The molecular basis of dementia

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Veröffentlicht: New York, NY New York Acad. of Sciences 2000
Schriftenreihe:New York Academy of Sciences: Annals of the New York Academy of Sciences 920
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adam_text ANNALS OF THE NEW YORK ACADEMY OF SCIENCES Volume 920 December 2000 THE MOLECULAR BASIS OF DEMENTIA Editors and Conference Organizers John H. Growdon, Richard J. Wurtman, Suzanne Corkin, and Roger M. Nitsch [These papers were presented at the ninth meeting of the International Study Group on the Pharmacology of Memory Disorders Associated with Aging, held on February 18 20, 2000 in Zurich, Switzerland.] CONTENTS Preface. By John H. Growdon, Richard J. Wurtman, Suzanne Corkin, and Roger M. Nitsch xi Part I. a Synuclein in Neurodegenerative Disease Clinical Lewy Body Syndromes. By I.G. McKeith 1 Clinical and Neuropathological Correlates of Dementia with Lewy Bodies. By E. G6MEZ TORTOSA, M.C. IRIZARRY, T. G6MEZ ISLA, AND B.T. Hyman 9 The a Synucleinopathies: Parkinson s Disease, Dementia with Lewy Bodies, and Multiple System Atrophy. By Maria Grazia Spillantini and Michel Goedert 16 Genetics of Parkinson s Disease. By Mihael H. Polymeropoulos 28 Physiology and Pathophysiology of a Synuclein: Cell Culture and Transgenic Animal Models Based on a Parkinson s Disease associated Protein. By Philipp J. Kahle, Manuela Neumann, Laurence Ozmen, and Christian Haass 33 Accelerated Oligomerization by Parkinson s Disease Linked a Synuclein Mutants. By K.A. Conway, S. J. Lee, J. C. Rochet, T.T. Ding, J.D. Harper, R.E. Williamson, and P.T. Lansbury, Jr 42 Part II. Novel Mutations in Dementia Classification and Description of Frontotemporal Dementias. By D. Neary, J.S. Snowden, and D.M.A. Mann 46 Progress in Hereditary Tauopathies: A Mutation in the Tau Gene (G389R) Causes a Pick Disease like Syndrome. By Bernardino Ghetti, Jill R. Murrell, Paolo Zolo, Maria Grazia Spillantini, and Michel Goedert 52 Molecular Genetics of Chromosome 17 Tauopathies. By Michael Hutton . 63 Tau Gene Mutations in Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17 (FTDP 17): Their Relevance for Understanding the Neurodegenerative Process. By MICHEL GOEDERT, BERNARDINO Ghetti, and Maria Grazia Spillantini 74 Amyloidogenesis in Familial British Dementia Is Associated with a Genetic Defect on Chromosome 13. By J. Ghiso, R. Vidal, A. Rostagno, L. MlRAVALLE, J.L. HOLTON, S. MEAD, T. REVESZ, G. PLANT, AND B. Frangione 84 Familial British Dementia: Expression and Metabolism of BRI. By Seong Hun Kim, Rong Wang, David J. Gordon, Joseph Bass, Donald F. Steiner, Gopal Thinakaran, David G. Lynn, Stephen C. Meredith, and Sangram S. Sisodia 93 High Frequency of Mutations in Four Different Disease Genes in Early Onset Dementia. By Ulrich Finckh, Tomas Muller Thomsen, Ulrike Mann, Christian Eggers, Josef Marksteiner, Wolfgang Meins, Giuliano Binetti, Antonella Alberici, Peter Sonderegger, Christoph Hock, Roger M. Nitsch, and Andreas Gal 100 Pathological Tau Phenotypes: The Weight of Mutations, Polymorphisms, and Differential Neuronal Vulnerabilities. By Christel Mailliot, Thierry Bussiere, Malika Hamdane, Nicolas Sergeant, Marie Laure Caillet, Andre Delacourte, and Luc Buee 107 Coexistent Tau and Amyloid Pathology in Hereditary Frontotemporal Demen¬ tia with Tau Mutations. By S.M. Rosso, W. Kamphorst, R. Ravid, and J.C. Van Swieten 115 The Clinical Spectrum of Guam ALS and Parkinson Dementia Complex: 1997 1999. By Douglas Galasko, David Salmon, Ulla Katrina Craig, and Wigbert Wiederholt 120 Part III. Transgenic and Knockout Approaches to Neurodegenerative Diseases In Vivo Analysis of Wild type and FTDP 17 Tau Transgenic Mice. By J. Gotz, R. Barmettler, A. Ferrari, M. Goedert, A. Probst, and R.M. Nitsch 126 Pathogenic Mechanisms of Alzheimer s Disease Analyzed in the APP23 Transgenic Mouse Model. By Christine Sturchler Pierrat and Matthias Staufenbiel 134 Prions: Pathogenesis and Reverse Genetics. By Adriano Aguzzi, Michael A. Klein, Fabio Montrasio, Vladimir Pekarik, Sebastian Brandner, Hisako Furukawa, Pascal Kaser, Christiane Rockl, and Markus Glatzel 140 Presenilin Function in APP Processing. By Wim Annaert, Philippe Cupers, Paul Saftig, and Bart de Strooper 158 Role of Presenilin 1 in Murine Neural Development. By Xudong YANG, Melissa Handler, and Jie Shen 165 Modulation of Ap Deposition in APP Transgenic Mice by an Apolipoprotein E Null Background. By M.C. Irizarry, G.W. Rebeck, B. Cheung, K. Bales, S.M. Paul, D. Holzman, and B.T. Hyman 171 The Value of Transgenic Models for the Study of Neurodegenerative Diseases. By Donald L. Price, Philip C. Wong, Alicja L. Markowska, Michael K. Lee, Gopal Thinakaren, Donald W. Cleveland, Sangram S. Sisodia, and David R. Borchelt 179 Part IV. Proteases in Alzheimer s Disease Identifying Proteases That Cleave APP. By Martin Citron 192 Toward the Characterization and Identification of y Secretases Using Transition state Analogue Inhibitors. By Chad L. Moore, Thekla S. Diehl, Dennis J. Selkoe, and Michael S. Wolfe 197 Recent Advances in the Understanding of the Processing of APP to Beta Amy¬ loid Peptide. By S. Sinha, J. Anderson, V. John, L. McConlogue, G. Basi, E. Thorsett, and D. Schenk 206 Presenilin 1: A Component of Synaptic and Endothelial Adherens Junctions. By Anastasios Georgakopoulos, Philippe Marambaud, Victor L. Friedrich, Jr., Junichi Shioi, Spiros Efthimiopoulos, and NlKOLAOS K. ROBAKIS 209 cc Secretase Activity of the Disintegrin Metalloprotease ADAM 10: Influences of Domain Structure. By Falk Fahrenholz, Sandra Gilbert, Elzbieta Kojro, Sven Lammich, and Rolf Postina .... 215 Rapid Notchl Nuclear Translocation after Ligand Binding Depends on Presenilin associated y Secretase Activity. By Oksana Berezovska, Christine Jack, Pamela McLean, Jon C. Aster, Carol Hicks, Weiming Xia, Michael S. Wolfe, Gerry Weinmaster, Dennis J. Selkoe, and Bradley T. Hyman 223 GSK3p Forms a Tetrameric Complex with Endogenous PS1 CTF/NTF and p Catenin: Effects of the D257/D385A and FAD linked Mutations. By G. Tesco and R.E. Tanzi 227 An Empirical Model of y Secretase Activity. By M.P. Murphy, R. Wang, P.E. Fraser, A. Fauq, and T.E. Golde 233 Overexpression of Presenilin 2 Enhances Apoptotic Death of Cultured Corti¬ cal Neurons. By W. Araki, K. Yuasa, S. Takeda, K. Shirotani, K. Takahashi, and T. Tabira 241 al Antichymotrypsin Inhibits A0 Degradation in Vitro and in Vivo. By Carmela R. Abraham, Walker T. McGraw, Franchot Slot, and Rina Yamin 245 Activated Mitogenic Signaling Induces a Process of Dedifferentiation in Alzheimer s Disease That Eventually Results in Cell Death. By Thomas Arendt, Max Holzer, Andrea Stobe, Ulrich Gartner, Hans Joachim Luth, Martina K. Bruckner, and Uwe Ueberham 249 Inhibition of the Neuronal Insulin Receptor: An in Vivo Model for Sporadic Alzheimer Disease? By Siegfried Hoyer, Sae Kyung Lee, Thomas LOFFLER, AND REINHARD SCHLIEBS 256 Cytoplasmic Presenilin Aggregates in Proteasome Inhibitor treated Cells. By L.A. Mackenzie Ingano, K.M. Lentini, I. Kovacs, R.E. Tanzi, and D.M. Kovacs 259 Part V. Therapies for Alzheimer s Disease beyond AChE Inhibitors Regulation of APP Synthesis and Secretion by Neuroimmunophilin Ligands and Cyclooxygenase Inhibitors. By Robert K.K. Lee and Richard J. Wurtman 261 A(J Modulation: The Next Generation of AD Therapeutics. By KEVIN M. Felsenstein 269 Prevention and Reduction of AD type Pathology in DPAPP Mice Immunized with Ap]^2 By Dora Games, Frederique Bard, Henry Grajeda, Terry Guido, Karen Khan, Ferdie Soriano, Nicki Vasquez, Nancy Wehner, Kelly Johnson Wood, Ted Yednock, Peter Seubert, and Dale Schenk 274 Treatment with the Selective Muscarinic Agonist Talsaclidine Decreases Cerebrospinal Fluid Levels of Total Amyloid p Peptide in Patients with Alzheimer s Disease. By C. Hock, A. Maddalena, I. Heuser, D. Naber, W. Oertel, H. von der Kammer, M. Wienrich, A. Raschig, M. Deng, J.H. Growdon, and R.M. Nitsch 285 Metal Chelation as a Potential Therapy for Alzheimer s Disease. By Math P. Cuajungco, Kyle y. Faget, Xudong Huang, Rudolph E. Tanzi, and Ashley I. Bush 292 Regulation of Gene Expression by Muscarinic Acetylcholine Receptors: A Comprehensive Approach for the Identification of Regulated Genes. By Heinz von der Kammer, Manuel Mayhaus, Claudia Albrecht, Barbara Andresen, Jaroslav Klaudiny, Cuneyt Demiralay, and Roger M. Nitsch 305 Cholinergic Modulation of Amyloid Processing and Dementia in Animal Models of Alzheimer s Disease. By O. Isacson and L. Lin 309 Ml Muscarinic Agonists as Potential Disease Modifying Agents in Alzheimer s Disease: Rationale and Perspectives. By A. Fisher, D.M. Michaelson, R. Brandeis, R. Haring, S. Chapman, and Z. PITTEL 315 Cholinesterase Inhibitors Stabilize Alzheimer s Disease. By Ezio Giacobini 321 Nasal AP Treatment Induces Anti Ap Antibody Production and Decreases Cerebral Amyloid Burden in PD APP Mice. By C.A. Lemere, R. Maron, E.T. Spooner, T.J. Grenfell, C. Mori, R. Desai, W.W. Hancock, H.L. Weiner, and D.J. Selkoe 328 Cytidine (5 )Diphosphocholine Modulates Dopamine K+ evoked Release in Striatum Measured by Microdialysis. By J. AGUT, J. A. Ortiz, and RJ. Wurtman 332 Index of Contributors 337
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spellingShingle The molecular basis of dementia
New York Academy of Sciences: Annals of the New York Academy of Sciences
Dementie gtt
Démence - Aspect moléculaire - Congrès
Moleculaire biologie gtt
Ziekte van Alzheimer gtt
Dementia Molecular aspects
Dementia drug therapy Congresses
Dementia genetics Congresses
Dementia physiopathology Congresses
Molekularpathologie (DE-588)4170396-0 gnd
Demenz (DE-588)4011404-1 gnd
Molekularbiologie (DE-588)4039983-7 gnd
subject_GND (DE-588)4170396-0
(DE-588)4011404-1
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(DE-588)1071861417
title The molecular basis of dementia
title_auth The molecular basis of dementia
title_exact_search The molecular basis of dementia
title_full The molecular basis of dementia ed. by John H. Growdon ...
title_fullStr The molecular basis of dementia ed. by John H. Growdon ...
title_full_unstemmed The molecular basis of dementia ed. by John H. Growdon ...
title_short The molecular basis of dementia
title_sort the molecular basis of dementia
topic Dementie gtt
Démence - Aspect moléculaire - Congrès
Moleculaire biologie gtt
Ziekte van Alzheimer gtt
Dementia Molecular aspects
Dementia drug therapy Congresses
Dementia genetics Congresses
Dementia physiopathology Congresses
Molekularpathologie (DE-588)4170396-0 gnd
Demenz (DE-588)4011404-1 gnd
Molekularbiologie (DE-588)4039983-7 gnd
topic_facet Dementie
Démence - Aspect moléculaire - Congrès
Moleculaire biologie
Ziekte van Alzheimer
Dementia Molecular aspects
Dementia drug therapy Congresses
Dementia genetics Congresses
Dementia physiopathology Congresses
Molekularpathologie
Demenz
Molekularbiologie
Konferenzschrift 2000 Zürich
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