The touchstone of life molecular information, cell communication, and the foundations of life
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| 100 | 1 | |a Loewenstein, Werner Randolph |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a The touchstone of life |b molecular information, cell communication, and the foundations of life |c Werner R. Loewenstein |
| 264 | 1 | |a New York [u.a.] |b Oxford Univ. Press |c 1999 | |
| 300 | |a XVIII, 366 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 7 | |a Biologie |2 ram | |
| 650 | 7 | |a Cellules - Interaction |2 ram | |
| 650 | 4 | |a Cell Communication | |
| 650 | 4 | |a Cell interaction | |
| 650 | 4 | |a Cellular signal transduction | |
| 650 | 4 | |a Information Theory | |
| 650 | 4 | |a Information theory in biology | |
| 650 | 4 | |a Signal Transduction | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-008570481 | ||
Datensatz im Suchindex
| _version_ | 1804127271315832832 |
|---|---|
| adam_text | The Touchstone of Life
Molecular Information,
Cell Communication,
and the Foundations of Life
Werner R Loewenstein
New York Oxford Oxford University Press 1999
Contents
Acknowledgments xiii
Introduction xv
PART ONE INFORMATION AND THE ORIGINS OF LIFE 1
1 Information and Organisms 3
Maxwell s Demon 3
What Is Information? 6
The Information-Entropy Trade-Off 9
The Act of a Molecular Demon 12
How the Molecular Demons in Organisms
Gather Information 13
Organisms Are Densely Packed with Information 15
The Law that Rules It All 16
2 The Cosmic Origins of Information 19
The Bigger Picture of Organizations 19
The Universal Quartet of Forces and Its Soloist
in Molecular Organization 19
Origins 22
The Elusive Wellspring of Information 24
Debut of the Cosmic Quartet 25
3 The Growth of the Cosmic Inheritance on Earth 28
From Symmetric to Asymmetric Molecules 28
The Advantages of Molecular Complementarity 31
The Animated Moment: The Begetting of
Information Circularity 32
A Synoptic View of the Beginnings 33
The Lively Twig of the Cosmic Tree 34
The Missing Hand: A Phylogenetic Mystery 36
The Hobson s Choice of Molecular Evolution 39
Chance and Determinism 40
The Retreat of Scientific Determinism:
Deterministic Chaos 42
The Randomness that Contains Information 44
A Farewell to Arms 45
Molecular Organization from Chaos 45
viii Contents
The New Alchemy and the First Stirrings in the
Twiglet of the Cosmic Tree 48
A Question of Time 51
From Energy to Bonds to
Molecular Information:
The Information/Entropy Balancing Act 54
How to Pull die Information Rabbit from
the Cosmic Hat 54
A Simple Organic Genesis 55
The Energy for Organizing Molecules with
High-Information Content Must Be Supplied
in Small Doses 56
The Energy Flux Nursing Biomolecular Organization 57
Light into Bonds into Information 59
The Three-Dimensional Carriers
of Biological Information 61
Slam-Bang Is No Substitute for Information 61
The Molecular Jigs 62
Information Is Transferred from Molecule to
Molecule by Weak and Strong Electromagnetic
Interactions 65
Molecular Relays: The Foolproof Genies 67
The Molecular Machines for Coherent Transfer
of Information 70
The Proteus Stuff 71
Transmission of Information by Weak Forces
Hinges on Goodness of Molecular Fit 72
Weak Forces Are Good for Da Capos in Information
Transfer: The Useful Nook in Interacting
Atomic Fields 73
Why Proteins p o Not Run Out of Wit 74
The Recharging of the Protein Demons 77
The Limits of Biological Demons and Demon Watchers 78
The Growth of Biological Information 79
How Sloppy Demons Save Information 79
Chemical Performance Guides the Selection
of Molecular Complementarity in the Laboratory
of Evolution 80
An Evolutionary Hypothesis of Conservative Selection 81
An Evolutionary Thought Experiment 82
The Game of Chance and Savvy 88
The Why and Wherefore of the Conservative Selection 88
The Principle of Evolutionary Information Economy 89
Keeping Things in the Family of Adam and Eve
Has Its Advantages 92
Contents ix
The Vestiges of Ancient Information 93
The First Commandment of Evolution 94
Rolling Uphill 95
The Basic Loop 96
Why Mutations Don t Rub Off Folded Molecular
Structures 98
And Why They Rub Off Linear Structures 99
Mutatis Mutandis 101
Cybernetic Loops and the Mass Capture of Photon
Information 102
The Indispensable Insulator for Natural Selection 103
Natural Selection Is Not a Gentle Game 103
The Garden of Eden 104
The Oldest Circus on Earth 108
PART TWO INFORMATION FLOW INSIDE CELLS 111
7 The Two Information Realms 113
The Flip Sides of Information: Life s Two Realms 113
The Two Major Information Streams 115
The Quintessence of Conservation of Information: DNA 117
The Information Subsidy for DNA Replication and
Error Correction 121
Information Is Pumped into DNA as It Leaks Out 122
The Spooling of the Golden Thread 123
Cells Know More Than They Let On 124
DNA s Various information Tiers 125
The DNA Transform Pro Tempore 127
The First-Tier Code 127
The Genetic Code 128
Transcription 132
Splicing 133
The Genie that Dances to Its Own Tune 135
A Punishment that Fits die Crime 137
How to Bridge the Information Gap 138
8 The Game of Seek and Find 140
Seek and Find 140
How to Keep Molecular Informadon
Broadcasts under Wraps 141
The Virtues of Molecular Coherence 142
The Transfiguration Called Biological Specificity 143
The Maturing of Biological Communication 144
How Biological Systems Break the Fetters of
Quantum Chemistry 145
The Creative Kaleidoscope 146
The Paradox of the Progressive Reactionary 148
What If the Cellular Information Stream Ran Backward? 149
x Contents
The Elusive Second Wheel of Change 151
Can Organisms Promote Useful Mutations? 152
The Solid-State Apparatus at the Headgates
of the Mainstream 154
Three Protein Designs for Tapping Positional
Information from DNA 154
What Do Proteins See Where They Plug into the DNA 156
If the Mountain Will Not Come to Mahomet 158
The Multiplex Adaptor 159
Supramolecular Organization Out of Molecular Hum 161
A Ledger for Supramolecular Information 163
PART THREE INFORMATION FLOW BETWEEN CELLS 165
9 Rules of the Intercellular
Communication Game 167
The End of the Cell Era: The Merger of Circuses 167
The Innards of the Cell Membrane 169
Strategies for Breaching the Membrane Barrier 172
The Bare Bones of Intercellular Communication 174
The Intercellular Communication Channels 175
The Imperturbable Biological Signal Stuff 178
Nature s Sole Mistake 179
How to Get a Message Through a Noisy Channel:
The Second Theorem 181
The Virtues of Redundant Small Talk 182
What Is a Code? 184
Why There Are No Double-Entendres in Biological
Communications 186
The Question of the Origin of Natural Codes 188
The Why and Wherefore of Encoding 190
What Can We Learn from Game Theory? 192
The Master Demons of Intercellular Communication 194
The Game of Seek and Find in the Membrane 196
The Communications Between Cells Are Lean
in Information But Rich in Meaning 197
How to Pull the Strings of a Cell 198
Telecontrol 199
10 The Broadcasting of Cellular Information 201
The Begetting of Social Graces 201
The Emanations from Organs 201
The Pervasive Messengers 203
Tango a Trois 204
The Transfer of Steroid Hormone Information 207
The DNA Multiplex and Remote Gene Control 207
The Rise of a Demon 209
Contents xi
The Intercellular Functions of the DNA Multiplex 210
Demons with an Esprit de Corps 211
A Smoke Signal 213
Cyclic AMP 216
From Hunger Signal to Inter-Circus Signal 218
The Information Relays in the Cell Membrane 218
The Alpha Demon 220
The Alpha Merry-Go-Round 221
The G-Show Libretto 223
Crescendos 225
The Cast of Characters 226
Ion Channels as Maxwell Demons 227
How to Make Signals from Informational Chicken Feed 230
A Small Ion with Cachet: The Calcium Signal 236
Signal Mopping: An Economical Cure for Cross Talk 238
The Shoo-in Called Calcium 241
A Streamlined G-Map 242
T Junctions and Organismic Harmony 243
Snapshots of Two T Demons 245
The G-Pathway in Synopsis 249
11 Intercellular Communication
Cheek-by-Jowl 250
Membrane Hot Spots: The Syncretic Communication Unit 251
The Case for Syncretic Communication 253
How Syncretic Information Flows 255
The Information-Crossover Gambit 257
Metamorphosis 261
12 Intercellular Communication Via
Channels in the Cell Membrane 263
The Cell-to-Cell Channels 263
How They Form 264 -
How Cells Are Excommunicated and When 268
How to Achieve Control in One s Birthday Suit 270
The Channel Shutter 271
A Channel Yin-Yang 273
What Goes Through the Cell-Cell Channels 274
Viewing the Signals Through the Looking Glass of
Game Theory 276
How Cell Communities Stay on an Even Keel 278
E Pluribus Unum 278
How to Ferret Out the Functions of a Channel 282
The Regulation of Cellular Growth 282
The Cellcosm-in-the-Dish 285
How Do Cells Know Their Number? 286
Parlez Vous Cellulaise? 288
xll Contents
Where Canalicular Communication Holds the
Trump Card 289
A Model of Growth Control for Small Cell Populations 290
A Model for Large Cell Populations 293
Controls for Two Seasons 296
X Determines Cellular Growth 297
What Is Cancer? 298
X Is Reduced in Cancer 300
A Cancer Cure in the Test Tube 301
Our First Line of Defense 302
A Ray of Hope 304
13 Neuronal Communication,
Neuronal Computation, and
Conscious Thought 306
Neuronal Communication and Computation 306
Consciousness 309
Quantum Coherence 311
Quantum Computations? 314
Two Worlds Unbridged 318
PART FOUR THE SCIENCE OF THE PECULIAR 323
14 How Can You Explain So Wise an
Old Bird in a Few Words? 325
An Occam s Razor for Biology 326
The Mistress We Can Live Without 326
The Arduous Minuet 328
The Processing of Information Called Science 329
The Limits of Scientific Knowledge 331
Epilogue 335
Appendix A Brief Chronicle of Information 337
The Form-Giving Principle 337
The Tribulations of the Two Great Laws 338
The Ripening of an Afterthought 338
Recommended Reading 341
References 344
Index 360
|
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| spelling | Loewenstein, Werner Randolph Verfasser aut The touchstone of life molecular information, cell communication, and the foundations of life Werner R. Loewenstein New York [u.a.] Oxford Univ. Press 1999 XVIII, 366 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biologie ram Cellules - Interaction ram Cell Communication Cell interaction Cellular signal transduction Information Theory Information theory in biology Signal Transduction Zellkommunikation (DE-588)4136131-3 gnd rswk-swf Zellkommunikation (DE-588)4136131-3 s DE-604 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008570481&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Loewenstein, Werner Randolph The touchstone of life molecular information, cell communication, and the foundations of life Biologie ram Cellules - Interaction ram Cell Communication Cell interaction Cellular signal transduction Information Theory Information theory in biology Signal Transduction Zellkommunikation (DE-588)4136131-3 gnd |
| subject_GND | (DE-588)4136131-3 |
| title | The touchstone of life molecular information, cell communication, and the foundations of life |
| title_auth | The touchstone of life molecular information, cell communication, and the foundations of life |
| title_exact_search | The touchstone of life molecular information, cell communication, and the foundations of life |
| title_full | The touchstone of life molecular information, cell communication, and the foundations of life Werner R. Loewenstein |
| title_fullStr | The touchstone of life molecular information, cell communication, and the foundations of life Werner R. Loewenstein |
| title_full_unstemmed | The touchstone of life molecular information, cell communication, and the foundations of life Werner R. Loewenstein |
| title_short | The touchstone of life |
| title_sort | the touchstone of life molecular information cell communication and the foundations of life |
| title_sub | molecular information, cell communication, and the foundations of life |
| topic | Biologie ram Cellules - Interaction ram Cell Communication Cell interaction Cellular signal transduction Information Theory Information theory in biology Signal Transduction Zellkommunikation (DE-588)4136131-3 gnd |
| topic_facet | Biologie Cellules - Interaction Cell Communication Cell interaction Cellular signal transduction Information Theory Information theory in biology Signal Transduction Zellkommunikation |
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