Neural repair, transplantation and rehabilitation
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| Hauptverfasser: | , |
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Hove
Psychology Press
1999
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| Schriftenreihe: | Neuropsychological rehabilitation
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| Online-Zugang: | Inhaltsverzeichnis |
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| 245 | 1 | 0 | |a Neural repair, transplantation and rehabilitation |c Roger A. Barker and Stephen B. Dunnett |
| 264 | 1 | |a Hove |b Psychology Press |c 1999 | |
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Datensatz im Suchindex
| _version_ | 1804127082206199808 |
|---|---|
| adam_text | Contents
Series preface vii
Preface ix
Chapter One The limits of regeneration in the central nervous system 1
Introduction 1
The absence of regeneration within the CNS 3
Spontaneous recovery after CNS damage 17
Limited regeneration in the CNS 21
Clinical strategies to deal with CNS damage 27
Summary 31
Chapter Two Strategies for protection and repair of damage in the CNS 33
Introduction 33
Cell death in the CNS 33
Neuroprotective therapies 39
Neurotrophic and other growth factors 42
Neural transplantation 48
Summary 50
Chapter Three Experimental principles of neural transplantation 51
Introduction 51
Techniques of transplantation 53
Sources of cells for transplantation 58
Immunological factors in graft survival 62
Practical aspects of cell survival 64
Summary 66
iv CONTENTS
Chapter Four Nigral grafts in animal models of Parkinson s disease 67
Parkinson s disease (PD) 67
Animal models of PD 69
Nigral grafts in animal models of PD 76
Functional analysis of nigral grafts 84
Summary 91
Chapter Five First clinical trials: Neural grafts in Parkinson s disease 93
Introduction 93
Adrenal medulla transplants 95
Clinical trials of adrenal medulla transplants 105
Embryonic nigral transplants in humans 115
Summary 131
Chapter Six Striatal grafts: Circuit reconstruction and Huntington s disease 133
Introduction 133
Huntington s disease (HD) 134
Animal models of HD 136
Striatal grafts in experimental rats 141
Clinical applications of striatal grafts in HD 152
Summary 156
Chapter Seven Alzheimer s disease: A difficult target for transplantation 157
The problem of dementia 157
Cholinergic models of ageing and dementia 158
Models of trophic factor deficiency 166
The critical neuropathology of Alzheimer s disease 167
Graft models of the cellular pathology 169
Clinical prospects in dementia 172
Summary 174
Chapter Eight Spinal cord injury: The ultimate challenge 175
Spinal cord injury 175
Spinal cord grafts 177
Motor neurone disease 189
Pain 192
Demyelination and Remyelination 197
Summary 201
Chapter Nine Other sources of cells for transplantation 203
Introduction 203
The nature of repair 205
Secretory cells and tissues 209
Cell lines 212
Ex vivo gene transfer 220
In vivo gene transfer 225
Xenografts 229
CONTENTS V
Encapsulation 230
Summary 232
Chapter Ten Psychological factors in graft function 233
Mechanisms of graft function 233
Environment 236
Conditioning effects 237
Learning to use the transplant 239
Rehabilitation of transplant patients? 244
Summary and Conclusions 245
References 247
Glossary 285
Abbreviations 303
Author Index 307
Subject Index 327
|
| any_adam_object | 1 |
| author | Barker, Roger A. Dunnett, Stephen B. |
| author_facet | Barker, Roger A. Dunnett, Stephen B. |
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| author_sort | Barker, Roger A. |
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| building | Verbundindex |
| bvnumber | BV012444764 |
| classification_rvk | CW 6880 |
| ctrlnum | (OCoLC)231847154 (DE-599)BVBBV012444764 |
| discipline | Psychologie |
| format | Book |
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| illustrated | Illustrated |
| indexdate | 2024-07-09T18:27:41Z |
| institution | BVB |
| isbn | 0863776280 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008444418 |
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| physical | XII, 339 S. Ill., graph. Darst. |
| publishDate | 1999 |
| publishDateSearch | 1999 |
| publishDateSort | 1999 |
| publisher | Psychology Press |
| record_format | marc |
| series2 | Neuropsychological rehabilitation |
| spelling | Barker, Roger A. Verfasser aut Neural repair, transplantation and rehabilitation Roger A. Barker and Stephen B. Dunnett Hove Psychology Press 1999 XII, 339 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Neuropsychological rehabilitation Krankheit (DE-588)4032844-2 gnd rswk-swf Nervensystem (DE-588)4041643-4 gnd rswk-swf Neuropsychologie (DE-588)4135740-1 gnd rswk-swf Gehirn (DE-588)4019752-9 gnd rswk-swf Gewebetransplantation (DE-588)4157246-4 gnd rswk-swf Rehabilitation (DE-588)4049078-6 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Nervensystem (DE-588)4041643-4 s Krankheit (DE-588)4032844-2 s Rehabilitation (DE-588)4049078-6 s Neuropsychologie (DE-588)4135740-1 s DE-604 Gehirn (DE-588)4019752-9 s Gewebetransplantation (DE-588)4157246-4 s Dunnett, Stephen B. Verfasser aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008444418&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Barker, Roger A. Dunnett, Stephen B. Neural repair, transplantation and rehabilitation Krankheit (DE-588)4032844-2 gnd Nervensystem (DE-588)4041643-4 gnd Neuropsychologie (DE-588)4135740-1 gnd Gehirn (DE-588)4019752-9 gnd Gewebetransplantation (DE-588)4157246-4 gnd Rehabilitation (DE-588)4049078-6 gnd |
| subject_GND | (DE-588)4032844-2 (DE-588)4041643-4 (DE-588)4135740-1 (DE-588)4019752-9 (DE-588)4157246-4 (DE-588)4049078-6 (DE-588)4143413-4 |
| title | Neural repair, transplantation and rehabilitation |
| title_auth | Neural repair, transplantation and rehabilitation |
| title_exact_search | Neural repair, transplantation and rehabilitation |
| title_full | Neural repair, transplantation and rehabilitation Roger A. Barker and Stephen B. Dunnett |
| title_fullStr | Neural repair, transplantation and rehabilitation Roger A. Barker and Stephen B. Dunnett |
| title_full_unstemmed | Neural repair, transplantation and rehabilitation Roger A. Barker and Stephen B. Dunnett |
| title_short | Neural repair, transplantation and rehabilitation |
| title_sort | neural repair transplantation and rehabilitation |
| topic | Krankheit (DE-588)4032844-2 gnd Nervensystem (DE-588)4041643-4 gnd Neuropsychologie (DE-588)4135740-1 gnd Gehirn (DE-588)4019752-9 gnd Gewebetransplantation (DE-588)4157246-4 gnd Rehabilitation (DE-588)4049078-6 gnd |
| topic_facet | Krankheit Nervensystem Neuropsychologie Gehirn Gewebetransplantation Rehabilitation Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008444418&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT barkerrogera neuralrepairtransplantationandrehabilitation AT dunnettstephenb neuralrepairtransplantationandrehabilitation |