Treatment of leukemia and lymphoma

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Veröffentlicht: Amsterdam [u.a.] Elsevier, Acad. Press 2004
Schriftenreihe:Advances in pharmacology 51
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adam_text PV-I-H TREATMENT OF LEUKEMIA AND LYMPHOMA EDITED BY DAVID A. SCHEINBERG MOLECULAR PHARMACOLOGY AND CHEMISTRY PROGRAM EXPERIMENTAL THERAPEUTICS CENTER LEUKEMIA SERVICE MEMORIAL SLOAN-KETTERING CANCER CENTER NEW YORK, NEW YORK JOSEPH G. JURCIC LEUKEMIA SERVICE DEPARTMENT OF MEDICINE MEMORIAL SLOAN-KETTERING CANCER CENTER NEW YORK, NEW YORK ADVANCES IN PHARMACOLOGY VOLUME 51 ELSEVIER ACADEMIC PRESS AMSTERDAM * BOSTON * HEIDELBERG * LONDON NEW YORK * OXFORD * PARIS * SAN DIEGO SAN FRANCISCO * SINGAPORE * SYDNEY * TOKYO CONTENTS CONTRIBUTORS XI PREFACE XV KINASE INHIBITORS IN LEUKEMIA MARK LEVIS AND DONALD SMALL I. CHAPTER OVERVIEW 1 II. INTRODUCTION 2 III. FACTORS IN IDENTIFYING AN IDEAL THERAPEUTIC TARGET 2 IV. KINASE TARGETS IN LEUKEMIA: CURRENT TREATMENT OPTIONS V. KINASE TARGETS IN LEUKEMIA: ON THE HORIZON 14 VI. CONCLUSIONS 20 REFERENCES 20 THERAPY OF ACUTE PROMYELOCYTIC LEUKEMIA STEVEN SOLGNET AND PETER MASLAK I. CHAPTER OVERVIEW 35 II. INTRODUCTION 35 III. DISEASE BACKGROUND AND BIOLOGY 36 VI CONTENTS IV. TREATMENT APPROACHES 38 REFERENCES 52 INVESTIGATIONAL AGENTS IN MYELOID DISORDERS FARHAD RAVANDI AND JORGE CORTES I. CHAPTER OVERVIEW 59 II. INTRODUCTION 60 III. NUCLEOSIDE ANALOGS 60 IV. REVERSAL OF MULTIDRUG RESISTANCE 66 V. BIOLOGICAL AGENTS 68 VI. SIGNALING MODULATORS 74 VII. CONCLUSIONS 82 REFERENCES 82 METHODOLOGIC ISSUES IN INVESTIGATION OF TARGETED THERAPIES IN ACUTE MYELOID LEUKEMIA ELIHU ESTEY I. CHAPTER OVERVIEW 99 II. INTRODUCTION 99 III. PATIENT SELECTION FOR TARGETED THERAPY TRIALS IN ACUTE MYELOID LEUKEMIA 100 IV. ENDPOINTS FOR CLINICAL TRIALS OF TTS IN AML 102 V. NEED FOR RANDOMIZED TRIALS OF TTS AND A PROPOSED STATISTICAL DESIGN 103 REFERENCES 106 PURINE ANALOGS IN LEUKEMIA NICOLE LAMANNA AND MARK WEISS I. CHAPTER OVERVIEW 107 II. INTRODUCTION 107 III. MECHANISMS OF ACTION 108 IV. PURINE ANALOGS IN CHRONIC LYMPHOCYTIC LEUKEMIA 110 V. PURINE ANALOGS IN HAIRY CELL LEUKEMIA 114 VI. PURINE ANALOGS IN ACUTE MYELOID LEUKEMIA 114 VII. PURINE ANALOGS IN CHRONIC MYELOID LEUKEMIA 116 VIII. PURINE ANALOGS IN ALLOGENEIC STEM CELL TRANSPLANTATION 117 IX. CONCLUSION AND FUTURE DIRECTIONS 118 REFERENCES 118 CONTENTS VII MONOCLONAL ANTIBODY THERAPY IN LYMPHOID LEUKEMIAS THOMAS S. LIN AND JOHN C. BYRD I. CHAPTER OVERVIEW 127 II. INTRODUCTION 128 III. CHRONIC LYMPHOCYTIC LEUKEMIA 130 IV. T-CELL PROLYMPHOCYTIC LEUKEMIA 152 V. HAIRY CELL LEUKEMIA 153 VI. CONCLUSIONS 155 REFERENCES 156 NATIVE ANTIBODY AND ANTIBODY-TARGETED CHEMOTHERAPY FOR ACUTE MYELOID LEUKEMIA ERIC L. SIEVERS I. CHAPTER OVERVIEW 169 II. INTRODUCTION 170 III. LINGERING QUESTIONS REGARDING IMMUNOCONJUGATE THERAPIES 178 IV. SUMMARY 180 REFERENCES 181 RADIOIMMUNOTHERAPY OF LEUKEMIA JOHN M. BURKE AND JOSEPH G. JURCIC I. CHAPTER OVERVIEW 185 II. INTRODUCTION 186 III. ANTIGENIC TARGETS 186 IV. RADIOISOTOPE SELECTION 187 V. RADIOLABELING 190 VI. PHARMACOKINETICS AND DOSIMETRY 193 VII. RADIOIMMUNOTHERAPY WITH /3-PARTICLE EMITTERS 194 VIII. RADIOIMMUNOTHERAPY WITH A-PARTICLE EMITTERS 199 IX. SUMMARY 202 REFERENCES 203 IMMUNOTOXINS AND TOXIN CONSTRUCTS IN THE TREATMENT OF LEUKEMIA AND LYMPHOMA MICHAEL ROSENBLUM I. CHAPTER OVERVIEW 209 II. INTRODUCTION 209 VIII CONTENTS III. TARGETS OF OPPORTUNITY IN LEUKEMIA AND LYMPHOMA 210 REFERENCES 221 ANTIBODY THERAPY OF LYMPHOMA GEORGE J. WEINER AND BRIAN K. LINK I. CHAPTER OVERVIEW 229 II. HISTORY 230 III. CHIMERIC ANTI-CD20*A CLINICAL BREAKTHROUGH 232 IV. ALTERNATIVE MOLECULAR TARGETS 234 V. MECHANISMS OF ACTION 236 VI. RADIOIMMUNOTHERAPY 241 VII. MABS COMBINED WITH CHEMOTHERAPY 243 VIII. MABS COMBINED WITH IMMUNOTHERAPY 246 IX. CONCLUSION 247 REFERENCES 248 VACCINES IN LEUKEMIA SIJIE LU, ERIC WIEDER, KRISHNA KOMANDURI, QING MA, AND JEFFREY J. MOLLDREM I. CHAPTER OVERVIEW 255 II. INTRODUCTION 256 III. POTENTIAL TARGET ANTIGENS 257 IV. CLINICAL VACCINE TRIALS WITH LEUKEMIA-ASSOCIATED ANTIGENS 262 V. CONCLUSION 264 REFERENCES 264 THERAPEUTIC IDIOTYPE VACCINES FOR NON-HODGKIN S LYMPHOMA JOHN M. TIMMERMAN I. CHAPTER OVERVIEW 271 II. INTRODUCTION 272 III. DEVELOPMENT OF THE IDIOTYPE VACCINE APPROACH 272 IV. RECOMBINANT IDIOTYPE VACCINES 278 V. PHASE III IDIOTYPE VACCINE TRIALS 282 VI. PHARMACOLOGIC CONSIDERATIONS AND INTEGRATION WITH STANDARD THERAPIES 283 VII. NEW AND ONGOING PHASE I/II CLINICAL TRIALS OF IDIOTYPE VACCINATION 285 VIII. CONCLUSIONS AND FUTURE PROSPECTS 287 REFERENCES 288 CONTENTS IX CYTOKINE MODULATION OF THE INNATE IMMUNE SYSTEM IN THE TREATMENT OF LEUKEMIA AND LYMPHOMA SHERIF S. FARAG AND MICHAEL A. CALIGIURI I. CHAPTER OVERVIEW 295 II. INTRODUCTION 296 III. EFFECTOR CELLS OF THE INNATE IMMUNE SYSTEM: RELEVANCE TO CYTOKINE THERAPY 296 IV. CYTOKINE THERAPY: EXPLOITING INNATE IMMUNE EFFECTORS 302 V. NOVEL APPROACHES FOR THE IMMUNOMODULATION OF LEUKEMIA AND LYMPHOMA 306 VI. CONCLUSION 311 REFERENCES 311 DONOR LYMPHOCYTE INFUSIONS VINCENT T. HO AND EDWIN P. ALYEA I. CHAPTER OVERVIEW 319 II. INTRODUCTION 319 III. GRAFT-VERSUS-LEUKEMIA: EXPERIMENTAL MODELS 320 IV. DONOR LYMPHOCYTE INFUSIONS FOR CHRONIC MYELOID LEUKEMIA 321 V. MULTIPLE MYELOMA 324 VI. MYELODYSPLASTIC SYNDROME AND ACUTE LEUKEMIA 326 VII. CHRONIC LYMPHOCYTIC LEUKEMIA AND LYMPHOMA 327 VIII. EBV-ASSOCIATED LYMPHOPROLIFERATIVE DISORDERS AFTER BONE MARROW TRANSPLANTATION 327 IX. COMPLICATIONS OF DLI 328 X. METHODS TO ENHANCE THE GVL RESPONSE AFTER DLI 330 XI. MEDIATORS OF THE GVL EFFECT 330 XII. POTENTIAL TARGETS OF THE GVL EFFECT 332 XIII. TUMOR-SPECIFIC TARGETS OF THE DLI/GVL RESPONSE 335 XIV. FUTURE DIRECTIONS 336 REFERENCES 337 SOMATIC CELL ENGINEERING AND THE IMMUNOTHERAPY OF LEUKEMIAS AND LYMPHOMAS RENIER J. BRENTJENS AND MICHEL SADELAIN I. CHAPTER OVERVIEW 347 II. INTRODUCTION 348 X CONTENTS III. IMMUNE EFFECTOR CELL ACTIVATION 350 IV. IMMUNIZATION AGAINST HEMATOLOGIC MALIGNANCIES: TUMOR CELL VACCINES 351 V. IMMUNIZATION AGAINST HEMATOLOGIC MALIGNANCIES: DENDRITIC CELL VACCINES 357 VI. ADOPTIVE T-CELL THERAPY DIRECTED AGAINST HEMATOLOGIC MALIGNANCIES 359 VII. CONCLUSION 362 REFERENCES 363 INDEX 371 CONTENTS OF PREVIOUS VOLUMES 383
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series Advances in pharmacology
series2 Advances in pharmacology
spelling Treatment of leukemia and lymphoma ed. by David A. Scheinberg ...
Amsterdam [u.a.] Elsevier, Acad. Press 2004
XVII, 393 S. Ill., graph. Darst.
txt rdacontent
n rdamedia
nc rdacarrier
Advances in pharmacology 51
Leucémie
Lymphome
Sang - Maladies - Traitement
Blood Diseases Treatment
Leukemia
Leukemia drug therapy
Lymphoma drug therapy
Lymphomas
Scheinberg, David A. Sonstige oth
Advances in pharmacology 51 (DE-604)BV002534644 51
GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012968917&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle Treatment of leukemia and lymphoma
Advances in pharmacology
Leucémie
Lymphome
Sang - Maladies - Traitement
Blood Diseases Treatment
Leukemia
Leukemia drug therapy
Lymphoma drug therapy
Lymphomas
title Treatment of leukemia and lymphoma
title_auth Treatment of leukemia and lymphoma
title_exact_search Treatment of leukemia and lymphoma
title_full Treatment of leukemia and lymphoma ed. by David A. Scheinberg ...
title_fullStr Treatment of leukemia and lymphoma ed. by David A. Scheinberg ...
title_full_unstemmed Treatment of leukemia and lymphoma ed. by David A. Scheinberg ...
title_short Treatment of leukemia and lymphoma
title_sort treatment of leukemia and lymphoma
topic Leucémie
Lymphome
Sang - Maladies - Traitement
Blood Diseases Treatment
Leukemia
Leukemia drug therapy
Lymphoma drug therapy
Lymphomas
topic_facet Leucémie
Lymphome
Sang - Maladies - Traitement
Blood Diseases Treatment
Leukemia
Leukemia drug therapy
Lymphoma drug therapy
Lymphomas
url http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012968917&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
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work_keys_str_mv AT scheinbergdavida treatmentofleukemiaandlymphoma