Combinatorial library design and evaluation principles, software tools, and applications in drug discovery
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| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Dekker
2001
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| Online-Zugang: | Inhaltsverzeichnis |
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| 245 | 1 | 0 | |a Combinatorial library design and evaluation |b principles, software tools, and applications in drug discovery |c ed. by Arup K. Ghose ... |
| 264 | 1 | |a New York [u.a.] |b Dekker |c 2001 | |
| 300 | |a XV, 631 S. |b Ill., graph. Darst. | ||
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| 650 | 4 | |a Combinatorial Chemistry Techniques | |
| 650 | 4 | |a Combinatorial chemistry | |
| 650 | 4 | |a Combinatorial chemistry |x Computer simulation | |
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| 650 | 4 | |a Drug Design | |
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Datensatz im Suchindex
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|---|---|
| adam_text | COMBINATORIAL LIBRARY DESIGN AND EVALUATION PRINCIPLES, SOFTWARE TOOLS,
AND APPLICATIONS IN DRUG DISCOVERY EDITED BY ARUP K. GHOSE VELLARKAD
N.VISWANADHAN AMGEN INC. THOUSAND OAKS, CALIFORNIA MARCEL DEKKER, INC.
NEW YORK * BASEL CONTENTS PREFACE HI CONTRIBUTORS XI PART I INTRODUCTION
1. LIBRARY DESIGN CONCEPTS AND IMPLEMENTATION STRATEGIES 1 DOUG W. HOBBS
AND TAO GUO PART II DESIGN PRINCIPLES 2. FUNDAMENTALS OF PHARMACOPHORE
MODELING IN COMBINATORIAL CHEMISTRY 51 ARUP K. GHOSE, VELLARKAD N.
VISWANADHAN, AND JOHN J. WENDOLOSKI VII VIII CONTENTS 3. QUANTITATIVE
STRUCTURE-ACTIVITY RELATIONSHIP (QSAR): A VERSATILE TOOL IN DRUG DESIGN
73 ASIM KUMAR DEBNATH 4. QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS
(QSAR): A REVIEW OF 3D QSAR 131 GORDON M. CRIPPEN AND SCOTT A. WILDMAN
5. BINDING ENERGY LANDSCAPES OF LIGAND-PROTEIN COMPLEXES AND MOLECULAR
DOCKING: PRINCIPLES, METHODS, AND VALIDATION EXPERIMENTS 157 GENNADY M.
VERKHIVKER, DJAMAL BOUZIDA, DANIEL K. GEHLHAAR, PAUL A. REJTO, SANDRA
ARTHURS, ANTHONY B. COLSON, STEPHAN T. FREER, VEDA LARSON, BROCK A.
LUTY, TAMI MARRONE, AND PETER W. ROSE 6. FAST CONTINUUM ELECTROSTATICS
METHODS FOR STRUCTURE-BASED / LIGAND DESIGN ,197 CATHERINE
TENETTE-SOUAILLE, NICOLAS BUDIN, NICOLAS MAJEUX, ANDAMEDEO CAFLISCH 1.
QVO VADIS, SCORING FUNCTIONS? TOWARD AN INTEGRATED PHARMACOKINETIC AND
BINDING AFFINITY PREDICTION FRAMEWORK 233 TUDOR I. OPREA, ISMAEL ZAMORA,
AND PEDER SVENSSON PART III CURRENT METHODS AND SOFTWARE TOOLS 8.
KNOWLEDGE-BASED APPROACHES FOR THE DESIGN OF SMALL- MOLECULE LIBRARIES
FOR DRUG DISCOVERY 267 VELLARKAD N. VISWANADHAN, ARUP K. GHOSE, ALEX
KISELYOV, JOHN J. WENDOLOSKI AND JOHN N. WEINSTEIN 9. DRUGLIKENESS
PROFILES OF CHEMICAL LIBRARIES 291 JENS SADOWSKI 10. TOOLS FOR DESIGNING
DIVERSE, DRUGLIKE, COST-EFFECTIVE COMBINATORIAL LIBRARIES 301 ROBERT D.
BROWN, MOISES HASSAN, AND MARVIN WALDMAN CONTENTS IX 11. RELATIVE AND
ABSOLUTE DIVERSITY ANALYSIS OF COMBINATORIAL LIBRARIES 337 ROBERT D.
CLARK 12. RATIONAL COMBINATORIAL LIBRARY DESIGN AND DATABASE MINING
USING INVERSE QSAR APPROACH 363 ALEXANDER TROPSHA 13.
DISSIMILARITY-BASED COMPOUND SELECTION FOR LIBRARY DESIGN 379 VALERIE J.
GILLET AND PETER WILLETT 14. PHARMACOPHORE-BASED APPROACHES TO
COMBINATORIAL LIBRARY DESIGN 399 ANDREW C. GOOD, JONATHAN S. MASON,
DARREN V. S. GREEN, AND ANDREW R. LEACH I 15. HIGH THROUGHPUT
CONFORMATIONAL SAMPLING AND FUZZY / SIMILARITY METRICS: A NOVEL APPROACH
TO SIMILARITY SEARCHING AND FOCUSED COMBINATORIAL LIBRARY DESIGN AND ITS
ROLE IN THE DRUG DISCOVERY LABORATORY 429 DRAGOS HORVATH PART IV
APPLICATIONS 16. APPLICATIONS OF CELL-BASED DIVERSITY METHODS TO
COMBINATORIAL LIBRARY DESIGN 473 DORA SCHNUR AND PRABHA VENKATARANGAN
17. STRUCTURE-BASED COMBINATORIAL LIBRARY DESIGN AND SCREENING:
APPLICATION OF THE MULTIPLE COPY SIMULTANEOUS SEARCH METHOD 503 DIANE
JOSEPH-MCCARTHY 18. GENETIC ALGORITHM-DIRECTED LEAD GENERATION 531
JASBIR SINGH AND ADI M. TREASURYWALA 19. ENHANCING THE DRUG DISCOVERY
PROCESS BY INTEGRATION OF STRUCTURE-BASED DRUG DESIGN AND COMBINATORIAL
SYNTHESIS 563 DONATELLA TONDI AND MARIA PAOLA COSTI X CONTENTS 20.
DESIGN OF STRUCTURAL COMBINATORIAL LIBRARIES THAT MIMIC BIOLOGICAL
MOTIFS 605 HANOCH SENDEROWITZ AND RAKEFET ROSENFELD INDEX 625
|
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| callnumber-first | R - Medicine |
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| callnumber-raw | RS419 |
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| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615/.19 |
| dewey-search | 615/.19 |
| dewey-sort | 3615 219 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Biologie Medizin |
| format | Book |
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| id | DE-604.BV014631746 |
| illustrated | Illustrated |
| indexdate | 2024-12-23T15:58:33Z |
| institution | BVB |
| isbn | 0824704878 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009941762 |
| oclc_num | 46792625 |
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| owner_facet | DE-20 DE-355 DE-BY-UBR DE-11 |
| physical | XV, 631 S. Ill., graph. Darst. |
| publishDate | 2001 |
| publishDateSearch | 2001 |
| publishDateSort | 2001 |
| publisher | Dekker |
| record_format | marc |
| spellingShingle | Combinatorial library design and evaluation principles, software tools, and applications in drug discovery Chimie combinatoire Chimie combinatoire - Simulation par ordinateur Médicaments - Design Médicaments - Design - Simulation par ordinateur Combinatorial Chemistry Techniques Combinatorial chemistry Combinatorial chemistry Computer simulation Computer Simulation Drug Design Drugs Design Drugs Design Computer simulation |
| title | Combinatorial library design and evaluation principles, software tools, and applications in drug discovery |
| title_auth | Combinatorial library design and evaluation principles, software tools, and applications in drug discovery |
| title_exact_search | Combinatorial library design and evaluation principles, software tools, and applications in drug discovery |
| title_full | Combinatorial library design and evaluation principles, software tools, and applications in drug discovery ed. by Arup K. Ghose ... |
| title_fullStr | Combinatorial library design and evaluation principles, software tools, and applications in drug discovery ed. by Arup K. Ghose ... |
| title_full_unstemmed | Combinatorial library design and evaluation principles, software tools, and applications in drug discovery ed. by Arup K. Ghose ... |
| title_short | Combinatorial library design and evaluation |
| title_sort | combinatorial library design and evaluation principles software tools and applications in drug discovery |
| title_sub | principles, software tools, and applications in drug discovery |
| topic | Chimie combinatoire Chimie combinatoire - Simulation par ordinateur Médicaments - Design Médicaments - Design - Simulation par ordinateur Combinatorial Chemistry Techniques Combinatorial chemistry Combinatorial chemistry Computer simulation Computer Simulation Drug Design Drugs Design Drugs Design Computer simulation |
| topic_facet | Chimie combinatoire Chimie combinatoire - Simulation par ordinateur Médicaments - Design Médicaments - Design - Simulation par ordinateur Combinatorial Chemistry Techniques Combinatorial chemistry Combinatorial chemistry Computer simulation Computer Simulation Drug Design Drugs Design Drugs Design Computer simulation |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009941762&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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