Introduction to genetic analysis
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| Sprache: | English |
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New York, NY [u.a.]
Freeman
2005
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| Ausgabe: | 8. ed., 3. print. |
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| adam_text | INTRODUCTION TO GENETIC ANALYSIS NINTH EDITION ANTHONY J. F. GRIFFITHS
UNIVERSITY OF BRITISH COLUMBIA SUSAN R. WESSLER UNIVERSITY OF GEORGIA
RICHARD C. LEWONTIN HARVARD UNIVERSITY SEAN B. CARROLL HOWARD HUGHES
MEDICAL INSTITUTE UNIVERSITY OF WISCONSIN IS W. H. FREEMAN AND COMPANY *
NEW YORK CONTENTS IN BRIEF I 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
19 20 PREFACE THE GENETIC APPROACH TO BIOLOGY PART 1 TRANSMISSION
GENETICS SINGLE-GENE INHERITANCE INDEPENDENT ASSORTMENT OF GENES MAPPING
EUKARYOTE CHROMOSOMES BY RECOMBINATION THE GENETICS OF BACTERIA AND
THEIR VIRUSES GENE INTERACTION PART II FROM DNA TO PHENOTYPE DNA:
STRUCTURE AND REPLICATION RNA: TRANSCRIPTION AND PROCESSING PROTEINS AND
THEIR SYNTHESIS REGULATION OF GENE EXPRESSION IN BACTERIA AND THEIR
VIRUSES REGULATION OF GENE EXPRESSION IN EUKARYOTES THE GENETIC CONTROL
OF DEVELOPMENT GENOMES AND GENOMICS PART III MUTATION, VARIATION, AND
EVOLUTION THE DYNAMIC GENOME MUTATION, REPAIR, AND RECOMBINATION
LARGE-SCALE CHROMOSOMAL CHANGES POPULATION GENETICS QUANTITATIVE
GENETICS EVOLUTIONARY GENETICS PART IV TECHNIQUES GENE ISOLATION AND
MANIPULATION A BRIEF GUIDE TO MODEL ORGANISMS APPENDIX A: GENETIC
NOMENCLATURE APPENDIX B: BIOINFORMATICS RESOURCES FOR GENETICS AND
GENOMICS GLOSSARY ANSWERS TO SELECTED PROBLEMS INDEX XIII 1 31 89 129
181 221 265 295 319 351 385 415 453 487 513 555 603 639 679 715 759 775
776 779 803 815 CONTENTS PREFACE XIII J_ THE GENETIC APPROACH TO BIOLOGY
1 1.1 GENETICS AND THE QUESTIONS OF BIOLOGY 3 1.2 THE MOLECULAR BASIS OF
GENETIC INFORMATION 5 SPECIFYING THE AMINO ACID SEQUENCE OF A PROTEIN 6
GENE REGULATION 9 1.3 THE PROGRAM OF GENETIC INVESTIGATION 9 THE
NECESSITY OF VARIATION 9 STARTING WITH VARIATION: FORWARD GENETICS 10
STARTING WITH DNA: REVERSE GENETICS 13 1.4 METHODOLOGIES USED IN
GENETICS 14 AN OVERVIEW 14 DETECTING SPECIFIC MOLECULES OF DNA, RNA, AND
PROTEIN 15 1.5 MODEL ORGANISMS 17 LESSONS FROM THE FIRST MODEL ORGANISMS
17 THE NEED FOR A VARIETY OF MODEL ORGANISMS 17 1.6 GENES, THE
ENVIRONMENT, AND THE ORGANISM 21 MODEL I: GENETIC DETERMINATION 21 MODEL
II: ENVIRONMENTAL DETERMINATION 22 MODEL III: GENOTYPE-ENVIRONMENT
INTERACTION 23 THE USE OF GENOTYPE AND PHENOTYPE 23 DEVELOPMENTAL NOISE
24 THREE LEVELS OF DEVELOPMENT 26 PART I TRANSMISSION GENETICS J2J
SINGLE-GENE INHERITANCE 2.1 GENES AND CHROMOSOMES 33 2.2 SINGLE-GENE
INHERITANCE PATTERNS 37 MENDEL S LAW OF EQUAL SEGREGATION 37 2.3 THE
CHROMOSOMAL BASIS OF SINGLE-GENE INHERITANCE PATTERNS 42 SINGLE-GENE
INHERITANCE IN HAPLOIDS 46 THE MOLECULAR BASIS OF SINGLE-GENE
SEGREGATION AND EXPRESSION 50 31 VI CONTENTS 2.4 DISCOVERING GENES BY
OBSERVING SEGREGATION RATIOS 57 DISCOVERING A GENE ACTIVE IN THE
DEVELOPMENT OF FLOWER COLOR 57 DISCOVERING A GENE FOR WING DEVELOPMENT
58 DISCOVERING A GENE FOR SPORE PRODUCTION 58 THE RESULTS OF GENE
DISCOVERY 59 FORWARD GENETICS 60 PREDICTING PROGENY PROPORTIONS OR
PARENTAL GENOTYPES BY APPLYING THE PRINCIPLES OF SINGLE-GENE INFLUENCE
60 2.5 SEX-LINKED SINGLE-GENE INHERITANCE PATTERNS 61 SEX CHROMOSOMES 61
SEX-LINKED PATTERNS OF INHERITANCE 62 MODEL ORGANISM BOX DROSOPHILA 63
X-LINKED INHERITANCE 63 2.6 HUMAN PEDIGREE ANALYSIS 66 AUTOSOMAL
RECESSIVE DISORDERS 66 AUTOSOMAL DOMINANT DISORDERS 68 AUTOSOMAL
POLYMORPHISMS 69 X-LINKED RECESSIVE DISORDERS 71 X-LINKED DOMINANT
DISORDERS 73 Y-LINKED INHERITANCE 73 CALCULATING RISKS IN PEDIGREE
ANALYSIS 74 ^ INDEPENDENT ASSORTMENT OF GENES 89 3.1 MENDEL S LAW OF
INDEPENDENT ASSORTMENT 90 3.2 WORKING WITH INDEPENDENT ASSORTMENT 94
PREDICTING PROGENY RATIOS 94 USING THE CHI-SQUARE TEST ON MONOHYBRID AND
DIHYBRID RATIOS 97 SYNTHESIZING PURE LINES 99 HYBRID VIGOR 101 3.3 THE
CHROMOSOMAL BASIS OF INDEPENDENT ASSORTMENT 102 INDEPENDENT ASSORTMENT
IN DIPLOID ORGANISMS 103 INDEPENDENT ASSORTMENT IN HAPLOID ORGANISMS 103
INDEPENDENT ASSORTMENT OF COMBINATIONS OF AUTOSOMAL AND X-LINKED GENES
105 RECOMBINATION 106 MODEL ORGANISM BOX NEUROSPORA 107 3.4 POLYGENIC
INHERITANCE 110 3.5 ORGANELLE GENES: INHERITANCE INDEPENDENT OF THE
NUCLEUS 112 PATTERNS OF INHERITANCE IN ORGANELLES 112 CYTOPLASM IC
SEGREGATION 114 CYTOPLASMIC MUTATIONS IN HUMANS 116 4.1 MAPPING
EUKARYOTE CHROMOSOMES BY RECOMBINATION 129 DIAGNOSTICS OF LINKAGE 131
USING RECOMBINANT FREQUENCY TO RECOGNIZE LINKAGE 131 HOW CROSSOVERS
PRODUCE RECOMBINANTS FOR LINKED GENES 133 LINKAGE SYMBOLISM AND
TERMINOLOGY 134 EVIDENCE THAT CROSSING OVER IS A BREAKAGE-AND-REJOINING
PROCESS 134 EVIDENCE THAT CROSSING OVER TAKES PLACE AT THE FOUR-
CHROMATID STAGE 135 MULTIPLE CROSSOVERS CAN INCLUDE MORE THAN TWO
CHROMATIDS 136 4.2 MAPPING BY RECOMBINANT FREQUENCY 137 MAP UNITS 137
THREE-POINT TESTCROSS 140 DEDUCING GENE ORDER BY INSPECTION 142
INTERFERENCE 143 USING RATIOS AS DIAGNOSTICS 145 4.3 MAPPING WITH
MOLECULAR MARKERS 146 SINGLE NUCLEOTIDE POLYMORPHISMS 147 MAPPING BY
USING SNP HAPLOTYPES 149 SIMPLE SEQUENCE LENGTH POLYMORPHISMS 151 4.4
CENTROMERE MAPPING WITH LINEAR TETRADS 154 4.5 USING THE CHI-SQUARE TEST
FOR TESTING LINKAGE ANALYSIS 155 4.6 USING LOD SCORES TO ASSESS LINKAGE
IN HUMAN PEDIGREES 158 4.7 ACCOUNTING FOR UNSEEN MULTIPLE CROSSOVERS 159
A MAPPING FUNCTION 160 THE PERKINS FORMULA 162 CONTENTS VII 4.8 USING
RECOMBINATION-BASED MAPS IN CONJUNCTION WITH PHYSICAL MAPS 163 ^ THE
GENETICS OF BACTERIA AND THEIR VIRUSES 181 5.1 WORKING WITH
MICROORGANISMS 183 5.2 BACTERIAL CONJUGATION 185 DISCOVERY OF
CONJUGATION 185 MODEL ORGANISM BOX ESCHERICHIA COLI 185 DISCOVERY OF THE
FERTILITY FACTOR (F) 187 HFR STRAINS 188 MAPPING OF BACTERIAL
CHROMOSOMES 192 F PLASMIDS THAT CARRY GENOMIC FRAGMENTS 195 RPLASMIDS
196 5.3 BACTERIAL TRANSFORMATION 198 CHROMOSOME MAPPING USING
TRANSFORMATION 199 5.4 BACTERIOPHAGE GENETICS 199 INFECTION OF BACTERIA
BY PHAGES 200 MAPPING PHAGE CHROMOSOMES BY USING PHAGE CROSSES 202 5.5
TRANSDUCTION 204 DISCOVERY OF TRANSDUCTION 204 GENERALIZED TRANSDUCTION
205 SPECIALIZED TRANSDUCTION 207 MECHANISM OF SPECIALIZED TRANSDUCTION
208 5.6 PHYSICAL MAPS AND LINKAGE MAPS COMPARED 209 6^ GENE INTERACTION
221 6.1 INTERACTIONS BETWEEN THE ALLELES OF A SINGLE GENE: VARIATIONS ON
DOMINANCE 223 COMPLETE DOMINANCE AND RECESSIVENESS 223 INCOMPLETE
DOMINANCE 225 CODOMINANCE 225 RECESSIVE LETHAL ALLELES 227 MODEL
ORGANISM BOX MOUSE 228 6.2 INTERACTION OF GENES IN PATHWAYS 230
BIOSYNTHETIC PATHWAYS IN NEUROSPORA 230 GENE INTERACTION IN OTHER TYPES
OF PATHWAYS 233 6.3 INFERRING GENE INTERACTIONS 235 DEFINING THE SET OF
GENES BY USING THE COMPLEMENTATION TEST 235 ANALYZING DOUBLE MUTANTS OF
RANDOM MUTATIONS 239 6.4 PENETRANCE AND EXPRESSIVITY 247 PART II FROM
DNA TO PHENOTYPE _7_ DNA: STRUCTURE AND REPLICATION 265 7.1 DNA: THE
GENETIC MATERIAL 266 DISCOVERY OF TRANSFORMATION 266 HERSHEY-CHASE
EXPERIMENT 268 7.2 THE DNA STRUCTURE 269 DNA STRUCTURE BEFORE WATSON AND
CRICK 270 THE DOUBLE HELIX 272 7.3 SEMICONSERVATIVE REPLICATION 275
MESELSON-STAHL EXPERIMENT 276 THE REPLICATION FORK 277 DNA POLYMERASES
278 7.4 OVERVIEW OF DNA REPLICATION 279 7.5 THE REPLISOME: A REMARKABLE
REPLICATION MACHINE 281 UNWINDING THE DOUBLE HELIX 283 ASSEMBLING THE
REPLISOME: REPLICATION INITIATION 284 7.6 REPLICATION IN EUKARYDTIC
ORGANISMS 284 THE EUKARYOTIC REPLISOME 284 EUKARYOTIC ORIGINS OF
REPLICATION 285 DNA REPLICATION AND THE YEAST CELL CYCLE 286 REPLICATION
ORIGINS IN HIGHER EUKARYOTES 287 7.7 TELOMERES AND TELOMERASE:
REPLICATION TERMINATION 287 TELOMERES, CANCER, AND AGING 288 *8_ RNA:
TRANSCRIPTION AND PROCESSING 295 8.1 RNA 297 EARLY EXPERIMENTS SUGGEST
AN RNA INTERMEDIATE 297 PROPERTIES OF RNA 297 CLASSES OF RNA 298 8.2
TRANSCRIPTION 300 OVERVIEW: DNA AS TRANSCRIPTION TEMPLATE 300 STAGES OF
TRANSCRIPTION 301 8.3 TRANSCRIPTION IN EUKARYOTES 304 TRANSCRIPTION
INITIATION IN EUKARYOTES 306 ELONGATION, TERMINATION, AND PRE-MRNA
PROCESSING IN EUKARYOTES 307 VIII CONTENTS 8.4 FUNCTIONAL RNAS 309 SMALL
NUCLEAR RNAS (SNRNAS): THE MECHANISM OF EXON SPLICING 310 SELF-SPLICING
INTRONS AND THE RNA WORLD 312 SMALL INTERFERING RNAS (SIRNAS) 312 9
PROTEINS AND THEIR SYNTHESIS 319 9.1 PROTEIN STRUCTURE 321 9.2
COLINEARITY OF GENE AND PROTEIN 324 9.3 THE GENETIC CODE 325 OVERLAPPING
VERSUS NONOVERLAPPING CODES 325 NUMBER OF LETTERS IN THE CODON 326 USE
OF SUPPRESSORS TO DEMONSTRATE A TRIPLET CODE 326 DEGENERACY OF THE
GENETIC CODE 328 CRACKING THE CODE 328 STOP CODONS 329 9.4 TRNA: THE
ADAPTER 330 CODON TRANSLATION BY TRNA 331 DEGENERACY REVISITED 332 9.5
RIBOSOMES 333 RIBOSOME FEATURES 334 TRANSLATION INITIATION, ELONGATION,
AND TERMINATION 336 NONSENSE SUPPRESSOR MUTATIONS 339 9.6 THE PROTEOME
340 ALTERNATIVE SPLICING GENERATES PROTEIN ISOFORMS 340
POSTTRANSLATIONAL EVENTS 340 1C| REGULATION OF GENE EXPRESSION IN
BACTERIA AND THEIR VIRUSES 351 10.1 GENE REGULATION 353 THE BASICS OF
PROKARYOTIC TRANSCRIPTIONAL REGULATION: GENETIC SWITCHES 354 A FIRST
LOOK AT THE LAC REGULATORY CIRCUIT 355 10.2 DISCOVERY OF THE LAC SYSTEM:
NEGATIVE CONTROL 358 GENES CONTROLLED TOGETHER 358 GENETIC EVIDENCE FOR
THE OPERATOR AND REPRESSOR 359 GENETIC EVIDENCE FOR ALLOSTERY 361
GENETIC ANALYSIS OF THE LAC PROMOTE R 362 MOLECULAR CHARACTERIZATION OF
THE LAC REPRESSOR AND THE LAC OPERATOR 363 POLAR MUTATIONS 363 10.3
CATABOLIC REPRESSION OF THE LAC OPERON: POSITIVE CONTROL 364 THE BASICS
OF CATABOLITE REPRESSION OF THE LAC OPERON: CHOOSING THE BEST SUGAR TO
METABOLIZE 364 THE STRUCTURES OF TARGET DNA SITES 365 A SUMMARY OF THE
LAC OPERON 366 10.4 DUAL POSITIVE AND NEGATIVE CONTROL: THE ARABINOSE
OPERON 368 10.5 METABOLIC PATHWAYS AND ADDITIONAL LEVELS OF REGULATION:
ATTENUATION 369 TRANSCRIPTION OF THE TRP OPERON IS REGULATED AT TWO
STEPS 369 10.6 BACTERIOPHAGE LIFE CYCLES: MORE REGULATORS, COMPLEX
OPERONS 372 MOLECULAR ANATOMY OF THE GENETIC SWITCH 375
SEQUENCE-SPECIFIC BINDING OF REGULATORY PROTEINS TO DNA 376 10.7
ALTERNATIVE SIGMA FACTORS REGULATE LARGE SETS OF GENES 378
REGULATION OF GENE EXPRESSION IN EUKARYOTES 385 11.1 TRANSCRIPTIONAL
REGULATION IN EUKARYOTES: AN OVERVIEW 386 MODEL ORGANISM BOX YEAST 390
11.2 LESSONS FROM YEAST: THE GAL SYSTEM 390 GAL4 REGULATES MULTIPLE
GENES THROUGH UPSTREAM ACTIVATION SEQUENCES 391 THE GAL4 PROTEIN HAS
SEPARABLE DNA-BINDING AND ACTIVATION DOMAINS 392 GAL4 ACTIVITY IS
PHYSIOLOGICALLY REGULATED 392 GAL4 FUNCTIONS IN MOST EUKARYOTES 393
ACTIVATORS RECRUIT THE TRANSCRIPTIONAL MACHINERY 393 11.3 DYNAMIC
CHROMATIN AND EUKARYOTIC GENE REGULATION 394 CHROMATIN-REMODELING
PROTEINS AND GENE ACTIVATION 395 HISTONES AND CHROMATIN REMODELING 396
11.4 MECHANISM OF ENHANCER ACTION 398 THE (3-INTERFERON ENHANCEOSOME 398
! THE CONTROL OF YEAST MATING TYPE: COMBINATORIAL INTERACTIONS 399
DNA-BINDING PROTEINS COMBINATORIALLY REGULATE THE EXPRESSION OF
CELL-TYPE-SPECIFIC GENES 399 CONTENTS IX ENHANCER-BLOCKING INSULATORS
401 11.5 GENOMIC IMPRINTING 402 BUT WHAT ABOUT DOLLY AND OTHER CLONED
MAMMALS? 404 11.6 CHROMATIN DOMAINS AND THEIR INHERITANCE 404
MATING-TYPE SWITCHING AND GENE SILENCING 404 HETEROCHROMATIN AND
EUCHROMATIN COMPARED 405 POSITION-EFFECT VARIEGATION IN DROSOPHILA
REVEALS GENOMIC NEIGHBORHOODS 406 GENETIC ANALYSIS OF PEV REVEALS
PROTEINS NECESSARY FOR HETEROCHROMATIN FORMATION 407 SILENCING AN ENTIRE
CHROMOSOME: X-CHROMOSOME INACTIVATION 409 THE INHERITANCE OF EPIGENETIC
MARKS AND CHROMATIN STRUCTURE 410 12 THE GENETIC CONTROL OF DEVELOPMENT
415 12.1 THE GENETIC APPROACH TO DEVELOPMENT 416 MODEL ORGANISM BOX
DROSOPHILA 418 12.2 THE GENETIC TOOLKIT FOR DROSOPHILA DEVELOPMENT 418
CLASSIFICATION OF GENES BY DEVELOPMENTAL FUNCTION 419 HOMEOTIC GENES AND
SEGMENTAL IDENTITY 420 ORGANIZATION AND EXPRESSION OF HOX GENES 421 THE
HOMEOBOX 423 CLUSTERS OF HOX GENES.CONTROL DEVELOPMENT IN MOST ANIMALS
424 12.3 DEFINING THE ENTIRE TOOLKIT 427 THE ANTEROPOSTERIOR AND
DORSOVENTRAL AXES 428 EXPRESSION OF TOOLKIT GENES 428 12.4 SPATIAL
REGULATION OF GENE EXPRESSION IN DEVELOPMENT 432 MATERNAL GRADIENTS AND
GENE ACTIVATION 432 DRAWING STRIPES: INTEGRATION OF GAP-PROTEIN INPUTS
434 MAKING SEGMENTS DIFFERENT: INTEGRATION OF HOX INPUTS 436 12.5
POSTTRANSCRIPTIONAL REGULATION OF GENE EXPRESSION IN DEVELOPMENT 439 RNA
SPLICING AND SEX DETERMINATION IN DROSOPHILA 439 REGULATION OF MRNA
TRANSLATION AND CELL LINEAGE IN C. ELEGANS 441 TRANSLATIONAL CONTROL IN
THE EARLY EMBRYO 441 MODEL ORGANISM BOX CAENORHABDITIS ELEGANS 442 MIRNA
CONTROL OF DEVELOPMENTAL TIMING IN C. ELEGANS AND OTHER SPECIES 444 12.6
THE MANY ROLES OF INDIVIDUAL TOOLKIT GENES 445 FROM FLIES TO FINGERS,
FEATHERS, AND FLOOR PLATES 445 12.7 DEVELOPMENT AND DISEASE 446
POLYDACTYLY 446 HOLOPROSENCEPHALY 447 CANCER AS A DEVELOPMENTAL DISEASE
447 2^5 GENOMES AND GENOMICS 453 13.1 THE GENOMICS REVOLUTION 455 13.2
CREATING THE SEQUENCE MAP OF A GENOME 456 TURNING SEQUENCE READS INTO A
SEQUENCE MAP 456 ESTABLISHING A GENOMIC LIBRARY OF CLONES 459 SEQUENCING
A SIMPLE GENOME BY USING THE WHOLE- GENOME SHOTGUN APPROACH 459 USING
THE WHOLE-GENOME SHOTGUN APPROACH TO CREATE A DRAFT SEQUENCE OF A
COMPLEX GENOME 460 USING THE ORDERED-CLONE APPROACH TO SEQUENCE A
COMPLEX GENOME 461 FILLING SEQUENCE GAPS 462 13.3 BIOINFORMATICS:
MEANING FROM GENOMIC SEQUENCE 463 THE NATURE OF THE INFORMATION CONTENT
OF DNA 463 DEDUCING THE PROTEIN-ENCODING GENES FROM GENOMIC SEQUENCE 464
13.4 THE STRUCTURE OF THE HUMAN GENOME 468 13.5 COMPARATIVE GENOMICS 470
OF MICE AND HUMANS 471 COMPARATIVE GENOMICS OF CHIMPANZEES AND HUMANS
472 CONSERVED AND ULTRACONSERVED NONCODING ELEMENTS 472 COMPARATIVE
GENOMICS OF NON-PATHOGENIC AND I PATHOGENIC COLI 473 13.6 FUNCTIONAL
GENOMICS AND REVERSE GENETICS 475 OME, SWEET OME 475 REVERSE GENETICS
479 XII CONTENTS PART IV TECHNIQUES 20 GENE ISOLATION AND MANIPULATION
715 20.1 GENERATING RECOMBINANT MOLECULES 716 TYPE OF DONOR DNA 717
CUTTING GENOMIC DNA 717 ATTACHING DONOR AND VECTOR DNA 719 AMPLIFICATION
INSIDE A BACTERIAL CELL 720 ENTRY OF RECOMBINANT MOLECULES INTO THE
BACTERIAL CELL 723 RECOVERY OF AMPLIFIED RECOMBINANT MOLECULES 723
MAKING GENOMIC AND CDNA LIBRARIES 724 FINDING A SPECIFIC CLONE OF
INTEREST 724 20.2 DNA AMPLIFICATION IN VITRO: THE POLYMERASE CHAIN
REACTION 731 20.3 DETERMINING THE BASE SEQUENCE OF A DNA SEGMENT 732
20.4 FORWARD GENETIC ANALYSIS BY USING POSITIONAL CLONING 735 A FORWARD
ANALYSIS TO IDENTIFY A HUMAN DISEASE GENE 737 A FORWARD ANALYSIS TO
IDENTIFY A GENE IMPORTANT TO CORN DOMESTICATION 738 20.5 DETECTING HUMAN
DISEASE ALLELES: MOLECULAR GENETIC DIAGNOSTICS 739 20.6 GENETIC
ENGINEERING 741 GENETIC ENGINEERING IN SACCHAROMYCES CEREVISIAE 741
GENETIC ENGINEERING IN PLANTS 742 GENETIC ENGINEERING IN ANIMALS 745
HUMAN GENE THERAPY 749 A BRIEF GUIDE TO MODEL ORGANISMS 759 APPENDIX A:
GENETIC NOMENCLATURE 775 APPENDIX B: BIOINFORMATICS RESOURCES FOR
GENETICS AND GENOMICS 776 GLOSSARY 779 ANSWERS TO SELECTED PROBLEMS 803
INDEX 815
|
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| genre_facet | Einführung Lehrbuch |
| id | DE-604.BV019817009 |
| illustrated | Illustrated |
| indexdate | 2024-12-23T18:16:35Z |
| institution | BVB |
| isbn | 0716749394 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-013142334 |
| oclc_num | 62525527 |
| open_access_boolean | |
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| owner_facet | DE-355 DE-BY-UBR DE-526 |
| physical | XVI, 782 S. Ill., graph. Darst. |
| publishDate | 2005 |
| publishDateSearch | 2005 |
| publishDateSort | 2005 |
| publisher | Freeman |
| record_format | marc |
| spellingShingle | Introduction to genetic analysis Biotechnologie ram Génétique Génétique - analyse Génétique ram Genetics Genetics Methodology Molecular genetics Methode (DE-588)4038971-6 gnd Genetik (DE-588)4071711-2 gnd CD-ROM (DE-588)4139307-7 gnd |
| subject_GND | (DE-588)4038971-6 (DE-588)4071711-2 (DE-588)4139307-7 (DE-588)4151278-9 (DE-588)4123623-3 |
| title | Introduction to genetic analysis |
| title_auth | Introduction to genetic analysis |
| title_exact_search | Introduction to genetic analysis |
| title_full | Introduction to genetic analysis Anthony J. F. Griffiths .... |
| title_fullStr | Introduction to genetic analysis Anthony J. F. Griffiths .... |
| title_full_unstemmed | Introduction to genetic analysis Anthony J. F. Griffiths .... |
| title_short | Introduction to genetic analysis |
| title_sort | introduction to genetic analysis |
| topic | Biotechnologie ram Génétique Génétique - analyse Génétique ram Genetics Genetics Methodology Molecular genetics Methode (DE-588)4038971-6 gnd Genetik (DE-588)4071711-2 gnd CD-ROM (DE-588)4139307-7 gnd |
| topic_facet | Biotechnologie Génétique Génétique - analyse Genetics Genetics Methodology Molecular genetics Methode Genetik CD-ROM Einführung Lehrbuch |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=013142334&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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