gtt Immunogenetica gtt Immunogénétique Methodologie gtt Methode Immunogenetics Immunogenetics methods Genetic Techniques Genomics methods Immunity genetics Immungenetik (DE-588)4130579-6 gnd |
| subject_GND | (DE-588)4130579-6 |
| title | Immunogenomics and human disease |
| title_auth | Immunogenomics and human disease |
| title_exact_search | Immunogenomics and human disease |
| title_exact_search_txtP | Immunogenomics and human disease |
| title_full | Immunogenomics and human disease [ed. by] András Falus |
| title_fullStr | Immunogenomics and human disease [ed. by] András Falus |
| title_full_unstemmed | Immunogenomics and human disease [ed. by] András Falus |
| title_short | Immunogenomics and human disease |
| title_sort | immunogenomics and human disease |
| topic | Genomica gtt Immuniteit gtt Immunogenetica gtt Immunogénétique Methodologie gtt Methode Immunogenetics Immunogenetics methods Genetic Techniques Genomics methods Immunity genetics Immungenetik (DE-588)4130579-6 gnd |
| topic_facet | Genomica Immuniteit Immunogenetica Immunogénétique Methodologie Methode Immunogenetics Immunogenetics methods Genetic Techniques Genomics methods Immunity genetics Immungenetik |
| url | http://www.loc.gov/catdir/toc/ecip061/2005027905.html http://www.loc.gov/catdir/enhancements/fy0623/2005027905-d.html http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016149644&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016149644&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT falusandras immunogenomicsandhumandisease |