Osteoarthritis
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| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Oxford [u.a.]
Oxford Univ. Press
2003
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| Ausgabe: | 2. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
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| 245 | 1 | 0 | |a Osteoarthritis |c ed. by Kenneth D. Brandt ... |
| 250 | |a 2. ed. | ||
| 264 | 1 | |a Oxford [u.a.] |b Oxford Univ. Press |c 2003 | |
| 300 | |a XII, 511 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Osteoarthritis | |
| 650 | 0 | 7 | |a Osteoarthritis |0 (DE-588)4172921-3 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Osteoarthritis |0 (DE-588)4172921-3 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Brandt, Kenneth D. |e Sonstige |4 oth | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010449505&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-010449505 | |
Datensatz im Suchindex
| _version_ | 1819735211069407232 |
|---|---|
| adam_text | List of contributors
1 Definition and classification of
osteoarthritis 1
2 Epidemiology of osteoarthritis 9
3 The economics of osteoarthritis 17
4 Genetic aspects of osteoarthritis 23
4.1 Evidence for the inheritance of osteoarthritis 25
4.2 Specific gene defects associated with
osteoarthritis 33
4.3 Laboratory approaches to the identification of
genetic association in osteoarthritis 41
5 Pathology of osteoarthritis 49
6 Paleopathology of osteoarthritis 59
7 Pathogenesis of osteoarthritis 67
7.1 Introduction: the concept of osteoarthritis as
failure of the diarthrodial joint 69
7.2 Pathogenesis of structural changes in the
osteoarthritic joint 73
7.2.1 Articular cartilage 73
7.2.1.1 Biochemistry and metabolism of normal and
osteoarthritic cartilage 73
7.2.1.2 Proteolytic degradation of normal and
osteoarthritic cartilage matrix 82
7.2.1.3 Articular cartilage repair 93
7.2.1.4 Mechanical properties of normal and
osteoarthritic articular cartilage, and the
mechanobiologyofchondrocytes 102
7.2.1.5 Response of the chondrocyte to mechanical
stimuli 112
7.2.1.6 Crystals and osteoarthritis 120
7.2.2 Bone 125
7.2.2.1 Subchondral bone in the pathogenesis of
osteoarthritis. Mechanical aspects 125
7.2.2.2 Subchondral bone in the pathogenesis of
osteoarthritis. Biological effects 133
7.2.2.3 Systemic changes in bone in osteoarthritis 142
7.2.3 Synovium 147
7.2.3.1 Synovial mediators of cartilage damage and
repair in osteoarthritis 47
7.2.3.2 Synovial physiology in the context of
osteoarthritis 155
7.2.4 Neuromuscular system 161
7.2.4.1 Innervation of the joint and its role in
osteoarthritis 161
7.2.4.2 Neuromuscular protective mechanisms 167
7.2.4.3 Proprioception in osteoarthritis / 72
7.2.5 Local mechanical factors in the natural history of
knee osteoarthritis. Malalignment and joint
laxity 177
73 Pathogenesis of joint pain in osteoarthritis 185
7.3.1 Peripheral and central pain mechanisms in
osteoarthritis 185
7.3.2 Why does the patient with osteoarthritis
hurt? 189
8 Clinical features of osteoarthritis
and standard approaches to the
diagnosis 195
8.1 Signs, symptoms, and laboratory tests 197
8.2 Plain radiographic features of osteoarthritis 211
8.3 The natural history and prognosis of
osteoarthritis 227
9 Management of osteoarthritis 235
9.1 Introduction: the comprehensive approach 237
9.2 Systemic analgesics 243
9.3 The role of NSAIDs in the treatment of
osteoarthritis 251
9.4 Economic considerations in pharmacologic
management of osteoarthritis 259
9.5 Topical NSAIDs 267
9.6 Topical Capsaicin Cream 273
9.7 Intra articular glucocorticoids and other injection
therapies 277
9.8 Intra artiuclar hyaluronan injection 283
9.9 Nutritional therapies 289
9.10 Mechanisms by which micronutrients may
influence osteoarthritis 293
9.11 Physical therapy 299
9.11.1 Exercise for the patient with osteoarthritis 299
9.11.2 Other physical therapies 305
9.12 Occupational therapy for the patient with
osteoarthritis 311
9.13 Patient education 321
9.14 Social support 327
9.15 Depression in osteoarthritis 333
9.16 Coping strategies for the patient with
osteoarthritis 339
9.17 Irrigation of the osteoarthritic joint 347
9.18 Surgical approaches to preserving and restoring
articular cartilage 353
9.19 Arthroplasty and its complications 361
9.20 Weight loss and osteoarthritis 371
9.21 Patient adherence 375
10 Outcome assessment in
osteoarthritis: a guide for research
and clinical practice 381
11 Prospects for pharmacological
modification of joint breakdown in
osteoarthritis 391
11.1 Pharmacological modification of joint breakdown
in OA: Do we need it, can we do it, can we prove
it, is it good? 393
11.2 Disease modifying osteoarthritis drugs
(DMOADs) 395
11.2.1 The biological perspective 395
11.2.2 The clinical perspective 401
11.3 Advantages and limitations of animal models
in the discovery and evaluation of novel disease
modifying osteoarthritis drugs (DMOADs) 411
11.4 Assessment of changes in joint tissues in patients
treated with disease modifying osteoarthritis
drugs (DMOADs): monitoring outcomes 417
11.4.1 Radiographic grading systems 417
11.4.2 Quantitation of radiographic changes 426
11.4.3 Magnetic resonance imaging 433
11.4.4 Arthroscopic evaluation of knee articular
cartilage 451
11.4.5 Bone scintigraphy 456
11.4.6 Ultrasonography 462
11.4.7 Defining and validating the clinical role of
molecular markers in osteoarthritis 468
12 Design of clinical trials for
evaluation of structure modifying
drugs and new agents for
symptomatic treatment of
osteoarthritis 479
Appendices 489
Al The American College of Rheumatology (ACR)
criteria for the classification and reporting of
osteoarthritis 491
A2 Lequesne s algofunctional lower limb indices 493
A3 WOMAC osteoarthritis Index 495
A4 Protocols for radiography 497
Index 501
|
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| discipline | Medizin |
| edition | 2. ed. |
| format | Book |
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| id | DE-604.BV017332748 |
| illustrated | Illustrated |
| indexdate | 2024-12-23T16:20:03Z |
| institution | BVB |
| isbn | 0198509677 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-010449505 |
| oclc_num | 248561620 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
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| physical | XII, 511 S. Ill., graph. Darst. |
| publishDate | 2003 |
| publishDateSearch | 2003 |
| publishDateSort | 2003 |
| publisher | Oxford Univ. Press |
| record_format | marc |
| spellingShingle | Osteoarthritis Osteoarthritis Osteoarthritis (DE-588)4172921-3 gnd |
| subject_GND | (DE-588)4172921-3 |
| title | Osteoarthritis |
| title_auth | Osteoarthritis |
| title_exact_search | Osteoarthritis |
| title_full | Osteoarthritis ed. by Kenneth D. Brandt ... |
| title_fullStr | Osteoarthritis ed. by Kenneth D. Brandt ... |
| title_full_unstemmed | Osteoarthritis ed. by Kenneth D. Brandt ... |
| title_short | Osteoarthritis |
| title_sort | osteoarthritis |
| topic | Osteoarthritis Osteoarthritis (DE-588)4172921-3 gnd |
| topic_facet | Osteoarthritis |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=010449505&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT brandtkennethd osteoarthritis |