Principles of tissue engineering
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| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
San Diego [u.a.]
Academic Press
2000
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| Ausgabe: | 2. ed. |
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| Online-Zugang: | Inhaltsverzeichnis |
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| 245 | 1 | 0 | |a Principles of tissue engineering |c ed. by Robert P. Lanza ... |
| 250 | |a 2. ed. | ||
| 264 | 1 | |a San Diego [u.a.] |b Academic Press |c 2000 | |
| 300 | |a XLI, 995 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
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| 650 | 4 | |a Cellules - Biotechnologie | |
| 650 | 4 | |a Greffe (Chirurgie) | |
| 650 | 4 | |a Tissus (Histologie) - Culture | |
| 650 | 7 | |a Tissus (histologie) |2 ram | |
| 650 | 4 | |a Animal cell biotechnology | |
| 650 | 4 | |a Biocompatible Materials | |
| 650 | 4 | |a Biomedical Engineering | |
| 650 | 4 | |a Cell Transplantation | |
| 650 | 4 | |a Culture Techniques | |
| 650 | 4 | |a Tissue Transplantation | |
| 650 | 4 | |a Tissue engineering | |
| 650 | 4 | |a Transplantation of organs, tissues, etc | |
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| 650 | 0 | 7 | |a Transplantat |0 (DE-588)4185918-2 |2 gnd |9 rswk-swf |
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| 700 | 1 | |a Lanza, Robert P. |d 1956- |e Sonstige |0 (DE-588)136341640 |4 oth | |
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Datensatz im Suchindex
| DE-BY-TUM_call_number | 0702/MED 379f 2001 B 12(2) |
|---|---|
| DE-BY-TUM_katkey | 1203614 |
| DE-BY-TUM_media_number | 040070810447 |
| _version_ | 1816712087231004672 |
| adam_text | I CONTENTS =——=
Contributors xxi
Foreword xxix
Preface to the Second Edition xxxi
Preface to the First Edition xxxiii
Tissue Engineering in Perspective xxxv
Eugene Bell
Origins of Tissue Engineering xxxv
The Tissue Engineering Triad xxxv
What Parts of the Body Can Tissue Engineering Replace? xxxvi
Acellular Prostheses xxxvii
The Relevance of Developmental Biology xxxvii
Can Nature Be Imitated? xxxviii
The Need for Vascularization in Vitro and in Vivo xxxix
Stem Cells xxxix
Cell Signaling xxxix
Looking Forward xl
References xl
Introduction to Tissue Engineering 1
1. The History and Scope of Tissue Engineering 3
Joseph P. Vacanti and Charles A. Vacanti
Introduction 3
Scientific Challenges 4
General Scientific Issues 6
Social Challenges 6
References 7
2. The Challenge of Imitating Nature 9
Robert M. Nerem
Introduction 9
Cell Technology 10
Construct Technology 12
Integration into the Living System 13
Concluding Discussion 14
References 15
Part I. The Basis of Growth and Differentiation 17
3. Organization of Cells into Higher Ordered Structures 19
Carol A. Erickson
Introduction 19
Cellular Changes Involved in the EMT 20
Stimuli of the Transformation 24
Conclusion 26
References 27
4. Dynamics of Cell ECM Interactions 33
Manuela Martins Green
Introduction 33
Composition and Diversity of the ECM 34
Receptors for Extracellular Matrix Molecules 34
Cell ECM Interactions 36
Signal Transduction Events during Cell—ECM Interactions 42
Relevance for Tissue Engineering 46
References 48
5. Matrix Molecules and Their Ligands 57
Bjb rn Reino Olsen
Introduction 57
Fibrillar Collagens: Major Scaffold Proteins in the ECM 58
Elastic Fibers and Microfibrils 63
Fibronectin: A Multidomain, Multifunctional Adhesive
ECM Glycoprotein 63
Laminins: Large, Adhesive Basement Membrane Molecules 64
Modulators of Cell—Matrix Interactions 66
Proteoglycans: Multifunctional ECM and Cell Surface Molecules...67
Summary 68
References 68
6. Inductive Phenomena 73
Matthias Hebrok and Douglas A. Melton
Introduction 73
Epithelial to Mesenchymal Signaling in Endoderm Development...73
Lung Development and Instructive Signaling 73
Permissive Signaling during Pancreas Development 75
References 78
7. Morphogenesis and Tissue Engineering 81
A. H. Reddi
Introduction 81
Bone Morphogenetic Proteins 82
Cartilage Derived Morphogenetic Proteins 84
Pleitropy and Thresholds 85
BMPs Bind to Extracellular Matrix 85
BMPs: Actions Beyond Bone 85
BMP Receptors 85
Responding Stem Cells 86
Morphogens and Gene Therapy 87
Biomimetic Biomaterials 87
Tissue Engineering of Bones and Joints 88
Future Challenges 88
References 89
8. Cell Determination and Differentiation 93
Leon W. Browder
Introduction 93
Roles of MRFs during Embryogenesis 94
Initiation of Skeletal Muscle Development 95
References 96
Part II: In Vitro Control of Tissue Development 99
9. Mechanical and Chemical Determinants
of Tissue Development 101
Donald E. Ingber
Introduction 101
Extracellular Matrix Structure and Function 101
Pattern Formation through ECM Remodeling 104
Mechanochemical Switching between Growth
and Differentiation 105
Summary 107
References 108
10. Animal Cell Culture Ill
Gordon H. Sato and David W. Barnes
References 116
11. Regulation of Cell Behavior by Matricellular Proteins 119
Amy D. Bradshaw and E. Helene Sage
Introduction 119
Matricellular Proteins 119
Conclusions 124
References 125
12. Growth Factors 129
Thomas F Deuel and Nan Zhang
Introduction 129
Wound Healing 130
Role of Basic Fibroblast Growth Factor
and Angiogenesis 136
Other Roles of Growth Factors and Cytokines 137
Conclusions 137
References 137
13. Tissue Engineering Bioreactors 143
Lisa E. Freed and Gordana Vunjak Novakovic
Introduction 143
Cell Polymer Constructs 143
Bioreactor Technologies 144
Bioreactor Modulation of Tissue Formation 147
Bioreactor Cultivation of Functional Tissues 151
Tissue Engineering Bioreactors: State of the Art 152
Summary and Research Needs 154
References 154
14. Tissue Assembly in Microgravity 157
Brian R. Unsworth and Peter I. Lelkes
Introduction 157
Microgravity as a Novel Tissue Culture Venue 158
Vascularization: Overcoming Size Limitations
of Tissue Assemblies 159
From Single Cells to Tissues in Space 159
In Vitro Embryology 160
Gravitational Sensing 161
Caveats 161
Conclusions 162
References 162
Part III: In Vivo Synthesis of Tissues and Organs 165
15. In Vivo Synthesis of Tissues and Organs 167
Ioannis V. Yannas
Scale of Functional Deficit: Macromolecule versus Organ 167
Basic Parameters of the Living Environment during in Vivo
Organ Synthesis 168
Fundamental Design Principles for Tissue and Organ
Regeneration Templates 170
Examples of in Vivo Organ Synthesis 174
Summary 177
References 177
Part IV. Models for Tissue Engineering 179
16. Organotypic and Histiotypic Models of Engineered Tissues 181
Eugene Bell
Introduction 181
The Collagen Gel Model 181
Models of Cell Interactions in Collagen Lattices 182
Other Types of Epithelial Mesenchymal Models 184
Vascular Models 186
Selection of Scaffolds Other Than Gels for Model Systems 188
Cell Signaling and the Enrichment of Scaffolds 189
Goals and Uses of Model Tissue and Organ Building 190
References 191
17. Quantitative Aspects of Tissue Engineering: Basic Issues
in Kinetics, Transport, and Mechanics 195
AlanJ. Grodzinsky, Roger D. Kamm,
and Douglas A. Lauffenburger
Introduction 195
Molecular Interactions with Cells 196
Molecular and Cell Transport through Tissue 198
Cell and Tissue Mechanics 201
References 205
Part V. Biomaterials in Tissue Engineering 207
18. Patterning of Cells and Their Environment 209
Shuichi Takayama, Robert G. Chapman, Ravi S. Kane,
and George M. Whitesides
Introduction 209
Soft Lithography 209
Self Assembled Monolayers 210
Microcontact Printing 212
Microfluidic Patterning 214
Laminar Flow Patterning 216
Conclusion and Future Prospects 217
References 218
19. Cell Interactions with Polymers 221
W. Mark Saltzman
Introduction 221
Methods for Characterizing Cell Interactions with Polymers 221
Cell Interaction with Polymer Surfaces 224
Cell Interactions with Polymers in Suspension 229
Cell Interactions with Three Dimensional Polymer Scaffolds
and Gels 230
References 231
20. Matrix Effects 237
Jeffrey A Hubbell
Introduction 237
Extracellular Matrix Proteins and Their Receptors 237
Model Systems for Study of Matrix Interactions 242
Cell Pattern Formation by Substrate Patterning 244
Signal Transduction and Functional Regulation via
the Extracellular Matrix 244
Translation to Working Biomaterial Systems 246
References 246
21. Polymer Scaffold Processing 251
Robert C. Thomson, Albert K. Shung, Michael J. Yaszemski,
andAntonios G. Mikos
Introduction 251
Fiber Bonding 252
Solvent Casting and Paniculate Leaching 253
Membrane Lamination 255
Melt Molding 256
Extrusion 256
Three Dimensional Printing 257
Gas Foaming 257
Freeze Drying 258
Phase Separation 258
Polymer/Ceramic Composite Foams 259
In Situ Polymerization 260
Conclusions 261
References 261
22. Biodegradable Polymers 263
James M. Pachence and Joachim Kohn
Introduction 263
Biodegradable Polymer Selection Criteria 263
Biologically Derived Bioresorbables 264
Experimental Biologically Derived Bioresorbables 266
Creating Materials for Tissue Engineered Products 273
Conclusion 274
References 274
Part VI. Transplantation of Engineered Cells and Tissues 279
23. Approaches to Transplanting Engineered Cells and Tissues 281
Janet Hardin Young, Jeffrey Teumer, RobertN. Ross,
and Nancy L. Parenteau
Introduction 281
Developing Workable Strategies 281
Mode of Action—An Important Design Consideration 283
Role of the Host 284
Source of Cells 285
The Immunology of Nonautologous Cells 287
Safety Considerations 288
Conclusion 288
References 289
24. Cryopreservation 293
Jens O. M. Karlsson and Mehmet Toner
Introduction 293
Applications of Cryopreservation Technology
in Tissue Engineering 293
Challenges in Cryopreservation Protocol Development 294
Cryobiology of Cells 295
Cryobiology of Tissue 302
Summary and Future Directions 304
References 305
25. Immunomodulation 309
Denise Faustman
Introduction 309
Origin of the Designer Tissue Concept 310
Expansion of Research on Designer Tissues 311
Mechanisms of Graft Survival after Class I Donor Ablation
or Antibody Masking 314
The Launching of Xenogeneic Human Clinical Trials in
the United States Using Immunomodulation 316
Gene Addition 317
RNA Ablation 317
Comment 318
References 318
26. Immunoisolation 321
Beth A. Zielinski and Michael J. Lysaght
Introduction 321
Technology 321
Clinical 323
Future Directions 326
References 328
27. Engineering Challenges in Immunoisolation
Device Development 331
Efitathios S. Avgoustiniatos, Haiyan Wu, and Clark K. Colton
Introduction 331
Engineering Challenges 331
Oxygen Supply Limitations 336
Theoretical Analysis of in Situ Oxygen Generation 339
Calculations 345
Concluding Remarks 348
References 348
Part VII. Fetal Tissue Engineering 35I
28. Fetal Tissue Engineering 353
Dario O. Fauza
Introduction 353
General Characteristics of Fetal Cells 354
The Fetus as a Transplantation Host 355
Fetal Tissue Engineering 357
Ethical Considerations 360
Future Perspectives 363
References 364
29. Pluripotent Stem Cells 369
Michael J. Shamblott, Brian E. Edwards, and John D. Gearhart
Introduction 369
Differentiation in Vitro 371
Examples of in Vitro Differentiation and Markers 374
In Vivo Applications 376
Summary and Future Prospects 378
References 378
Part VIII. Gene Therapy 383
30. Gene Based Therapeutics 385
Lee G. Fradkin, J. Dezz Ropp, and John E Warner
Introduction 385
Gene Delivery 386
Persistent Gene Expression 390
Safety Considerations for Gene Based Therapeutics 394
Large Scale Production Issues 396
Conclusion 397
References 397
Part IX. Breast 407
31. Breast Reconstruction 409
Kuen Yong Lee, Craig R. Halberstadt, Walter D. Holder,
and David J. Mooney
Introduction 409
Cell Types for Soft Tissue Engineering 410
Materials 412
Animal Models • 417
Strategies to Enhance the Vascularization of Engineered Tissue 419
Concluding Remarks 420
References 420
Part X. Cardiovascular System 425
32. Bloodvessels 427
Lian Xue and Howard P. Greisler
Introduction 427
Graft Healing 428
Strategies for the Development of Vascular Grafts 432
References 441
33. Small Diameter Vascular Grafts 447
Susan J. Sullivan and Kelvin G. M. Brockbank
Introduction 447
Synthetic Grafts 448
In Vitro Blood Vessel Tissue Engineering 448
In VwoTissue Engineering of Blood Vessels 449
Summary 453
References 453
34. Cardiac Prostheses 455
Jack W. Love
Introduction 455
A Short History of Tissue Heart Valves 456
The Status of Tissue Valves in 1999 459
The Issue of Whether to Use a Stent 461
The Issue of Repair versus Replacement 463
Speculation about the Future 463
Recent Developments 464
The Ideal Valve Repair or Replacement 465
References 466
Part XI. Cornea 469
35. Cornea 471
Vickery Trinkaus Randall
Introduction 471
Biology of the Cornea 473
Criteria for Keratoprostheses 477
Development of the Keratoprosthesis 478
Evaluation of Intact Devices 484
Other Devices Used to Change the Curvature of the Cornea 489
References 489
Part XII. Endocrinology and Metabolism 493
36. Bioartificial Pancreas 495
Taylor G. Wang and Robert P. Lanza
Introduction 495
Theoretical Background 497
Experiment 500
Capsule Development 501
Discussion 504
References 505
37. Parathyroid 509
C. Hasse, A. Zielke, T. Bohrer, U. Zimmermann, andM. Rothmund
History of Parathyroid Allotransplantation 509
Hypoparathyroidism 511
Microencapsulation 517
Alginates 517
Experimental and Clinical Transplantation of
Microencapsulated Parathyroid Tissue 518
Alternative Approaches and Perspectives 518
References 519
Part XIII. Gastrointestinal System 523
38. Alimentary Tract 525
Gregory M. Organ and Joseph P. Vacanti
Introduction 525
Enterocyte Isolation 528
Procedural Steps 530
Discussion 532
References 537
39. Liver 541
Hugo O. Jauregui
Introduction 541
Anatomy and Function of the Liver 541
Liver Failure: Pathophysiological Classification 544
Mechanisms of HE in Liver Failure 545
Medical Need for Liver Assist Devices 545
Biological Component of Liver Assist Devices 546
Liver Assist Device Configurations 548
References 550
40. HepatAssist Liver Support System 553
Claudy Mullon and Barry A. Solomon
Introduction 553
HepatAssist System 553
Cell Preparation 553
Clinical Study 554
Conclusion 557
References 557
41. Lineage Biology and Liver 559
Arron S. L. Xu, Thomas L. Luntz, Jeffrey M. Macdonald,
Hiroshi Kubota, Edward Hsu, Robert E. London,
and Lola M. Reid
Introduction 559
Liver Organization and Development 560
Identification, Isolation, and Sourcing of Cells
for Tissue Engineering 562
Sourcing of Human Cells for Tissue Engineering 569
Microenvironment 570
Biodegradable Polymers 576
Designing Bioreactors for Tissue Engineering 583
Technical Aspects of Tissue Engineering 585
Future Considerations 587
Summary 588
References 589
Part XIV. Hematopoietic System 599
42. Red Blood Cell Substitutes 601
Thomas Ming Swi Chang
Introduction 601
Why Do We Have to Modify Hemoglobin? 601
Sources of Hemoglobin 605
Circulating Time of Modified Hemoglobin 606
Safety of Modified Hemoglobin Blood Substitute 606
Efficacy of Modified Hemoglobin Blood Substitute 607
Present Status and Future Research and Development 607
References 608
43. Lymphoid Cells 611
Una Chen
Introduction 611
Lymphocyte Engineering: Reality and Potential 612
Concluding Remarks and Prospects
for Lymphocyte Engineering 625
References 626
44. Hematopoietic Stem Cells 631
Anne Kessinger and Graham Sharp
Introduction 631
Overview of Hematopoiesis: Properties and Regulation of
Hematopoietic Stem Cells Relevant to Tissue Engineering 632
Organization of the Stem Cell Compartment 633
Stromal Microenvironments 633
References 638
Part XV. Kidney and Genitourinary System 643
45. Renal Replacement Devices 645
H. David Humes
Introduction 645
Basics of Kidney Function 645
Tissue Engineering Approach to Renal Function Replacement GAG
Summary 652
References 652
46. Genitourinary System 655
Byung Soo Kim, David J. Mooney, and Anthony Atala
Introduction 655
Tissue Engineering Strategies in the Genitourinary System 655
Engineering Genitourinary Tissues 656
Future Directions 664
References 664
Part XVI. Musculoskeletal System 669
47. Structural Tissue Engineering 671
Charles A. Vacanti, Lawrence J. Bonassar, and Joseph P. Vacanti
Introduction 671
Materials Development 672
Structural Tissues 674
Biomechanics 679
Conclusion 680
References 680
48. Bone Regeneration through Cellular Engineering 683
Scott P. Bruder and Arnold I. Caplan
Introduction 683
Marrow: The Source of Mesenchymal Progenitor Cells 683
Delivery of Osteoprogenitor Cells 687
Bone Regeneration by MSCs 689
MSCs and Gene Therapy 692
Prevention of Age Related Bone Loss 693
Conclusion 694
References 694
49. Articular Cartilage Injury 697
John M. McPherson and Ross Tubo
Introduction 697
Autologous Chondrocyte Transplantation 699
Commercialization of Autologous Chondrocyte Implantation 701
Alternative Strategies for the Delivery of Cell Based Therapies
for Cartilage Repair 706
Conclusions 707
References 708
50. Tendons and Ligaments 711
Francine Goulet, Denis Rancourt, Rejean Cloutier, Lucie Germain,
A. Robin Poole, and Frangois A. Auger
Introduction 711
The Need for Bioengineered Tendon and Ligament Substitutes ....711
Histologic Description of Tendons and Ligaments 712
Production of Bioengineered Tendons and Ligaments 713
A New Living Bioengineered Ligament Model 713
Technical Steps to Produce and Analyze Our bACL 715
Conclusions 718
Perspectives in Tendon and Ligament Bioengineering 719
References 720
51. Mechanosensory Mechanisms in Bone 723
Stephen C. Cowin and Melvin L. Moss
Introduction 723
The Connected Cellular Network 724
Mechanosensation on the CCN 725
Questions for Future Research; Socratic Questions 731
References 732
52. Myoblast Therapy 739
Joanne C. Cousins, Jennifer E. Morgan, and Terence A. Partridge
Introduction 739
Myoblast Mediated Gene Transfer 739
Therapeutic Myoblast Transplantation for Myopathies 740
References 745
Part XVII. Nervous System 749
53. Protection and Repair of Hearing 751
Richard A. Altschuler, Yehoash Raphael, Jochen Schacht,
David J. Anderson, and JosefM. Miller
Introduction 751
Basis for Interventions 751
Methods of Intervention 755
Conclusions 757
References 757
54. Vision Enhancement Systems 761
Gislin Dagnelie, Mark S. Humayun, and Robert W. Massof
Visual System: Architecture and (Dys)Function 761
Possible Approaches to Vision Restoration 763
Current Approaches 763
Applications of Engineered Cells and Tissues: Challenges
and Tentative Solutions 768
Toward 2020 Vision 770
References 770
55. Brain Implants 773
Lars U. Wahlberg
Introduction 773
Naked Cell Implants 773
Encapsulated Cell Implants 777
Controlled Release Implants 777
Axonal Guidance Implants 778
Disease Targets 778
Surgical Considerations 780
Conclusions 780
References 780
56. Nerve Regeneration 785
Eric G Fine, Robert E Valentini, and Patrick Aebischer
Nerve Regeneration and Neural Tissue Engineering 785
Overview of Neural Regeneration 786
Experimental Use of Guidance Channels 788
Biomaterial Based Approaches to Nerve Repair 790
Tissue Engineering Approaches to Nerve Repair 794
Specificity of Nerve Reconnections 796
Summary 796
References 796
57. Transplantation Strategies for Treatment of Spinal Cord
Dysfunction and Injury 799
Jacqueline Sagen, Mary Bartlett Bunge, and Naomi Kleitman
Introduction 799
Spinal Implants as Axon Bridges 799
Spinal Implants for Replacement of Specific Cell Populations 805
Spinal Implants for Provision of Neurotransmitters 808
References 813
58. Neural Stem Cells 821
Martin P. Vacanti
Introduction 821
Background 821
Neural Stem Cell Applications in Tissue Engineering 824
Summary 828
References 828
Part XVIII. Periodontal and Dental Applications 831
59. Periodontal Applications 833
NealA. Miller, Marie C. Bene, Jacques Penaud, PascalAmbrosini,
and Gilbert C. Faure
Introduction 833
Guided Tissue Regeneration 834
Bone Substitutes 836
Dental Implants 838
Growth Factors and Plasma Proteins 839
Cell Culture Techniques 843
Conclusion 843
References 843
60. Regeneration of Dentin 847
R. Bruce Rutherford
Introduction 847
Dentin 847
Bone Morphogenetic Proteins 847
Induction Potential of Dentin 848
Recombinant Human BMPs Induce Dentin Formation 848
Delivery Systems 850
Clinical Considerations 850
Additional Considerations 851
Potential Applications of BMP Induced Dentinogenesis 851
References 852
Part XIX. Skin 855
61. Wound Repair: Basic Biology to Tissue Engineering 857
Richard A. F. Clark and Adam J. Singer
Introduction 857
Inflammation 858
Epithelialization 858
Granulation Tissue 862
Wound Contraction and Extracellular Matrix
Reorganization 868
References 870
62. Skin 879
Nancy L. Parenteau, Janet Hardin Young, andRobertN. Ross
Introduction 879
Skin Structure and Function 880
Engineering Skin Tissue 883
Epidermal Regeneration 884
Dermal Replacement 884
Composite Skin Grafts 885
Conclusion 887
References 887
63. Dermal Equivalents 891
Gail K. Naughton
Introduction 891
Cell Testing and Establishment of Manufacturing
Cell Banks 891
Manufacturing a Dermal Replacement 891
Clinical Results ofWound Healing 900
Summary 901
References 901
Part XX. Womb 903
64. Artificial Womb 905
Christopher S. Muratore and Jay M. Wilson
What Does the Field of Tissue Engineering Have to Offer
the Premature Infant? 906
Prematurity—The Consequences 906
The Ideal Artificial Womb 907
State of the Art Artificial Placenta Design 909
Organ Maturation during Maintenance with Artificial Womb 911
Variations of Artificial Womb Technology 911
Conclusion 912
References 912
Part XXI. Regulatory Issues 913
65. Regulatory Considerations 915
Kiki B. Hellman, Ruth R. Solomon, Claudia Gaffey,
Charles N. Durfor, and John G. Bishop
Introduction 915
Legislative Authority/Oversight 916
Product Evaluation and the Regulatory Process 917
Recent Developments in Product Evaluation 922
Interaction between FDA Headquarters and Field Offices 925
Development of Standards 925
Communications with Industry 926
The FDA and Future Perspectives for Tissue Engineered
Medical Products 927
References 927
Epilogue 929
Index 931
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| edition | 2. ed. |
| format | Book |
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| id | DE-604.BV013277447 |
| illustrated | Illustrated |
| indexdate | 2024-11-25T17:19:56Z |
| institution | BVB |
| isbn | 0124366309 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009052290 |
| oclc_num | 44120690 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-91G DE-BY-TUM DE-703 DE-526 DE-634 |
| owner_facet | DE-355 DE-BY-UBR DE-91G DE-BY-TUM DE-703 DE-526 DE-634 |
| physical | XLI, 995 S. Ill., graph. Darst. |
| publishDate | 2000 |
| publishDateSearch | 2000 |
| publishDateSort | 2000 |
| publisher | Academic Press |
| record_format | marc |
| spellingShingle | Principles of tissue engineering Cellules - Biotechnologie Greffe (Chirurgie) Tissus (Histologie) - Culture Tissus (histologie) ram Animal cell biotechnology Biocompatible Materials Biomedical Engineering Cell Transplantation Culture Techniques Tissue Transplantation Tissue engineering Transplantation of organs, tissues, etc Implantat (DE-588)4026658-8 gnd Transplantat (DE-588)4185918-2 gnd Tissue Engineering (DE-588)4646061-5 gnd Gewebekultur (DE-588)4157245-2 gnd |
| subject_GND | (DE-588)4026658-8 (DE-588)4185918-2 (DE-588)4646061-5 (DE-588)4157245-2 |
| title | Principles of tissue engineering |
| title_auth | Principles of tissue engineering |
| title_exact_search | Principles of tissue engineering |
| title_full | Principles of tissue engineering ed. by Robert P. Lanza ... |
| title_fullStr | Principles of tissue engineering ed. by Robert P. Lanza ... |
| title_full_unstemmed | Principles of tissue engineering ed. by Robert P. Lanza ... |
| title_short | Principles of tissue engineering |
| title_sort | principles of tissue engineering |
| topic | Cellules - Biotechnologie Greffe (Chirurgie) Tissus (Histologie) - Culture Tissus (histologie) ram Animal cell biotechnology Biocompatible Materials Biomedical Engineering Cell Transplantation Culture Techniques Tissue Transplantation Tissue engineering Transplantation of organs, tissues, etc Implantat (DE-588)4026658-8 gnd Transplantat (DE-588)4185918-2 gnd Tissue Engineering (DE-588)4646061-5 gnd Gewebekultur (DE-588)4157245-2 gnd |
| topic_facet | Cellules - Biotechnologie Greffe (Chirurgie) Tissus (Histologie) - Culture Tissus (histologie) Animal cell biotechnology Biocompatible Materials Biomedical Engineering Cell Transplantation Culture Techniques Tissue Transplantation Tissue engineering Transplantation of organs, tissues, etc Implantat Transplantat Tissue Engineering Gewebekultur |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009052290&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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