Toxicology for the next millennium
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New York Acad. of Sciences
2000
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| Schriftenreihe: | New York Academy of Sciences: Annals of the New York Academy of Sciences
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Datensatz im Suchindex
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| adam_text | ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Volume 919
September 2000
TOXICOLOGY FOR THE
NEXT MILLENNIUM
Editors and Conference Organizers
Robert J. Isfort and Joshua Lederberg
[This volume is the result of a conference entitled Toxicology for the Next Millennium held
by the New York Academy of Sciences on September 20 23, 1999, in Warrenton, Virginia.]
CONTENTS
Introduction. By Robert J. Isfort ix
What s Important about Toxicology? By Joshua Lederberg xi
Part I. Molecular Technologies
Use of Oligonucleotide Arrays to Analyze Drug Toxicity. By Naftali
Kaminski, John Allard, and Renu A. Heller 1
Analysis of Drug Pharmacology towards Predicting Drug Behavior by
Expression Profiling Using High Density Oligonucleotide Arrays. By
Jing Shan Hu, Mark Durst, Reinhold Kerb, Vivi Truong,
Jing Tyan Ma, Elina Khurgin, David Balaban, Thomas R.
GlNGERAS, AND BRIAN B. HOFFMAN 9
Part II. Cellular/Organismal Technologies
Development of Human Cell Lines from Multiple Organs. By
Johng S. Rhim 16
Fluorometric High Throughput Screening for Inhibitors of Cytochrome P450.
By Vaughn P. Miller, David M. Stresser, Andrew P.
Blanchard, Stephanie Turner, and Charles L. Crespi 26
Part HI. Genomics/Proteomics
Quantitative Proteome Analysis: Methods and Applications. By Ruedi
Aebersold, Beate Rist, and Steven P. Gygi 33
Pharmaceutical Proteomics. By Sandra Steiner and N. Leigh Anderson 48
Part IV. Computer Modeling/Bioinformatics
Gene Expression Microarray Data Analysis for Toxicology Profiling. By
M. J. Cunningham, S. Liang, S. Fuhrman, J. J. Seilhamer, and
R. Somogyi 52
In Silico Toxicology. By SAMUEL HOLTZMAN 68
Toxicity Testing: The FDA Perspective. By Jane E. Henney 75
Part V. Cancer
p53 Tumor Suppressor Gene: At the Crossroads of Molecular Carcinogenesis,
Molecular Epidemiology, and Human Risk Assessment. By S. Perwez
Hussain, Monica H. Hollstein, and Curtis C. Harris 19
Mechanisms of Cell Transformation in the Syrian Hamster Embryo (SHE)
Cell Transformation System. By Robert J. Isfort 86
Part VI. Neurotoxicology
Neurochemical Effects of Environmental Chemicals: In Vitro and In Vivo
Correlations on Second Messenger Pathways. By Prasada Rao S.
KODAVANTI AND HUGH A. TlLSON 97
Culture Models of Neurodegenerative Disease. By D. A. FiGLEWlCZ,
L. Dong, M. Mlodzienski, and J. C. Turcotte 106
In Vitro Systems as Simulations of In Vivo Conditions: The Study of Cognition
and Synaptic Plasticity in Neurotoxicology. By M. E. GILBERT 119
Part VII. Acute Toxicology
Transgenic Zebrafish as Sentinels for Aquatic Pollution. By MICHAEL J.
Carvan III, Timothy P. Dalton, Gary W. Stuart, and
Daniel W. Nebert 133
Gene Swap Knock in Cassette in Mice to Study Allelic Differences in
Human Genes. By Daniel W. Nebert, Timothy P. Dalton,
Gary W. Stuart, and Michael J. Carvan III 148
The Use of Explant Lens Culture to Assess Cataractogenic Potential. By
Michael D. Aleo, Michael J. Avery, William P. Beierschmitt,
Cynthia A. Drupa, Jay H. Fortner, Adam H. Kaplan, Kimberly
A. Navetta, Richard M. Shepard, and Colleen M. Walsh 171
In Vitro Percutaneous Absorption Models. By ROBERT L. BRONAUGH 188
In Vitro and Human Testing Strategies for Skin Irritation. By Michael
K. Robinson, Rosemarie Osborne, and Mary A. Perkins 192
Part VIII. Immunotoxicology
New Technologies to Prevent and Treat Contact Hypersensitivity Responses.
By Akira Takashima, Mark Mummert, Toshiyuki Kitajima, and
Hiroyuki Matsue 205
The Role of Tumor Necrosis Factor a in Chemical Induced Hepatotoxicity. By
Michael I. Luster, Petia P. Simeonova, Randle M. Gallucci,
Alex Bruccoleri, Mark E. Blazka, Berran Yucesoy, and
Joanna M. Matheson 214
Aging and Resistance to Trichinella spiralis Infection following Xenobiotic
Exposure. By Robert W. Luebke, Carey B. Copeland, and
Debora L. Andrews 221
Animal Models to Assess the Effects of Air Pollutants on Allergic Lung
Disease. By MaryJane K. Selgrade, Amy L. Lambert,
Marsha D. W. Ward, and M. Ian Gilmour 230
Part IX. Developmental Toxicology
From Developmental Biology to Developmental Toxicology. By
Rudi Balling and Martin Hrabe de Angelis 239
Molecular Genetic Control of Axis Patterning during Early Embryogenesis of
Vertebrates. By GARY C. SCHOENWOLF 246
Genetic Basis of Susceptibility to Environmentally Induced Neural Tube
Defects. By Richard H. Finnell, Janee Gelineau van Waes,
Gregory D. Bennett, Robert C. Barber, Bogdan Wlodarczyk,
Gary M. Shaw, Edward J. Lammer, Jorge A. Piedrahita, and
James H. Eberwine 261
Transient Modulation of Gene Expression in the Neurulation Staged Mouse
Embryo. By E. Sidney Hunter III and Phillip Hartig 278
Part X. Poster Papers
Queueing and Inventory Theory in Clinical Practice: Application to Clinical
Toxicology. By C. P. Arun 284
The Rodent Carcinogen Dilemma: Formidable Challenge for the Technolo¬
gies of the New Millennium. By F. M. Johnson 288
Use of Bone Marrow Chimeras to Identify Cell Targets in the Immune System
for the Actions of Chemicals. By Thomas A. Gasiewicz, T. Scott
Thurmond, J. Erin Staples, Francis G. Murante, and
Allen E. Silverstone 300
The Effects of Lead on PKC Isoforms. By Aldo A. Coppi, Jacob Lesniak,
Diane Zieba, and Francis A. X. Schanne 304
Lead Induced Activation of Protein Kinase C in Rat Brain Cortical Synapto
SOITieS. By CHRISTOPHER D. TOSCANO AND FRANCIS A. X. SCHANNE . . 307
Reactivities of the Skin Sensitization Test in Guinea Pig (GPMT) as a
Function of Three Parameters: Induction Doses (MID), Challenge Doses
(SCD), and Direct Exposures (DED). By SATOSHI KlTAJlMA,
JUNKO MOMMA, AND TOHRU INOUE 312
Toxicity of Ethylene Glycol Metabolites in Normal Human Kidney Cells. By
K. E. McMartin and T. A. Cenac 315
Cadmium Induced Bioaccumulation in the Selected Tissues of a Freshwater
Teleost, Oreochromis mossambicus (Tilapia). By A. USHA RANI 318
Concluding Remarks. By Robert J. ISFORT 321
Index of Contributors 323
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| publishDate | 2000 |
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| spellingShingle | Toxicology for the next millennium New York Academy of Sciences: Annals of the New York Academy of Sciences Toxicologie - Congrès Toxicologie - Innovations - Congrès Toxicologie moléculaire - Congrès Toxicologie gtt Molecular toxicology Congresses Technology, Pharmaceutical trends Congresses Toxicology Congresses Toxicology Technological innovations Congresses Toxicology trends Congresses Wissenschaftlich-technischer Fortschritt (DE-588)4132508-4 gnd Toxikologie (DE-588)4060538-3 gnd |
| subject_GND | (DE-588)4132508-4 (DE-588)4060538-3 (DE-588)1071861417 |
| title | Toxicology for the next millennium |
| title_auth | Toxicology for the next millennium |
| title_exact_search | Toxicology for the next millennium |
| title_full | Toxicology for the next millennium ed. by Robert J. Isfort ... |
| title_fullStr | Toxicology for the next millennium ed. by Robert J. Isfort ... |
| title_full_unstemmed | Toxicology for the next millennium ed. by Robert J. Isfort ... |
| title_short | Toxicology for the next millennium |
| title_sort | toxicology for the next millennium |
| topic | Toxicologie - Congrès Toxicologie - Innovations - Congrès Toxicologie moléculaire - Congrès Toxicologie gtt Molecular toxicology Congresses Technology, Pharmaceutical trends Congresses Toxicology Congresses Toxicology Technological innovations Congresses Toxicology trends Congresses Wissenschaftlich-technischer Fortschritt (DE-588)4132508-4 gnd Toxikologie (DE-588)4060538-3 gnd |
| topic_facet | Toxicologie - Congrès Toxicologie - Innovations - Congrès Toxicologie moléculaire - Congrès Toxicologie Molecular toxicology Congresses Technology, Pharmaceutical trends Congresses Toxicology Congresses Toxicology Technological innovations Congresses Toxicology trends Congresses Wissenschaftlich-technischer Fortschritt Toxikologie Konferenzschrift 1999 Warrenton Va. |
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