Severe pneumonia

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Sprache:English
Veröffentlicht: Boca Raton, Fla. Taylor & Francis 2005
Schriftenreihe:Lung biology in health and disease 206
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Datensatz im Suchindex

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adam_text Contents Introduction Claude Lenfant Hi Preface v Contributors vii 1. Severe Pneumonia: Definition of Severity / Santiago Ewig Introduction .... 1 Role of Severity Assessment of CAP .... 2 Nosocomial Pneumonia .... 18 References .... 20 2. Why Do Some Patients Get Severe Pneumonia? 25 Grant W. Waterer and Richard G. Wunderink Introduction .... 25 Pathogen Virulence .... 26 Comorbid Illnesses .... 27 Genetic Factors .... 29 Conclusion .... 32 References .... 33 3. What Is the Role of Mechanical Ventilation in Pneumonia Pathogenesis and How Can Noninvasive Ventilation Be Used to Prevent Nosocomial Pneumonia 39 Massimo Antonelli and Giorgio Conti Introduction .... 39 x xii Contents Does Noninvasive Ventilation Prevent Pneumonia in Patients with Acute Respiratory Failure? .... 43 Conclusions .... 53 References .... 53 4. Community Acquired Pneumonia: Defining the Patient at Risk of Severe Illness and the Role of Mortality Prediction Models in Patient Management 59 Mark Woodhead Introduction .... 59 Why Might We Need Severity Assessment? .... 60 Some Basic Principles .... 61 Denning the Patient at Risk: Presentation to Hospital .... 62 Denning the Patient at Risk: Presentation to the ICU .... 68 Denning the Patient at Risk: Presenting in the Community .... 69 Does Severity Assessment Alter Outcome? .... 70 How to Use Severity Prediction Rules in Practice .... 73 Conclusions .... 74 References .... 74 5. The Bacteriology of Severe Community Acquired Pneumonia and the Choice of Appropriate Empiric Therapy 81 Mauricio Valencia, Manuela Cavalcanti, and Antoni Torres Introduction .... 81 Etiology of Severe CAP .... 82 Specific Risk Groups .... 87 Treatment of Severe CAP .... 91 Conclusion .... 100 References .... 100 6. Risk Factors for Ventilator Associated Pneumonia: A Complex and Dynamic Problem 109 Donald E. Craven, Catherine A. Fleming, Jordi Roig, and Francesco G. De Rosa Introduction .... 110 Epidemiology .... 110 Pathogenesis .... 112 Etiologic Agents .... 114 Contents xiii Diagnosis of VAP .... 114 Risk Factors and Prophylaxis .... 115 Risk Factors Are Dynamic .... 126 Summary .... 128 References .... 129 7. Attributable Mortality and Mortality Predictors in Ventilator Associated Pneumonia 137 Jean Yves Fagon and Jean Chastre Attributable Mortality .... 138 Mortality Predictors in VAP Patients .... 143 References .... 149 8. The Clinical Diagnosis of Ventilator Associated Pneumonia 155 Michael S. Niederman What Is the Clinical Approach to Empiric Therapy of VAP, and Is It Accurate? .... 157 Problems with Quantitative Cultures and Their Use for the Management of Suspected VAP .... 163 Can a Bacteriologic Approach Impact Mortality in VAP? .... 165 What Are the Existing Benefits to Invasive Diagnostic Methods? .... 167 References .... 168 9. Establishing the Diagnosis of Ventilator Associated Pneumonia: An Invasive/Microbiologic Approach Compared to a Clinical Approach 171 Jean Chastre and Jean Yves Fagon Procedure .... 174 Complications .... 175 Specimen Types and Laboratory Methods .... 176 Usefulness of PSB and BAL Techniques .... 178 Patients Already Receiving Antimicrobial Therapy .... 179 Potential Drawbacks of Bronchoscopic Techniques .... 180 Argument for Bronchoscopy in the Diagnosis of VAP .... 182 Conclusion .... 185 Key Points .... 186 References .... 186 xiv Contents 10. Mechanisms of Antimicrobial Resistance in the Intensive Care Unit 191 Jan E. Patterson, Nina M. Clark, John P. Quinn, and Joseph P. Lynch III Introduction .... 191 Enterobacteriaceae .... 193 Pseudomonas aeruginosa .... 201 Acinetobacter spp 207 Burkholderia cepacia Complex .... 209 Stenotrophomonas maltophilia .... 213 Gram Positive Cocci .... 214 Prevention of Resistance (All Pathogens) .... 233 References .... 234 11. What Are the Optimal Regimens for Adequate Empiric Therapy of Ventilator Associated Pneumonia and How Can De Escalation Therapy Be Achieved? 275 George H. Karam Appropriateness of Empiric Antibiotic Therapy .... 276 Pathogens in VAP .... 277 Staphylococcus aureus .... 277 Gram Negative Bacteria .... 286 Anaerobes .... 298 How De Escalation Can Be Achieved .... 300 Conclusion .... 310 References .... 311 12. What Is the Role of Microbiological Surveillance in the Management of Ventilator Associated Pneumonia? 323 Dolors Mariscal and Jordi Rello Introduction .... 323 Basic Approaches to Surveillance .... 326 Microbiological Considerations .... 328 Cost Effectiveness .... 330 Summary .... 331 References .... 332 13. Antibiotic Pharmacokinetics and Pharmacodynamics: How Can They Be Used to Optimize Therapy in Ventilator Associated Pneumonia? 337 Sungmin Kiem and Jerome J. Schentag Introduction .... 337 Contents xv Limitations of Traditional Susceptibility Breakpoints .... 338 Pharmacokinetics/Pharmacodynamics of Antibiotics .... 339 Application of Antibiotic PK/PD in the Treatment of Nosocomial Pneumonia .... 347 Conclusion .... 354 References .... 355 14. Prevention of Ventilator Associated Pneumonia 367 Marc J. M. Bonten and Robert A. Weinstein Introduction .... 367 Guidelines and Systematic Reviews .... 368 Prevention of Colonization .... 368 Prevention of Aspiration .... 376 Conclusions .... 377 References .... 377 15. Pulmonary Host Defense: Basic Mechanisms and Strategies for Immunomodulation 383 Lee J. Quinton, Kyle I. Happel, Lisa Gamble and Steve Nelson Anatomic Barriers and Innate Defenses .... 384 Pathogen Recognition: The Gatekeeper of Host Defense .... 385 Pulmonary Neutrophil Recruitment and the Inflammatory Cascade .... 387 Pulmonary G CSF and the Maintenance of Neutrophil Homeostasis .... 393 Innate Immunity and the Acquired Immune Response .... 397 Regulation of the Pulmonary Host Response .... 399 Conclusion .... 401 References .... 401 Index 413 li l! s j i
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physical XV, 422 S. Ill.
publishDate 2005
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series Lung biology in health and disease
series2 Lung biology in health and disease
spelling Severe pneumonia ed. by Michael Niederman
Boca Raton, Fla. Taylor & Francis 2005
XV, 422 S. Ill.
txt rdacontent
n rdamedia
nc rdacarrier
Lung biology in health and disease 206
Includes bibliographical references and index
Pneumonie ram
Pneumonia Prognosis
Pneumonia, Bacterial
Cross Infection etiology
Intensive Care
Ventilators, Mechanical adverse effects
Komplikation (DE-588)4123547-2 gnd rswk-swf
Hospitalismus Hygiene (DE-588)4113962-8 gnd rswk-swf
Künstliche Beatmung (DE-588)4033439-9 gnd rswk-swf
Lungenentzündung (DE-588)4036659-5 gnd rswk-swf
Intensivtherapie (DE-588)4027258-8 gnd rswk-swf
(DE-588)4143413-4 Aufsatzsammlung gnd-content
Lungenentzündung (DE-588)4036659-5 s
Intensivtherapie (DE-588)4027258-8 s
DE-604
Künstliche Beatmung (DE-588)4033439-9 s
Komplikation (DE-588)4123547-2 s
Hospitalismus Hygiene (DE-588)4113962-8 s
b DE-604
Niederman, Michael S. 1953- Sonstige (DE-588)154542083 oth
Lung biology in health and disease 206 (DE-604)BV000008326 206
HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013370605&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle Severe pneumonia
Lung biology in health and disease
Pneumonie ram
Pneumonia Prognosis
Pneumonia, Bacterial
Cross Infection etiology
Intensive Care
Ventilators, Mechanical adverse effects
Komplikation (DE-588)4123547-2 gnd
Hospitalismus Hygiene (DE-588)4113962-8 gnd
Künstliche Beatmung (DE-588)4033439-9 gnd
Lungenentzündung (DE-588)4036659-5 gnd
Intensivtherapie (DE-588)4027258-8 gnd
subject_GND (DE-588)4123547-2
(DE-588)4113962-8
(DE-588)4033439-9
(DE-588)4036659-5
(DE-588)4027258-8
(DE-588)4143413-4
title Severe pneumonia
title_auth Severe pneumonia
title_exact_search Severe pneumonia
title_full Severe pneumonia ed. by Michael Niederman
title_fullStr Severe pneumonia ed. by Michael Niederman
title_full_unstemmed Severe pneumonia ed. by Michael Niederman
title_short Severe pneumonia
title_sort severe pneumonia
topic Pneumonie ram
Pneumonia Prognosis
Pneumonia, Bacterial
Cross Infection etiology
Intensive Care
Ventilators, Mechanical adverse effects
Komplikation (DE-588)4123547-2 gnd
Hospitalismus Hygiene (DE-588)4113962-8 gnd
Künstliche Beatmung (DE-588)4033439-9 gnd
Lungenentzündung (DE-588)4036659-5 gnd
Intensivtherapie (DE-588)4027258-8 gnd
topic_facet Pneumonie
Pneumonia Prognosis
Pneumonia, Bacterial
Cross Infection etiology
Intensive Care
Ventilators, Mechanical adverse effects
Komplikation
Hospitalismus Hygiene
Künstliche Beatmung
Lungenentzündung
Intensivtherapie
Aufsatzsammlung
url http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013370605&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
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work_keys_str_mv AT niedermanmichaels severepneumonia