Pharmacology and physiology in anesthetic practice
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Philadelphia [u.a.]
Lippincott-Raven
1999
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| Ausgabe: | 3. ed. |
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| 100 | 1 | |a Stoelting, Robert K. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Pharmacology and physiology in anesthetic practice |c Robert K. Stoelting |
| 250 | |a 3. ed. | ||
| 264 | 1 | |a Philadelphia [u.a.] |b Lippincott-Raven |c 1999 | |
| 300 | |a XIV, 814 S. |b Ill., graph. Darst. | ||
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| 650 | 7 | |a Farmacologie |2 gtt | |
| 650 | 7 | |a Fysiologie |2 gtt | |
| 650 | 4 | |a Anesthetics |x Physiological effect |x Handbooks, manuals, etc | |
| 650 | 4 | |a Anesthetics |x pharmacology | |
| 650 | 4 | |a Physiology | |
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Datensatz im Suchindex
| _version_ | 1804127076587929600 |
|---|---|
| adam_text | Contents
Preface xv
Section I. Pharmacology
1. Pharmacokinetics and Pharmacodynamics of Injected
and Inhaled Drugs 3
Stereochemistry, 3
Description of Drug Response, 4
Pharmacology of Injected Drugs, 4
Pharmacodynamics of Injected Drugs, 17
Pharmacokinetics of Inhaled Anesthetics, 20
Pharmacodynamics of Inhaled Anesthetics, 30
2. Inhaled Anesthetics 36
History, 36
Clinically Useful Inhaled Anesthetics, 37
Comparative Pharmacology, 39
Central Nervous System Effects, 40
Circulatory Effects, 43
Ventilation Effects, 53
Hepatic Effects, 57
Renal Effects, 61
Skeletal Muscle Effects, 64
Obstetric Effects, 65
Resistance to Infection, 65
Genetic Effects, 66
Bone Marrow Function, 66
Peripheral Neuropathy, 67
Total Body Oxygen Requirements, 67
Metabolism, 67
3. Opioid Agonists and Antagonists 77
Structure Activity Relationships, 77
Mechanism of Action, 77
Opioid Receptors, 78
Neuraxial Opioids, 79
Opioid Agonists, 83
Opioid Agonist Antagonists, 104
Opioid Antagonists, 106
Anesthetic Requirements, 108
4. Barbiturates 113
Commercial Preparations, 113
Structure Activity Relationships, 113
Mechanism of Action, 113
V
vi / Contents
Pharmacokinetics, 114
Clinical Uses, 118
Side Effects, 120
5. Benzodiazepin.es 126
Structure Activity Relationships, 126
Mechanism of Action, 126
Side Effects, 127
Midazolam, 128
Diazepam, 132
Lorazepam, 136
Oxazepam, 137
Clonazepam, 137
Flurazepam, 137
Temazepam, 137
Triazolam, 137
Quazepam, 137
Flumazenil, 138
6. Nonbarbiturate Induction Drugs 140
Propofol, 140
Etomidate, 145
Ketamine, 148
Eltanolone, 155
7. Local Anesthetics 158
Commercial Preparations, 158
Structure Activity Relationships, 158
Mechanism of Action, 160
Minimum Concentration, 161
Pharmacokinetics, 161
Side Effects, 167
Uses of Local Anesthetics, 171
Cocaine Toxicity, 178 !
8. Neuromuscular Blocking Drugs 182
Pharmacodynamics, 182
Pharmacokinetics, 184
History, 185 :
Clinical Uses, 185
Structure Activity Relationships, 186
Neuromuscular Junction, 187
Depolarizing Neuromuscular Blocking Drugs, 189
Nondepolarizing Neuromuscular Blocking Drugs, 194
Long Acting Nondepolarizing Neuromuscular Blocking Drugs, 202
Intermediate Acting Nondepolarizing Neuromuscular Blocking Drugs, 205
Short Acting Nondepolarizing Neuromuscular Blocking Drugs, 216
ORG 9487, 219
9. Anticholinestemse Drugs and Cholinergic Agonists 224
Mechanism of Action, 224
Classification, 224
Structure Activity Relationships, 226
Pharmacokinetics, 226
Pharmacologic Effects, 229
Clinical Uses, 231
Overdose of Anticholinesterase Drugs, 235
Synthetic Cholinergic Agonists, 235
Contents / vii
10. Anticholinergic Drugs 238
Structure Activity Relationships, 238
Mechanism of Action, 238
Pharmacokinetics, 240
Clinical Uses, 241
Central Anticholinergic Syndrome, 245
Overdose, 245
Decreased Barrier Pressure, 246
11. Nonsteroidal Antiinflammatory Drugs 247
Mechanism of Action, 247
Pharmacokinetics, 247
Adverse Reactions, 249
Perioperative Use of Nonsteroidal Antiinflammatory Drugs, 250
Aspirin (Acetylsalicylic Acid), 251
Acetaminophen, 253
Diflunisal, 254
Indomethacin, 254
Sulindac, 254
Tolmetin, 254
Propionic Acid Derivatives, 255
Phenylbutazone, 255
Piroxicam, 255
Ketorolac, 255
Miscellaneous Antiarthritis Drugs, 256
12. Sympathomimetics 259
Clinical Uses, 259
Structure Activity Relationships, 259
Mechanism of Action, 262
Metabolism, 264
Route of Administration, 264
Naturally Occurring Catecholamines, 264
Synthetic Catecholamines, 268
Synthetic Noncatecholamines, 270
Selective Betaj Adrenergic Agonists, 274
13. Digitalis and Related Drugs 278
Clinical Uses, 278
Structure Activity Relationships, 278
Mechanism of Action, 278
Pharmacokinetics, 280
Cardiovascular Effects, 281
Electrocardiographic Effects, 281
Digitalis Toxicity, 281
Preoperative Prophylactic Digitalis, 283
Drug Interactions, 283
Selective Phosphodiesterase Inhibitors (Noncatecholamine, Nonglycoside
Cardiac Inotropic Agents), 284
Nonselective Phosphodiesterase Inhibitors, 285
Calcium, 286
Glucagon, 286
14. Alpha and Beta Adrenergic Receptor Antagonists 288
Alpha Adrenergic Receptor Antagonists, 288
Beta Adrenergic Receptor Antagonists, 290
Combined Alpha and Beta Adrenergic Receptor Antagonists, 300
viii / Contents
15. Antihypertensive Drugs 302
Sympatholytics, 302
Angiotensin Converting Enzyme Inhibitors, 307
Angiotensin Receptor Blockers, 309
Calcium Channel Blockers, 310
Vasodilating Drugs, 310
Diuretics, 311
16. Peripheral Vasodilators 313
Nitric Oxide, 313
Sodium Nitroprusside, 315
Nitroglycerin, 322
Isosorbide Dinitrate, 325
Dipyridamole, 325
Papaverine, 326
Trimethaphan, 326
Diazoxide, 327
Purines, 328
Sildenafil, 329
17. Cardiac Antidysrhythmic Drugs 331
Classification, 331
Decision to Treat Cardiac Dysrhythmias, 333
Quinidine, 333
Procainamide, 334
Disopyramide, 335
Lidocaine, 335
Mexiletine, 336
Tocainide, 337
Phenytoin, 337
Moricizine, 337
Flecainide, 337
Propafenone, 338
Propranolol, Metoprolol, and Esmolol, 338
Amiodarone, 339
Sotalol, 341
Bretylium, 341
Verapamil and Diltiazem, 341
Digitalis, 342
Adenosine, 342
Prodysrhythmic Effects, 343
18. Calcium Channel Blockers 344
Classification, 344
Mechanism of Action, 344
Pharmacologic Effects, 348
Risks of Chronic Treatment, 348
Clinically Available Drugs, 348
Drug Interactions, 351
19. Drugs Used for Psychopharmacologic Therapy 357
Antidepressants, 357
Anxiolytics, 367
Lithium, 368
Antipsychotic (Neuroleptic) Drugs, 369
20. Prostaglandins 377
Nomenclature and Structure Activity Relationships, 377
Contents / ix
Synthesis, 377
Mechanism of Action, 378
Metabolism, 378
Effects on Organ Systems, 378
21. Histamine and Histamine Receptor Antagonists 385
Histamine, 385
Histamine Receptor Antagonists, 388
Proton Pump Inhibitors, 396
Cromolyn, 397
22. Renin, Plasma Kinins, and Serotonin 398
Renin, 398
Plasma Kinins, 401
Serotonin, 403
23. Hormones as Drugs 409
Anterior Pituitary Hormones, 409
Thyroid Gland Hormones, 410
Drugs That Inhibit Thyroid Hormone Synthesis, 410
Ovarian Hormones, 411
Androgens, 414
Corticosteroids, 415
Melatonin, 422
Posterior Pituitary Hormones, 422
Chymopapain, 425
24. Insulin and Oral Hypoglycemics 427
Insulin, 427
Structure Activity Relationships, 427
Oral Hypoglycemics, 430
Biguanides, 433
Intestinal Glycosidase Inhibitors, 434
25. Diuretics 435
Thiazide Diuretics, 435
Loop Diuretics, 437
Osmotic Diuretics, 440
Potassium Sparing Diuretics, 442
Aldosterone Antagonists, 442
Carbonic Anhydrase Inhibitors, 443
26. Antacids and Gastrointestinal Prokinetics 444
Antacids, 444
Drug Interactions, 445
Sucralfate, 447
Gastrointestinal Prokinetics, 447
27. Anticoagulants 453
Heparin, 453
Low Molecular Weight Heparin, 459
Oral Anticoagulants, 459
Thrombolytic Drugs, 461
Antithrombotic Drugs, 463
28. Antimicrobials 465
Antimicrobial Prophylaxis for Surgical Procedures, 465
Penicillins, 465
Cephalosporins, 470
x / Contents
Other Beta Lactam Antimicrobials, 471
Aminoglycoside Antimicrobials, 472
Tetracyclines, 474
Macrolides, 475
Clindamycin, 476
Chloramphenicol, 476
Vancomycin, 476
Polymyxin B and Colistimethate, 477
Bacitracins, 478
Sulfonamides, 478
Metronidazole, 480
Fluoroquinolones, 480
Nitrofurantoin, 481
Drugs for Treatment of Tuberculosis, 481
Antifungal Drugs, 484
Antiviral Drugs, 485
29. Chemotherapeutic Drugs 490
Classification, 490
Alkylating Drugs, 490
Antimetabolites, 495
Plant Alkaloids, 498
Antibiotics, 499
Enzymes, 503
Synthetics, 503
Hormones, 504
30. Antiepileptic Drugs 506
Principles of Dosing, 506
Plasma Concentrations, 506
Drug Interactions, 509
Mechanism of Seizure Activity, 509
Mechanism of Drug Action, 509
Major Antiepileptic Drugs, 510
New Antiepileptic Medications, 514
31. Drugs Used for Treatment of Parkinson s Disease 515
Levodopa, 515
Peripheral Decarboxylase Inhibitors, 517
Synthetic Dopamine Agonists, 518
Anticholinergic Drugs, 518
Amantadine, 518
Selegiline, 519
Nonpharmacologic Treatment, 519
32. Drug Treatment ofLipid Disorders 520
Drugs for Treatment of Increased Plasma Low Density Lipoprotein
Cholesterol Concentrations, 520
Drugs for Treatment of Increased Plasma Triglyceride Concentrations, 523
33. Central Nervous System Stimulants and Muscle Relaxants 525
Central Nervous System Stimulants, 525
Centrally Acting Muscle Relaxants, 528
34. Vitamins 532
Water Soluble Vitamins, 532
Fat Soluble Vitamins, 537
Contents / xi
35. Minerals and Electrolytes 541
Calcium, 541
Potassium, 547
Hypokalemic Drug Effects, 547
Phosphate, 548
Magnesium, 549
Iron, 550
Copper, 552
Zinc, 552
Chromium, 552
Selenium, 552
Manganese, 552
Molybdenum, 553
36. Blood Components and Substitutes 554
Blood Components, 554
Topical Hemostatics, 560
Blood Substitutes, 561
37. Hyperalimentation Solutions 565
Enteral Nutrition, 565
Parenteral Nutrition, 566
38. Antiseptics and Disinfectants 570
Alcohols, 570
Quaternary Ammonium Compounds, 570
Chlorhexidine, 570
Iodine, 570
Hexachlorophene, 571
Formaldehyde, 571
Glutaraldehyde, 571
Pasteurization, 572
Cresol, 572
Silver Nitrate, 572
Mercury, 572
Ethylene Oxide, 572
Section II. Physiology
39. Cell Structure and Function 575
Cell Anatomy, 575
Transfer of Molecules across Cell Membranes, 578
Transfer of Molecules through Cell Membranes, 578
Electrical Potentials across Cell Membranes, 581
Intracellular Communication, 583
40. Body Fluids 586
Blood Volume, 586
Measurement of Compartmental Fluid Volumes, 587
Constituents of Body Fluid Compartments, 587
Osmosis, 588
Changes in Volumes of Body Fluid Compartments, 589
41. Central Nervous System 591
Cerebral Hemispheres, 591
Brainstem, 594
xii / Contents
Spinal Cord, 596
Pathways for Peripheral Sensory Impulses, 598
Pathways for Peripheral Motor Responses, 599
Anatomy of Nerve Fibers, 600
Neurotransmitters, 601
Electrical Events during Neuronal Excitation, 603
Cerebral Blood Row, 604
Electroencephalogram, 605
Evoked Potentials, 606
Cerebrospinal Fluid, 607
Vision, 608
Hearing, 611
Equilibrium, 612
Chemical Senses, 612
Body Temperature, 612
Nausea and Vomiting, 617
42. Autonomic Nervous System 619
Anatomy of the Sympathetic Nervous System, 619
Anatomy of the Parasympathetic Nervous System, 619
Physiology of the Autonomic Nervous System, 620
Interactions of Neurotransmitters with Receptors, 625
Residual Autonomic Nervous System Tone, 626
Adrenal Medulla, 626
43. Pain 628
Types of Pain, 628
Pain Receptors, 628
Transmission of Pain Signals, 629
Reaction to Pain, 631
Preemptive Analgesia, 631
Description of Pain, 631
Embryologic Origin and Localization of Pain, 633
44. Systemic Circulation 634
Components of the Systemic Circulation, 634
Physical Characteristics of the Systemic Circulation, 634
Physical Characteristics of Blood, 639
Determinants of Tissue Blood Flow, 640
Control of Tissue Blood Flow, 640
Regulation of Systemic Blood Pressure, 642
Regulation of Cardiac Output and Venous Return, 645
Fetal Circulation, 647
45. Capillaries and Lymph Vessels 649
Capillaries, 649
Lymph Vessels, 652
Edema, 653
46. Pulmonary Circulation 654
Anatomy, 654
Intravascular Pressures, 654
Interstitial Fluid Space, 655
Pulmonary Blood Volume, 655
Pulmonary Blood Flow and Distribution, 656
Pulmonary Edema, 658
Events That Obstruct Pulmonary Blood Flow, 658
Contents / xiii
47. Heart 660
Cardiac Physiology, 660
Coronary Blood Flow, 663
Dynamics of Heart Sounds, 666
Conduction of Cardiac Impulses, 667
Circulatory Effects of Heart Disease, 669
Myocardial Infarction, 670
Angina Pectoris, 671
Cardiac Failure, 671
48. The Electrocardiogram and Analysis of Cardiac Dysrhythmias 672
Electrocardiogram, 672
Cardiac Dysrhythmias, 675
49. Lungs 682
Anatomy, 682
Mechanics of Breathing, 683
Surface Tension and Pulmonary Surfactant, 685
Compliance, 685
Lung Volumes and Capacities, 685
Minute Ventilation, 687
Control of Ventilation, 687
Effects of Sleep on Breathing, 690
Apneic Periods during Sleep, 690
Periodic Breathing, 690
Nonventilatory Functions of the Lungs, 691
50. Pulmonary Gas Exchange and Blood Transport of Gases 692
Pulmonary Gas Exchange, 692
Blood Transport of Oxygen and Carbon Dioxide, 694
Changes Associated with High Altitude, 699
Changes Associated with Excessive Barometric Pressure, 700
51. Acid Base Balance 702
Mechanism for Regulation of Hydrogen Ion Concentration, 702
Acid Base Disturbances, 705
Gastric Intramucosal pH, 707
52. Endocrine System 708
Mechanism of Hormone Action, 708
Pituitary Gland, 708
Thyroid Gland, 712
Parathyroid Glands, 714
Adrenal Cortex, 714
Reproductive Glands, 716
Pancreas, 718
53. Kidneys 722
Nephron, 722
Renal Blood Flow, 722
Glomerular Filtrate, 726
Renal Tubular Function, 726
Tubular Transport Maximum, 727
Regulation of Body Fluid Characteristics, 728
Atrial and Renal Natriuretic Factors, 730
Acute Renal Failure, 730
Chronic Renal Failure, 732
Transport of Urine to the Bladder, 734
xiv / Contents
54. Liver and Gastrointestinal Tract 736
Liver, 736
Gastrointestinal Tract, 739
55. Skeletal and Smooth Muscle 748
Skeletal Muscle, 748
Smooth Muscle, 750
56. Erythrocytes and Leukocytes 752
Erythrocytes, 752
Blood Groups, 753
Leukocytes, 755
Inflammation, 757
Immunity, 758
Tissue Typing, 760
57. Hemostasis and Blood Coagulation 762
Hemostatic Mechanism, 762
Thromboembolism, 764
Disseminated Intravascular Coagulation, 765
58. Metabolism of Nutrients 766
Carbohydrate Metabolism, 766
Lipid Metabolism, 768
Protein Metabolism, 769
Obesity, 771
Drug Index 773
Subject Index 777
|
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| dewey-raw | 615/.781 |
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| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
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| id | DE-604.BV012440153 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:27:36Z |
| institution | BVB |
| isbn | 0781716217 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008440532 |
| oclc_num | 39399630 |
| open_access_boolean | |
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| owner_facet | DE-355 DE-BY-UBR DE-29 DE-384 |
| physical | XIV, 814 S. Ill., graph. Darst. |
| publishDate | 1999 |
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| publisher | Lippincott-Raven |
| record_format | marc |
| spelling | Stoelting, Robert K. Verfasser aut Pharmacology and physiology in anesthetic practice Robert K. Stoelting 3. ed. Philadelphia [u.a.] Lippincott-Raven 1999 XIV, 814 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturangaben Anesthesie gtt Farmacologie gtt Fysiologie gtt Anesthetics Physiological effect Handbooks, manuals, etc Anesthetics pharmacology Physiology Pharmakologie (DE-588)4045687-0 gnd rswk-swf Anästhetikum (DE-588)4001839-8 gnd rswk-swf Anästhetikum (DE-588)4001839-8 s Pharmakologie (DE-588)4045687-0 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008440532&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Stoelting, Robert K. Pharmacology and physiology in anesthetic practice Anesthesie gtt Farmacologie gtt Fysiologie gtt Anesthetics Physiological effect Handbooks, manuals, etc Anesthetics pharmacology Physiology Pharmakologie (DE-588)4045687-0 gnd Anästhetikum (DE-588)4001839-8 gnd |
| subject_GND | (DE-588)4045687-0 (DE-588)4001839-8 |
| title | Pharmacology and physiology in anesthetic practice |
| title_auth | Pharmacology and physiology in anesthetic practice |
| title_exact_search | Pharmacology and physiology in anesthetic practice |
| title_full | Pharmacology and physiology in anesthetic practice Robert K. Stoelting |
| title_fullStr | Pharmacology and physiology in anesthetic practice Robert K. Stoelting |
| title_full_unstemmed | Pharmacology and physiology in anesthetic practice Robert K. Stoelting |
| title_short | Pharmacology and physiology in anesthetic practice |
| title_sort | pharmacology and physiology in anesthetic practice |
| topic | Anesthesie gtt Farmacologie gtt Fysiologie gtt Anesthetics Physiological effect Handbooks, manuals, etc Anesthetics pharmacology Physiology Pharmakologie (DE-588)4045687-0 gnd Anästhetikum (DE-588)4001839-8 gnd |
| topic_facet | Anesthesie Farmacologie Fysiologie Anesthetics Physiological effect Handbooks, manuals, etc Anesthetics pharmacology Physiology Pharmakologie Anästhetikum |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008440532&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT stoeltingrobertk pharmacologyandphysiologyinanestheticpractice |