Immunology
This Sixth Edition brings this book up to date. 250 photographs and over 400 color illustrations bring immunology to life. Case Studies have been added placing immunology in a clinical context. (Midwest).
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| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Edinburgh [u.a.]
Mosby
2001
|
| Ausgabe: | 6. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
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| 245 | 1 | 0 | |a Immunology |c Ivan Roitt ; Jonathan Brostoff ; David Male |
| 250 | |a 6. ed. | ||
| 264 | 1 | |a Edinburgh [u.a.] |b Mosby |c 2001 | |
| 300 | |a XII, 480 S. |b zahlr. Ill., graph. Darst. |e 1 CD-ROM (12 cm) | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 520 | 3 | |a This Sixth Edition brings this book up to date. 250 photographs and over 400 color illustrations bring immunology to life. Case Studies have been added placing immunology in a clinical context. (Midwest). | |
| 650 | 2 | |a Hypersensibilité | |
| 650 | 2 | |a Immunité | |
| 650 | 4 | |a Immunologie | |
| 650 | 4 | |a Immunologie clinique | |
| 650 | 7 | |a Immunologie |2 ram | |
| 650 | 2 | |a Système immunitaire | |
| 650 | 0 | 7 | |a Immunologie |0 (DE-588)4026637-0 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a CD-ROM |0 (DE-588)4139307-7 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4151278-9 |a Einführung |2 gnd-content | |
| 655 | 4 | |a Matériel didactique | |
| 689 | 0 | 0 | |a Immunologie |0 (DE-588)4026637-0 |D s |
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| 700 | 1 | |a Roitt, Ivan M. |e Sonstige |4 oth | |
| 700 | 1 | |a Brostoff, Jonathan |e Sonstige |4 oth | |
| 700 | 1 | |a Male, David K. |d 1954- |e Sonstige |0 (DE-588)130540846 |4 oth | |
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| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-009348447 | |
Datensatz im Suchindex
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| DE-BY-UBR_katkey | 3145545 |
| DE-BY-UBR_location | 00 |
| DE-BY-UBR_media_number | 069030252042 |
| _version_ | 1822754490089996288 |
| adam_text | Contents
Contributors xi
1. Introduction to the immune system
David Male
Adaptive and innate immunity 1
Cells of the immune system 2
Soluble mediators of immunity 5
Antigens 7
Immune responses 7
Inflammation 10
Defences against extracellular and intracellular
pathogens 11
Vaccination 11
Immunopathology 12
2. Cells, tissues and organs of the
immune system
Peter M. Lvdvard, Carlo E. Grossi
Cells of the innate immune system 15
Cells of the adaptive immune system 22
Lymphoid tissues 30
Lymphocyte traffic 42
3. Cell migration and inflammation
David Male
Mechanisms of cell migration 47
Patterns of cell migration 52
Inflammation 52
Complement 54
Auxiliary cells in acute inflammation 61
4. Antibodies
Malcolm Turner
Immunoglobulins a family of proteins 65
Interaction of antibodies with antigens 71
Functions of antibodies 74
¥c receptors 76
Generation of antibody diversity 78
Immunoglobulin gene recombination 80
Somatic mutation 83
5. T cell receptors and major histo
compatibility complex molecules
David Male
The T ccll receptor 87
Genes of the T ccll antigen receptor 89
Major histocompatibility complex (MHC)
molecules 91
Interactions of MHC molecules with antigenic
peptides 93
Interaction of the T cell receptor with MH( and
antigen 95
MHC genomic organization and expression 97
Antigen presentation by GDI 100
6. Antigen presentation
John Trowsdale
Antigen presenting cells 105
Antigen processing and presentation 106
Co stimulatory molecules 112
T cell activation 115
7. Cytokines and cytokine receptors
Frances Ralkwill
Cytokine and cytokine receptor families 119
Mechanisms of cell activation 123
Cytokine production by T cell subsets 125
The cytokine network 127
8. Cell cooperation in the antibody
response
Marc Feldman, Joseph (. . Marini
Development of B cells 131
Activation of B cells by T independent
antigens 132
Activation of B cells by T dcpendcnt
antigens 134
Activation and differentiation of B cells in the
germinal centre 138
Antibody responses in vivo 139
Differentiation of B cells 141
9. Mononuclear phagocytes in immune
defence
Siamon Gordon
Resident and mobile populations of
macrophages 148
Receptors on macrophages 153
Responses of macrophages 157
Conclusion 160
10. Cell mediated cytotoxicity
David Male
Natural killer cell receptors 164
Mechanisms of cytotoxicity 167
Noivlymphoid cytotoxic effectors 170
11. Regulation of the immune response
Anne Cooke
Regulation by antigen 173
The antigen presenting cell 174
Regulation by antibody 175
Regulation by lymphocytes 176
Regulation by NK and NKT cells 179
Regulation by localization of cells 179
Idiotypic modulation of responses 180
Neuroendocrine modulation of immune
responses 181
Genetic control of immune responses 182
12. Immunological tolerance
David Wraith
Introduction 191
Experimental induction of tolerance 192
Central thymic tolerance to self antigens 192
Peripheral or post thymic tolerance to self
antigens 198
B cell tolerance to self antigens 203
Artificially induced tolerance in vivo 205
Potential therapeutic applications of
tolerance 208
13. Evolution of immunity
John Hoiton, Norman A. Ratcliffc
Invertebrate immunity 211
Vertebrate immunity 218
Lymphomyeloid tissues in lower vertebrates 226
Amphibian models for studying ontogeny of
immunity 229
14. Immunity to viruses
Tony Nash
Modes ot virus infection 235
Innate immune response to viruses 236
Host defence involving B and T cells 237
Strategies for evading immune defences 239
Immunopathology 240
15. Immunity to bacteria and fungi
Graham A. W. Rook
Immunity to bacteria 245
Immunity to fungi 256
16. Immunity to protozoa and worms
Janette E. Bradley
Features of parasitic infections 259
Effector mechanisms 261
Pivotal role of T cells in the development of
immunity 264
Escape mechanisms 270
Immunopathological consequences of parasitic
infections 274
Vaccines 275
17. Vaccination
Peter Beverley
Antigens used as vaccines 277
Effectiveness of vaccines 281
Vaccine safety 282
Cost of vaccination 282
Current vaccines 283
Adjuvants 284
Passive immunization 285
Non specific immunotherapy 286
Vaccinating against cancer 286
Future vaccines 286
18. Tumour immunology
Peter Beverley
The tumour as a tissue graft 289
Immune surveillance 289
Tumour antigens 291
Human tumour associated antigens detected by
immune cells 293
Tumour associated antigens detected by
antibodies 294
Immunodiagnosis 296
Immunotherapy 297
Passive immunotherapy 299
Immune escape mechanisms 300
19. Primary immunodeficiency
Fred S. Rosen
B cell deficiencies 303
T cell deficiencies 304
Defects in complement proteins 308
Defects in phagocytes 309
20. Secondary immunodeficiency
Ian Weller
Immunodeficiency caused by drugs 313
Nutrition and immune responses 315
AIDS 317
21. Hypersensitivity Type I
Tom Platts Mills
Immediate hypersensitivity 324
Immunoglobulin E 325
Role of T cells in the immune response to inhalant
allergens 326
Allergens: the antigens that give rise to immediate
hypersensitivity 328
Mast cells and basophils 330
Genetics of allergic disease 333
Skin tests for diagnosis and investigation 334
Factors that influence the symptoms of allergic
disease 336
Asthma and bronchial reactions to inhaled
antigens 338
Immunotherapy with allergen extracts 339
New treatments for allergic disease 340
The biological role of IgE 341
22. Hypersensitivity Type II
David Male
Mechanisms of damage 345
Reactions against blood cells and platelets 346
Reactions against tissue antigens 351
23. Hypersensitivity Type III
Frank Hay, Olwyn M. R. Westivood
Types of immune complex disease 357
Mechanisms in Type III hypersensitivity 358
Experimental models of immune complex
disease 359
Persistence of complexes 361
Deposition of complexes in tissues 364
Detection of immune complexes 367
24. Hypersensitivity Type IV
Warwick Britton
Contact hypersensitivity 371
Tuberculin type hypersensitivity 374
Granulomatous hypersensitivity 376
Cellular reactions in Type IV hypersensitivity 377
Diseases manifesting type IV granulomatous
hypersensitivity 378
25. Transplantation and rejection
Ian Hutchinson
Barriers to transplantation 385
Histocompatibility antigens 386
The laws of transplantation 387
The role of T lymphocytes in rejection 387
The tempo of rejection 390
Genetic predisposition to graft rejection 392
Prevention of rejection 394
26. Autoimmunity and autoimmune
disease
Ivan Roitt
The association of autoimmunity with disease 401
The spectrum of autoimmune diseases 401
Genetic factors 402
Pathogenesis 403
Aetiology 407
Diagnostic and prognostic value of
autoantibodies 412
Treatment 412
27. Immunological techniques
Michael Steward
Antigen antibody interactions 417
Isolation of pure antibodies 423
Assays of complement 426
Assays for circulating immune complexes 427
Isolation of lymphocyte populations 427
Effector cell assays 429
Gene targeting and transgenic animals 433
Appendices
1: Major histocompatibility complex 435
2: CD markers 437
3: The major cytokines 441
4: Chemokinc receptors and chemokines 443
Glossary 445
Explanations for critical thinking and case
studies 453
Index 465
|
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| ctrlnum | (OCoLC)300278715 (DE-599)BVBBV013681570 |
| dewey-full | 616.07/9 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.07/9 |
| dewey-search | 616.07/9 |
| dewey-sort | 3616.07 19 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Biologie Medizin |
| edition | 6. ed. |
| format | Book |
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| genre_facet | Einführung Matériel didactique |
| id | DE-604.BV013681570 |
| illustrated | Illustrated |
| indexdate | 2024-12-23T15:33:41Z |
| institution | BVB |
| isbn | 0723431892 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009348447 |
| oclc_num | 300278715 |
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| physical | XII, 480 S. zahlr. Ill., graph. Darst. 1 CD-ROM (12 cm) |
| publishDate | 2001 |
| publishDateSearch | 2001 |
| publishDateSort | 2001 |
| publisher | Mosby |
| record_format | marc |
| spellingShingle | Immunology Hypersensibilité Immunité Immunologie Immunologie clinique Immunologie ram Système immunitaire Immunologie (DE-588)4026637-0 gnd CD-ROM (DE-588)4139307-7 gnd |
| subject_GND | (DE-588)4026637-0 (DE-588)4139307-7 (DE-588)4151278-9 |
| title | Immunology |
| title_auth | Immunology |
| title_exact_search | Immunology |
| title_full | Immunology Ivan Roitt ; Jonathan Brostoff ; David Male |
| title_fullStr | Immunology Ivan Roitt ; Jonathan Brostoff ; David Male |
| title_full_unstemmed | Immunology Ivan Roitt ; Jonathan Brostoff ; David Male |
| title_short | Immunology |
| title_sort | immunology |
| topic | Hypersensibilité Immunité Immunologie Immunologie clinique Immunologie ram Système immunitaire Immunologie (DE-588)4026637-0 gnd CD-ROM (DE-588)4139307-7 gnd |
| topic_facet | Hypersensibilité Immunité Immunologie Immunologie clinique Système immunitaire CD-ROM Einführung Matériel didactique |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009348447&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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