MRS of the brain and neurological disorders
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CRC Pr.
2000
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Datensatz im Suchindex
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| adam_text | xvii
CONTENTS
Contributors iii
Collaborators iv
Preface Paul A. Bottomley vii
Words of Recommendation Teruo Nagai ix
A Message of Congratulation on the Publication of MRS of the Brain
and Neurological Disorders Haruo Akimoto xi
Preface to the First Edition Tetsuhiko Asakura, Akihiro Igata, and Toshiro Fujimoto xiii
Pulse Sequence and Informed Consent xxii
Introduction Toshiro Fujimoto 1
PART I BACKGROUND AND THEORETICAL BASIS 9
Chapter 1 History of MRS Toshiro Fujimoto 11
1.1 Magnet and Physical Background 11
1.2 Major Accomplishments Concerning MRS and MRI 12
Chapter 2 Basic Principles of MRS
Tohru Yamamoto, Norio Iriguchi, and Toshiyuki Miyazaki 21
2.1 Principles of measurements 21
2.1.1 RF coil 21
2.1.2 Localization 21
(1) Single voxel method 22
(2) Multivoxel method 23
(3) Comparison of the single voxel and multivoxel methods 24
2.1.3 Water suppression 26
2.1.4 Reception of signals and RF detection 26
2.2 Post processing 27
2.2.1 Automatic baseline correction for 31P CSI 27
(1) Baseline correction 27
(2) Theory 27
Complete spectrum 27
Observed spectrum 27
Baseline correction spectrum 28
Peak parameters 28
Estimation scheme of values of peak parameters 29
(3) Simulation and discussion 29
(4) Features of the baseline correction 29
2.2.2 Various post processing techniques 30
(1) Apodization 30
(2) Phase correction 30
Constant phase correction 31
Linear phase correction 31
(3) Curve fitting 31
2.3 Factors restricting measurements 32
2.3.1 The sensitivity of the MRS involving biological samples 32
(1) The nuclear sensitivities of various elements 32
(2) The SNR of MRS studies 32
(3) The upper limit of achievable MRS sensitivities 33
2.3.2 Various limitation factors 34
(1) Spatial resolution 34
(2) Spatial contamination 34
(3) Temporal resolution 34
(4) Delay time 34
xviii CONTENTS
(5) Eddy currents 34
2.4 Factors affecting the performance 35
2.4.1 Selection of the RF coil 35
2.4.2 Fat suppression 36
2.4.3 Water suppression 36
2.4.4 Local shim 36
2.5 Prospects for the future 36
2.5.1 Improvements in the RF coil technology 37
2.5.2 Quantification 37
Chapter 3 Understanding Spectra of 31P MRS and H MRS
Toshiro Fujimoto and Toshihiko Nakano 40
3.1 Major parameters of MRS 40
3.1.1 Chemical shift 40
3.1.2 Spin spin coupling 40
3.1.3 Relaxation mechanisms 40
(1) Spin lattice (longitudinal) relaxation 41
(2) Spin spin (transverse) relaxation 41
(3) Dipole dipole relaxation mechanism of protons in liquids
and variation of Ti and T2 with correlation time (rc) 41
3.1.4 Nuclear Overhauser Effect (NOE) and proton decoupling 41
3.2 31P MRS 42
3.2.1 Resonance of PME 42
3.2.2 Resonance of PDE 43
3.2.3 Phospholipids 43
3.2.4 Resonance of ATP, Pi, and PCr 45
3.3 H MRS 46
3.3.1 Resonance of NAA (./V acetylaspartate) 46
3.3.2 Resonance of Cr (creatine and phosphocreatine) 49
3.3.3 Resonance of Cho (choline containing compounds) 50
3.3.4 Resonance of lactate 50
3.3.5 Resonance of NAAG (N acetylaspartylglutamate) 51
3.3.6 Resonance of ml (myo inositol) 52 ,
3.3.7 Resonance of Glx (glutamate and glutamine) 52 j
3.3.8 Resonance of GAB A (y aminobutyric acid) 52
Chapter 4 MRS of Healthy Individuals Toshiro Fujimoto 59
4.1 31P MRS by CSI 60
4.1.1 Examples of the 31P spectrum of a healthy individual t
31P spectra of voxels 1 10 60 S
4.1.2 Examples of the 31P spectrum in a healthy individual I
31P spectra of voxels 11 13 63 {
4.1.3 Examples of the 31P spectrum in a healthy individual j
31P spectra of voxels 14 and 15 64 !
4.1.4 Examples of the 31P spectrum in a healthy individual j
31P spectra obtained by averaging over voxels 65 I
4.1.5 Mean ratios of peaks of the 31P spectrum of healthy individuals 67 }
4.1.6 Examples of the metabolite image and contour map of a healthy individual . • 71 |
4.2 H MRS by the single voxel method 77 j
4.2.1 Examples of the H spectrum of the basal ganglia in a healthy individual . • • • 78
4.2.2 Mean peak ratios in the H spectrum of the basal ganglia regions
in healthy individuals 80
4.2.3 Examples of H spectra in mesial temporal lobes in a healthy individual 82
4.2.4 Mean peak ratios in H spectra in mesial temporal lobes in healthy individuals 84
PART II CLINICAL APPLICATIONS 87
Chapter 5 Brain Tumors Masahiro Sasahira 89
5.1 Characteristics of the spectrum 89
CONTENTS xix
5.1.1 31P MRS of brain tumors 89
(1) Quantity of phosphorus compounds 89
(2) Intratumoral pH 89
(3) 31P MRS as a means to monitor therapeutic effects on brain tumors 91
5.1.2 H MRS of brain tumors 91
5.2 Cases (1 21) 94
1 : Pituitary adenoma 94
2 : Pituitary adenoma 96
3 : Meningioma 98
4 : Meningioma 100
5 : Meningioma 102
6 : Neurinoma 104
7 : Epidermoid 106
8 : Astrocytoma (grade I) 108
9: Astrocytoma (grade II) Evaluations before and after ACNU chemotherapy 110
10 : Astrocytoma (grade III) 124
11 : Astrocytoma (grade III) 126
12 : Astrocytoma (grade III) 130
13 : Astrocytoma (grade IV) 132
14: Glioblastoma 134
15 : Glioblastoma 138
16 : Oligodendroglioma 140
17 : Metastatic brain tumor (from the rectum) 142
18 : Metastatic brain tumor (from the lung) 144
19 : Metastatic brain tumor (from the lung) 146
20 : Chondrosarcoma 148
21 : Mucocele 150
5.3 Evaluation of the effects of radiotherapy and chemotherapy on brain tumors 152
5.4 Evaluation of the effects of radiotherapy for brain tumors on normal
brain tissue 154
Chapter 6 Cerebral Infarction Kousaku Terada 157
6.1 Characteristics of the spectrum 157
6.2 Cases (24 35) 160
24: 5 hours and 1 year after the stroke
(Cerebral infarction of the left and right occipital lobes) 160
25 :2 and 7 days after the stroke
(Cerebral infarction of the right temporal and occipital lobes) 162
26 : 2 days after the stroke (Cerebral infarction of the right temporal lobe) 166
27 : 2 days after the stroke
(Cerebral infarction of the left frontal and temporal lobes) 168
28 : 3 days after the stroke (Cerebral infarction of the left temporal lobe) 170
29 : 6 days after the stroke
(Cerebral infarction of the right frontal and temporal lobes) 172
30: 7 days after the stroke (Cerebral infarction of the right frontal lobe) 174
31:7 days after the stroke
(Cerebral infarction in a medial part of the right occipital lobe) 176
32 : 11 weeks after the stroke (Cerebral infarction of the right temporal lobe) 178
33 : 17 months after the stroke (Cerebral infarction of the left temporal lobe) 180
34 : 6 years after the stroke (Cerebral infarction of the left temporal lobe) 182
35 : Course of 31P MRS of cerebral infarction. A summary of 12 cases 184
Chapter 7 Cerebral Arteriovenous Malformation (AVM), Moya Moya Disease
Kousaku Terada 185
7.1 Characteristics of the spectrum 185
7.2 Cases (36 40) 186
36 : AVM of the right parietal lobe 186
37 : AVM of the right frontal lobe 188
38 : AVM of the left frontal lobe 190
xx CONTENTS
39 : Moya Moya disease (the blood flow on the right side is maintained due to
a bypass operation performed 7 years before) 192
40 : Moya Moya disease 194
Chapter 8 Intracerebral Hemorrhage Kousaku Terada 197
8.1 Characteristics of the spectrum 197
8.2 Cases (41 53) 198
41 : on the day of the stroke (hemorrhage of the left thalamus) 198
42 : 1 day after the stroke (hemorrhage of the right thalamus) 200
43 : 1 day after the stroke (hemorrhage of the left thalamus) 202
44 : 2 days after the stroke (subcortical hemorrhage of the left frontal lobe) 204
45 : 2 days after the stroke (subcortical hemorrhage of the right temporal
and parietal lobes) 206
46 : 3 days after the stroke (hemorrhage of the right putamen) 208
47 : 3 days after the stroke (hemorrhage of the right putamen) 210
48 : 4 days after the stroke (hemorrhage of the left putamen) 212
49 : 6 days after the stroke (hemorrhage of the left putamen) 214
50: 7 days after the stroke (hemorrhage of the right thalamus) 216
51:9 days after the stroke (hemorrhage of the right putamen) 218
52 : 11 days after the stroke (hemorrhage of the left thalamus) 220
53 : 14 days after the stroke (hemorrhage of the right putamen) 222
Chapter 9 Dementia Toshiro Fujimoto and Yasuhiko Utatsu 225
9.1 Characteristics of spectrum 225
9.1.1 Dementia of Alzheimer type (AD) 225
9.1.2 Pick s disease 226
9.1.3 Multi infarct dementia (MID) 227
9.1.4 Binswanger s disease 227
9.2 Cases (54 60) 232
54 : Dementia of Alzheimer type 232
55 : Dementia of Alzheimer type 234
56 : Dementia of Alzheimer type 236
57 1 : Probable Pick s disease (First 31P MRS study at 44 years) 238
57 2 : Probable Pick s disease
(Second 31P MRS study at 44 years; 4 months after the first examination) 240
57 3 : Probable Pick s disease
(Third 31P MRS study at 45 years; 10 months after the first examination) 242
57 4: Probable Pick s disease
(Fourth 31P MRS study at 45 years; 2 years after the first examination) 244
57 5 : Probable Pick s disease (JH and 31P spectra) 246
58 : Multi infarct dementia 248
59 : Multi infarct dementia 250
60 : Binswanger s disease 252
Chapter 10 Other Neurological Disorders Toshiro Fujimoto and Yasuhiko Utatsu 255
10.1 Characteristics of the spectrum 255
10.1.1 Multiple sclerosis (MS) 255
10.1.2 Leukodystrophy 255
10.1.3 Huntington s disease 256
10.2 Cases (61 64) 258
61 : Multiple sclerosis 258
62 : Leukodystrophy 260
63 : Huntington s disease 262
64 : Huntington s disease 264
Chapter 11 Epilepsy Toshiro Fujimoto and Katsumi Nakamura 267
11.1 Characteristics of the spectrum 267
11.2 Cases (65 75) 272
65 : Symptomatic epilepsy 272
CONTENTS xxi
66 : Symptomatic epilepsy 274
67 : Symptomatic epilepsy 276
68 : Symptomatic epilepsy 278
69 : Symptomatic epilepsy 280
70 : Symptomatic epilepsy 282
71 : Absence (before and after corpus callosotomy) 284
72 : Symptomatic temporal lobe epilepsy. Complex partial seizures
(focus on the left temporal lobe on EEG) 286
73 : Symptomatic temporal lobe epilepsy. Complex partial seizures
(focus on the left temporal lobe on EEG) 288
74 : Symptomatic temporal lobe epilepsy. Complex partial seizures
(focus on the left temporal lobe on EEG) 290
75 : Generalized seizures 292
Chapter 12 Psychiatric Disorders Toshiro Fujimoto 295
12.1 Characteristics of the spectrum 295
12.1.1 Schizophrenia 295
12.1.2 Depression 297
12.1.3 Mania 297
12.1.4 Alcoholism 297
12.2 Cases (76 85) 302
76 : Schizophrenia (Disorganized type) 302
77 : Schizophrenia (Disorganized type) 304
78 : Schizophrenia (Disorganized type) 306
79 : Schizophrenia (Catatonic type) 308
80 : Bipolar 1 Disorder, Most Recent Episode Depressed 310
81 : Bipolar 1 Disorder, Most Recent Episode Depressed 312
82: Bipolar 1 Disorder, Most Recent Episode Manic 314
83 : Alcohol Dependence (History of drinking : about 20 years) 316
84 : Alcohol induced mood disorder (History of drinking : about 20 years) 318
85 : Alcohol Dependence (History of drinking : about 28 years) 320
Author Index 323
Subject Index 326
|
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| id | DE-604.BV013351912 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:44:18Z |
| institution | BVB |
| isbn | 084930346X |
| language | English Japanese |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009106158 |
| oclc_num | 248644890 |
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| owner_facet | DE-355 DE-BY-UBR |
| physical | XXII, 329 S. Ill. |
| publishDate | 2000 |
| publishDateSearch | 2000 |
| publishDateSort | 2000 |
| publisher | CRC Pr. |
| record_format | marc |
| spelling | Igata, Akihiro Verfasser aut MRS of the brain and neurological disorders supervisors Akihiro Igata ... Boca Raton [u.a.] CRC Pr. 2000 XXII, 329 S. Ill. txt rdacontent n rdamedia nc rdacarrier Nervensystem (DE-588)4041643-4 gnd rswk-swf Gehirn (DE-588)4019752-9 gnd rswk-swf Krankheit (DE-588)4032844-2 gnd rswk-swf NMR-Spektroskopie (DE-588)4075421-2 gnd rswk-swf Nervensystem (DE-588)4041643-4 s Krankheit (DE-588)4032844-2 s NMR-Spektroskopie (DE-588)4075421-2 s DE-604 Gehirn (DE-588)4019752-9 s HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009106158&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Igata, Akihiro MRS of the brain and neurological disorders Nervensystem (DE-588)4041643-4 gnd Gehirn (DE-588)4019752-9 gnd Krankheit (DE-588)4032844-2 gnd NMR-Spektroskopie (DE-588)4075421-2 gnd |
| subject_GND | (DE-588)4041643-4 (DE-588)4019752-9 (DE-588)4032844-2 (DE-588)4075421-2 |
| title | MRS of the brain and neurological disorders |
| title_auth | MRS of the brain and neurological disorders |
| title_exact_search | MRS of the brain and neurological disorders |
| title_full | MRS of the brain and neurological disorders supervisors Akihiro Igata ... |
| title_fullStr | MRS of the brain and neurological disorders supervisors Akihiro Igata ... |
| title_full_unstemmed | MRS of the brain and neurological disorders supervisors Akihiro Igata ... |
| title_short | MRS of the brain and neurological disorders |
| title_sort | mrs of the brain and neurological disorders |
| topic | Nervensystem (DE-588)4041643-4 gnd Gehirn (DE-588)4019752-9 gnd Krankheit (DE-588)4032844-2 gnd NMR-Spektroskopie (DE-588)4075421-2 gnd |
| topic_facet | Nervensystem Gehirn Krankheit NMR-Spektroskopie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009106158&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT igataakihiro mrsofthebrainandneurologicaldisorders |