Selected nitro- and nitro-oxy-polycyclic aromatic hydrocarbons
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World Health Organization
2003
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| Schriftenreihe: | Environmental health criteria
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| 245 | 1 | 0 | |a Selected nitro- and nitro-oxy-polycyclic aromatic hydrocarbons |c first draft prep. by J. Kielhorn ... |
| 264 | 1 | |a Geneva |b World Health Organization |c 2003 | |
| 300 | |a XXVI, 480 S. |b graph. Darst. | ||
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| 830 | 0 | |a Environmental health criteria |v 229 |w (DE-604)BV000011459 |9 229 | |
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| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-010672273 | |
Datensatz im Suchindex
| _version_ | 1819675188773519360 |
|---|---|
| adam_text | CONTENTS
ENVIRONMENTAL HEALTH CRITERIA FOR
SELECTED NITRO AND NITRO OXY POLYCYCLIC
AROMATIC HYDROCARBONS
PREAMBLE xm
ACRONYMS AND ABBREVIATIONS xxih
1. SUMMARY 1
1.1 Identity, physical and chemical properties, and
analytical methods 1
1.2 Sources of human and environmental exposure 2
1.3 Environmental transport, distribution and
transformation 4
1.3.1 Environmental transport and distribution 4
1.3.2 Biotransformation 4
1.3.3 Abiotic degradation 5
1.4 Environmental levels and human exposure 6
1.4.1 Indoor air 7
1.4.2 Food and beverages 7
1.4.3 Other products 8
1.4.4 Occupational exposure 8
1.5 Kinetics and metabolism in laboratory animals
and humans 9
1.6 Effects on laboratory mammals and in vitro
test systems 10
1.7 Effects on humans 14
1.8 Effects on other organisms in the laboratory and
field 14
2. IDENTITY, PHYSICAL AND CHEMICAL
PROPERTIES, AND ANALYTICAL METHODS 16
2.1 Identity 16
2.2 Physical and chemical properties 23
2.3 Conversion factors 23
2.4 Analytical methods 30
EHC 229: Selected Nltro and Nitro oxyPAHs 2.4.1 Sampling 31
2.4.2 Extraction 38
2.4.3 Cleanup 38
2.4.4 Analytical separation and detection 39
2.4.4.1 Difficulties in analysis 42
2.4.4.2 Complex mixtures 43
2.4.4.3 Analysis of nitro oxyPAHs 43
2.4.5 Use of bioassay (mutagenicity) fractionation
and chemical analysis 43
3. SOURCES OF HUMAN AND ENVIRONMENTAL
EXPOSURE 47
3.1 Industrially produced nitroPAHs 47
3.1.1 Production levels and processes 47
3.1.2 Uses of commercially produced nitroPAHs 47
3.2 Other sources of nitroPAHs 48
3.2.1 Direct sources of nitroPAHs from
combustion processes 54
3.2.1.1 Diesel exhaust 54
3.2.1.2 Diesel compared with gasoline
exhaust 62
3.2.1.3 Aeroplane emissions 62
3.2.1.4 Emissions from combustion of
heating oils 63
3.2.1.5 Fumes from cooking oils 63
3.2.1.6 Other combustion sources 63
3.2.2 Atmospheric formation of nitroPAHs 64
3.2.2.1 Reactions of gas phase PAHs (and
nitroPAHs) with the hydroxyl
radical (daytime reactions) 66
3.2.2.2 Reactions of gas phase PAHs (and
nitroPAHs) with the nitrate radical
(nighttime reactions) 68
3.3 Oxygen containing nitroPAHs 68
4. ENVIRONMENTAL TRANSPORT, DISTRIBUTION
AND TRANSFORMATION 70
4.1 Transport and distribution between media 70
4.1.1 Distribution and transport in the atmosphere 70
4.1.1.1 Distribution of nitroPAHs between
fine and coarse fractions of
inhalable atmospheric participates 71
4.1.2 Distribution and transport in the hydrosphere 71
4.1.3 Adsorption onto soils and sediments 71
4.1.4 Bioaccumulation 72
4.1.5 Biomagnification 72
4.2 Transformation 72
4.2.1 Biotransformation 72
4.2.1.1 Bacteria 72
4.2.1.2 Fungi 75
4.2.1.3 Plants 75
4.2.1.4 Aquatic animals 76
4.2.2 Abiotic degradation 76
4.2.2.1 Direct photolysis 76
4.2.2.2 Other atmospheric
transformations 85
5. ENVIRONMENTAL LEVELS AND HUMAN
EXPOSURE 87
5.1 Environmental levels 87
5.1.1 Air 87
5.1.1.1 Ambient air 87
5.1.1.2 Indoor air 107
5.1.2 Water 109
5.1.3 Soil, sewage sludge, sediment and
incinerator ash 109
5.1.4 Food and beverages 110
5.1.4.1 Food 110
5.1.4.2 Beverages 114
5.1.5 Other sources 116
5.1.5.1 Carbon black and toners 116
5.1.5.2 Cigarette smoke 116
5.2 General population exposure 116
5.3 Occupational exposure 117
6. KINETICS AND METABOLISM IN LABORATORY
ANIMALS AND HUMANS 121
6.1 Overview of the metabolism of nitroPAHs 121
EHC 229: Selected Nitro and Nitro oxyPAHs 6.2 1 Nitropyrene metabolism in mammals 125
6.2.1 Absorption 125
6.2.2 Distribution 125
6.2.3 Metabolism 126
6.2.3.1 Introduction 126
6.2.3.2 Identification of metabolites 126
6.2.3.3 Cytochrome P450 mediated ring
C oxidative pathway 13 7
6.2.3.4 Nitroreduction pathway 138
6.2.3.5 Human and rodent intestinal
microflora 139
6.2.3.6 Suggested metabolic pathway 140
6.2.4 Elimination and excretion 141
6.2.4.1 Elimination 141
6.2.4.2 Excretion 142
6.2.4.3 Biliary excretion and enterohepatic
circulation 142
6.2.5 Reaction with body components 142
6.2.5.1 Protein binding 143
6.2.5.2 DNA adducts 143
6.2.6 Biomonitoring studies 151
6.3 Mononitropyrenes (1 , 2 and 4 nitropyrene) —
a comparison 152
6.3.1 Faecal and urinary excretion 152
6.3.2 Metabolism 152
6.3.3 DNA adducts 154
6.4 2 Nitrofluorene 155
6.4.1 Absorption, distribution and elimination 155
6.4.2 Metabolism/mechanism of action 158
6.4.2.1 Metabolites 158
6.4.2.2 DNA adducts 160
6.4.2.3 Haemoglobin adducts 161
6.5 Dinitropyrenes (1,3 , 1,6 and 1,8 dinitropyrene) 161
6.6 Mononitrobenzo[a]pyrenes (1 , 3 and
6 nitrobenzo[fl]pyrene) 164
6.7 The nirrofluoranthene family 165
6.8 2 and 9 nitroanthracene 167
6.9 6 Nitrochrysene 168
6.10 K and W ras mutations in tumours produced by
nitroPAHs 170
6.11 Human enzymes expected to be involved in
nitroPAH metabolism 171
7. EFFECTS ON LABORATORY MAMMALS AND
IN VITRO TEST SYSTEMS 172
7.1 Acute toxicity 172
7.1.1 1 Nitronaphthalene 172
7.1.2 2 Nitronaphthalene 173
7.1.3 5 Nitroacenaphthene 173
7.1.4 2 Nitrofluorene 173
7.1.5 3,9 Dinitrofluoranthene 173
7.1.6 1 Nitropyrene 173
7.2 Short term and long term exposure (non
neoplastic effects) 174
7.2.1 1 Nitronaphthalene 174
7.2.2 5 Nitroacenaphthene 174
7.2.3 2 Nitrofluorene 219
7.2.4 1 Nitropyrene 219
7.2.5 1,3 Dinitropyrene 220
7.2.6 1,6 Dinitropyrene 220
7.2.7 1,8 Dinitropyrene 220
7.2.8 6 Nitrochrysene 220
7.2.9 1 and 3 nitrobenzo[a]pyrene 220
7.2.10 1,6 Dinitrobenzo[a]pyrene 221
7.3 Skin and eye irritation and sensitization 221
7.4 Reproductive toxicity, embryotoxicity and
teratogenicity 221
7.5 Mutagenicity and related end points 221
7.5.1 In vitro genotoxicity studies 237
7.5.1.1 Salmonella typhimurium
microsome assay 237
7.5.1.2 Comparison of the mutagenic
potency of nitroPAHs in the
Salmonella microsome assay 293
7.5.1.3 Studies into the pathways of
microbial metabolism 294
7.5.1.4 Relationship between mutagenic
potency in S. typhimurium and the
chemical structure of nitroPAHs 303
EHC 229: Selected Nitro and Nitro oxyPAHs 7.5.1.5 Bacterial test systems other than the
Salmonella microsome assay 305
7.5.1.6 Eukaryotic test systems 306
7.5.1.7 High potency in the Salmonella
microsome assay in relation to gene
mutation results from other in vitro
assays 307
7.5.1.8 Assessment of data on genotoxicity
in vitro 309
7.5.2 In vivo genotoxicity studies 310
7.5.2.1 Comparison with in vitro results 321
7.5.3 Genotoxicity of oxygen containing
nitroPAHs 325
7.5.3.1 3 Nitrobenzanthrone 325
7.5.3.2 Nitrodibenzopyranones 326
7.5.3.3 Nitropyrene lactones 328
7.5.3.4 Comparison of mutation frequency
at hprt versus tk locus in human B
lymphoblastoid cell lines 326
7.5.4 Summary of the genotoxicity of nitroPAHs 329
7.5.5 Mutagenicity of complex mixtures 329
7.5.5.1 Difficulties encountered when
interpreting the mutagenicity of
complex mixtures compared with
individual compounds 329
7.5.5.2 Mutagenicity of diesel engine
exhaust 330
7.5.5.3 Mutagenic effect of urban air
samples 331
7.5.5.4 Bioassay directed chemical analysis
of airborne paniculate matter using
a human cell mutagenicity assay 334
7.5.5.5 DNAadducts 334
7.5.5.6 Mutagenic contribution of selected
nitroPAHs from their occurrence in
air samples multiplied by the
mutagenicity in the Salmonella
mutagenicity test 335
7.5.5.7 Municipal waste incinerator
emissions 335
7.5.5.8 Mutagenicity of soils exposed to
automobile exhaust 336
7.5.6 Effects of antimutagenic compounds on
nitroPAH mutagenicity 336
7.6 Carcinogenicity 337
7.6.1 Route of administration 341
7.6.2 Adequacy of data 342
7.6.3 Type of induced tumours 343
7.6.4 Ranking of carcinogenic potency in
comparative studies on nitroPAHs 349
7.6.4.1 Comparison of the carcinogenicity
of nitroPAHs with parent PAHs 352
7.6.4.2 Comparison of the dose 355
7.6.5 Carcinogenicity of oxygen containing
nitroPAHs 356
7.6.6 Carcinogenicity of the metabolites 356
7.6.7 Carcinogenic potency of nitroPAHs in
diesel exhaust 357
7.6.8 Genotoxicity in vivo and in vitro versus
carcinogenicity 358
7.6.9 Potency equivalency factors for nitroPAHs 359
7.6.10 Mechanisms of carcinogenesis 360
7.7 Special studies: Target organ effects 360
7.7.1 1 Nitronaphthalene 360
7.7.2 2 Nitronaphthalene 361
7.7.3 1 Nitropyrene 362
8. EFFECTS ON HUMANS 363
8.1 General population exposure 365
8.2 Occupational exposure 366
8.3 Indicators of exposure to nitroPAHs in diesel
exhaust 366
8.3.1 Biomonitoring of exposure/effect 366
8.3.1.1 DNAadducts 366
8.3.1.2 Protein adducts 367
8.3.1.3 1 Nitropyrene metabolites 368
8.3.1.4 Immunochemical determination 369
8.3.2 Biomarkers of susceptibility 369
8.3.2.1 Cytochrome P450 369
8.3.2.2 Influence of polymorphisms on
biomarkers 370
IV
EHC 229: Selected Nitro and Nitro oxyPAHs 9. EFFECTS ON OTHER ORGANISMS IN THE
LABORATORY AND FIELD 372
9.1 Laboratory experiments 372
9.1.1 Aquatic species 372
9.1.2 Biotransformation studies in aquatic
species 372
9.1.3 DNA damage in aquatic species 373
9.2 Field observations 375
10. EVALUATION OF HUMAN HEALTH RISKS AND
EFFECTS ON THE ENVIRONMENT 376
10.1 Evaluation of human health risks 376
10.1.1 Exposure levels 376
10.1.1.1 NitroPAHs 376
10.1.1.2 Nitroketones 378
10.1.1.3 Nitrolactones 378
10.1.2 Fate in the body 379
10.1.2.1 NitroPAHs 379
10.1.2.2 Nitroketones 380
10.1.2.3 Nitrolactones 380
10.1.3 Toxic effects 380
10.1.3.1 Non neoplastic effects 380
10.1.3.2 Genotoxicity 381
10.1.3.3 Neoplastic effects 385
10.1.4 Evaluation of nitroPAHs,
nitroketones and nitrolactones that
seem to be of importance in the
environment 386
10.2 Evaluation of effects on the environment 386
10.3 General considerations 390
10.4 Overall evaluation 391
11. RECOMMENDATIONS FOR PROTECTION OF
HUMAN HEALTH AND THE ENVIRONMENT 392
12. RECOMMENDATIONS FOR FURTHER RESEARCH 393
13. PREVIOUS EVALUATIONS BY INTERNATIONAL
BODIES 394
REFERENCES 395
RESUME 448
RESUMEN 465
vi
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| id | DE-604.BV017770466 |
| illustrated | Illustrated |
| indexdate | 2024-12-23T16:27:01Z |
| institution | BVB |
| language | English Spanish |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-010672273 |
| oclc_num | 248980825 |
| open_access_boolean | |
| owner | DE-12 |
| owner_facet | DE-12 |
| physical | XXVI, 480 S. graph. Darst. |
| publishDate | 2003 |
| publishDateSearch | 2003 |
| publishDateSort | 2003 |
| publisher | World Health Organization |
| record_format | marc |
| series | Environmental health criteria |
| series2 | Environmental health criteria |
| spellingShingle | Selected nitro- and nitro-oxy-polycyclic aromatic hydrocarbons Environmental health criteria Toxikologie (DE-588)4060538-3 gnd Polycyclische Aromaten (DE-588)4175141-3 gnd Nitroaromaten (DE-588)4171935-9 gnd |
| subject_GND | (DE-588)4060538-3 (DE-588)4175141-3 (DE-588)4171935-9 |
| title | Selected nitro- and nitro-oxy-polycyclic aromatic hydrocarbons |
| title_auth | Selected nitro- and nitro-oxy-polycyclic aromatic hydrocarbons |
| title_exact_search | Selected nitro- and nitro-oxy-polycyclic aromatic hydrocarbons |
| title_full | Selected nitro- and nitro-oxy-polycyclic aromatic hydrocarbons first draft prep. by J. Kielhorn ... |
| title_fullStr | Selected nitro- and nitro-oxy-polycyclic aromatic hydrocarbons first draft prep. by J. Kielhorn ... |
| title_full_unstemmed | Selected nitro- and nitro-oxy-polycyclic aromatic hydrocarbons first draft prep. by J. Kielhorn ... |
| title_short | Selected nitro- and nitro-oxy-polycyclic aromatic hydrocarbons |
| title_sort | selected nitro and nitro oxy polycyclic aromatic hydrocarbons |
| topic | Toxikologie (DE-588)4060538-3 gnd Polycyclische Aromaten (DE-588)4175141-3 gnd Nitroaromaten (DE-588)4171935-9 gnd |
| topic_facet | Toxikologie Polycyclische Aromaten Nitroaromaten |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010672273&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000011459 |
| work_keys_str_mv | AT kielhornj selectednitroandnitrooxypolycyclicaromatichydrocarbons |