Statistical evidence in medical trials what do the data really tell us?
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| Format: | Buch |
| Sprache: | English |
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Oxford [u.a.]
Oxford Univ. Press
2006
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| Ausgabe: | 1. publ. |
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| 245 | 1 | 0 | |a Statistical evidence in medical trials |b what do the data really tell us? |c Stephen D. Simon |
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| 650 | 4 | |a Biomedical Research |x methods | |
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Datensatz im Suchindex
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| adam_text | STATISTICAL EVIDENCE IN MEDICAL TRIALS WHAT DO THE DATA REALLY TELL US?
STEPHEN D. SIMON, PH.D. OXPORD UNIVERSITY PRESS CONTENTS PREFACE IX
ACKNOWLEDGMENTS XIII OVERVIEW XIV 1 APPLES OR ORANGES? SELECTION OF THE
CONTROL GROUP 1 1.1 INTRODUCTION 1 1.2 RANDOMLY SELECTED CONTRO S 3 1.3
VARIATIONS ON RANDOMIZATION 8 1.4 NONRANDOMIZED STUDIES 11 1.5
PREVENTING COVARIATE IMBALANCE BEFORE IT OCCURS 17 1.6 STATISTICAL
ADJUSTMENTS 22 1.7 COUNTERPOINT: RANDOMIZED TRIALS ARE OVERRATED 29 1.8
SUMMARY*APPLES OR ORANGES 30 1.9 ON YOUR OWN 30 2 WHO WAS LEFT OUT?
EXCLUSIONS, REFUSALS, AND DROP-OUTS 37 2.1 INTRODUCTION 37 2.2 WHO WAS
EXCLUDED AT THE START OF THE STUDY? 39 2.3 WHO REFUSED TO JOIN THE
STUDY? 43 2.4 WHO STOPPED OR SWITCHED THERAPIES? 45 2.5 WHO DROPPED OUT
DURING THE STUDY? 47 2.6 COUNTERPOINT: INTENTION TO TREAT IS OVERRATED
49 2.7 SUMMARY*WHO WAS LEFT OUT? 50 2.8 ON YOUR OWN 51 3 MOUNTAIN OR
MOLEHILL? THE CLINICAL IMPORTANCE OF THE RESULTS 55 3.1 INTRODUCTION 55
3.2 DID THEY MEASURE THE RIGHT THING? 57 3.3 DID THEY MEASURE THE
OUTCOME WELL? 62 3.4 WERE THE CHANGES CLINICALLY IMPORTANT? 69 3.5
COUNTERPOINT: BLINDING IS OVERRATED 75 3.6 SUMMARY*MOUNTAIN OR MOLEHILL?
76 3.7 ON YOUR OWN 76 CONTENTS 4 WHAT DO THE OTHER WITNESSES SAY?
CORROBORATING EVIDENCE 83 4.1 INTRODUCTION 83 4.2 IS THERE A STRONG
ASSOCIATION? 85 4.3 IS THERE A DOSE-RESPONSE PATTERN? 86 4.4 IS THE
ASSOCIATION CONSISTENT? 87 4.5 IS THE ASSOCIATION SPECIFIC? 89 4.6 IS
THE ASSOCIATION BIOLOGICALLY PLAUSIBLE? 91 4.7 IS THERE A CONFLICT OF
INTEREST? 93 4.8 IS THERE ANY EVIDENCE OF FRAUD? 94 4.9 COUNTERPOINT:
BIOLOGICAL PLAUSIBILITY IS OVERRATED 95 4.10 SUMMARY*WHAT DO THE OTHER
WITNESSES SAY? 97 4.11 ON YOUR OWN 98 5 DO THE PIECES FIT TOGETHER?
SYSTEMATIC OVERVIEWS AND META-ANALYSES 101 5.1 INTRODUCTION 101 5.2 WERE
APPLES COMBINED WITH ORANGES? 5.3 WERE SOME APPLES LEFT ON THE TREE? 118
5.4 WERE ALL OF THE APPLES ROTTEN? 1 ?3 5.5 DID THE PILE OF APPLES
AMOUNT TO MORE THAN JUST A HILL OF BEANS? 197 5.6 COUNTERPOINT:
META-ANALYSIS IS OVERRATED 5.7 SUMMARY*DO THE PIECES FIT TOGETHER? 5.8
ON YOUR OWN 6 WHAT DO ALL THESE NUMBERS MEAN? 137 6.1 INTRODUCTION ,GG
6.2 SAMPLES AND POPULATIONS ,OG 6.3 TYPE I AND II ERRORS 141 6.4
CONFIDENCE INTERVAL 144 6.5 P-VALUE 145 6.6 ODDS RATIO AND RELATIVE RISK
147 6.7 CORRELATION 149 6.8 SURVIVAL CURVES -CA 6.9 PREVALENCE AND
INCIDENCE ^ 6.10 ON YOUR OWN CONTENTS 7 WHERE IS THE EVIDENCE? SEARCHING
FOR INFORMATION 167 7.1 7.2 7.3 7.4 7.5 7.6 7.7 INTRODUCTION PICO FORMAT
SEARCH HIGH LEVEL SOURCES FIRST SEARCHING IN PUBMED SEARCHING THE
INTERNET SUMMARY*WHERE IS THE EVIDENCE? ON YOUR OWN BIBLIOGRAPHY INDEX
167 168 168 169 172 175 176 177 193
|
| any_adam_object | 1 |
| author | Simon, Stephen D. |
| author_facet | Simon, Stephen D. |
| author_role | aut |
| author_sort | Simon, Stephen D. |
| author_variant | s d s sd sds |
| building | Verbundindex |
| bvnumber | BV020011429 |
| callnumber-first | R - Medicine |
| callnumber-label | R853 |
| callnumber-raw | R853.C55 |
| callnumber-search | R853.C55 |
| callnumber-sort | R 3853 C55 |
| callnumber-subject | R - General Medicine |
| classification_rvk | XF 3500 |
| ctrlnum | (OCoLC)61424800 (DE-599)BVBBV020011429 |
| dewey-full | 615.50724 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.50724 |
| dewey-search | 615.50724 |
| dewey-sort | 3615.50724 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| edition | 1. publ. |
| format | Book |
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| id | DE-604.BV020011429 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T20:10:47Z |
| institution | BVB |
| isbn | 019856760X 9780198567608 0198567618 9780198567615 |
| language | English |
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| physical | XVII, 196 S. Ill., graph. Darst. |
| publishDate | 2006 |
| publishDateSearch | 2006 |
| publishDateSort | 2006 |
| publisher | Oxford Univ. Press |
| record_format | marc |
| spelling | Simon, Stephen D. Verfasser aut Statistical evidence in medical trials what do the data really tell us? Stephen D. Simon 1. publ. Oxford [u.a.] Oxford Univ. Press 2006 XVII, 196 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Geneeskunde gtt Statistiek gtt Medizin Statistik Biomedical Research methods Clinical Trials statistics & numerical data Clinical trials Statistical methods Data Interpretation, Statistical Research Design Klinisches Experiment (DE-588)4164223-5 gnd rswk-swf Medizinische Statistik (DE-588)4127563-9 gnd rswk-swf Medizinische Statistik (DE-588)4127563-9 s Klinisches Experiment (DE-588)4164223-5 s b DE-604 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013332976&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Simon, Stephen D. Statistical evidence in medical trials what do the data really tell us? Geneeskunde gtt Statistiek gtt Medizin Statistik Biomedical Research methods Clinical Trials statistics & numerical data Clinical trials Statistical methods Data Interpretation, Statistical Research Design Klinisches Experiment (DE-588)4164223-5 gnd Medizinische Statistik (DE-588)4127563-9 gnd |
| subject_GND | (DE-588)4164223-5 (DE-588)4127563-9 |
| title | Statistical evidence in medical trials what do the data really tell us? |
| title_auth | Statistical evidence in medical trials what do the data really tell us? |
| title_exact_search | Statistical evidence in medical trials what do the data really tell us? |
| title_full | Statistical evidence in medical trials what do the data really tell us? Stephen D. Simon |
| title_fullStr | Statistical evidence in medical trials what do the data really tell us? Stephen D. Simon |
| title_full_unstemmed | Statistical evidence in medical trials what do the data really tell us? Stephen D. Simon |
| title_short | Statistical evidence in medical trials |
| title_sort | statistical evidence in medical trials what do the data really tell us |
| title_sub | what do the data really tell us? |
| topic | Geneeskunde gtt Statistiek gtt Medizin Statistik Biomedical Research methods Clinical Trials statistics & numerical data Clinical trials Statistical methods Data Interpretation, Statistical Research Design Klinisches Experiment (DE-588)4164223-5 gnd Medizinische Statistik (DE-588)4127563-9 gnd |
| topic_facet | Geneeskunde Statistiek Medizin Statistik Biomedical Research methods Clinical Trials statistics & numerical data Clinical trials Statistical methods Data Interpretation, Statistical Research Design Klinisches Experiment Medizinische Statistik |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013332976&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT simonstephend statisticalevidenceinmedicaltrialswhatdothedatareallytellus |