The neurobiology of epilepsy and aging
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| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier AP
2007
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| Schriftenreihe: | International review of neurobiology
81 |
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| Online-Zugang: | Inhaltsverzeichnis |
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| 245 | 1 | 0 | |a The neurobiology of epilepsy and aging |c ed. by R. Eugene Ramsay ... |
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier AP |c 2007 | |
| 300 | |a XVII, 343 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
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| 490 | 0 | |a International review of neurobiology |v 81 | |
| 500 | |a Einzelaufnahme eines Zeitschr.-Bd. | ||
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| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-015609521 | |
Datensatz im Suchindex
| _version_ | 1819762425967149056 |
|---|---|
| adam_text | CONTENTS
Contributors xv
Acknowledgment xvii
Epilepsy in the Elderly: Scope of the Problem
Ilo E. Leppik
I. Introduction 2
II. Known Knowns 2
III. Known Unknowns 11
IV. Unknown Unknowns 11
V. Unknown Knowns 12
VI. Conclusion 12
References 12
Animal Models in Gerontology Research
Nancy L. Nadon
I. Animal Models in Aging Research: Considerations for
Experimental Design 15
II. The Age Factor 16
III. Genetic Background 18
IV. Choice of Strain 19
V. Environmental Influences 22
VI. Genomic Manipulations 24
VII. Resources 25
References 26
Animal Models of Geriatric Epilepsy
Lauren J. Murphree, Lynn M. Rundhaugen, and Kevin M. Kelly
I. Introduction 30
II. Mouse Models 30
III. Gerbil Model 32
IV. Rat Models 33
V. Conclusions 37
References 37
vii
viii CONTENTS
Life and Death of Neurons in the Aging Cerebral Cortex
John H. Morrison and Patrick R. Hof
I. Introduction 42
II. Cortical Circuitry and Alzheimer s Disease 42
III. AAMI: Functional Decline Without Neuron Loss 46
IV. Interactions Between Neural and Endocrine Senescence 50
V. Conclusions 53
References 53
An In Vitro Model of Stroke Induced Epilepsy: Elucidation of the Roles of
Glutamate and Calcium in the Induction and Maintenance of
Stroke Induced Epileptogenesis
Robert J. DeLorenzo, David A. Sun, Robert E. Blair, and
SOMPONG SOMBATI
I. Introduction 60
II. Role of Glutamate in the Pathophysiology of Stroke 61
III. Developing an In Vitro Model of Glutamate Injury That Causes a
Mixed Population of Injured and Dead Neurons in Preparations of
Hippocampal Neurons in Culture 63
FV. Development of SREDs in Neurons Surviving Injury 64
V. Neuronal Networks Display Synchronized SREDs and Respond to
Anticonvulsant Treatment 67
VI. Use of the In Vitro Model of Stroke Induced AE to Evaluate the Calcium
Hypothesis of Epileptogenesis 68
VII. Role of Ca2+ and NMDA Receptor Activation in Epileptogenesis 69
VIII. Antagonism of Non NMDA Receptor Subtypes of Glutamate Receptors
Does Not Inhibit Glutamate Injury Induced AE 72
IX. Stroke Induced AE Is Associated With Prolonged Elevations in Neuronal
[Ca2+]j Levels and Alterations in Ca2+ Homeostatic Mechanisms 73
X. Glutamate Injury Induced Epileptogenesis Causes Long Lasting
Elevations in Basal Neuronal [Ca2+]j Levels 73
XI. Epileptic Neurons Demonstrate Impaired Recovery of Resting [Ca2+];
After Brief Glutamate Induced Ca2+ Loading 75
XII. The Importance of In Vitro Models of Stroke Induced AE 75
XIII. Calcium Plays a Role in the Induction of
Stroke Induced Epileptogenesis 78
XIV. Long Lasting Changes in [Ca2+]i Levels and Ca2+ Homeostatic
Mechanisms Play a Role in Maintaining AE 80
References 81
CONTENTS ix
Mechanisms of Action of Antiepileptic Drugs
H. Steve White, Misty D. Smith, and Karen S. Wilcox
I. Introduction 86
II. Modulation of Voltage Gated Ion Channels 86
III. Enhanced Inhibition 88
IV. Excitation Reduction 88
V. First Generation AEDs 89
VI. Second Generation AEDs 93
VII. Summary and Implications for the Management of the Older Patient
With Epilepsy 102
References 102
Epidemiology and Outcomes of Status Epilepticus in the Elderly
Alan R. Towne
I. Introduction 112
II. Definitions 112
III. The Epidemiology of SE in the Older Patient 113
IV. Etiologies of SE in the Elderly 115
V. Mortality of SE in the Elderly 116
VI. Electroencephalogram 118
VII. Treatment 119
VIII. Conclusions 123
References 124
Diagnosing Epilepsy in the Elderly
R. Eugene Ramsay, Flavia M. Macias, and A. James Rowan
I. Introduction 130
II. Etiology 131
III. Clinical Manifestations 132
IV. Differential Diagnosis 133
V. Cardiovascular and Cerebrovascular Diseases 135
VI. Confusional Migraine 135
VII. Drug Use 136
VIII. Infection 136
IX. Metabolic Disturbances 138
X. Sleep Disorders 141
XI. Syncope 141
XII. Psychiatric Disorders 142
XIII. Transient Global Amnesia 146
XTV. Dementia 147
XV. Primary Generalized Seizures (Idiopathic) 147
XVI. Summary 148
References 148
X CONTENTS
Pharmacoepidemiology in Community Dwelling Elderly Taking
Antiepileptic Drugs
Dan R. Berlowitz and Mary Jo V. Pugh
I. Introduction 154
II. Methods 154
III. Results 156
IV. Discussion 159
References 162
Use of Antiepileptic Medications in Nursing Homes
Judith Garrard, Susan L. Harms, Lynn E. Eberly, and Ilo E. Leppik
I. Introduction 166
II. Methods 168
III. Results 173
IV. Discussion 178
References 180
Age Related Changes in Pharmacokinetics: Predictability and
Assessment Methods
Emilio Perucca
I. Introduction 184
II. The Effect of Aging on Pharmacokinetics 185
III. Predicting Aging Associated Pharmacokinetic Changes 189
IV. Assessing Aging Associated Pharmacokinetic Changes 192
V. Conclusions 195
References 196
Factors Affecting Antiepileptic Drug Pharmacokinetics in
Community Dwelling Elderly
James C. Cloyd, Susan Marino, and Angela K. Birnbaum
I. Introduction 202
II. Preliminary Studies of PHT and CBZ Pharmacokinetics in
Community Dwelling Elderly 205
III. Discussion and Conclusion 209
References 209
CONTENTS xi
Pharmacokinetics of Antiepileptic Drugs in Elderly Nursing
Home Residents
Angela K. Birnbaum
I. Introduction 212
II. Older AEDs 212
III. Newer AEDs 218
References 218
The Impact of Epilepsy on Older Veterans
Mary Jo V. Pugh, Dan R. Berlowitz, and Lewis Kazis
I. Introduction 222
II. Methods 223
III. Results 225
IV. Discussion 230
References 232
Risk and Predictability of Drug Interactions in the Elderly
Rene H. Levy and Carol Collins
I. Introduction 236
II. Antiepileptic Drugs Used in the Elderly 237
III. Methods for Pharmacokinetic Evaluation 238
IV. Antidepressants and Drugs Used to Treat Dementia 238
V. Cardiovascular Agents 242
VI. Conclusions 245
References 246
Outcomes in Elderly Patients With Newly Diagnosed and
Treated Epilepsy
Martin J. Brodie and Linda J. Stephen
I. Introduction 254
II. The Glasgow Registry 255
III. Analysis of the 1982 2001 Cohort 256
IV. Supplemental Analysis 258
V. Difficulties in Diagnosing Epilepsy in the Elderly 258
xii CONTENTS
VI. Studies Comparing Newer and Older AEDs 259
VII. Initiating AED Treatment 261
VIII. Conclusions 262
References 262
Recruitment and Retention in Clinical Trials of the Elderly
Flavia M. Macias, R. Eugene Ramsay, and A. James Rowan
I. Introduction 266
II. Recruitment Outcomes of Veterans Affairs Cooperative Study 428 266
III. Factors Influencing Recruitment 270
IV. Cost of Recruitment 271
V. Retention Results From VA Cooperative Study 428 271
References 272
Treatment of Convulsive Status Epilepticus
David M. Treiman
I. Introduction 274
II. Presentation, Progression, and Diagnosis 275
III. Consequences and Prognosis 276
IV. Treatment 277
V. Conclusions 283
References 283
Treatment of Nonconvulsive Status Epilepticus
Matthew C. Walker
I. Introduction 288
II. Diagnosis 288
III. Neuronal Damage Models 291
IV. Complex Partial Status Epilepticus 292
V. NCSEinComa 294
VI. Typical Absence Status Epilepticus 295
VII. Conclusions 295
References 296
CONTENTS xiii
Antiepileptic Drug Formulation and Treatment in the Elderly:
Biopharmaceutical Considerations
Barry E. Gidal
I. Introduction 300
II. Biopharmaceutical Considerations 300
III. GI Function and Age 303
IV. Conclusions 308
References 309
Index 313
Contents of Recent Volumes 321
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| illustrated | Illustrated |
| indexdate | 2024-12-23T20:01:47Z |
| institution | BVB |
| isbn | 9780123740182 0123740185 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-015609521 |
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| physical | XVII, 343 S. Ill., graph. Darst. |
| publishDate | 2007 |
| publishDateSearch | 2007 |
| publishDateSort | 2007 |
| publisher | Elsevier AP |
| record_format | marc |
| series2 | International review of neurobiology |
| spellingShingle | The neurobiology of epilepsy and aging Epilepsie (DE-588)4015035-5 gnd Alter (DE-588)4001446-0 gnd |
| subject_GND | (DE-588)4015035-5 (DE-588)4001446-0 (DE-588)4143413-4 |
| title | The neurobiology of epilepsy and aging |
| title_auth | The neurobiology of epilepsy and aging |
| title_exact_search | The neurobiology of epilepsy and aging |
| title_full | The neurobiology of epilepsy and aging ed. by R. Eugene Ramsay ... |
| title_fullStr | The neurobiology of epilepsy and aging ed. by R. Eugene Ramsay ... |
| title_full_unstemmed | The neurobiology of epilepsy and aging ed. by R. Eugene Ramsay ... |
| title_short | The neurobiology of epilepsy and aging |
| title_sort | the neurobiology of epilepsy and aging |
| topic | Epilepsie (DE-588)4015035-5 gnd Alter (DE-588)4001446-0 gnd |
| topic_facet | Epilepsie Alter Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015609521&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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