Gastrointestinal disorders during pregnancy

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Veröffentlicht: Philadelphia [u.a.] Saunders 2003
Schriftenreihe:Gastroenterology clinics of North America 32,1
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adam_text GASTROINTESTINAL DISORDERS DURING PREGNANCY CONTENTS Preface xi Mitchell S. Cappell General Considerations Abdominal Pain During Pregnancy 1 Mitchell S. Cappell and David Friedel Abdominal pain during pregnancy presents unique clinical chal¬ lenges. The differential diagnosis during pregnancy is extensive, in that the abdominal pain may be caused by obstetric or gyneco¬ logic disorders related to pregnancy, as well as intraabdominal diseases incidental to pregnancy. Gastroenterologists, as well as ob¬ stetricians, gynecologists, internists, and surgeons, should be famil¬ iar with the medical and surgical conditions that can present in pregnancy and how these conditions affect and are affected by pregnancy. This article reviews obstetric, gynecologic, medical, and surgical causes of abdominal pain during pregnancy, with a focus on aspects of abdominal diseases unique to pregnancy. Nutritional Assessment and Support During Pregnancy 59 Elie Hamaoui and Michal Hamaoui This article thoroughly updates the authors previous review of nu¬ tritional assessment and support during pregnancy. After briefly reviewing nutrient metabolism and requirements, the authors dis¬ cuss the nutritional assessment of the pregnant woman and review the nutritional support principles in hyperemesis gravidarum and other conditions that can compromise the nutritional health of mother or fetus. The Fetal Safety and Clinical Efficacy of Gastrointestinal Endoscopy During Pregnancy 123 Mitchell S. Cappell More than 12,000 pregnant patients in the United States per annum have conditions that are normally evaluated by esophagogastro duodenoscopy (EGD). More than 6000 pregnant patients in the VOLUME 32 • NUMBER 1 • MARCH 2003 V United States per annum have conditions that are normally eval¬ uated by sigmoidoscopy or colonoscopy. About 1000 more have symptomatic choledocholithiasis during pregnancy, a strong indi¬ cation for endoscopic sphincterotomy in nonpregnant patients. En doscopy during pregnancy raises the unique issue of fetal safety. Endoscopic medications comprise a significant component of fetal endoscopic risks. EGD, sigmoidoscopy, and endoscopic retrograde cholangiopancreatography (ERCP) should be performed during pregnancy when strongly indicated: EGD for significant upper gas¬ trointestinal bleeding, sigmoidoscopy for nonhemorrhoidal rectal bleeding, and ERCP for symptomatic choledocholithiasis when sphincterotomy is contemplated. Percutaneous endoscopic gastro stomy (PEG) and colonoscopy are currently considered experimen¬ tal during pregnancy because of insufficient data on fetal safety. Several cases of PEG and colonoscopy have been successfully per¬ formed during pregnancy. Performance of endoscopy during preg¬ nancy should increase with further technical refinements, and greater awareness of procedure safety. Gastrointestinal Surgery and Pregnancy 181 Mark A. Malangoni During pregnancy, gastrointestinal disorders that require surgery often mimic the symptoms and signs of conditions that do not re¬ quire surgery. Anatomic and physiologic changes of pregnancy can alter the usual clinical presentation of gastrointestinal disorders. These alterations can be a challenge to diagnosis. Prompt treatment is critical to successful management. Most elective and urgent op¬ erations can be performed during pregnancy with minimal mater¬ nal and fetal risk. The condition of the mother should always take priority because proper treatment of the mother usually benefits the fetus, as well. Upper Gastrointestinal Disorders Nausea and Vomiting During Pregnancy 201 Kenneth L. Koch and Christine L. Frissora The differential diagnosis of nausea and vomiting is extensive and the underlying cause can be difficult to diagnose. Treatment of nausea and vomiting also can be unsatisfactory because the avail¬ able pharmacotherapy does not correct the fundamental under¬ lying pathophysiologic abnormalities. In contrast, the diagnosis of nausea and vomiting of pregnancy generally is straightforward. Almost 80% of women have some degree of nausea in the first tri¬ mester of pregnancy, and the diagnosis of pregnancy is established easily by the patient or physician. The spectrum varies from mild nausea to hyperemesis gravidarum. Various treatment approaches are addressed. Gastroesophageal Reflux Disease During Pregnancy 235 Joel E. Richter Gastroesophageal reflux disease (GERD) with heartburn and acid regurgitation is exceedingly common in pregnancy. The pathophy siology involves primarily a decrease in lower esophageal sphinc¬ ter pressure. Most, if not all, of these patients are managed by obstetricians, but gastroenterologists may be consulted in diffi¬ cult to treat cases. Because of the concern about the use of systemic medications during pregnancy and lactation, it is important for gastroenterologists to understand the pathogenesis, natural history, and diagnostic and therapeutic options available for treating GERD during pregnancy. Gastric and Duodenal Ulcers During Pregnancy 263 Mitchell S. Cappell Peptic ulcer disease (PUD) in pregnancy should be considered se¬ parately from PUD in the general population. This article focuses on how the clinical presentation, natural history, medical therapy, and surgical therapy of PUD differ in pregnancy from that in the general population to help the clinician to evaluate, manage, and treat PUD during pregnancy and to stimulate the researcher to study the role of Helicobacter pylori in ulcerogenesis and to perform controlled endoscopic studies during pregnancy. Lower Gastrointestinal Disorders Constipation, Diarrhea, and Symptomatic Hemorrhoids During Pregnancy 309 Arnold Wald Constipation, diarrhea, and symptomatic hemorrhoids are disor¬ ders common in the general population, particularly in women. These conditions, if mild, often are self treated with various home remedies or nonprescription preparations. Few of these patients, moreover, are referred to gastroenterologists, as primary care pro¬ viders generally are confident managing these conditions, unless they are severe, refractory to conventional management, or require additional diagnostic studies. Inflammatory Bowel Disease in Pregnancy 323 Sunanda Kane The term inflammatory bowel disease (IBD) refers to ulcerative co¬ litis and Crohn s disease, two chronic conditions of unknown cause. Whereas the incidence of ulcerative colitis has remained stable, the incidence of Crohn s disease has increased during the past few decades. The consequence of this trend is a growing CONTENTS vii population of women in their childbearing years with concerns about the effects of IBD on fertility and pregnancy. Important is¬ sues concerning a woman with IBD who is pregnant or contem¬ plating pregnancy include inheritance of IBD in the offspring, fertility, the effect of pregnancy on IBD, and, conversely, the effect of IBD on the pregnancy, as well as the safety of drugs on the de¬ veloping fetus and nursing newborn. A male partner afflicted with IBD also raises concerns regarding fertility and potential terato genicity of prescribed medications. This article reviews these issues with a focus on recent studies and developments. Colon Cancer During Pregnancy 341 Mitchell S. Cappell Colon cancer in pregnancy is a distinct entity from colon cancer in the general population. Pregnancy affects the clinical presentation, evaluation, therapy, and prognosis of the colon cancer. Pregnant patients typically present with advanced colon cancer that is, un¬ fortunately, usually the result of delayed diagnosis. Patients fre¬ quently postpone self referral because of confusion of symptoms from cancer, such as rectal bleeding or constipation, with symp¬ toms of a normal pregnancy. Physicians may delay diagnostic tests because of potential fetal risks and because of inattention to the potential significance of symptoms given the relative rarity of co¬ lon cancer in this young population. Diagnostic delays often lead to the tragic demise of a young woman from a potentially curable disease and of an otherwise viable fetus. Arguably, colon cancer should be diagnosed expeditiously during pregnancy because of frequent obstetric office visits. This article reviews this uncommon, but not rare, entity with a focus on the special and unique fea¬ tures of colon cancer in pregnancy to facilitate earlier diagnosis, to optimize the therapy, and to improve the maternal and fetal outcomes. The Irritable Bowel Syndrome During Pregnancy 385 William L. Hasler The irritable bowel syndrome (IBS) is characterized by altered bo¬ wel habits and abdominal discomfort in the absence of organic dis¬ ease. No markers exist for IBS, and the definition of IBS is based on the presence of specific symptoms. The Rome II criteria for defin¬ ing IBS include abdominal pain or discomfort for 12 weeks or longer, which need not be continuous, over the past 12 months plus two of the following: (1) relief of discomfort with defecation; (2) association of discomfort with altered stool frequency; and (3) association of discomfort with altered stool form. Nine per¬ cent to 22% of the population report symptoms consistent with IBS. IBS is the most prevalent digestive disease, representing 12% of visits to primary care physicians and 28% of referrals to gastroenterologists. Other Disorders Pregnancy and Liver Disease 407 Bimaljit S. Sandhu and Arun J. Sanyal Liver disease has an impact on women s health during pregnancy because of the complex interactions between the physiologic changes induced by pregnancy and the pathophysiologic changes of liver disease. In particular, liver diseases that predominantly af¬ flict females, such as primary biliary cirrhosis and autoimmune he¬ patitis, pose a special problem for conception and management of pregnancy. Pregnancy, moreover, specifically is associated with several potentially life threatening liver diseases. This article re¬ views comprehensively the impact of liver diseases on pregnancy and of pregnancy on liver function and liver disease. Human Immunodeficiency Virus and Pregnancy 437 Donald P. Kotler The recent spread of HIV infection into the heterosexual population in the United States, Europe, and Australia, as well as its earlier heterosexual presence in the developing world, has led to increased scientific and clinical attention to the role of HIV infection in preg¬ nancy. In managing a pregnant HIV positive woman, it is most im¬ portant to treat the patient as someone who is HIV positive rather than someone who is pregnant. Withholding antiviral or prophy¬ lactic therapies from the mother for fear of harming the child is not justified, because failure to treat the mother increases the fetal risk. The most important parameter to follow is the maternal plasma HIV RNA level, and the most important treatment issue is to reduce this level because it is directly related to the risk of vertical transmission. Index 449 CONTENTS ix
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series Gastroenterology clinics of North America
series2 Gastroenterology clinics of North America
spellingShingle Gastrointestinal disorders during pregnancy
Gastroenterology clinics of North America
Gastrointestinale Krankheit (DE-588)4114483-1 gnd
Schwangerschaft (DE-588)4053724-9 gnd
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title Gastrointestinal disorders during pregnancy
title_auth Gastrointestinal disorders during pregnancy
title_exact_search Gastrointestinal disorders during pregnancy
title_full Gastrointestinal disorders during pregnancy Mitchell S. Cappell guest ed.
title_fullStr Gastrointestinal disorders during pregnancy Mitchell S. Cappell guest ed.
title_full_unstemmed Gastrointestinal disorders during pregnancy Mitchell S. Cappell guest ed.
title_short Gastrointestinal disorders during pregnancy
title_sort gastrointestinal disorders during pregnancy
topic Gastrointestinale Krankheit (DE-588)4114483-1 gnd
Schwangerschaft (DE-588)4053724-9 gnd
topic_facet Gastrointestinale Krankheit
Schwangerschaft
Aufsatzsammlung
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