Molecular and cellular gerontology
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New York, NY
New York Acad. of Sciences
2000
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| Schriftenreihe: | New York Academy of Sciences: Annals of the New York Academy of Sciences
908 |
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Datensatz im Suchindex
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| adam_text | ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Volume 908
June 2000
MOLECULAR AND CELLULAR
GERONTOLOGY*
Editors
Olivier Toussaint, Heinz D. Osiewacz, Gordon J. Lithgow, and
Christine Brack
Conference Organizers
Christine Brack, Olivier Toussaint, Heinz D. Osiewacz, and
Gordon J. Lithgow
CONTENTS
Preface. By Christine Brack, Gordon J. Lithgow, Heinz D. Osiewacz, and
Olivier Toussaint ix
Some New Directions for Research on the Biology of Aging. By George M.
Martin 1
Molecular Gerontology. Bridging the Simple and the Complex. By Thomas
B.L. Kirkwood 14
Metabolic Control and Gene Dysregulation in Yeast Aging. By S. MlCHAL
Jazwinski 21
Mitochondrial Oxidative Stress and Aging in the Filamentous Fungus
Podospora anserina. By HEINZ D. OSIEWACZ AND CORINA BORGHOUTS 31
Molecular Genetic Mechanisms of Life Span Manipulation in Caenorhabdi
tis elegans. By Shin Murakami, Patricia M. Tedesco, James R.
Cypser, and Thomas E. Johnson 40
Genetics of Human Aging. The Search for Genes Contributing to Human
Longevity and Diseases of the Old. By P. ELINE Slagboom, Bastiaan
T. Heumans, Marian Beekman, Rudi G.J. Westendorp, and
INGRID MEULENBELT 50
Genetics of Survival. By Francois Schachter 64
This volume is the result of a conference entitled EMBO Workshop on Molecular and
Cellular Gerontology, held in Serpiano, Ticino, Switzerland, September 18 22, 1999.
Melanin Accumulation Accelerates Melanocyte Senescence by a Mecha¬
nism Involving pl6INK4a/CDK4/pRB and E2F1. By DEBDUTTA
BANDYOPADHYAY AND ESTELA E. MEDRANO 71
Stress Induced Premature Senescence. Essence of Life, Evolution, Stress, and
Aging. By OLIVIER TOUSSAINT, PATRICK DUMONT, JEAN FRANCOIS
Dierick, Thierry Pascal, Christophe Frippiat, Florence
Chainiaux, Francis Sluse, Francois Eliaers, and Jose Remacle .. 85
Role of Oxidative Stress in Telomere Length Regulation and Replicative
Senescence. By Thomas von Zglinicki 99
Replicative Senescence and Oxidant Induced Premature Senescence. Be¬
yond the Control of Cell Cycle Checkpoints. By QlN M. Chen Ill
Poly(ADP Ribosyl)ation, Genomic Instability, and Longevity. By
Alexander Burkle 126
Aging and Longevity. A Paradigm of Complementation between Homeostatic
Mechanisms and Genetic Control? By Chariklia Petropoulou,
Niki Chondrogianni, Davina Simoes, Georgia Agiostratidou,
Natalia Drosopoulos, Violetta Kotsota, and
Efstathios S. Gonos 133
Protein Degradation by the Proteasome and Its Implications in Aging. By
Bertrand Friguet, Anne Laure Bulteau, Niki Chondrogianni,
Mariangela Conconi, and Isabelle Petropoulos 143
Fibroblast Responses to Exogenous and Autocrine Growth Factors Relevant
to Tissue Repair. The Effect of Aging. By DIMITRIS Kletsas,
Harris Pratsinis, Irene Zervolea, Panagiotis Handris, Eleni
Sevaslidou, Enzo Ottaviani, and Dimitri Stathakos 155
The Werner Syndrome. A Model for the Study of Human Aging. By Jan O.
Nehlin, Gunhild Lange Skovgaard, and Vilhelm A. Bohr 167
Calorie Restriction and Age Related Oxidative Stress. By B.J. Merry 180
Role of Mitochondrial DNA Mutations in Disease and Aging. By
D.A. Cottrell, E.L. Blakely, G.M. Borthwick, M.A. Johnson,
G.A. Taylor, E.J. Brierley, P. Ince, and D.M. Turnbull 199
Inherited Variability of the Mitochondrial Genome and Successful Aging in
Humans. By G. De Benedictis, G. Carrieri, O. Varcasia,
M. BONAFE, AND C. FRANCESCHI 208
Mitochondrial Oxidative Stress. Physiologic Consequences and Potential for
a Role in Aging. By Simon Melov 219
Tissue Mitochondrial DNA Changes. A Stochastic System. By
George Kopsidas, Sergey A. Kovalenko, Damien R. Heffernan,
Natalia Yarovaya, Ludmilla Kramarova, Diane Stojanovski,
Judy Borg, Monirul Islam, Aphrodite Caragounis, and
Anthony W. Linnane 226
Inflamm aging. An Evolutionary Perspective on Immunosenescence. By
Claudio Franceschi, Massimiliano Bonafe, Silvana Valensin,
Fabiola Olivieri, Maria De Luca, Enzo Ottaviani, and
Giovanna De Benedictis 244
The CA1 Region of the Human Hippocampus Is a Hot Spot in Alzheimer s
Disease. By M.J. West, C.H. Kawas, L.J. Martin, and
J.C. Troncoso 255
Transgenic Mouse Models of Alzheimer s Disease. By KLAUS D.
BORNEMANN AND MATTHIAS STAUFENB1EL 260
Molecular Misreading. A New Type of Transcript Mutation in Gerontology.
By Fred W. van Leeuwen, David F. Fischer, Rob Benne, and
Elly M. Hol 267
Biogerontology: The Next Step. By SURESH I.S. RATTAN 282
Nuclear Mitochondrial Interactions Involved in Aging in Podospora
anserina. By CORINA BORGHOUTS AND HEINZ D. OSIEWACZ 291
Inherited Frailty. ApoE Alleles Determine Survival after a Diagnosis of
Heart Disease or Stroke at Ages 85+. By E.H. Corder, H. Basun,
L. Fratiglioni, Z. Guo, L. Lannfelt, M. Viitanen, L.S. Corder,
K.G. Manton, and B. Winblad 295
MtDNA Deletions in Aging and in Nonmitochondrial Pathology. By
A. Cormio, A.M.S. Lezza, J. Vecchiet, G. Felzani, L. Marangi,
F.W. Guglielmi, A. Francavilla, P. Cantatore, and
M.N. Gadaleta 299
Transcriptome and Proteome Analysis in Human Senescent Fibroblasts and
Fibroblasts Undergoing Premature Senescence Induced by Repeated
Sublethal Stresses. By Jean Francois Dierick, Thierry Pascal,
Florence Chainiaux, Francois Eliaers, Jose Remacle, Peter
Mose Larsen, Peter Roepstorff, and Olivier Toussaint 302
Human Diploid Fibroblasts Display a Decreased Level of c fos mRNA at 72
Hours after Exposure to Sublethal H2O2 Stress. By Patrick Dumont,
Maggi Burton, Qin M. Chen, Christophe Frippiat,
Thierry Pascal, Jean Francois Dierick, Francois Eliaers,
Florence Chainiaux, Jose Remacle, and Olivier Toussaint 306
Replicative Senescence of Interleukin 2 Dependent Human T Lympho¬
cytes. Flow Cytometric Characteristics of Phenotype Changes. By
Ewa Jaruga, Janusz Skierski, Ewa Radzieszewska, and
EWA SlKORA 310
Age Related Changes in Irradiation Induced Apoptosis and Expression of
p21 and p53 in Crypt Stem Cells of Murine Intestine. By Kareen
Martin, Christopher S. Potten, and Thomas B.L. Kirkwood 315
Testing Evolutionary Theories of Aging. By Gawain McColl, Nicole L.
Jenkins, David W. Walker, and Gordon J. Lithgow 319
A Novel in Vitro Model of Conditionally Immortalized Human Vascular
Smooth Muscle Cells. A Tool for Aging Studies. By Harris Pratsinis,
Catherine Demoliou Mason, Alun Hughes, and
Dmitris Kletsas 321
Using Stress Resistance to Isolate Novel Longevity Mutations in Cae
norhabditis elegans. By James N. Sampayo, Nicole L. Jenkins, and
Gordon J. Lithgow 324
Telomere Length As a Marker of Oxidative Stress in Primary Human Fibro
blast Cultures. By Violeta Serra, Ttlman Grune, Nicolle Sitte,
Gabriele Saretzki, and Thomas von Zglinicki 327
Programmed Cell Death and Senescence in Skeletal Muscle Stem Cells. By
Kathryn Woods, Anna Marrone, and Janet Smith 331
Study of the HI Linker Histone Variant, Hlo, during the in Vitro Aging of
Human Diploid Fibroblasts. By D.S. Tsapali, K.E. Sekeri Pataryas,
AND T.G. SOURLINGAS 336
Aging Related Muscle Dysfunction. Failure of Adaptation to Oxidative
Stress? By S. Spiers, F. McArdle, and M.J. Jackson 341
A Theoretical Model for in machina Experiments on Immunosenescence.
by sllvana valensin and gianni di caro 344
Index of Contributors 349
Financial assistance was received from:
• AETAS, FONDATION POUR LA RECHERCHE SUR LE VIEILLISSEMENT,
GENEVA
• BIOGERONTOLOGY, KLUWER ACADEMIC PUBLISHERS
• CLONTECH AG, BASEL
• CROSSAIR LTD. CO. FOR REGIONAL EUROPEAN AIR TRANSPORT,
BASEL
• F. HOFFMANN LA ROCHE AG, BASEL
• FREIWILLIGE AKADEMISCHE GESELLSCHAFT, BASEL
• GERIATRIC UNIVERSITY CLINIC, BASEL
• NOVARTIS PHARMA AG, BASEL
• PUK PSYCHIATRIC UNIVERSITY CLINIC, BASEL
• RIA RESEARCH INTO AGEING, LONDON
• SAMW SWISS ACADEMY OF MEDICAL SCIENCES, BASEL
• VERUM, FOUNDATION FOR BEHAVIOUR AND ENVIRONMENT,
MUNICH
The New York Academy of Sciences believes it has a responsibility to provide an open
forum for discussion of scientific questions. The positions taken by the participants in
the reported conferences are their own and not necessarily those of the Academy. The
Academy has no intent to influence legislation by providing such forums.
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| illustrated | Illustrated |
| indexdate | 2024-12-23T15:25:35Z |
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| isbn | 1573312711 157331272X |
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| publishDateSearch | 2000 |
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| publisher | New York Acad. of Sciences |
| record_format | marc |
| series | New York Academy of Sciences: Annals of the New York Academy of Sciences |
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| spellingShingle | Molecular and cellular gerontology New York Academy of Sciences: Annals of the New York Academy of Sciences Cellules - Vieillissement - Congrès Longévité - Congrès Moleculaire biologie gtt Veroudering (biologie, psychologie) gtt Vieillissement - Aspect moléculaire - Congrès Aging Molecular aspects Congresses Aging physiology Congresses Cell Aging Congresses Cells Aging Congresses Longevity Congresses Molecular Biology Congresses Molekularpathologie (DE-588)4170396-0 gnd Alterskrankheit (DE-588)4132293-9 gnd Apoptosis (DE-588)4291096-1 gnd Altern (DE-588)4068596-2 gnd Molekularbiologie (DE-588)4039983-7 gnd |
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| title | Molecular and cellular gerontology |
| title_auth | Molecular and cellular gerontology |
| title_exact_search | Molecular and cellular gerontology |
| title_full | Molecular and cellular gerontology ed. by Olivier Toussaint ... |
| title_fullStr | Molecular and cellular gerontology ed. by Olivier Toussaint ... |
| title_full_unstemmed | Molecular and cellular gerontology ed. by Olivier Toussaint ... |
| title_short | Molecular and cellular gerontology |
| title_sort | molecular and cellular gerontology |
| topic | Cellules - Vieillissement - Congrès Longévité - Congrès Moleculaire biologie gtt Veroudering (biologie, psychologie) gtt Vieillissement - Aspect moléculaire - Congrès Aging Molecular aspects Congresses Aging physiology Congresses Cell Aging Congresses Cells Aging Congresses Longevity Congresses Molecular Biology Congresses Molekularpathologie (DE-588)4170396-0 gnd Alterskrankheit (DE-588)4132293-9 gnd Apoptosis (DE-588)4291096-1 gnd Altern (DE-588)4068596-2 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| topic_facet | Cellules - Vieillissement - Congrès Longévité - Congrès Moleculaire biologie Veroudering (biologie, psychologie) Vieillissement - Aspect moléculaire - Congrès Aging Molecular aspects Congresses Aging physiology Congresses Cell Aging Congresses Cells Aging Congresses Longevity Congresses Molecular Biology Congresses Molekularpathologie Alterskrankheit Apoptosis Altern Molekularbiologie Konferenzschrift 1999 Serpiano |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009082801&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002532608 |
| work_keys_str_mv | AT toussaintolivier molecularandcellulargerontology |