Centrosomes in development and disease
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| 245 | 1 | 0 | |a Centrosomes in development and disease |c ed. by Erich A. Nigg |
| 264 | 1 | |a Weinheim |b Wiley-VCH |c 2004 | |
| 300 | |a XLII, 431 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Literaturangaben | ||
| 650 | 4 | |a Cell Division |x physiology | |
| 650 | 4 | |a Centrosome |x physiology | |
| 650 | 4 | |a Centrosomes | |
| 650 | 4 | |a Neoplasms | |
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| 700 | 1 | |a Nigg, Erich A. |d 1952- |e Sonstige |0 (DE-588)172290716 |4 oth | |
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Datensatz im Suchindex
| _version_ | 1819582772081065984 |
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| adam_text | Contents
Preface XV
List of Contributors XVII
Color Plates XXIII
Part I Microtubule Organization and Dynamics 1
1 Early Studies on Centrioles and Centrosomes 3
Joseph G. Gall
1.1 Introduction 3
1.2 Pioneering Studies 4
1.3 Self replication versus De Novo Formation 7
1.4 Centrioles and Basal Bodies 7
1.5 Blepharoplasts 9
1.6 The Search for DNA 11
1.7 On to Self assembly 12
References 14
2 The Tubulin Superfamily 17
Tim Stearns
2.1 History 17
2.2 Family Relations 18
2.3 Localization and Function 21
2.4 v Tubulin 21
2.5 6 Tubulin 22
2.6 e Tubulin 22
2.7 Other Members of the Fold 23
References 24
3 Microtubule Nucleation 27
Michelle Moritz, Luke M. Rice and David A. Agard
3.1 Introduction 27
Centrosomes in Development and Disease. Edited by Erich A. Nigg
Copyright © 2004 WILEY VCH Verlag GmbH Co. KGaA, Weinheim
ISBN 3 527 30980 2
VI I Contents
3.1.1 The Nucleation of Microtubules can occur Spontaneously In Vitro,
but Requires y Tubulin In Vivo 28
3.1.2 Models for the Mechanism of Y TuRC/Tub4 Complex mediated
Microtubule Nucleation 29
3.2 Kinetic Models of the Mechanism of Microtubule Nucleation 31
3.3 The Involvement of Non y TuRC Proteins in Microtubule Nucleation 36
3.4 Future Directions 37
Acknowledgments 38
References 38
4 The Budding Yeast Spindle Pole Body: A Centrosome Analog 43
Suzanne van Kreevdd Naone and Mark Winey
4.1 Introduction 43
4.2 Molecular Composition of the Spindle Pole Body 45
4.2.1 The Central Plaque 47
4.2.2 The Inner Plaque 48
4.2.3 The Outer Plaque 49
4.2.4 Nuclear Membrane Factors 49
4.2.5 The Halfbridge 50
4.2.6 Structure Summary 50
4.3 Microtubule Nucleation 51
4.4 Assembly/Duplication of SPBs and Centrosomes 53
4.4.1 Electron Microscopic Description of Duplication 53
4.4.2 Cell Cycle Regulation of Duplication 55
4.4.3 Genetic Analysis of Duplication 55
4.5 Signaling Platform 57
4.6 Developmental Alteration of SPB Function 60
4.7 Parting Thoughts 61
Acknowledgments 61
References 62
5 Dissection of Basal Body and Centriole Function in the Unicellular Creen Alga
Chlamydomonas reinhardtii 71
Susan K. Dutcher
5.1 Introduction 71
5.2 Why Study a Green Alga to Learn about Centrioles and Basal Bodies? 72
5.3 Structure of the Basal Body and Centriole in Chlamydomonas 72
5.4 Additional Fibers that Connect Basal Bodies and Centrioles 76
5.4.1 Contractile Fibers 76
5.4.2 Rootlet Microtubules 77
5.4.3 Non contractile Fibers 77
5.5 Overview of the Cell Cycle of Chlamydomonas 78
5.6 Duplication of Basal Bodies in Chlamydomonas 78
5.7 Role of Tubulin Isoforms in Basal Body Duplication 82
5.8 Timing of Basal Body/Centriole Duplication in Chlamydomonas 83
Contents I VII
5.9 Function of Basal Bodies and Centrioles in Chlamydomonas 83
5.10 What Makes a Basal Body Different from a Centriole? 84
5.10.1 Transition Zone and Docking 84
5.10.2 Transition Zone and Autonomy 84
5.10.3 Maturation of Basal Bodies 86
5.11 Conclusion 87
Acknowledgments 87
References 88
6 The Centrosome in Evolution 93
Juliette Azimzadeh and Michel Bornens
6.1 Introduction 93
6.2 The Centriole/Basal Body Structure is a Derived Characteristic
of Eukaryotes 94
6.3 The Basal Body/Axoneme is the Ancestral Structure 94
6.4 Functions Associated with the Flagellar Apparatus 96
6.4.1 Cell Locomotion 97
6.4.2 Sensory Reception 97
6.4.3 Cell Division 98
6.5 The Conservative Mode of Duplication of the Basal Body/Centriole/SPB:
An Essential Clue for Cell Morphogenesis 100
6.6 The Centrosome or Central Body 102
6.7 Evolution of Centrosome associated Gene Products 104
6.7.1 Y Tubulin 104
6.7.2 Centrin 306
6.7.3 Centrin binding Proteins 111
6.8 Conclusion: The Centrosome A Cell Individuation Organ? 113
6.8.1 Survival Value of Coupling Basic Functional Modules
on the Same Organ 113
6.8.2 Co Evolution of the Centrosome and the Cleavage Apparatus 114
6.8.3 The Biological Significance of Having a Cell Center 335
Acknowledgments 3 36
References 336
Part II The Integration of Centrosome and Chromosome Cycles 123
7 A Proteomic Approach to the Inventory of the Human Centrosome 325
Christopher J. Wilkinson, Jens S. Andersen, Matthias Mann
and Erich A. Nigg
7.1 Introduction 325
7.2 What is a Centrosome Component? 326
7.3 Composition of the Human Centrosome: A Proteomic Approach 127
7.4 Inspection of Novel Centrosome Proteins by Sequence Analysis 132
7.5 Cell Cycle Changes in Centrosome Composition 335
VI I Contents
3.1.1 The Nucleation of Microtubules can occur Spontaneously In Vitro,
but Requires y Tubulin In Vivo 28
3.1.2 Models for the Mechanism of Y TuRC/Tub4 Complex mediated
Microtubule Nucleation 29
3.2 Kinetic Models of the Mechanism of Microtubule Nucleation 31
3.3 The Involvement of Non y TuRC Proteins in Microtubule Nucleation 36
3.4 Future Directions 37
Acknowledgments 38
References 38
4 The Budding Yeast Spindle Pole Body: A Centrosome Analog 43
Suzanne van Kreeveld Naone and Mark Winey
4.1 Introduction 43
4.2 Molecular Composition of the Spindle Pole Body 45
4.2.1 The Central Plaque 47
4.2.2 The Inner Plaque 48
4.2.3 The Outer Plaque 49
4.2.4 Nuclear Membrane Factors 49
4.2.5 The Halfbridge 50
4.2.6 Structure Summary 50
4.3 Microtubule Nucleation 51
4.4 Assembly/Duplication of SPBs and Centrosomes 53
4.4.1 Electron Microscopic Description of Duplication 53
4.4.2 Cell Cycle Regulation of Duplication 55
4.4.3 Genetic Analysis of Duplication 55
4.5 Signaling Platform 57
4.6 Developmental Alteration of SPB Function 60
4.7 Parting Thoughts 61
Acknowledgments 61
References 62
5 Dissection of Basal Body and Centriole Function in the Unicellular Green Alga
Chlamydomonas reinhardtii 71
Susan K. Dutcher
5.1 Introduction 71
5.2 Why Study a Green Alga to Learn about Centrioles and Basal Bodies? 72
5.3 Structure of the Basal Body and Centriole in Chlamydomonas 72
5.4 Additional Fibers that Connect Basal Bodies and Centrioles 76
5.4.1 Contractile Fibers 76
5.4.2 Rootlet Microtubules 77
5.4.3 Non contractile Fibers 77
5.5 Overview of the Cell Cycle of Chlamydomonas 78
5.6 Duplication of Basal Bodies in Chlamydomonas 78
5.7 Role of Tubulin Isoforms in Basal Body Duplication 82
5.8 Timing of Basal Body/Centriole Duplication in Chlamydomonas 83
Contents I VII
5.9 Function of Basal Bodies and Centrioles in Chlamydomonas 83
5.10 What Makes a Basal Body Different from a Centriole? 84
5.10.1 Transition Zone and Docking 84
5.10.2 Transition Zone and Autonomy 84
5.10.3 Maturation of Basal Bodies 86
5.11 Conclusion 87
Acknowledgments 87
References 88
6 The Centrosome in Evolution 93
Juliette Azimzadeh and Michel Bomens
6.1 Introduction 93
6.2 The Centriole/Basal Body Structure is a Derived Characteristic
of Eukaryotes 94
6.3 The Basal Body/Axoneme is the Ancestral Structure 94
6.4 Functions Associated with the Flagellar Apparatus 96
6.4.1 Cell Locomotion 97
6.4.2 Sensory Reception 97
6.4.3 Cell Division 98
6.5 The Conservative Mode of Duplication of the Basal Body/Centriole/SPB:
An Essential Clue for Cell Morphogenesis 100
6.6 The Centrosome or Central Body 102
6.7 Evolution of Centrosome associated Gene Products 104
6.7.1 y Tubulin 104
6.7.2 Centrin 306
6.7.3 Centrin binding Proteins 111
6.8 Conclusion: The Centrosome A Cell Individuation Organ? 113
6.8.1 Survival Value of Coupling Basic Functional Modules
on the Same Organ 113
6.8.2 Co Evolution of the Centrosome and the Cleavage Apparatus 114
6.8.3 The Biological Significance of Having a Cell Center 335
Acknowledgments 336
References 336
Part II The Integration of Centrosome and Chromosome Cycles 123
7 A Proteomic Approach to the Inventory of the Human Centrosome 325
Christopher J. Wilkinson, Jens S. Andersen, Matthias Mann
and Erich A. Nigg
7.1 Introduction 325
7.2 What is a Centrosome Component? 326
7.3 Composition of the Human Centrosome: A Proteomic Approach 127
7.4 Inspection of Novel Centrosome Proteins by Sequence Analysis 332
7.5 Cell Cycle Changes in Centrosome Composition 335
VIII I Contents
7.6 The Impact of MS on Centrosome Analysis during Cell Cycle
and Development 137
7.7 Expanding Proteomic Information into Knowledge about Function 138
7.8 Conclusion and Prospects 138
Acknowledgments 139
References 139
8 The Role of the Centrosome in Cell Cycle Progression 143
Andrew M. Fry and Rebecca S. Hames
8.1 Introduction 143
8.2 Cell Cycle Dynamics of Centrosome Structure 144
8.3 Old and New Functions of the Centrosome 345
8.4 The Centrosome in G2/M Control 146
8.5 Initiation of Cydin B Destruction at the Centrosome 149
8.6 The Contribution of Centrosomes to Cytokinesis 153
8.7 A Role for Centrosomes in Gl/S Progression? 157
8.8 In Conclusion 159
Acknowledgments 159
References 160
9 Centrosome Duplication and its Regulation in the Higher Animal Cell 167
Greenfield Sluder
9.1 Introduction 167
9.2 The Events of Centrosome Reproduction 168
9.2.1 Centriole Disorientation 168
9.2.2 Centriole Duplication 169
9.2.3 Centrosome Disjunction 170
9.2.4 Centrosome Separation 170
9.2.5 Some Proteins Needed for Centrosome Reproduction 172
9.3 Control of Centrosome Duplication 373
9.3.1 Control of Centrosome Number Intrinsic Mechanisms 173
9.3.2 Block to Re replication 175
9.3.3 Time of Centrosome Duplication: Extrinsic Controls 176
9.3.4 Cyclin dependent Kinases in the Control
of Centrosome Reproduction 176
9.3.4.1 Zygote Systems 177
9.3.4.2 Mammalian Somatic Cells 177
9.3.5 Targets of Cdk2 Cyclin E Kinase 179
9.3.6 Other Kinases Involved in Centrosome Duplication 180
9.3.7 Ubiquitin mediated Proteolysis in the Control
of Centrosome Duplication 181
9.4 Closing Remarks 183
Acknowledgments 183
References 383
Contents I IX
10 A Synergy of Technologies: Using Green Fluorescent Protein Tagging
and Laser Microsurgery to Study Centrosome Function and Duplication
in Vertebrates 191
Alexey Khodjakov and Conly L. Rieder
10.1 Introduction 191
10.2 Laser Microsurgery 293
10.2.1 A Brief History of Development 193
10.2.2 Utility for Removing the Centrosome 195
10.3 Roles of the Centrosome during Cell Division 199
10.3.1 Role of the Centrosome during Spindle Assembly 199
10.3.2 Role of the Centrosome during Cytokinesis 202
10.4 The Centrosome in the Cell Cycle 203
10.4.1 Role of the Centrosome in Progression through the Cell Cycle 203
10.4.2 De Novo Centrosome Formation 205
10.5 For the Future 208
Acknowledgments 208
References 209
11 Centrosome Regulation in Response to Environmental
and Cenotoxic Stress 211
Ody C. M. Sibon and William E. Theurkauf
11.1 Introduction 211
11.2 Heat Shock 211
11.3 Centrosomes and the Unfolded Protein Response 213
11.4 Centrosome Disruption in Response to Genotoxic Stress 215
11.4.1 Centrosome Inactivation in Early Embryos 215
11.4.2 Chk2 is Required for DNA Damage induced Mitotic Catastrophe 216
11.4.3 DNA Damage and Mitosis in Mammalian Cells 218
11.5 Final Thoughts 229
References 221
Part III The Centrosome in Development and Tissue Architecture 225
12 The C. elegans Centrosome during Early Embryonic Development 227
Laurence Pelletier, Thomas Muller Reichert, Martin Srayko,
Nurhan Ozlii, Anne Lore Schlaitz and Anthony A. Hyman
Abbreviations 227
12.1 Introduction 227
12.1.1 C. elegans as a Tool to Study Centrosome Biogenesis 227
12.1.2 The First Cell Division of the C. elegans Embryo 228
12.2 The C. elegans Centrosome 230
12.2.1 The Centrioles 232
12.2.2 The Pericentriolar Material (PCM) 233
12.3 The Centrosome Cycle in C. elegans Embryos 234
12.3.1 Centriole Duplication 236
X Contents
12.3.2 PCM Recruitment 237
12.3.3 Centrosome Maturation 238
12.4 Centrosome Functions 240
12.4.1 Spindle Assembly and Microtubule Nucleation 240
12.4.2 Determination of Anterior Posterior Polarity 242
12.4.3 Spindle Positioning 243
12.5 Concluding Remarks 244
Acknowledgments 245
References 245
13 Centrosomes in a Developing Organism: Lessons from Drosophila 251
Jordan W. Raff
13.1 Introduction 253
13.2 Centrosome and Microtubule Organisation during
the Drosophila Life Cycle 251
13.2.1 Oogenesis 251
13.2.2 Spermatogenesis 253
13.2.3 Early Embryogenesis 254
13.2.4 Asymmetric Divisions of Embryonic Neuroblasts 255
13.2.5 Larval Development 256
13.3 Drosophila Centrosomal Proteins 257
13.3.1 Microtubule Nucleation from Centrosomes:
Y Tubulin and the v TuRC 257
13.3.2 The Recruitment of the y TuRC to Centrosomes:
The Potential Roles of Asp, Polo, CNN, Aurora A, and CP309/D PLP 258
13.3.3 The Interaction between Centrosomes and Microtubules:
The Role of D TACC and Msps 259
13.3.4 Centrosomes and the Organization of the Actin/Myosin Cytoskeleton
in Early Fly Embryos: The Role of Scrambled, Nuf, and CP190 260
13.3.5 Centrosomes and Cytokinesis:
Studies on asl, cnn, and y Tubulin Mutant Spermatocytes 262
13.3.6 Centrosomes and the Cell Cycle 263
13.3.7 Centrosome Dynamics: Inactivation and Flares 264
13.3.8 Microtubule Motors and Plus end Tracking Proteins
at the Centrosome 265
13.3.9 The Interphase Centrosome in Flies: Missing in Action? 265
13.4 The Role of Centrosomes and Centrosomal Proteins In Vivo 266
13.4.1 The Essential Role of Centrosomes In Drosophila 266
13.4.2 The Role of Centrosomal Proteins in Oogenesis 268
13.5 Summary 270
Acknowledgments 270
References 270
Contents I XI
14 Centrosome Inheritance during Human Fertilization and Therapeutic Cloning:
Reproductive and Developmental Diseases and Disorders Caused by
Centrosome Dysfunction 279
C. S. Navara, C. Simerly and G. Schatten
14.1 Introduction 279
14.2 Centrosomes during Human Fertilization 281
14.3 Centrosome Dysfunction as Causes of Human Infertility 281
14.4 Centrosome Functional Assays for Diagnosing Male Infertility 284
14.5 Polyspermy in Humans 285
14.6 Dispermy Hypothesis for the Origins of
Genomic Imprinted Disorders 287
14.7 Maternal Centrosome Anomalies and Birth Defects 288
14.8 Resolving the Special Problem of Parthenogenesis:
Roles of Cytoplasmic Motors and NuMA 289
14.9 Centrosomes during Cloning, and Centrosomes in Embryonic Stem Cells
Derived after Nuclear Transfer 290
14.10 Research Challenges for Centrosome Developmental Biologists:
Developmental Centrosomopathies 292
References 293
15 Microtubule Organizing Centers in Polarized Epithelial Cells 299
Mette M. Mogensen
15.1 Introduction 299
15.2 Centrosomal Microtubule Nucleation 300
15.3 Non centrosomal Microtubule Arrays 301
15.4 Microtubule Minus end Anchorage at Centrosomal
and Non centrosomal Sites 305
15.5 Centrosomal Release of Microtubules and Anchoring Complexes 307
15.6 Stabilization of Non centrosomal Microtubules 308
15.7 Release and Capture 310
Acknowledgments 312
References 312
Part IV Centrosomes in Disease 321
16 Centrosome Anomalies in Cancer:
From Early Observations to Animal Models 323
Thea M. Goepfert and William R. Brinkley
16.1 Early Observations 323
16.2 Origin of Centrosome Anomalies 326
16.2.1 Deregulation of Centrosome Duplication 326
16.2.2 De Novo Formation of Centrioles or Uncontrolled Separation
of Centriole Pairs 327
16.2.3 Failure to Undergo Cytokinesis 327
16.2.4 Fusion of Cells 327
XII I Contents
16.3 Animal Models 328
16.3.1 Centrosome Anomalies and the p53 Pathway 328
16.3.2 Centrosome Anomalies and BRCA 1 329
16.3.3 Centrosome Anomalies and Aurora A 330
Acknowledgments 333
References 333
17 Radiation Therapy and Centrosome Anomalies in Pancreatic Cancer 337
Norihiro Sato, Kazuhiro Mizumoto, and Masao Tanaka
Abstract 337
17.1 Introduction 337
17.2 Radiation induced Cell Death: Apoptosis or Mitotic Cell Death? 338
17.3 Centrosome Anomalies Induced by Radiation 339
17.4 The Mechanism(s) Leading to Centrosome Anomalies after
Radiation Treatment 341
17.5 The Consequence of Centrosome Anomalies after Irradiation 343
17.6 Factors Affecting Centrosome Anomalies after Irradiation 345
17.7 Conclusions and Future Directions 346
References 347
18 Human Papillomavirus Infection and Centrosome Anomalies
in Cervical Cancer 353
Karl Munger and Stefan Duensing
18.1 Genomic Instability and Malignant Progression 353
18.2 Human Papilloma viruses 354
18.3 Biological Activities of HPV E6/E7 Oncogenes 355
18.4 HPV mediated Cervical Carcinogenesis as a Model System
to Study Genomic Instability and Malignant Progression 357
18.5 Centrosome Abnormalities and Genomic Instability: Cause or Effect? 358
18.6 Induction of Centrosome Abnormalities by HPV Oncoproteins:
Boveris Model Revisited 359
18.7 Do HPV E7 induced Centrosome Anomalies Contribute
to Carcinogenic Progression? 362
18.8 Mechanistic Considerations 363
18.9 Concluding Remarks 365
Acknowledgments 366
References 367
Contents I XIII
19 Manipulation of Centrosomes and the Microtubule Cytoskeleton
during Infection by Intracellular Pathogens 371
Niki Scaplehorn and Michael Way
19.1 Introduction 371
19.2 Microtubule directed Movement of Viruses and Membrane Compartments
during Viral Infection 372
19.2.1 Targeting the Nucleus using Motor proteins and the Microtubule Network:
Herpes Simplex Virus, Poliovirus and Retroviruses 373
19.2.2 Hijacking Motor Proteins to Promote Cytoplasmic Assembly and Spread:
Vaccinia Virus and African Swine Fever Virus 375
19.2.3 Conclusion 379
19.3 Virus mediated Damage to the Centrosome
and Microtubule Network 380
19.3.1 Viral Disruption of Microtubule Organization 380
19.3.2 Virus mediated Centrosomal Damage 381
19.3.3 Summary 383
19.4 Viral Disruption of the Centrosome Duplication Cycle
and Spindle Checkpoints 383
19.4.1 Early Studies on Centrosome Number Paramyxoviral Syncytia 384
19.4.2 Multiple Centrosomes: Human Immunodeficiency Virus
and the DNA Damage Checkpoint 385
19.4.3 Multiple Centrosomes:
DNA Tumor Viruses, Retinoblastoma and Ran GTPase 387
19.4.4 Targeting the Spindle Assembly Checkpoint:
Human T Cell Leukemia Virus 1 388
19.4.5 Summary 389
19.5 Bacterial Manipulation of the Centrosome and Microtubules 390
19.5.1 Bacterial Manipulation of the Microtubule Network 390
19.5.2 Interactions between Bacteria and the Centrosome 393
19.5.3 Summary 394
19.6 Conclusion 394
Acknowledgments 394
References 395
20 Basal Bodies and Microtubule Organization in Pathogenic Protozoa 401
Keith Gull, Laura Briggs and Sue Vaughan
20.1 Introduction and Appreciation 401
20.2 The Dispersed MTOC Complement of Protozoal Cells 403
20.3 The Trypanosoma brucei Microtubule Biology 403
20.3.1 The Spindle and Cell Division 404
20.3.2 Basal Bodies 407
20.4 The Microtubule Biology of the Apicomplexa 408
20.4.1 The Apical Polar Ring: A Unique Cytoplasmic MTOC 408
20.4.2 The Conoid 409
20.4.3 Apicomplexan Basal Bodies 410
XIV I Contents
20.4.4 The Spindle MTOC 411
20.4.5 Apicomplexan Cell Division and Cell Morphogenesis 411
20.5 Basal Bodies Are More than Just Microtubule Organizers:
The Hitchhikers Guide to the Cytoskeleton! 414
20.6 Cytoskeletal Adaptations to Parasitism 416
20.7 Conclusion 419
Acknowledgments 420
References 420
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| discipline | Biologie Medizin |
| format | Book |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV019591042 |
| illustrated | Illustrated |
| indexdate | 2024-12-23T17:51:33Z |
| institution | BVB |
| isbn | 3527309802 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-012927792 |
| oclc_num | 56538940 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-11 |
| owner_facet | DE-355 DE-BY-UBR DE-11 |
| physical | XLII, 431 S. Ill., graph. Darst. |
| publishDate | 2004 |
| publishDateSearch | 2004 |
| publishDateSort | 2004 |
| publisher | Wiley-VCH |
| record_format | marc |
| spellingShingle | Centrosomes in development and disease Cell Division physiology Centrosome physiology Centrosomes Neoplasms Centrosom (DE-588)4295334-0 gnd |
| subject_GND | (DE-588)4295334-0 (DE-588)4143413-4 |
| title | Centrosomes in development and disease |
| title_auth | Centrosomes in development and disease |
| title_exact_search | Centrosomes in development and disease |
| title_full | Centrosomes in development and disease ed. by Erich A. Nigg |
| title_fullStr | Centrosomes in development and disease ed. by Erich A. Nigg |
| title_full_unstemmed | Centrosomes in development and disease ed. by Erich A. Nigg |
| title_short | Centrosomes in development and disease |
| title_sort | centrosomes in development and disease |
| topic | Cell Division physiology Centrosome physiology Centrosomes Neoplasms Centrosom (DE-588)4295334-0 gnd |
| topic_facet | Cell Division physiology Centrosome physiology Centrosomes Neoplasms Centrosom Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=012927792&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT niggericha centrosomesindevelopmentanddisease |