PET and PET-CT in oncology 60 tables

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Datensatz im Suchindex

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adam_text Parti: Basics 1 Physical Principles, Dedicated/ Coincidence PET 3 S. ZlEGLER 1.1 Physics Background 3 1.2 Detectors for PET 4 1.3 Tomograph Design 5 2 Dual Modality PET/CT Acquisition Systems for Clinical Oncology 9 T. Beyer and D. W. Townsend 2.1 Adding Anatomical to Functional Information 9 2.2 Anato metabolic Imaging: The Proof of principle for Dual Modality Imaging 11 2.3 PET/CT Design Considerations: The Second Generation of PET/CT Tomographs 15 2.4 Experiences with Existing PET/CT Technology 19 2.5 Recent Developments and Trends for Tomorrow 25 3 Transport and Metabolism of Glucose and FDG 30 P. Oehr 3.1 Biological Functions of Carbohydrate Metabolism 30 3.2 Metabolism of Glucose, 2 DG, 2 FDG and3 FDG 31 3.3 FDG Uptake 33 4 Radiopharmaceutical Production and Safety of [18F]FDG 43 P. Oehr 4.1 Radiopharmaceutical Chemistry of[18F]FDG 43 4.2 [18F]FDG Pharmacokinetics, Toxicity and Interactions 45 4.3 [18F]FDG Activity Dosages and Radiation Exposure 46 4.4 Conclusions 47 5 Image Fusion 49 U. PlETRZYK 5.1 Introduction 49 5.2 Basic Remarks 49 5.3 Properties of PET, SPECT, CT and MR Images Relevant for Image Fusion 50 5.4 Technical Issues in Image Fusion 50 5.5 Image Fusion in Brain Imaging 53 5.6 Image Fusion Strategies for Extra cranial Images 54 5.7 Combined Devices for Functional Anatomical Imaging (PET/CT) 55 6 PET Scanner Quality Control 59 T. G. TURKINGTON 6.1 Quality Control Issues 59 6.2 Basic Ring Function and the Sinogram 59 6.3 Impact of Malfunctioning Detectors 62 6.4 A Simple Daily Protocol 63 6.5 Quantitative Accuracy 63 6.6 Determining Whether or Not to Scan 64 Part II: Experimental Oncology 7 Introduction to Experimental PET in Oncology 67 P. Oehr 7.1 PET and Molecular Imaging 67 7.2 Assay Models for Experimental PET 67 7.3 Conclusions 71 8 PET in Cell Cultures: Oncology, Genetics, and Therapy 73 P. Oehr, N. Gilbert, H. Lemmoch, M. Ludwig, R. Wagner, H. Schuller, and H. Rink 8.1 Introduction 73 8.2 Material and Methods 73 8.3 Results 74 8.4 Discussion 74 8.5 Conclusion 75 VIII Contents 9 Small Animal PET in Oncology 77 M. Honer, M. Bruhlmeier, I. NOVAK HOFER, AND S. AMETAMEY 9.1 Dedicated Small Animal PET Cameras 77 9.2 Applications of Small Animal PET in Oncology 79 10 Small Animal PET in Neuro oncology and Gene Therapy 87 A.H. Jacobs and W. D. Heiss 10.1 Introduction 87 10.2 Gliomas General and Molecular Aspects 87 10.3 Gene Therapy for Gliomas Current Status and Future Perspectives 88 10.4 Small Animal PET Imaging of Endogenous Gene Expression for Characterization of Target Tissue 88 10.5 Small Animal PET Imaging of Expression of Exogenously Introduced Genes 90 10.6 Summary and Conclusion 94 Part III: Clinical Applications 11 PET/CT: Clinical Considerations 101 A. Bockisch, L. Freudenberg, G. Antoch, and St. Muller 11.1 Introduction 101 11.2 Present State and Use of PET/CT 102 11.3 Clinical Value of PET/CT at Present 102 11.4 Patient Selection and Clinical Protocols for PET/CT Scanning 105 11.5 Clinical Impact of PET/CT 105 12 Brain Tumors 113 T. Z. Wong, G. J. van der Westhuizen, AND R. E. COLEMAN 12.1 Incidence, Etiology, Epidemiology 113 12.2 Histopathological Classification 113 12.3 Imaging of Brain Tumors 114 12.4 FDG PET Imaging of Brain Tumors 114 12.5 Indications for FDG PET Imaging of Brain Tumors 115 12.6 Other PET Tracers 119 12.7 Summary and Outlook 121 12.8 Technical Recommendations 121 13 Head and Neck Tumors 127 H. Bender and H. J. Straehler Pohl 13.1 Incidence, Etiology and Epidemiology 127 13.2 Histopathology 127 13.3 Conventional Diagnostic Procedures 128 13.4 Functional Imaging/FDG PET 129 13.5 Summary and Outlook 133 13.6 Technical Recommendations 134 14 Thyroid Carcinomas 137 F. Grunwald and M. Diehl 14.1 Clinical Background 137 14.2 Therapy 137 14.3 UseofFDGPET 139 14.4 Indications 144 14.5 Results and Interpretation 145 14.6 Limits of Interpretation 146 15 Lung Cancer 149 J. F. Vansteenkiste and S.S. Stroobants 15.1 Incidence, Etiology and Epidemiology 149 15.2 Histopathological Classification 149 15.3 Conventional Diagnostic Procedures 150 15.4 PET 153 15.5 Indications for PET Practical Clinical Guidelines 158 15.6 New Tracer Developments 160 15.7 Summary and Outlook 161 15.8 Technical Recommendations 161 16 Breast Cancer 167 H. Palmedo 16.1 Incidence and Epidemiology 167 16.2 Histopathological Classification, Pathology and Prognosis of Breast Cancer 167 16.3 Conventional Diagnostic Procedures and Treatment Strategies 168 16.4 PET in Breast Cancer 171 16.5 Indications 175 16.6. Technical Recommendations 176 17 Pancreatic Cancer 179 D. Delbeke 17.1 Epidemiology and Histopathological Types 179 17.2 Conventional Diagnostic Imaging Modalities 179 17.3 FDG PET Imaging 180 17.4 FDG PET for Evaluation of Islet Cells and Other Endocrine Tumors of the Pancreas ... 183 17.5 Summary 184 18 Gastro Esophageal Cancer , 187 P. Flamen and L. Mortelmans 18.1 Introduction 187 18.2 PET: Current Status 189 18.3 Indications of PET 199 18.4 New Tracer Developments 199 18.5 Summary 200 18.6 Technical Recommendations 200 19 Liver Cancer 203 J. H. Risse 19.1 Incidence, Etiology and Epidemiology 203 19.2 Histopathological Classification 203 19.3 Conventional Diagnostic Procedures and Treatment Strategies 204 19.4 PET: Current Status in Liver Cancer 205 19.5 Judgement of Indications of PET in Liver Cancer 209 19.6 New Tracer Developments 209 19.7 Summary and Outlook 209 19.8 Technical Recommendations 209 20 Colorectal Cancer 213 M. T. KlTAPCI AND R. E. COLEMAN 20.1 Introduction 213 20.2 Diagnosis 215 20.3 FDG PET Imaging for Colorectal Cancer: Current State 216 20.4 Impact on Patient Management 223 20.5 Assessment of Prognosis and Cost Effectiveness 223 20.6 Limitations 223 20.7 Summary 224 20.8 New Tracers 224 20.9 Technical Recommendations 224 21 Ovarian Cancer 227 M. ZlMNY 21.1 Incidence, Etiology, Epidemiology 227 21.2 Histological Classification 227 21.3 Diagnosis and Treatment of Ovarian Cancer 227 21.4 Positron Emission Tomography 228 21.5 Summary 232 21.6 Technical Recommendations 232 22 Cancer of the Uterus 237 M. J. Reinhardt 22.1 Preface 237 22.2 Epidemiology 237 22.3 Pattern of Spread and Histology 237 Contents IX 22.4 Diagnosis, Staging and Prognostic Factors .. 237 22.5 Evidence for the Use of 18F FDG PET in the Management of Cervical Cancer 238 22.6 Technical Recommendations 240 22.7 Conclusion 240 23 PET in Bladder, Renal, and Prostate Cancer 243 M. Seltzer and O. Shvarts 23.1 Introduction 243 23.2 Bladder Cancer 243 23.3 Renal Cancer 244 23.4 Prostate Cancer 245 23.5 Summary 247 24 Testicular Tumors 251 P.Albers 24.1 Incidence, Epidemiology and Clinical Diagnosis 251 24.2 Pathological Diagnosis and Classification .. 251 24.3 PET in Diagnosis and Treatment 253 24.4 Summary and Future Directions 256 25 Malignant Melanoma 259 P. Paquet, R. Hustinx, P. Rigo, AND G.E. PlERARD 25.1 Introduction 259 25.2 Rationale for Using 18 FDG as a Radiotracer in Melanoma 260 25.3 Sensitivity and Specificity of 18 FDG PET in Cutaneous Melanoma 261 25.4 FDG PET Versus Conventional Imaging in Melanoma 262 25.5 Pitfalls of FDG PET in Melanoma 263 25.6 FDG PET in Ocular Melanoma 264 25.7. New Radiotracers for Melanoma 264 25.8 Conclusion 264 26 Malignant Lymphomas 267 C. Menzel 26.1 Hodgkin s disease 267 26.2 Non Hodgkin s Lymphoma 270 27 Musculoskeletal Tumors 275 A.K. Buck, H. Schirrmeister, and S.N. Reske 27.1 Incidence, Etiology, Epidemiology 275 27.2 Histopathological Classification 276 27.3 Conventional Diagnostic Procedures and Treatment Strategies 277 27.4 Positron Emission Tomography 278 X Contents 27.5 Judgement of Indications for FDG PET 280 27.6 New Tracer Developments 281 27.7 Summary and Outlook 281 27.8 Technical Recommendations 283 28 Skeletal imaging with F 18 285 H. Palmedo 28.1 Background 285 28.2 Conventional Screening for Bone Metastases 287 28.3 PET with F 18 Sodium Fluoride for Metastatic Bone Disease 287 28.4 Technical Recommendations 289 29 PET in Surgery 291 S. Yasuda, K. Nakai, M. Ide, S. Kawada, and A. Shohtsu 29.1 Introduction 291 29.2 Advantages of FDG PET 291 29.3 Limitations of FDG PET 291 29.4 Applications of FDG PET in Surgery 292 29.5 Summary 299 30 PET and Radiotherapy 303 Val J. Lowe 30.1 Background 303 30.2 PET Before Radiation Therapy 303 30.3 PET During Radiation Therapy 303 30.4 Deoxygenation and PET 304 30.5 PET Imaging After Completion of Radiation Therapy 304 30.6 Diagnosing Recurrent Disease with PET ... 306 30.7 Timing of PET After Radiation Therapy 306 30.8 Summary 308 31 Cancer Screening with 18F FDG PET 309 K. Nakai, S. Yasuda, M. Ide, S. Kawada, and A. Shohtsu 31.1. Background 309 31.2. Subjects and Methods 309 31.3. Results 309 31.4 Cancer Screening 310 31.5. Conclusions 320 32 Cost Effectiveness Studies of PET in Oncology 321 K. A. Miles and L. B. Connelly 32.1 Introduction 321 32.2 Definitions 321 32.3 Techniques for Assessing Cost Effectiveness 324 32.4 Cost Effectiveness Studies of PET in Oncology 326 32.5 Translating the Results of Cost Effectiveness Studies to Other Countries ... 328 32.6 Summary 329 33 Reimbursement (EU and USA) 33.1 PET Reimbursement: Europe 331 M. DlETLEIN 33.2 PET Reimbursement: United States 335 R. E. COLEMAN AND RUTH D. TeSAR Subject Index 339
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spellingShingle PET and PET-CT in oncology 60 tables
Krebs Medizin (DE-588)4073781-0 gnd
Positronen-Emissions-Tomografie (DE-588)4129799-4 gnd
Computertomografie (DE-588)4113240-3 gnd
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title PET and PET-CT in oncology 60 tables
title_auth PET and PET-CT in oncology 60 tables
title_exact_search PET and PET-CT in oncology 60 tables
title_full PET and PET-CT in oncology 60 tables P. Oehr ... [eds.]
title_fullStr PET and PET-CT in oncology 60 tables P. Oehr ... [eds.]
title_full_unstemmed PET and PET-CT in oncology 60 tables P. Oehr ... [eds.]
title_short PET and PET-CT in oncology
title_sort pet and pet ct in oncology 60 tables
title_sub 60 tables
topic Krebs Medizin (DE-588)4073781-0 gnd
Positronen-Emissions-Tomografie (DE-588)4129799-4 gnd
Computertomografie (DE-588)4113240-3 gnd
topic_facet Krebs Medizin
Positronen-Emissions-Tomografie
Computertomografie
Aufsatzsammlung
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