Cell culture and upstream processing
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| Format: | Buch |
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| Sprache: | English |
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New York, NY [u.a.]
Taylor & Francis
2007
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| 245 | 1 | 0 | |a Cell culture and upstream processing |c ed. by Michael Butler |
| 264 | 1 | |a New York, NY [u.a.] |b Taylor & Francis |c 2007 | |
| 300 | |a XIV, 187 S. |b Ill., graph. Darst., Tab. | ||
| 336 | |b txt |2 rdacontent | ||
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| 650 | 4 | |a Biochemical engineering |v Congresses | |
| 650 | 4 | |a Biotechnology |v Congresses | |
| 650 | 4 | |a Cell Culture Techniques |x methods |v Congresses | |
| 650 | 4 | |a Cell culture |v Congresses | |
| 650 | 4 | |a Genetic Engineering |x methods |v Congresses | |
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Datensatz im Suchindex
| DE-BY-TUM_call_number | 1002 CIT 940f 2007 A 4499 |
|---|---|
| DE-BY-TUM_katkey | 1591371 |
| DE-BY-TUM_location | 10 |
| DE-BY-TUM_media_number | 040050609097 |
| _version_ | 1820873118385700864 |
| adam_text | CELL CULTURE AND UPSTREAM PROCESSING EDITED BY MICHAEL BUTLER DEPARTMENT
OF MICROBIOLOGY, UNIVERSITY OF MANITOBA, MANITOBA, CANADA TAYLOR &
FRANCIS TAYLOR & FRANCIS GROUP CONTENTS CONTRIBUTORS IX ABBREVIATIONS XI
PREFACE XIII OVERVIEW ON MAMMALIAN CELL CULTURE 1 CELL LINE DEVELOPMENT
AND CULTURE STRATEGIES: FUTURE PROSPECTS TO IMPROVE YIELDS 3 MICHAEL
BUTLER 1.1 INTRODUCTION 3 1.2 CELL LINE TRANSFECTION AND SELECTION 5 1.3
INCREASE IN EFFICIENCY IN SELECTING A PRODUCER CELL LINE 6 1.4 STABILITY
OF GENE EXPRESSION 8 1.5 OPTIMIZATION OF THE FERMENTATION PROCESS 9 1.6
APOPTOSIS 11 1.7 BIOREACTORS 11 1.8 THE CAPACITY CRUNCH 12
ACKNOWLEDGMENT 13 REFERENCES 13 THE PRODUCER CELL LINE 2 USE OF DNA
INSULATOR ELEMENTS AND SCAFFOLD/MATRIX-ATTACHED REGIONS FOR ENHANCED
RECOMBINANT PROTEIN EXPRESSION 19 HELEN KIM 2.1 INTRODUCTION 19 2.2 THE
POSITION EFFECT 20 2.3 USE OF INSULATORS AND S/MARS CAN REDUCE THE
EFFECTS OF HETEROCHROMATIN ON TRANSGENE EXPRESSION 20 2.4 DNA INSULATOR
ELEMENTS 22 2.5 THE SCAFFOLD/MATRIX-ATTACHMENT REGIONS 23 2.6 BINDING
PROTEINS FOR DNA INSULATORS AND S/MARS 25 2.7 DNA INSULATORS OR S/MARS
CAN BE INCORPORATED INTO EXPRESSION VECTORS 26 2.8 DNA INSULATORS AND
S/MARS ACT IN A CONTEXT-DEPENDENT MANNER 30 2.9 CONCLUSION 31
ACKNOWLEDGEMENTS 32 REFERENCES 32 VI CONTENTS TARGETED GENE INSERTION TO
ENHANCE PROTEIN PRODUCTION FROM CELL LINES 37 TREVOR N. COLLINGWOOD AND
FYODOR D. URNOV 3.1 INTRODUCTION 37 3.2 IDENTIFICATION OF GENOMIC HOT
SPOT LOCI 39 3.3 RECOMBINASE-MEDIATED SITE-SPECIFIC GENE INSERTION 39
3.3.1 CRE, FLP, AND (( C31 RECOMBINASE SYSTEMS 40 3.3.2
RECOMBINASE-MEDIATED CASSETTE EXCHANGE 40 3.3.3 GENE INSERTION AT NATIVE
PSEUDO RECOMBINASE SITES 43 3.3.4 MODIFICATION OF RECOMBINASES AND
THEIR TARGET SITES 43 3.4 EMERGING TECHNOLOGIES FOR TARGETED GENE
INSERTION 44 3.4.1 HOMING ENDONUCLEASES IN HDR-MEDIATED TARGETED GENE
INSERTION 46 3.4.2 TARGETED GENE INSERTION INTO NATIVE LOCI BY ZINC
FINGER, NUCLEASE- MEDIATED, HIGH-FREQUENCY, HOMOLOGOUS RECOMBINATION 47
3.5 PERSPECTIVE 50 REFERENCES 52 RECOMBINANT HUMAN IGG PRODUCTION FROM
MYELOMA AND CHINESE HAMSTER OVARY CELLS 57 RAY FIELD 4.1 INTRODUCTION 57
4.2 THE NEED FOR RECOMBINANT HUMAN ANTIBODIES 57 4.3 RECOMBINANT
ANTIBODIES 58 4.4 DECOUPLING ANTIBODY ISOLATION AND PRODUCTION 58 4.5
CHOICE OF HOST CELLS 59 4.5.1 CHINESE HAMSTER OVARY CELLS 60 4.5.2
RODENT MYELOMA CELLS 60 4.6 THE GLUTAMINE SYNTHETASE SYSTEM 60 4.7 CELL
LINE STABILITY 61 4.8 BIOREACTOR PROCESS STRATEGIES 62 4.9 IGG SUPPLY
DURING ANTIBODY DEVELOPMENT 62 4.10 STRATEGIES FOR CELL LINE ENGINEERING
DURING CLINICAL DEVELOPMENT 63 4.11 COST OF GOODS AND INTELLECTUAL
PROPERTY 64 4.12 RECOMBINANT HUMAN IGG PRODUCTION FROM MYELOMA AND CHO
CELLS 64 4.12.1 CREATION OF CHO AND NS0 CELL LINES EXPRESSING IGG 64
4.12.2 CELL EXPANSION, SUBCULTURE AND PRODUCTION REACTOR EXPERIMENTS 65
4.12.3 NORTHERN AND WESTERN BLOTTING 65 4.12.4 COMPARISON OF RESULTS OF
TRANSFECTIONS FROM GS-NS0 AND GS-CHO 65 4.12.5 DILUTION CLONING AND
ANALYSIS OF CLONAL HETEROGENEITY 66 4.12.6 ANALYSIS OF INSTABILITY OF A
GS-NS0 CELL LINE 67 4.12.7 OUTPUT OF TRANSFECTIONS OF GS-NS0 AND GS-CHO
68 4.12.8 IGG PRODUCTION STABILITY OF CANDIDATE GS-NS0 CLONES 69 4.12.9
IGG PRODUCTION STABILITY OF GS-CHO TRANSFECTANTS 70 4.12.10 FED-BATCH
BIOREACTOR PROCESS FOR GS-NS0 AND GS-CHO 71 4.12.11 ANALYSIS OF IGG
QUALITY PRODUCED FROM GS-CHO AND GS-NS0 BIOREACTOR PROCESSES 71 4.12.12
COMPARATIVE YIELD OF DIFFERENT HUMAN IGGS PRODUCED FROM CHO OR NS0 CELLS
74 4.13 SUMMARY 74 ACKNOWLEDGMENTS 76 REFERENCES 76 CONTENTS VII MEDIA
DEVELOPMENT 5 CELL CULTURE MEDIA DEVELOPMENT: CUSTOMIZATION OF ANIMAL
ORIGIN-FREE COMPONENTS AND SUPPLEMENTS 81 STEPHEN GORFIEN 5.1
INTRODUCTION 81 5.2 TYPES OF CELL CULTURE MEDIA 82 5.3 COMPONENTS OF
ANIMAL ORIGIN 83 5.3.1 SEGREGATE 85 5.3.2 MITIGATE 87 5.3.3 REPLACE 88
5.4 SUMMARY AND CONSIDERATIONS FOR THE FUTURE 95 ACKNOWLEDGMENTS 98
REFERENCES 98 GLYCOSYLATED PROTEINS 6 POST-TRANSLATIONAL MODIFICATION OF
RECOMBINANT ANTIBODY PROTEINS 103 ROY JEFFRIES 6.1 INTRODUCTION 103 6.2
COMMON POST-TRANSLATIONAL MODIFICATIONS 104 6.3 RECOMBINANT ANTIBODY
THERAPEUTICS 105 6.4 STRUCTURAL AND FUNCTIONAL CHARACTERISTICS OF HUMAN
ANTIBODIES 106 6.5 THE HUMAN IGG SUBCLASSES: OPTIONS FOR ANTIBODY
THERAPEUTICS 106 6.6 THE STRUCTURE OF HUMAN IGG ANTIBODIES 108 6.7
IGG-FC GLYCOSYLATION 110 6.8 IGG-FAB GLYCOSYLATION 112 6.9 CELL
ENGINEERING TO INFLUENCE GLYCOFORM PROFILES 115 6.10 IGG GLYCOFORMS AND
FC EFFECTOR FUNCTIONS 116 6.11 GLYCOSYLATION ENGINEERING 118 6.12
PHARMACOKINETICS AND PLACENTAL TRANSPORT 118 6.13 ANTIBODY THERAPEUTICS
OF THE IGA CLASS 119 6.14 NON-ANTIBODY RECOMBINANT (GLYCO)PROTEIN
THERAPEUTICS, BIOSIMILAR AND FOLLOW-ON BIOLOGIES 120 6.14.1
ERYTHROPOIETIN 121 6.14.2 TISSUE-TYPE PLASMINOGEN ACTIVATOR 122 6.14.3
GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR (GM-CSF) 122 6.14.4
GRANULOCYTE-COLONY STIMULATING FACTOR 122 6.14.5 ACTIVATED PROTEIN C 122
6.15 CONCLUSIONS 123 REFERENCES 123 7 METABOLIC ENGINEERING TO CONTROL
GLYCOSYLATION 131 AMY SHEN, DOMINGOS NG, JOHN FOLY, BRAD SNEDECOR,
YANMEI LU, GLORIA MENG, GERALD NAKAMURA AND LYNNE KRUMMEN 7.1
INTRODUCTION 131 7.2 MANIPULATION OF FUCOSE CONTENT USING RNAI
TECHNOLOGY IN CHO CELLS 132 7.2.1 METABOLIC ENGINEERING OF FUCOSE
CONTENT WITH AN EXISTING ANTIBODY PRODUCTION LINE 132 7.2.2 METABOLIC
ENGINEERING OF FUCOSE CONTENT WITH SIMULTANEOUS NEW STABLE CELL LINE
GENERATION 136 7.2.3 EFFECT OF FUCOSYLATION LEVELS ON FCYR BINDING 140
VIII CONTENTS 7.2.4 EFFECTS OF FUCOSE CONTENT ON ANTIBODY-DEPENDENT
CELLULAR CYTOTOXICITY 143 7.3 DISCUSSION 143 ACKNOWLEDGMENTS 146
REFERENCES 146 8 AN ALTERNATIVE APPROACH: HUMANIZATION OF
N-GLYCOSYLATION PATHWAYS IN YEAST 149 STEFAN WILDT AND THOMAS POTGIETER
8.1 INTRODUCTION 149 8.2 YEAST AS HOST FOR RECOMBINANT PROTEIN
EXPRESSION 152 8.3 N-LINKED GLYCOSYLATION OVERVIEW: FUNGAL VERSUS
MAMMALIAN 152 8.4 A BRIEF HISTORY OF EFFORTS TO HUMANIZE N-LINKED
GLYCOSYLATION IN FUNGAL SYSTEMS 154 8.5 SEQUENTIAL TARGETING OF
GLYCOSYLATION ENZYMES IS A KEY FACTOR 155 8.6 REPLICATION OF HUMAN-LIKE
GLYCOSYLATION IN THE METHYLOTROPHIC YEAST PICHIA PASTORIS 157 8.7 A
LIBRARY OF A-1,2 MANNOSIDASES 157 8.8 TRANSFER OF N-ACETYLGLUCOSAMINE
158 8.9 TWO INDEPENDENT APPROACHES TOWARDS COMPLEX N-GIYCANS: HOW TO
ELIMINATE MORE MANNOSES 159 8.10 SOME METABOLIC ENGINEERING: TRANSFER OF
GALACTOSE 161 8.11 MORE METABOLIC ENGINEERING: SIALIC ACID TRANSFER. THE
FINAL STEP 162 8.12 GLYCO-ENGINEERED YEAST AS A HOST FOR PRODUCTION OF
THERAPEUTIC GLYCOPROTEINS 162 8.13 N-LINKED GLYCANS AND PHARMACDKINETICS
OF THERAPEUTIC GLYCOPROTEINS 164 8.14 N-GLYCANS AND THEIR ROLE IN TISSUE
TARGETING OF GLYCOPROTEINS 164 8.15 N-GLYCANS CAN MODULATE THE
BIOLOGICAL ACTIVITY OF THERAPEUTIC GLYCOPROTEINS 165 8.16 CONTROL OF
N-GLYCOSYLATION OFFERS ADVANTAGES 165 8.17 CONCLUSIONS 166 REFERENCES
166 THE BIOPROCESS 9 PERFUSION OR FED-BATCH? A MATTER OF PERSPECTIVE 173
MARCO CACCIUTTOLO 9.1 INTRODUCTION 173 9.2 FACTORS AFFECTING THE
DECISION ON CHOOSING THE MANUFACTURING TECHNOLOGY 175 9.2.1 TECHNOLOGY
EXPERTISE 175 9.2.2 FACILITY DESIGN AND SCOPE (PRODUCT DEDICATED VERSUS
MULTI-PRODUCT) 179 9.3 IMPACT OF SWITCHING FROM PERFUSION TO FED-BATCH
180 9.3.1 PERSONNEL REQUIREMENTS 180 9.3.2 LIQUID HANDLING I 181 9.3.3
EQUIPMENT 182 9.3.4 MANUFACTURING SPACE 182 9.3.5 DECREASE IN CYCLE TIME
182 9.3.6 DIRECT COSTS OF MANUFACTURING 182 9.3.7 PRODUCTIVITY AND
MORALE 183 9.4 CONCLUSIONS 183 ACKNOWLEDGMENTS 184 REFERENCES 184
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| id | DE-604.BV022396810 |
| illustrated | Illustrated |
| indexdate | 2024-12-23T20:01:00Z |
| institution | BVB |
| isbn | 9780415399692 0415399696 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-015605537 |
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| physical | XIV, 187 S. Ill., graph. Darst., Tab. |
| publishDate | 2007 |
| publishDateSearch | 2007 |
| publishDateSort | 2007 |
| publisher | Taylor & Francis |
| record_format | marc |
| spellingShingle | Cell culture and upstream processing Biochemical engineering Congresses Biotechnology Congresses Cell Culture Techniques methods Congresses Cell culture Congresses Genetic Engineering methods Congresses Tierzelle (DE-588)4185509-7 gnd Zellkultur (DE-588)4067547-6 gnd Bioverfahrenstechnik (DE-588)4307166-1 gnd |
| subject_GND | (DE-588)4185509-7 (DE-588)4067547-6 (DE-588)4307166-1 (DE-588)4143413-4 (DE-588)1071861417 |
| title | Cell culture and upstream processing |
| title_auth | Cell culture and upstream processing |
| title_exact_search | Cell culture and upstream processing |
| title_full | Cell culture and upstream processing ed. by Michael Butler |
| title_fullStr | Cell culture and upstream processing ed. by Michael Butler |
| title_full_unstemmed | Cell culture and upstream processing ed. by Michael Butler |
| title_short | Cell culture and upstream processing |
| title_sort | cell culture and upstream processing |
| topic | Biochemical engineering Congresses Biotechnology Congresses Cell Culture Techniques methods Congresses Cell culture Congresses Genetic Engineering methods Congresses Tierzelle (DE-588)4185509-7 gnd Zellkultur (DE-588)4067547-6 gnd Bioverfahrenstechnik (DE-588)4307166-1 gnd |
| topic_facet | Biochemical engineering Congresses Biotechnology Congresses Cell Culture Techniques methods Congresses Cell culture Congresses Genetic Engineering methods Congresses Tierzelle Zellkultur Bioverfahrenstechnik Aufsatzsammlung Konferenzschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015605537&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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