The impact of stereochemistry on drug development and use
The book explores analytical, pharmacological, and regulatory topics in dealing with the theory and practice of stereochemistry in the pharmarceutical industry today. This exciting, broad-appeal treatment extends from the analytical viewpoint in enantiomeric separation to the regulatory issues invol...
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| Format: | Buch |
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| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Wiley
1997
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| Schriftenreihe: | Chemical analysis
142 |
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| Online-Zugang: | Inhaltsverzeichnis |
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| 520 | 3 | |a The book explores analytical, pharmacological, and regulatory topics in dealing with the theory and practice of stereochemistry in the pharmarceutical industry today. This exciting, broad-appeal treatment extends from the analytical viewpoint in enantiomeric separation to the regulatory issues involved in the "racemate-versus-enantiomer" debate. The authors include numerous examples and case studies, and integrate material from a wide range of studies, publications, and workshops. The Impact of Stereochemistry on Drug Development and Use is an essential reference for medicinal and analytical chemists, pharmacologists, drug metabolism and pharmacokinetic scientists, and personnel of regulatory agencies. It is also a useful text for graduate students in stereochemistry, and for anyone who wants to keep up with the swift pace of change in this dynamic field. | |
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| 650 | 4 | |a Chemistry, Pharmaceutical |x methods | |
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Datensatz im Suchindex
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|---|---|
| adam_text | IMAGE 1
THE IMPACT OF STEREOCHEMISTRY
ON DRUG DEVELOPMENT AND USE
HASSAN Y. ABOUL-ENEIN KING FAISAL SPECIALIST HOSPITAL AND RESEARCH
CENTRE SAUDI ARABIA
AND
IRVING W. WAINER
MCGILL UNIVERSITY MONTREAL, CANADA
A WILEY-INTERSCIENCE PUBLICATION
JOHN WILEY & SONS, INC.
NEW YORK / CHICHESTER / WEINHEIM / BRISBANE / SINGAPORE / TORONTO
IMAGE 2
CONTENTS
CONTRIBUTORS XI
PREFACE XV
CUMULATIVE LISTING OF VOLUMES IN SERIES XXIII
CHAPTER 1 CHIRALITY AND DRUG HAZARDS 1
(HASSAN Y. ABOUL-ENEINANDLAILA I. ABOUBASHA)
CHAPTER 2 STEREOCHEMISTRY IN THE DRUG DEVELOPMENT PROCESS: ROLE OF
CHIRALITY AS A DETERMINANT OF DRUG ACTION, METABOLISM, AND TOXICITY 21
(THOMAS A. BAILLIE AND KATHLEEN M. SCHULTZ)
CHAPTER 3 STEREOCHEMICAL ASPECTS OF DRUG METABOLISM 45
(JONATHAN P. MASON AND ANDREW! HUTT)
CHAPTER 4 SOME EXAMPLES FOR STEREOSELECTIVE BIOTRANSFORMATION OF DRUGS
107
(GOTTFRIED BLASCHKE)
CHAPTER 5 KINETICS OF REACTIVE PHASE II METABOLITES: STEREOCHEMICAL
ASPECTS OF FORMATION OF EPIMERIC ACYL GLUCURONIDES AND THEIR REACTIVITY
125
(HILDEGARD SPAHN-LANGGUTH, LESLIEZ. BENET, PARNIAN ZIA-AMIRHOSSEINI,
SEIGOIWAKAWA. AND PETER LANGGUTH)
CHAPTER 6 STUDIES ON THE STEREOS ELECTIVITY OF THE BIOLOGICALLY
IMPORTANT METABOLISM OF ALKENE-ALKENE OXIDE (OXIRANE)-ALKANEDIOL 173
(DOROTHEE WISTUBA)
VU
IMAGE 3
VIII CONTENTS
CHAPTER 7 CHIRAL BARBITURATES: SYNTHESIS, CHROMATOGRAPHIC RESOLUTIONS,
AND BIOLOGICAL ACTIVITY 201
(JACEKBOJARSKI)
CHAPTER 8 ETHAMBUTOL AND TUBERCULOSIS, A NEGLECTED AND CONFUSED CHIRAL
PUZZLE 235 (BERNARD BLESSINGTON)
CHAPTER 9 STEREOGENIC ELEMENTS OF PHARMACEUTICAL COMPOUNDS: SOME ASPECTS
ON ISOMERISM, RESOLUTION, AND STEREOCHEMICAL
INTEGRITY 263
(STIGG ALLEN MARK)
CHAPTER 10 THE IMPORTANCE OF CHIRAL SEPARATIONS IN PHARMACEUTICALS 287
(SUTAHUJA)
CHAPTER 11 SEPARATION OF OPTICALLY ACTIVE PHARMACEUTICALS USING
CAPILLARY ELECTROPHORESIS 317
(TIMOTHY! WARD AND KAREN D. WARD)
CHAPTER 12 CHIRAL RECOGNITION MECHANISM OF POLYSACCHARIDES CHIRAL
STATIONARY PHASES 345 {EJI YASHIMA AND YOSHIO OKAMOTO)
CHAPTER 13 MICELLE-MEDIATED CAPILLARY ELECTROPHORETIC SEPARATION OF
ENANTIOMERIC COMPOUNDS 377
(MICHAEL E. SWARTZ AND PHYLLIS R. BROWN)
CHAPTER 14 UNIFIED ENANTIOSELECTIVE CHROMATOGRAPHY INVOLVING
CHIRASIL-DEX 401 {VOLKER SCHVRIG, SABINE MAYER, MARTIN JUNG,
MARKUSFLUCK, HANSJORG JAKUBETZ, ALEXANDRA
GLAUSCH, ANDSIMONA NEGURA)
CHAPTER 15 DERIVATIZED CYCLODEXTRINS AS CHIRAL GAS CHROMATOGRAPHIC
STATIONARY PHASES AND THEIR POTENTIAL APPLICATIONS IN THE PHARMACEUTICAL
INDUSTRY 415
( WEI YONG LI, AND THOMA S M. ROSSJ)
IMAGE 4
CONTENTS I
CHAPTER 16 CHIRAL DERIVATIZATION REAGENTS IN THE BIOANALYSIS OF
OPTICALLY ACTIVE DRUGS WITH CHROMOPHORE-BASED DETECTION 437
(RALFBUSCHGES, HASSAN Y. ABOUL-ENEIN, ERIC MARTIN, PETER LANGGUTH,
ANDHILDEGARD SPAHN-LANGGVTH)
CHAPTER 17 CIRCULAR DICHROISM SPECTROSCOPY IN THE ANALYSIS OF CHIRAL
DRUGS 493
(PIERA SALVADOR!, CARLO ROSIN I, AND CARLO BERTUCCI)
CHAPTER 18 CIRCULAR DICHROISM IN THE STUDY OF STEREOSELECTIVE BINDING OF
DRUGS TO SERUM PROTEINS 521
(CARLO BERTUCCI, PIERO SALVADOR!, AND ENRICO DOMENICI)
CHAPTER 19 CURRENT REGULATORY GUIDELINES OF STEREOISOMERIC DRUGS: NORTH
AMERICAN, EUROPEAN, AND JAPANESE POINT OF VIEW 545
(SYLVIE LAGANIERE)
CHAPTER 20 ENANTIOSELECTIVE ANALYSIS AND THE REGULATION OF CHIRAL DRUGS
565
(MICHAEL GROSS)
CHAPTER 21 FIRST PASS PHENOMENA: SOURCES OF STEREOSELECTIVITIES AND
VARIABILITIES OF CONCENTRATION-TIME PROFILES AFTER ORAL DOSAGE 573
(HILDEGARD SPAHN-LANGGUTH, LESLIEZ. BENET, WERNER MOHRKE, AND PETER
LANGGUTH)
CHAPTER 22 GASTROINTESTINAL TRANSPORT PROCESSES: POTENTIALS FOR
STEREOSELECTIVITIES AT SUBSTRATE-SPECIFIC AND NONSPECIFIC EPITHELIAL
TRANSPORT SYSTEMS 611
(PETER LANGGUTH, GORDONL AMIDON, ELKELIPKA, ANDHILDEGARD SPAHN-LANGGUTH)
IMAGE 5
X CONTENTS
CHAPTER 23 PREPARATION OF DRUG ENANTIOMERS BY CHROMATOGRAPHIC RESOLUTION
ON CHIRAL STATIONARY PHASES 633
(ERIC FRANCOTTE)
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| id | DE-604.BV011360334 |
| illustrated | Illustrated |
| indexdate | 2024-12-23T14:30:37Z |
| institution | BVB |
| isbn | 0471596442 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007634791 |
| oclc_num | 35262289 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-83 |
| owner_facet | DE-355 DE-BY-UBR DE-83 |
| physical | XXVII,695 S. graph. Darst. |
| publishDate | 1997 |
| publishDateSearch | 1997 |
| publishDateSort | 1997 |
| publisher | Wiley |
| record_format | marc |
| series | Chemical analysis |
| series2 | Chemical analysis |
| spellingShingle | The impact of stereochemistry on drug development and use Chemical analysis Médicaments chiraux Chemistry, Pharmaceutical methods Chiral drugs Molecular Conformation Stereoisomerism Stereochemie (DE-588)4129569-9 gnd Arzneimittel (DE-588)4003115-9 gnd Struktur-Aktivitäts-Beziehung (DE-588)4183784-8 gnd |
| subject_GND | (DE-588)4129569-9 (DE-588)4003115-9 (DE-588)4183784-8 |
| title | The impact of stereochemistry on drug development and use |
| title_auth | The impact of stereochemistry on drug development and use |
| title_exact_search | The impact of stereochemistry on drug development and use |
| title_full | The impact of stereochemistry on drug development and use Hassan Y. Aboul-Enein ... |
| title_fullStr | The impact of stereochemistry on drug development and use Hassan Y. Aboul-Enein ... |
| title_full_unstemmed | The impact of stereochemistry on drug development and use Hassan Y. Aboul-Enein ... |
| title_short | The impact of stereochemistry on drug development and use |
| title_sort | the impact of stereochemistry on drug development and use |
| topic | Médicaments chiraux Chemistry, Pharmaceutical methods Chiral drugs Molecular Conformation Stereoisomerism Stereochemie (DE-588)4129569-9 gnd Arzneimittel (DE-588)4003115-9 gnd Struktur-Aktivitäts-Beziehung (DE-588)4183784-8 gnd |
| topic_facet | Médicaments chiraux Chemistry, Pharmaceutical methods Chiral drugs Molecular Conformation Stereoisomerism Stereochemie Arzneimittel Struktur-Aktivitäts-Beziehung |
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