Neuroimmunomodulation perspectives at the new millenium
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adam_text | ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Volume
917
NEUROIMMUNOMODULATION
PERSPECTIVES AT THE NEW MILLENNIUM0
Editors
Ario
Conti,
Georges
J.M. Maestroni,
Samuel M. McCann,
Esther
M.
Sternberg,
James
M. Lipton,
and Craig
С.
Smith
Conference Organizers
G.J.M. Maestroni,
A. Conti, E. Pedrinis,
P. Luscieti, G.
Frigo,
and S.
Lecchini
Advisory Board
N.G. Abraham (USA), R.
Ader
(USA), A. Angeli
(Italy),
E. Artz (Argentina), T. Bartfai (Sweden), H. Besedovsky (Germany),
A. Catania (Italy), M. Dardenne (France), A. Del
Rey
(Germany),
E. Ferrari (Italy), P.
Gaillard
(Switzerland), T. Giraldi (Italy),
V. Geenen (Belgium), M. Guerrero (Spain),
A.B.
Grossman (UK),
F. Halberg
(USA), C. Heijnen (The Netherlands),
D.
Hellhammer
(Germany), T.
Hori
(Japan), E.A. Korneva (Russia),
J.M. Lipton (USA), W.
Maslinski
(Poland), L.
Matera
(Italy),
G. Norbiato (Italy), U. Otten (Switzerland), A. Ovadia (Israel),
A. Panerai
(Italy),
N.J. Rothwell
(UK), W. Savino (Brazil),
G. Soloman
(USA), M. Schwartz (Israel), M. Schedlowski (Poland),
J.F. Sheridan (USA), J. Szelenyi (Hungary), and R.L. Wilder (USA)
CONTENTS
1999
Novera
Herbert Spector Award for Significant Contributions in Both
Leadership and Research in Neuroimmunomodulation:
Recipient: George P. Chrousos, M.D., Sc.D
........................ xvii
Preface. By Esther
Sternberg
....................................... xix
Part I. Plenary Lectures
Does Stress Make You Sick and Belief Make You Well?
The Science Connecting Body and Mind. By Esther M.
Sternberg
...... 1
This volume contains the papers from a conference entitled 4th International Congress of the
International Society for Neuroimmunomodulation, which was held on September 29-October
2,
1999,
in Lugano, Switzerland.
The Mechanism of Action of Cytokines to Control the Release of Hypothalamic
and Pituitary Hormones in Infection. By S.M. McCann,
M. Kimura, S. Karanth, W.H. Yu, C.A. Mastronardi, and V.
Rettori
4
Bidirectional Heterologous Desensitization of Opioid and Chemokine Receptors.
By T.J. Rogers,
A.D.
Steele, O.M.Z. Howard, and J.J.
Oppenheim .... 19
Neurohormones
and Catecholamines as Functional Components of the Bone
Marrow
Microenvironment.
By Georges J.M. Maestroni
.............. 29
The Stress Response and Immune Function: Clinical Implications:
The
1999
Novera
H.
Spector
Lecture. By George P. Chrousos
.......... 38
Oncology in Neuroimmunomodulation: What Progress Has Been Made?
By
Ario
Conti................................................
68
Part
П.
Pro- and Antiinflammatory Cytokines and CNS
The Role of Pro- and Antiinflammatory Cytokines in Neurodegeneration.
By Stuart M. Allan
.......................................... 84
Neuroendocrine
Regulation of IL-12 and TNF-a/IL-10 Balance:
Clinical Implications. By Ilia J. Elenkov, George P. Chrousos,
and Ronald L. Wilder
........................................ 94
Hypothalamic Mechanisms of Pain
Modulatory
Actions of Cytokines and
Prostaglandin E2. By T.
Hori,
T. Oka, M. Hosoi, M. Abe, and K. Oka
.. 106
Molecular Mechanisms of Fever and Endogenous Antipyresis.
By
Wiesław Kozak,
Matthew
J.
Kluger, Johannes Tesfaigzi,
Anna
Kozak,
Kimberly P. Mayfield,
Maciej Wachulec,
and
Karol Dokładny.........................................
121
CXC Chemokine
Receptors
Expression
during Chronic Relapsing Experimental
Autoimmune Encephalomyelitis. By
Andrzej
R.
Glabinski,
Sage O Bryant,
Krzysztof
Selmaj, and Richard M. Ransohoff
..... 135
Contribution of Differently Localized a2- and
ß-Adrenoceptors in
the Modulation
of TNF-ot and IL-10 Production in Endotoxemic Mice.
By
J. SzELÉNYi,
J.P. Kiss,
É.
Puskás,
M. Szelényi,
and
B-S.
Vizi
...... 145
Regulation of Cytokine Secretion and Amyloid Precursor Protein
Processing by Proinflammatory Amyloid Beta
(Aß).
By Bruce D.
Gitter,
Leonard
N.
Boggs, Patrick
С
May,
Dan L. Czilli, and Christopher D. Carlson
...................... 154
Increased Sensitivity of the Baroreceptor Reflex after Bacterial Endotoxin.
By
Heiner
Rogausch, Ngoc-Thinh Vo,
Adriana
del
Rey,
and Hugo O. Besedovsky
...................................... 165
Not All Peripheral Immune Stimuli That Activate the
ΗΡΑ
Axis Induce
Proinflammatory Cytokine Gene Expression in the
Hypothalamus.
By
Adriana
del
Rey,
Anke
Randolf, Fernando Pitossi,
Heiner
Rogausch, and Hugo O. Besedovsky
...................... 169
Mechanisms of Behavioral and
Neuroendocrine
Effects of Interleukin-l in Mice.
By Pierre J.
Neveu
and
Stéphane Liège..........................
175
Genetic Regulation of Nerve Avulsion-Induced Spinal Cord Inflammation. By
Tomas Olsson,
Cecilia
Lundberg, Olle Lidman, and Fredrik Piehl.
. 186
С
-fos
and IL-2
Gene Expression in Rat Brain Cells and Splenic Lymphocytes
after Nonantigenic and Antigenic Stimuli. By E.A. Korneva,
S.V.
Barabanova, O.I. Golovko, M.A.
Nosov,
N.S. Novikova,
and T.B. Kazakova
........................................... 197
Tumor Necrosis Factor-a Induces
Neuronal
Death by Silencing Survival Signals
Generated by the Type I Insulin-Like Growth Factor Receptor.
By H.D. Venters, R. Dantzer, and K.W. Kelley
................... 210
Part III. MSH in Neuroimmunomodulation
The Neuroimmunomodulatory
Peptide
α
-MSH.
By Takashi Ichiyama,
Soichiro Sato, Kuniyuki Okada, Anna Catania, and James M. Lipton
221
The
Neuropeptide
α
-MSH
in Host Defense. By Anna Catania,
Mariagrazia Cutuli,
Letizia Garofalo,
Andrea Carlin,
lorena alraghi, wllma
barcellini,
and james m. llpton
.......... 227
The Role of
α
-MSH
as a Modulator of Cutaneous Inflammation.
By T.A.
Luger, T.
Brzoska,
Т.Е.
Scholzen,
D.-H.
Kalden,
C. SUNDERKÖTTER, C.
ARMSTRONG, AND J. ANSEL
.................... 232
Neuropeptide
Regulation of Immunity. By The Immunosuppressive
Activity of Alpha-Melanocyte-Stimulating Hormone
(α
-MSH).
By A.W. Taylor, D.G. Yee, T. Nishida, and K. Namba
.............. 239
Part IV. Peripheral Neuroimmunomodulation
Natural Immunity and
Neuroimmune
Host Defense. By
István Berczi,
Lóránd Bertók,
and Donna A. Chow
............................ 248
Control of Salivary Secretion by Nitric Oxide and Its Role in
Neuroimmunomodulation. By V.
Rettori,
A. Lomniczi, J.C. Elverdin,
A. Suburo, A. Faletti,
A. Franchi,
and S.M. McCann
............. 258
Nerve Growth Factor and
Neuroimmune
Interactions in Inflammatory Diseases.
By Andrew M. Stanisz and
Jolanta
A. Stanisz
................... 268
Role of
Neurotransmitter Autoantibodies
in the Pathogenesis of Chagasic
Peripheral Dysautonomia. By
Leonor
Sterin-Borda and Enri
Borda
... 273
Nuclear Factor-KB is Involved in the Catecholaminergic Suppression of
Immunocompetent Cells. By Jonas Bergquist,
Bertil Ohlsson,
and
Andrej Tarkowski........................................ 281
The Peripheral CRH/Urocortin System. By
Christoph
M.
Bamberger
and
Ana-Maria Bamberger.................................... 290
Neural Control of Ocular Immune Privilege. By J. Wayne Streilein,
Shigeki Okamoto, Yoichiro
Sano,
and Andrew W. Taylor
......... 297
Nerve-Driven Immunity: The Direct Effects of
Neurotransmitters
on
Т
-Cell
Function. By
Mia Levite
.................................. 307
Part V.
Neurodegenerative
Diseases and Neural-Immune
Communications in Normal and Injured Brain
Cytokines and Neurotrophins Interact in Normal and Diseased States.
By U. Otten, P.
März,
К.
Heese,
С.
Hock,
D.
Kunz,
and S.
Rose-John
322
Overproduction of
IFN
-γ
and TNF-a from Natural Killer (NK) Cells Is
Associated with Abnormal NK Reactivity and Cognitive Derangement
in Alzheimer s Disease. By S.B.
Solerte,
L.
Cra
vello,
E.
Ferrari, and M.
Fiora
v
anti..................................
331
Beneficial Autoimmune
Τ
Cells and Posttraumatic
Neuroprotection.
By
Michal
Schwartz
.......................................... 341
Part VI. Melatonin,
NIM,
and Hematopoiesis
Feedsidewards:
Intermodulation
(Strictly) among Time Structures,
Chronomes,
in
and around Us, and Cosmo-vasculo-neuroimmunity. About Ten-yearly
Changes: What Galileo Missed and
Schwabe
Found. By Franz Halberg,
Germaine Cornélissen,
George Katinas, Yoshihiko Watanabe,
Kuniaki
Otsuka,
Cristina Maggioni,
Federico Perfetto,
Roberto Tarquini, Othild
Schwartzkopff, and Earl
E.
Bakken
.... 348
Melatonin
and Its Relation to the Immune System and Inflammation.
By
Russel
J.
Reiter,
Juan R.
Calvo,
Małgorzata Karbownik,
Wenbo Qi, and Dun Xian Tan
.................................. 376
Gene Regulation by Melatonin. By
Carsten Carlberg.................... 387
Involvement of Nuclear Receptors in the Enhanced IL-2 Production by Melatonin
in Jurkat Cells. By Juan M.
Guerrero, David Pozo,
Sofía García-Mauriño,
С.
Osuna,
Р.
Molinero,
and
Juan R.
Calvo.
. 397
Melatonin
Mediates Seasonal Changes in Immune Function.
By Randy J. Nelson and Deborah L.
Dražen
..................... 404
Effects of Preprotachykinin-I Peptides on Hematopoietic Homeostasis:
A Role for Bone Marrow Endopeptidases. By P.
Gascón,
J.
Qian,
D.D.
Joshi, T.
Teli,
A. Haider, and P. Rameshwar
................. 416
Neuropeptide
Control of Bone Marrow Neutrophil Production: A Key Axis for
Neuroimmunomodulation. By Caroline S. Broome and Jaleel A. Miyan
424
Light and
Immunomodulation.
By Joan E. Roberts
....................... 435
Part
VII.
Behavior, Emotional Disorders, and Immunity
Complex Coping Patterns and Their Role in Adaptation and
Neuroimmunomodulation: Theory, Methodology, and Research.
By
Lydia
R.
Temoshok
......................................... 446
The Immune System and Schizophrenia: An
Integrative
View.
By
Norbert Müller, Michael Riedel, Rudolf Gruber,
Manfred Ackenheil, and Markus J. Schwarz.................... 456
Prenatal Influences on
Neuroimmune Set
Points in Infancy.
By Christopher
L.
Coe and
Gabriele
R. Lub ach
................... 468
Illness, Cytokines, and Depression. By
R. Yirmiya, Y. Pollak, M. Morag,
A.
Reichenberg,
O. Barak, R. Avitsur,
Y. Sha
vit,
H. Ovadia,
J.
Weidenfeld,
A. Morag, M.E.
Newman, and
T. Pollmächer
....... 478
Experimental
Immunomodulation,
Sleep, and Sleepiness in Humans. By Thomas
Pollmächer, Andreas Schuld, Thomas Kraus,
Monika
Haack,
Dunja
Hinze-Selch, and Janet Mullington
........ 488
Psychoneuroimmunology and HIV/AIDS.
Ő)1
George F. Solomon,
Gail H. Ironson, and Elizabeth
G. Balbin
....................... 500
Part
VIII.
Prolactin and
GB in
Neuroimmunomodulation
Cooperation of Pituitary Hormone Prolactin with Interleukin-2 and
Interleukin-12 on Production of
Interferon
-γ
by Natural Killer and
T
Cells. By
Lina Matera
and
Marcella Mori
..................... 505
Role of Cyclophilins in Somatolactogenic Action. By Michael A. Rycyzyn
and Charles
V.
Clevenger
.................................... 514
Prolactin
Regulation of Apoptosis-Associated Gene Expression
in T
Cells.
By Arthur R. Buckley and Donna J. Buckley
.................... 522
Growth Hormone and Prolactin Expression in the Immune System.
By Ron Kooijman,
Sarah Gerlo, Astrid Coppens,
and Elisabeth L. Hooghe-Peters
............................... 534
Part IX. Neuroimmunomodulation: Perspectives in Oncology
The Role of
Bim,
a Proapoptotic
ВНЗ
-Only
Member of the Bcl-2 Family, in
Cell-Death Control. By Andreas Strasser,
Hamsa
Puthalakath,
Philippe Bouillet, David C.S. Huang,
Liam
O Connor,
Lorraine A. O Reilly,
Leonie
Cullen, Suzanne Cory,
and Jerry M. Adams
.......................................... 541
Stress and Chemotherapy: Combined Effects on Tumor Progression and
Immunity in Animal Models. By
Tullio
Giraldi,
Sonia
Zorzet,
Laura Perissin, and
Valentina Rapozzi
......................... 549
Modulation of
Anticancer
Cytokines IL-2 and
IL-
12
by Melatonin and
the Other Pineal
índoles 5-Methoxytryptamine
and 5-Methoxytryptophol
in the Treatment of Human Neoplasms. By Paolo Lissoni
.............. 560
What s in a Name: Neuroimmunomodulation or Psychoneuroimmunology?
By Steven Greer
............................................. 568
Part X. Cytokines and
Neuroendocrine
Functions
Sympathetic
Innervation
Affects Superantigen-Induced Decrease in
CD4Vß8
Cells in the Spleen. By
Adriana
Del
Rey,
Alexa Kabiersch,
Sigrid Petzoldt, Anke
Randolf, and Hugo O. Besedovsky
......... 575
Variability of Interactions Between
Neuroendocrine
and Immunological
Functions in Physiological Aging and Dementia of the Alzheimer s Type.
By E. Ferrari, M.
Fiora vanti,
F.
Magri, and
S.B.
Solerte
.......... 582
Interleukin-lß and Thymic
Peptide
Regulation
of Pituitary and Glial Cell
Cytokine Expression and Cellular Proliferation. By Bryan L. Spangelo,
Derald D. Farrimond, Melissa Pompilius, and Kay-Lynn Bowman
.. 597
Cytokine Activation of the
ΗΡΑ
Axis. By Adrian J. Dunn
.................. 608
In Vivo
Immunomodulation
by Peripheral Adrenergic and Cholinergic
Agonists/Antagonists in Rat and Mouse Models. By K.
Schauenstein,
P. Felsner,
I. Rinner,
P.M.
Liebmann,
J.R. Stevenson,
J.
Westermann,
H.S. Haas, R.L. Cohen, and D.A. Chambers
........ 618
Possible Function of IL-6 and TNF as Intraadrenal Factors in the Regulation
of Adrenal Steroid Secretion. By Allan M. Judd, Gerald B. Call,
Michelle Barney, Christopher J. McIlmoil, Adam G. Balls,
Andrew Adams, and Gustavo K.
Oliveira
....................... 628
Part XI.
ΗΡΑ
Axis, Sex Hormones, and
NOS
Gaseous Neuromodulators in the Control of
Neuroendocrine
Stress Axis.
By P.
Navarra,
С.
Dello Russo,
С.
Mancuso,
P.
Preziosi,
and A. Grossman
............................................. 638
Cytokines, Leptin, and the Hypothalamo-Pituitary-Adrenal Axis.
By R.C.
Gaillard,
E.
Spinedi,
T. Chautard, and F.P. Pralong
....... 647
SOCS
Proteins: Modulators
of Neuroimmunoendocrine Functions:
Impact on Corticotroph LIF
Signaling,
ßy
C.J. Auernhammer,
C. Bousquet,
V.
Chesnokova, and S. Melmed
..................... 658
Macrophage Migration
Inhibitory Factor (MIF): A Critical
Neurohumoral
Mediator. By Nikolai
Petrovsky and
Richard Bucala
.............. 665
Functional Cross-talk among Cytokines,
Т
-Cell
Receptor, and Glucocorticoid
Receptor Transcriptional Activity and Action. By E.
Arzt,
D.
KovALOvsKY,
L.
Müller
Igaz,
M.
Costas,
P.
Plazas,
D. Refojo,
M.
Páez-Pereda, J.M.H.M. Reul, G.
Stalla,
and F. Holsboer
....... 672
Gender, Neuroendocrine-Immune Interactions and Neuron-Glial Plasticity:
Role
of Luteinizing Hormone-Releasing Hormone (LHRH).
By
Bianca Marchetti, Francesco Gallo,
Zelinda Farinella, Cataldo
Tirólo, Nuccio
Testa,
Salvo Caniglia, and Maria C. Morale
.......................... 678
Part
XII.
Neuroendocrine Control of Thymic Physiology
Thymic Neuroendocrine Self-Antigens: Role in T-Cell Development and
Central
Т
-Cell
Self-Tolerance. By Vincent Geenen, Henri Martens,
Fabienne Brilot, Chantal Renard, Denis
Franchimont,
AND OUAFAE KeCHA
............................................ 710
Human
Τ
Lymphopoiesis: In Vitro and In Vivo Study Models.
By J. Plum,
M. De
Smedt, B. Verhasselt, T. Kerre,
D. Vanhecke, B. Vandekerckhove, and G. Leclercq
.............. 724
Role of Glucocorticoids in Early
Т
-Cell
Differentiation.
By
Rosa Sacedón, Angeles Vicente, Alberto Varas,
Eva Jiménez, Juan José Muñoz,
and
Agustín
G.
Zapata
............ 732
The
Thymus
at the Crossroad of
Neuroimmune
Interactions.
By Marella
Maroder, Diana
Bella via,
Alessandra
Vacca,
Maria Pia Felli, and Isabella Screpanti
........................ 741
Is There a Role for Growth Hormone upon Intrathymic
Т
-Cell
Migration?
By Wilson Savino,
Sálete
Smaniotto,
Valéria
de Mello-Coelho,
and
Mireille Dardenne
....................................... 748
Part
XIII.
Opiates and the Immune System
The Opioid Antagonist Naloxone Induces a Shift from Type
2
to Type
1
Cytokine Pattern in Normal and Skin-Grafted Mice. By
Paola Sacerdote,
Leda Gaspani,
and
Alberto E. Panerai
.......................... 755
Expression of Delta Opioid Receptors and Transcripts by Splenic
T
Cells.
By
Burt
M. Sharp, Ming D. Li, Shannon G.
Matta,
Kathy McAllen, and Nahid A. Shahabi
......................... 764
Acute Effects of Morphine on Blood Lymphocyte Proliferation and Plasma
IL-6 Levels. By Richard A. Houghtling, R. Daniel Mellon,
Roderick J. Tan, and Barbara M. Bayer
......................... 771
Expression of Preproenkephalin mRNA and Production and Secretion of
Enkephalins by Human Thymocytes. By Annemieke
Kavelaars
and
Сові
J. Heunen
........................................... 778
Part
XIV.
Autoimmune Diseases
Susceptibility to Autoimmune Disease and Drug Addiction in Inbred Rats:
Are There Mechanistic Factors in Common Related to Abnormalities in
Hypothalamic-Pituitary-Adrenal Axis and Stress Response Function?
By Ronald L. Wilder, Marie M. Griffiths, Grant W. Cannon,
Rachel
Caspi,
and Elaine
F. Remmers
........................... 784
Neuroendocrine Manifestations in
Sjögren s
Syndrome: Relation to the
Neurobiology of Stress. By Elizabeth O. Johnson
and Haralampos M. Moutsopoulos
............................. 797
Gonadotropin-Releasing Hormone and
G
Proteins: Potential Roles in
Autoimmunity. By J.D.
Jacobson
................................. 809
Neuroendocrine
and Other Factors in the Regulation of Inflammation: Animal
Models. By Mehrnaz Jafarian-Tehrani and Esther M.
Sternberg.
... 819
Perturbations of
Arginine Vasopressin
Secretion during Inflammatory Stress:
Pathophysiologic Implications. By Ian
С
Chikanza, Petros
Petrou,
and George Chrousos
......................................... 825
The Hypothalamic-Pituitary-Adrenal and Gonadal Axes in Rheumatoid Arthritis.
By
Maurizio Cutolo, Barbara Villaggio, Luca Foppiani,
Melania
Briata, Alberto Sulli, Carmen Pizzorni,
Francesca Faelli, Camilla
Prete, Lamberto Felli,
Bruno Seriólo,
and Massimo Giusti
............................ 835
Part XV.
Stress,
Neuroendocrine
Responses, and Allergy
Environmental Factors Favoring the Allergen-specific Th2 Response in Allergic
Subjects. By
Marie-Pierre Piccinni, Enrico Maggi,
and Sergio Romagnani
........................................ 844
Conditioning Rhinitis in Allergic Humans. By Judith E. Barrett,
Maurice G. King, and Gerald Pang
............................. 853
Androstenetriol and Androstenediol: Protection Against Lethal Radiation and
Restoration of Immunity After Radiation Injury. By R.M.
Loria,
D.H.
Conrad, T. Huff, H. Carter, and D. Ben-Nathan
............. 860
Altered Glucocorticoid Regulation of the Immune Response in the Chronic
Fatigue Syndrome. By Jeroen T.J.
Visser, E.
Ronald
de Kloet,
and Lex
Nagelkerken.........................................
868
Acute Stress Enhances while Chronic Stress Suppresses Skin Immunity:
The Role of Stress Hormones and Leukocyte Trafficking.
By Firdaus S. Dhabhar
........................................ 876
Part
XVI.
Bacterial, Parasite, and
Non-
AIDS Viral Infections
Social Disruption, Immunity, and Susceptibility to Viral Infection: Role of
Glucocorticoid Insensitivity and NGF. By J.F. Sheridan, J.L. Stark,
R. Avitsur, and D.A. Padgett
.................................. 894
The Role of Oxidative Stress in Viral Infections. By M.A. Beck, J. Handy,
and
O.A.
Lev
ander........................................... 906
Local Regulation of Glucocorticoid Activity in Sites of Inflammation: Insights
from the Study of Tuberculosis. By G. Rook, R. Baker, B. Walker,
J. Honour, D. Jessop, R. Hernandez-Pando, K. Arriaga, R. Shaw,
A. ZUMLA, AND S. LlGHTMAN
.................................... 913
Chemical Sympathectomy Alters Cytotoxic
Τ
Lymphocyte Responses
to Herpes Simplex Virus Infection. By Nicole A. Leo and
Robert H. Bonneau
........................................... 923
Steroid Hormone Regulation of Antiviral Immunity.
By D.A. Padgett, R.M.
Loria,
and J.F. Sheridan
.................. 935
CNS Penetration by Noninvasive Viruses following Inhalational Anesthetics.
By D. Ben-Nathan, D. Kobiler, S. Rzotkiewicz, S.
Lustig,
and Y. Katz
................................................. 944
Part
XVII.
Hormonal and Immune Disorders in
HIV
Infection
Fat Redistribution in HlV-Infected Patients: A New Hormonal-Immune
Disorder? By
Guido Norbiato, Giuliana Trifirò, Massimo Galli,
Cristina
Gervasoni, and Mario Clerici
.......................... 951
Immunoendocrinologic
Abnormalities in Human Immunodeficiency
Virus
Infection. By
Mario Clerici, Massimo Galli,
Simona Bosis,
Cristina
Gervasoni, Mauro
Moroni, and
Guido Norbiato
......... 956
Changes in Cortisol/DHEA Ratio in HIV-Infected Men Are Related to
Immunological
and Metabolic Perturbations Leading to Malnutrition
and Lipodystrophy. By
Névéna Christeff,
Emmanuel A. Nunez,
and
Marie-Lise
Gougeon
...................................... 962
Toc-Hydroxy-Dehydroepiandrosterone and Immune Response. By R.
Morfin,
P. Lafaye,
A.C.
Cotillon, F.
Nato,
V. Chmielewski, and D. Pompon
. 971
Index of Contributors
............................................... 983
|
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genre | (DE-588)1071861417 Konferenzschrift 1999 Lugano gnd-content |
genre_facet | Konferenzschrift 1999 Lugano |
id | DE-604.BV013577520 |
illustrated | Illustrated |
indexdate | 2024-12-23T15:31:10Z |
institution | BVB |
isbn | 1573312878 1573312886 |
language | English |
oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009272453 |
oclc_num | 46434312 |
open_access_boolean | |
owner | DE-20 DE-12 DE-355 DE-BY-UBR |
owner_facet | DE-20 DE-12 DE-355 DE-BY-UBR |
physical | XX, 987 S. Ill., graph. Darst. |
publishDate | 2000 |
publishDateSearch | 2000 |
publishDateSort | 2000 |
publisher | New York Acad. of Sciences |
record_format | marc |
series | Annals of the New York Academy of Sciences |
series2 | Annals of the New York Academy of Sciences |
spellingShingle | Neuroimmunomodulation perspectives at the new millenium Annals of the New York Academy of Sciences Cytokines - Immunologie - Congrès Maladies auto-immunes - Immunologie - Congrès Maladies mentales - Immunologie - Congrès Mélatonine - Immunologie - Congrès Neuro-immunologie - Congrès Neuroimmunomodulation gtt Système nerveux - Maladies - Immunologie - Congrès Autoimmune Diseases immunology Congresses Cytokines immunology Congresses Melatonin immunology Congresses Mental Disorders immunology Congresses Nervous System Diseases immunology Congresses Neuroimmunology Congresses Neuroimmunomodulation Congresses Neuroimmunologie (DE-588)4115376-5 gnd |
subject_GND | (DE-588)4115376-5 (DE-588)1071861417 |
title | Neuroimmunomodulation perspectives at the new millenium |
title_auth | Neuroimmunomodulation perspectives at the new millenium |
title_exact_search | Neuroimmunomodulation perspectives at the new millenium |
title_full | Neuroimmunomodulation perspectives at the new millenium ed. by Ario Conti ... |
title_fullStr | Neuroimmunomodulation perspectives at the new millenium ed. by Ario Conti ... |
title_full_unstemmed | Neuroimmunomodulation perspectives at the new millenium ed. by Ario Conti ... |
title_short | Neuroimmunomodulation |
title_sort | neuroimmunomodulation perspectives at the new millenium |
title_sub | perspectives at the new millenium |
topic | Cytokines - Immunologie - Congrès Maladies auto-immunes - Immunologie - Congrès Maladies mentales - Immunologie - Congrès Mélatonine - Immunologie - Congrès Neuro-immunologie - Congrès Neuroimmunomodulation gtt Système nerveux - Maladies - Immunologie - Congrès Autoimmune Diseases immunology Congresses Cytokines immunology Congresses Melatonin immunology Congresses Mental Disorders immunology Congresses Nervous System Diseases immunology Congresses Neuroimmunology Congresses Neuroimmunomodulation Congresses Neuroimmunologie (DE-588)4115376-5 gnd |
topic_facet | Cytokines - Immunologie - Congrès Maladies auto-immunes - Immunologie - Congrès Maladies mentales - Immunologie - Congrès Mélatonine - Immunologie - Congrès Neuro-immunologie - Congrès Neuroimmunomodulation Système nerveux - Maladies - Immunologie - Congrès Autoimmune Diseases immunology Congresses Cytokines immunology Congresses Melatonin immunology Congresses Mental Disorders immunology Congresses Nervous System Diseases immunology Congresses Neuroimmunology Congresses Neuroimmunomodulation Congresses Neuroimmunologie Konferenzschrift 1999 Lugano |
url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009272453&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
volume_link | (DE-604)BV002532608 |
work_keys_str_mv | AT contiario neuroimmunomodulationperspectivesatthenewmillenium |