De la cellule au cerveau le cytosquelette, communication intra-et-inter-celluaire, le système nerveux central ; LesHouches, session LXV, 8 juillet - 26 juillet 1996 = From cell to brain
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| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier
1998
|
| Ausgabe: | 1. ed. |
| Schriftenreihe: | Ecole d'Eté de Physique Théorique: Session
65 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
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MARC
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| 245 | 1 | 0 | |a De la cellule au cerveau |b le cytosquelette, communication intra-et-inter-celluaire, le système nerveux central ; LesHouches, session LXV, 8 juillet - 26 juillet 1996 = From cell to brain |c UJFG ... Ed. par G. Zaccai ... |
| 246 | 1 | 1 | |a From cell to brain |
| 250 | |a 1. ed. | ||
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier |c 1998 | |
| 300 | |a XXXIV, 264 S. |b Ill., graph. Darst. | ||
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Datensatz im Suchindex
| _version_ | 1819581639510982656 |
|---|---|
| adam_text | CONTENTS
Lecturers ix
Seminar Speakers xi
Participants xiii
Preface (French) xvii
Preface (English) xxiii
SECTION I. CYTOSKELETON AND CELL CYCLE
Course 1. Microtubule Dynamics in vitro and their
Relationship with Cellular Function, by D. Job 3
1. Introduction 7
2. Basic microtubule dynamics 8
2.1. Tubulin and microtubules 8
2.2. Steady state microtubules 9
3. Microtubules and the generation of movement: the polymer biased diffusion model 10
3.1. Anaphase chromosome movement 10
3.2. Biased diffusion in the real world 12
4. Microtubules and self organization 12
4.1. Self organization of rapidly growing microtubules: a diffusion based model 12
4.2. Microtubule oscillations 14
4.3. Pattern formation in microtubular solutions 15
5. Conclusion 17
References 18
Course 2. Structure and Function of Two Molecular
Motors and their Pathways, by R.H. Wade 19
1. Introduction 23
2. General properties of muscle and its proteins 24
xxix
Contents
2.1. Actin 24
2.2. Myosin 25
3. Microtubule structure and organisation 27
3.1. Tubulin 27
3.2. Microtubule structure 28
4. The kinesin family of motor proteins 30
5. Structure of actin 30
6. The structure of myosin and kinesin 32
6.1. Low resolution structures 32
6.2. Structure of myosin 32
6.3. Structure of kinesin 33
7. Structure of microtubule kinesin and actin myosin complexes 36
8. Assaying molecular movement and forces 37
9. How do motor molecules move? 41
References 43
Course 3. The Cellular Machinery for Chromosome
Movement, by J.R. Mclntosh 47
1. Background ideas and facts 51
2. The events of mitosis 53
2.1. Chromosomes become attached to cytoplasmic microtubules 53
2.2. Chromosomes become arranged so that each chromatid is attached to one centrosome 58
2.3. Chromosomes become arranged at the equator of the spindle 60
2.4. Each chromosome separates into two identical parts and these move apart 61
3. The mechanisms for chromosome movement 63
3.1. Motor enzymes, as well as microtubules, are important for chromosome movement 63
3.2. Spindle motor enzymes can transduce the energy in assembled MTs into
mechanical work to move chromosomes 67
4. Summary and conclusion 68
References 69
Course 4. The Role of Microtubules in the Creation of
Order in the Cell, by R.L. Margolis 71
1. The cytoskeleton and its dynamics 75
2. Origins of microtubule cytoskeletal organization 78
2.1. Centrosomes/centrioles/basal bodies 78
2.1.1. The centrosome and microtubule dynamics 78
2.1.2. The centriole basal body 80
2.1.3. The centrosome constituents and their function in microtubule organization 81
2.2. Centromeres 83
2.2.1. Microtubule dynamics and the centromere 83
2.2.2. Composition of the centromere 84
2.3. Independent and highly ordered microtubule arrays 86
XXX
Contents
2.4. Microtubule based communication and ordering of cell space 87
References 89
SECTION II. INTRACELLULAR COMMUNICATION
Membranes Synapses Time
Course 5. Intracellular Membrane Traffic,
by M. McCaffrey and B. Goud 95
1. Introduction 99
2. Coated vesicles 99
2.1. Clathrin coated vesicles 100
2.2. COP vesicles 101
3. The SNARE hypothesis 102
4. The Rab family of GTPases 103
5. Conclusion 103
References 104
Course 6. I: Signaling in Sensory Cells
II: Molecular Structure and Function of Ion
Channels, by U.B. Kaupp 105
1. Signaling in sensory cells 109
References 113
2. Molecular structure and function of ion channels 113
References 115
Course 7. Theoretical Models for Oscillations in
Biochemical and Cellular Systems,
by A. Goldbeter 117
1. Introduction 121
2. Rhythmic phenomena in biological systems 121
3. Cellular regulation and oscillatory behavior 123
3.1. Enzymatic regulation: glycolytic oscillations 123
3.2. Receptor regulation: oscillations of cyclic AMP in Dictyostelium amoebae 125
3.3. Transport regulation: oscillations of intracellular calcium 127
3.4. Genetic regulation: circadian rhythms in Dmsophila 128
4. Conclusions 129
References 130
xxxi
Contents
SECTION III. DEVELOPMENT OF THE CENTRAL
NERVOUS SYSTEM
Course 8. An Overview of Nervous System Development,
by O. Pourquie and F. Bourrat 135
1. Neurogenesis and neural differentiation 139
1.1. Cell production and cell differentiation in the nervous system 139
1.2. The proliferative zones: the ventricular neuroepithelia 139
1.2.1. The tritiated thymidine method 139
1.2.2. Pattern of neuron production 141
1.2.3. Neuronal birthdates 141
1.3. Cell lineage in the CNS 141
1.3.1. The general problem of cell lineage 141
1.3.2. Cell lineage in Caenorhabditis elegans 142
1.3.3. Cell lineage studied by injection of intracellular tracers 143
1.3.4. Cell lineage studied with engineered retroviruses 144
1.3.5. Other techniques for the study of cell lineage in the CNS 145
1.4. Neuronal differentiation 145
1.4.1. Neuronal phenotype 145
1.4.2. Factors determining neuronal phenotypes 145
1.5. Conclusion 147
2. Neuronal migration and axon growth 147
2.1. Neuronal migration 148
2.1.1. The two main types of neuronal organisation in the vertebrate CNS 148
2.1.2. Radial migration and morphogenesis of cortical structures 148
2.1.3. Other patterns of neuronal migration 151
2.2. Axonal migration 152
2.2.1. The growth cone, motor of axonal elongation 152
2.2.2. Mechanisms of neuritic elongation 154
2.3. Conclusion 156
References 156
Course 9. G protein Coupled Receptors: Themes and
Variations on Membrane Transmission of
Extracellular Signals, by P. Vernier 159
1. Receptors are essential cell components 163
2. The mechanisms of signal transduction by G protein coupled receptors 165
2.1. The activated receptors catalyze the G protein cycle 167
2.2. Structure activity relationships in receptor G protein coupling 169
3. How cells modulate signal transmission by G protein coupled receptors: from
biosynthesis to regulation at the plasma membrane 175
3.1. Desensitization and down regulation of G protein coupled receptors and G proteins 175
3.2. The biosynthesis and intracellular transport of G protein coupled receptors 179
xxxii
Contents
4. The molecular diversity of transmission modules at the plasma membrane 182
5. The generation of receptor multiplicity in vertebrates: an evolutionary approach 185
5.1. Generalities about molecular evolution 186
5.2. The evolution of bioamine receptors in vertebrates 187
References 190
SECTION IV. Lectures and Seminars Presented at
the Summer School but not Published in the Proceedings
Course Summary 1. The Endomembrane System,
by D.D. Sabatini 195
1. Annotated bibliography of the course 199
Course Summary 2. The History of the Two stage Model
for Membrane Protein Folding,
by D.M. Engelman 201
1. Annotated bibliography relating to the course 205
2. Conclusion 208
Course Summary 3. Post Synaptic Receptors and the
Organisation of the Synapse, by R. Kelly 211
1. Bibliography relating to the course 215
1.1. Quantal release 215
1.2. The SNARE hypothesis 215
1.3. Calcium regulation 216
1.4. Synaptic regulation 216
1.5. Synaptic vesicle biogenesis 217
1.6. Secretory granule biogenesis 217
1.7. Synapse adhesion 218
Student Seminar 1. Inhibition as Binding Controller at the
Level of a Single Neuron (Information
Processing in a Pyramidal type Neuron),
byA.K. Vidybida 219
1. Introduction 223
xxxiii
Contents
2. Methods 223
3. Results 223
4. Conclusions and discussion 224
References 225
Student Seminar 2. Isolated Nerve Cell Response to Laser
Irradiation and Photodynamic Effect,
byA.B. Uzdensky 227
1. Introduction 231
2. Object and methods 231
3. Single neuron response to blue laser microirradiation 232
4. Neurophysiological conclusion 238
5. Possible application of stretch receptor neuron for PDT photosensitizers testing 239
References 240
Short Reports on Ph.D. Student Seminars 243
1. Structure and hydration of bacteriorhodopsin in its M state studied by neutron diffraction 247
2. Membranes, vesicles and micelles a density functional approach 247
3. Elastic properties of the Listeria Moncytogenes tail 248
4. Introduction to indirect detected I3C NMR imaging and spectroscopy 248
5. Crystallographic studies of the small ribosomal 30S subunit from Thermus
thermophilus and bovine pancreatic trypsin contrast variation and phasing with
anomalous dispersion of phosphorus and sulfur 249
SECTION V. CONCLUSION
Relations between Physics and Biology,
by B. Jacrot 253
1. Relations between physics and biology 257
References 264
xxxiv
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| genre | (DE-588)1071861417 Konferenzschrift 1996 Les Houches gnd-content |
| genre_facet | Konferenzschrift 1996 Les Houches |
| id | DE-604.BV012627036 |
| illustrated | Illustrated |
| indexdate | 2024-12-23T15:07:41Z |
| institution | BVB |
| isbn | 0444500863 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008577914 |
| oclc_num | 237338410 |
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| owner | DE-12 DE-355 DE-BY-UBR |
| owner_facet | DE-12 DE-355 DE-BY-UBR |
| physical | XXXIV, 264 S. Ill., graph. Darst. |
| publishDate | 1998 |
| publishDateSearch | 1998 |
| publishDateSort | 1998 |
| publisher | Elsevier |
| record_format | marc |
| series | Ecole d'Eté de Physique Théorique: Session |
| series2 | Ecole d'Eté de Physique Théorique: Session |
| spellingShingle | De la cellule au cerveau le cytosquelette, communication intra-et-inter-celluaire, le système nerveux central ; LesHouches, session LXV, 8 juillet - 26 juillet 1996 = From cell to brain Ecole d'Eté de Physique Théorique: Session Zellskelett (DE-588)4121944-2 gnd Nervenzelle (DE-588)4041649-5 gnd Zentralnervensystem (DE-588)4067637-7 gnd Zellkommunikation (DE-588)4136131-3 gnd |
| subject_GND | (DE-588)4121944-2 (DE-588)4041649-5 (DE-588)4067637-7 (DE-588)4136131-3 (DE-588)1071861417 |
| title | De la cellule au cerveau le cytosquelette, communication intra-et-inter-celluaire, le système nerveux central ; LesHouches, session LXV, 8 juillet - 26 juillet 1996 = From cell to brain |
| title_alt | From cell to brain |
| title_auth | De la cellule au cerveau le cytosquelette, communication intra-et-inter-celluaire, le système nerveux central ; LesHouches, session LXV, 8 juillet - 26 juillet 1996 = From cell to brain |
| title_exact_search | De la cellule au cerveau le cytosquelette, communication intra-et-inter-celluaire, le système nerveux central ; LesHouches, session LXV, 8 juillet - 26 juillet 1996 = From cell to brain |
| title_full | De la cellule au cerveau le cytosquelette, communication intra-et-inter-celluaire, le système nerveux central ; LesHouches, session LXV, 8 juillet - 26 juillet 1996 = From cell to brain UJFG ... Ed. par G. Zaccai ... |
| title_fullStr | De la cellule au cerveau le cytosquelette, communication intra-et-inter-celluaire, le système nerveux central ; LesHouches, session LXV, 8 juillet - 26 juillet 1996 = From cell to brain UJFG ... Ed. par G. Zaccai ... |
| title_full_unstemmed | De la cellule au cerveau le cytosquelette, communication intra-et-inter-celluaire, le système nerveux central ; LesHouches, session LXV, 8 juillet - 26 juillet 1996 = From cell to brain UJFG ... Ed. par G. Zaccai ... |
| title_short | De la cellule au cerveau |
| title_sort | de la cellule au cerveau le cytosquelette communication intra et inter celluaire le systeme nerveux central leshouches session lxv 8 juillet 26 juillet 1996 from cell to brain |
| title_sub | le cytosquelette, communication intra-et-inter-celluaire, le système nerveux central ; LesHouches, session LXV, 8 juillet - 26 juillet 1996 = From cell to brain |
| topic | Zellskelett (DE-588)4121944-2 gnd Nervenzelle (DE-588)4041649-5 gnd Zentralnervensystem (DE-588)4067637-7 gnd Zellkommunikation (DE-588)4136131-3 gnd |
| topic_facet | Zellskelett Nervenzelle Zentralnervensystem Zellkommunikation Konferenzschrift 1996 Les Houches |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008577914&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000022608 |
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