Models for assessing drug absorption and metabolism
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| Format: | Buch |
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New York [u.a.]
Plenum Press
1996
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| Schriftenreihe: | Pharmaceutical biotechnology
8 |
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| 245 | 1 | 0 | |a Models for assessing drug absorption and metabolism |c ed. by Ronald T. Borchardt ... |
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| 490 | 1 | |a Pharmaceutical biotechnology |v 8 | |
| 650 | 4 | |a Drugs |x Metabolism |x Research |x Methodology | |
| 650 | 4 | |a Models, Biological | |
| 650 | 4 | |a Pharmaceutical Preparations |x metabolism | |
| 650 | 4 | |a Pharmacokinetics | |
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| _version_ | 1819676151823466496 |
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| adam_text | MODELS FOR ASSESSING DRUG ABSORPTION AND METABOLISM EDITED BY RONALD T.
BORCHARDT THE UNIVERSITY OF KANSAS LAWRENCE, KANSAS PHILIP L. SMITH
SMITHKLINE BEECHAM PHARMACEUTICALS KING OF PRUSSIA, PENNSYLVANIA AND
GLYNN WILSON TACORA CORPORATION SEATTLE, WASHINGTON PLENUM PRESS * NEW
YORK AND LONDON CONTENTS CHAPTER 1 GENERAL PRINCIPLES IN THE
CHARACTERIZATION AND USE OF MODEL SYSTEMS FOR BIOPHARMACEUTICAL STUDIES
RONALD T. BORCHARDT, PHILIP L. SMITH, AND GLYNN WILSON 1. INTRODUCTION 1
2. BIOLOGICAL BARRIERS TO DRUG DELIVERY 3 3. DESIRABLE CHARACTERISTICS
OF A MODEL SYSTEM 4 4. CHARACTERIZATION OF MODEL SYSTEMS 5 5.
APPLICATIONS TO PHARMACEUTICAL PROBLEMS 7 6. FUTURE DIRECTIONS 8 7.
CONCLUSIONS 9 REFERENCES 9 CHAPTER 2 METHODS FOR EVALUATING INTESTINAL
PERMEABILITY AND METABOLISM IN VITRO PHILIP L. SMITH 1. INTRODUCTION 13
2. METHODS 14 2.1. MATERIALS 14 2.2. TISSUE PREPARATION 17 2.3.
TRANSPORT STUDIES 19 2.4. METABOLISM STUDIES 21 3. APPLICATIONS FOR
ABSORPTION AND METABOLISM 22 3.1. MECHANISTIC/SEGMENTAL TRANSPORT
STUDIES 22 XI XII CONTENTS 3.2. EVALUATION OF FORMULATION APPROACHES 24
3.3. METABOLISM STUDIES 27 3.4. DISCOVERY SCREENING 28 3.5. EVALUATION
OF DRUG-RELATED PATHOPHYSIOLOGY 28 4. ADVANTAGES AND DISADVANTAGES OF
TISSUE TECHNIQUES 29 REFERENCES 30 CHAPTER 3 CULTURED INTESTINAL
EPITHELIAL CELL MODELS ISMAEL J. HIDALGO 1. INTRODUCTION 35 2. METHODS
36 2.1. MATERIALS 36 2.2. SYSTEM ESTABLISHMENT AND MONITORING 36 2.3.
EXPERIMENTAL PROTOCOLS 39 2.4. CALCULATIONS OF DATA 42 3. APPLICATIONS
TO ABSORPTION AND METABOLISM STUDIES 45 3.1. DRUG ABSORPTION 45 3.2.
DRUG METABOLISM 46 3.3. IN VITRO-IN VIVO CORRELATIONS 47 4. ADVANTAGES
AND DISADVANTAGES OVER OTHER METHODS 48 4.1. ADVANTAGES 48 4.2.
DISADVANTAGES 48 REFERENCES 49 CHAPTER 4 INTESTINAL RINGS AND ISOLATED
INTESTINAL MUCOSAL CELLS JOSEPH A. FIX 1. INTRODUCTION 51 2. PREPARATION
OF EVERTED RINGS OR ISOLATED EPITHELIAL CELLS 52 2.1. INTESTINAL RINGS
52 2.2. ISOLATED INTESTINAL MUCOSAL CELLS 52 3. DEMONSTRATION OF
FUNCTIONAL VIABILITY OF RINGS AND CELLS 56 4. EXPERIMENTAL TECHNIQUES
FOR DRUG ABSORPTION MEASUREMENTS 57 4.1. INTESTINAL RINGS 58 4.2.
ISOLATED INTESTINAL MUCOSAL CELLS 61 5. ADVANTAGES, LIMITATIONS, AND
POTENTIAL APPLICATIONS OF RINGS AND CELLS IN QUANTITATING DRUG TRANSPORT
63 REFERENCES 64 CONTENTS XIII CHAPTER 5 MODELS OF DRUG ABSORPTION IN
SITU AND IN CONSCIOUS ANIMALS ROBIN GRIFFITHS, ANN LEWIS, AND PHILLIP
JEFFREY 1. INTRODUCTION 67 2. IN SITU ABSORPTION MODELS 68 2.1.
CANNULATION OF THE LUMEN ONLY 68 2.2. CANNULATION OF THE LUMEN WITH
BLOOD REPLACEMENT 69 2.3. CANNULATION OF THE LUMEN AND VASCULAR BED 69
2.4. SIMULTANEOUS PERFUSION OF THE RAT SMALL INTESTINE AND LIVER 71 2.5.
ASSESSMENT OF THE VIABILITY OF PERFUSION SYSTEMS 71 3. ABSORPTION
ASSESSMENT IN CONSCIOUS ANIMALS 73 3.1. SURGICAL TECHNIQUES 74 3.2. DATA
ANALYSIS IN IN VIVO EXPERIMENTS 81 4. COMPARISON OF METHODS USED TO
STUDY GASTROINTESTINAL ABSORPTION .... 82 REFERENCES 82 CHAPTER 6 MODEL
SYSTEMS FOR INTESTINAL LYMPHATIC TRANSPORT STUDIES CHRISTOPHER J. H.
PORTER AND WILLIAM N. CHARMAN 1. INTRODUCTION 85 2. METHODS 86 2.1.
MATERIALS 86 2.2. ANIMAL HANDLING AND PREPARATION 87 2.3. SURGICAL
PROCEDURES 88 2.4. GENERAL EXPERIMENTAL PROTOCOL AND ANIMAL MONITORING
92 2.5. LYMPH COLLECTION AND BLOOD SAMPLING 92 2.6. DRUG AND
TRIGLYCERIDE ANALYSIS 94 2.7. ALTERNATIVE ANIMAL MODELS 96 3.
METHODOLOGICAL DIFFERENCES IN TRANSPORT STUDIES 97 3.1. MESENTERIC
VERSUS THORACIC LYMPH DUCT CANNULATION 97 3.2. FASTING AND HYDRATION
EFFECTS 97 3.3. ANESTHETIZED VERSUS CONSCIOUS MODELS 98 3.4. CHOICE OF
COADMINISTERED LIPID 99 3.5. SCALING RAT LYMPHATIC TRANSPORT DATA TO
HIGHER SPECIES 100 4. APPLICATION TO ABSORPTION AND METABOLISM STUDIES
100 REFERENCES 101 X J V CONTENTS CHAPTER 7 BUCCAL TISSUES AND CELL
CULTURE ELIZABETH QUADROS, JAMES P. CASSIDY, AND HARRY LEIPOLD 1.
INTRODUCTION 103 2. METHODS 104 2.1. MODIFIED USSING CHAMBERS 104 2.2.
BUCCAL CELL CULTURE 107 2.3. IN VIVO DOG MODEL 109 3. APPLICATIONS TO
ABSORPTION AND METABOLISM 110 4. ADVANTAGES AND DISADVANTAGES COMPARED
TO OTHER METHODS ILL REFERENCES 112 CHAPTER 8 ISOLATED HEPATOCYTES M.
VORE, Y. LIU, AND T. C. GANGULY 1. INTRODUCTION 115 2. METHODS 116 2.1.
ISOLATION OF CELLS 116 2.2. EXPERIMENTAL PROTOCOLS FOR UPTAKE 116 2.3.
CALCULATIONS OF DATA 117 2.4. COMMENTS 118 3. ADVANTAGES AND
DISADVANTAGES OVER OTHER METHODS 119 REFERENCES 119 CHAPTER 9 CULTURED
RAT HEPATOCYTES EDWARD L. LECLUYSE, PETER L. BULLOCK, ANDREW PARKINSON,
AND JEROME H. HOCHMAN 1. INTRODUCTION 121 2. METHODS 122 2.1. CULTURE
MEDIA AND SUPPLEMENTS 122 2.2. HEPATOCYTE ISOLATION AND PRIMARY CELL
CULTURE 125 2.3. OVERLAY OF CELL CULTURES WITH EXTRACELLULAR MATRIX 127
3. PROPERTIES OF PRIMARY CULTURES OF RAT HEPATOCYTES 128 3.1. EVALUATION
OF MONOLAYER INTEGRITY 128 3.2. GENERAL MORPHOLOGICAL PROPERTIES OF
SANDWICHED HEPATOCYTES .... 128 3.3. REESTABLISHMENT OF STRUCTURAL AND
FUNCTIONAL BILE CANALICULI 128 CONTENTS XV 3.4. USE OF HEPATOCYTE
CULTURES FOR IN VITRO STUDIES 129 4. EFFECTS OF CULTURE CONDITIONS ON
LIVER-SPECIFIC FUNCTION 129 4.1. MEDIA EFFECTS 129 4.2. MATRIX EFFECTS
134 5. APPLICATIONS TO DRUG DEVELOPMENT AND METABOLISM 135 5.1. BILIARY
SECRETION 135 5.2. MICROSOMAL ENZYME INDUCTION 139 5.3. DRUG METABOLISM
143 6. ADVANTAGES AND DISADVANTAGES OF CULTURED HEPATOCYTES 144 7.
APPENDIX 146 7.1. MATERIALS 146 7.2. PROCEDURES FOR HEPATOCYTE ISOLATION
148 REFERENCES 152 CHAPTER 10 ISOLATED PERFUSED LIVER KIM L. R. BROUWER
AND RONALD G. THURMAN 1. INTRODUCTION 161 2. METHODS 163 2.1. PERFUSION
APPARATUS 163 2.2. PERFUSATE COMPOSITION AND FLOW RATE 167 2.3. SURGICAL
PROCEDURES 169 2.4. VIABILITY ASSESSMENTS 173 2.5. EXPERIMENTAL
PROTOCOLS AND DATA COLLECTION AND ANALYSIS 176 2.6. COMPARISON OF
TECHNIQUES 178 3. APPLICATIONS OF THE ISOLATED PERFUSED LIVER 179 3.1.
GENERAL APPLICATIONS 179 3.2. SPECIALIZED APPLICATIONS 182 4. ADVANTAGES
AND DISADVANTAGES OF THE ISOLATED PERFUSED LIVER AS COMPARED TO OTHER
MODELS 183 REFERENCES 186 CHAPTER 11 ISOLATED RENAL BRUSH BORDER AND
BASOLATERAL MEMBRANE VESICLES AND CULTURED RENAL CELLS MARCELO M.
GUTIERREZ, CLAIRE M. BRETT, AND KATHLEEN M. GIACOMINI 1 . INTRODUCTION
193 2. ISOLATED RENAL PLASMA MEMBRANE VESICLES 194 2.1. ADVANTAGES AND
DISADVANTAGES OF VESICLES 194 XVI CONTENTS 2.2. MATERIALS 195 2.3.
PROCEDURES 196 3. CULTURED RENAL EPITHELIAL CELLS 201 3.1. ADVANTAGES
AND DISADVANTAGES OF STUDIES IN CELLS 201 3.2. MATERIALS 202 3.3.
PROCEDURES 202 4. TRANSPORT STUDIES IN MEMBRANE VESICLES AND CELLS 205
4.1. SATURABILITY STUDIES 205 4.2. DRIVING FORCE STUDIES 206 4.3.
INHIBITION STUDIES 207 4.4. COUNTERFLUX STUDIES 208 4.5. CALCULATION OF
TRANSPORT PARAMETERS 208 REFERENCES 209 CHAPTER 12 USE OF AN ISOLATED
PERFUSED KIDNEY TO ASSESS RENAL CLEARANCE OF DRUGS: INFORMATION OBTAINED
IN STEADY-STATE AND NON-STEADY-STATE EXPERIMENTAL SYSTEMS NORIKO
OKUDAIRA AND YUICHI SUGIYAMA 1. INTRODUCTION 211 2. ISOLATED PERFUSED
KIDNEY 212 2.1. ISOLATION AND PERFUSION OF RAT KIDNEY 212 2.2.
HEMODYNAMIC PROPERTIES AND VIABILITY OF THE IPK 214 2.3. SINGLE-PASS AND
RECIRCULATING PERFUSED KIDNEY SYSTEMS 214 2.4. ASSESSMENT OF RENAL
CLEARANCE IN THE IPK 215 2.5. FACTORS THAT AFFECT RENAL CLEARANCE 215
2.6. THE NON-FILTERING PERFUSED KIDNEY SYSTEM 220 2.7. APPLICATION:
ANALYSIS OF RENAL HANDLING OF EPIDERMAL GROWTH FACTOR USING THE FK AND
NFK 221 3. MULTIPLE INDICATOR DILUTION METHOD 224 3.1. PULSE-INJECTION
MID METHOD USING THE RAT IPK 225 3.2. ANALYSIS OF DILUTION CURVES 225
3.3. MATHEMATICAL MODEL 228 3.4. ESTIMATION OF CAPILLARY PERMEABILITY
230 3.5. APPLICATION: KINETIC ANALYSIS OF THE RENAL TUBULAR SECRETION OF
ORGANIC ANIONS AND CATIONS BY THE MID METHOD COMBINED WITH A
MATHEMATICAL MODEL 231 4. ADVANTAGES AND DISADVANTAGES OF THE IPK 233
REFERENCES 236 CONTENTS XVII CHAPTER 13 BRAIN MICROVESSEL ENDOTHELIAL
CELL CULTURE SYSTEMS KENNETH L. AUDUS, LAWRENCE NG, WEN WANG, AND RONALD
T. BORCHARDT 1. INTRODUCTION 239 2. METHODS 240 2.1. MATERIALS 240 2.2.
SOLUTIONS AND REAGENTS 240 2.3. BRAIN MICROVESSEL ISOLATION 241 2.4.
PREPARATION OF GROWTH SURFACES FOR BRAIN MICROVESSELS 245 2.5. SEEDING
OF BRAIN MICROVESSELS ONTO GROWTH SURFACES 246 3. EXPERIMENTAL PROTOCOLS
FOR UPTAKE AND TRANSPORT STUDIES 248 3.1. UPTAKE STUDIES 248 3.2.
TRANSPORT STUDIES 248 3.3. PROTEIN ESTIMATION 249 4. CALCULATIONS OF
DATA 250 4.1. PERMEABILITY COEFFICIENTS 250 4.2. KINETIC PARAMETERS FOR
ACTIVE PROCESSES 250 5. PHARMACEUTICAL APPLICATIONS 251 5.1. UPTAKE AND
TRANSPORT 251 5.2. METABOLISM 251 5.3. PERMEABILITY REGULATION 252 6.
ADVANTAGES AND DISADVANTAGES OF BMEC CULTURE SYSTEMS 252 6.1. ADVANTAGES
OVER OTHER IN VITRO SYSTEMS 252 6.2. APPROPRIATE ROLES AND RELATIONSHIP
TO THE BBB IN VIVO 253 6.3. CURRENT LIMITATIONS 253 6.4. STATUS OF CELL
LINE DEVELOPMENT 254 7. CONCLUSIONS AND FUTURE PERSPECTIVES 255
REFERENCES 255 CHAPTER 14 METHODS TO STUDY DRUG TRANSPORT IN ISOLATED
CHOROID PLEXUS TISSUE AND CULTURED CELLS CARLA B. WASHINGTON, KATHLEEN
M. GIACOMINI, AND CLAIRE M. BRETT 1. INTRODUCTION 259 1.1. ROLE AND
FUNCTION OF THE CHOROID PLEXUS 259 1.2. IMPORTANCE OF THE CHOROID PLEXUS
IN DRUG DELIVERY AND TARGETING TO THE BRAIN 261 1.3. IMPORTANCE OF THE
CHOROID PLEXUS IN PHARMACOKINETICS AND PHARMACODYNAMICS 261 XVIII
CONTENTS 1.4. TECHNIQUES FOR THE STUDY OF DRUG TRANSPORT IN THE CHOROID
PLEXUS 262 2. TRANSPORT STUDIES IN ISOLATED CHOROID PLEXUS TISSUE SLICES
262 2.1. MATERIALS 263 2.2. PROCEDURES 264 2.3. MECHANISMS OF TRANSPORT
266 2.4. POTENTIAL PROBLEMS 271 2.5. CALCULATION OF TRANSPORT PARAMETERS
. 272 3. CULTURED CHOROID PLEXUS EPITHELIAL CELLS 273 3.1. MATERIALS
274 3.2. PROCEDURES 275 3.3. CALCULATION OF TRANSPORT PARAMETERS AND
FLUX 281 3.4. POTENTIAL PROBLEMS 281 4. SUMMARY 281 REFERENCES 282
CHAPTER 15 BRAIN PERFUSION SYSTEMS FOR STUDIES OF DRUG UPTAKE AND
METABOLISM IN THE CENTRAL NERVOUS SYSTEM QUENTIN R. SMITH 1.
INTRODUCTION 285 2. IN SITU BRAIN PERFUSION METHOD 287 2.1. GENERAL
CONSIDERATIONS 287 2.2. SURGICAL PREPARATION 288 2.3. PERFUSION FLUID
291 2.4. PERFUSION APPARATUS 293 2.5. PERFUSION EXPERIMENT 295 2.6.
CALCULATIONS 296 3. APPLICATIONS 299 4. ADVANTAGES AND DISADVANTAGES 302
REFERENCES 303 CHAPTER 16 IN VITRO NASAL MODELS PATRICIA M. REARDON 1.
INTRODUCTION 309 2. METHODS 310 2.1. MATERIALS 310 2.2. EXCISED NASAL
TISSUE MODEL 310 CONTENTS XIX 2.3. ISOLATED AIRWAY EPITHELIAL MEMBRANES
314 2.4. NASAL HOMOGENATE SYSTEMS 317 3. ABSORPTION AND METABOLISM
APPLICATIONS 319 4. ADVANTAGES AND DISADVANTAGES OF IN VITRO NASA L
MODELS 320 REFERENCES 321 CHAPTER 17 MODELS FOR INVESTIGATION OF PEPTIDE
AND PROTEIN TRANSPORT ACROSS CULTURED MAMMALIAN RESPIRATORY EPITHELIAL
BARRIERS KWANG-JIN KIM AND EDWARD D. CRANDALL 1. INTRODUCTION 325 2.
METHODS AND MATERIALS 326 2.1. PRIMARY CULTURE OF ALVEOLAR EPITHELIAL
CELLS 327 2.2. PRIMARY CULTURE OF AIRWAY EPITHELIAL CELLS 330 3.
AIR-INTERFACE CULTURE 333 4. APPLICATIONS TO ABSORPTION/METABOLISM 333
4.1. BIOELECTRIC MEASUREMENTS 333 4.2. FLUX MEASUREMENTS OF PEPTIDES AND
PROTEINS 335 4.3. METABOLISM OF PEPTIDES AND PROTEINS 336 4.4. FURTHER
CONSIDERATIONS 336 REFERENCES 339 CHAPTER 18 DRUG TRANSPORT ACROSS
XENOPUS ALVEOLAR EPITHELIUM IN VITRO DORIS WALL AND DOREEN PIERDOMENICO
1. INTRODUCTION 347 2. METHODS 348 2.1. MATERIALS 348 2.2. TISSUE
PREPARATION 348 2.3. ELECTRICAL PARAMETERS 349 2.4. TRANSPORT OF MODEL
COMPOUNDS 349 2.5. ELECTRON MICROSCOPY 350 3. EXPERIMENTAL PROTOCOLS 351
3.1. TRANSPORT MEASUREMENTS 351 3.2. EXPERIMENTAL APPROACHES TO
DISTINGUISH ACTIVE FROM PASSIVE TRANSPORT 351 3.3. DETERMINATION OF
TISSUE-ASSOCIATED RADIOACTIVITY 352 3.4. CALCULATION OF DATA 353
CONTENTS 4. APPLICATIONS TO STUDIES OF ABSORPTION MECHANISMS 353 5.
ADVANTAGES AND DISADVANTAGES OVER OTHER METHODS 356 REFERENCES 358
CHAPTER 19 IN SITU AND IN VIVO METHODS FOR PULMONARY DELIVERY MOHAMMED
ELJAMAL, SUDHA NAGARAJAN, AND JOHN S. PATTON 1. INTRODUCTION 361 2.
ISOLATED PERFUSED RAT LUNG MODEL (IPRL) 362 2.1. INTRODUCTION 362 2.2.
MATERIALS AND METHODS 363 2.3. TREATMENT OF THE DATA 364 3.
INTRATRACHEAL INSTILLATION MODEL 364 3.1. INTRODUCTION 364 3.2.
MATERIALS AND METHODS 365 3.3. TREATMENT OF THE DATA 366 4. AEROSOL
DEPOSITION MODEL 367 4.1. INTRODUCTION 367 4.2. MATERIALS AND METHODS
368 4.3. TREATMENT OF THE DATA 369 5. DISCUSSION 371 REFERENCES 373
CHAPTER 20 IN VITRO VIABLE SKIN MODEL ROBERT L. BRONAUGH 1. INTRODUCTION
375 2. METHODS 376 2.1. CHOICE OF MEMBRANE 376 2.2. PREPARATION OF
MEMBRANE 377 2.3. DIFFUSION CELL DESIGN 378 2.4. RECEPTOR FLUID 380 2.5.
TEMPERATURE 381 2.6. VEHICLE 381 2.7. DOSE 381 2.8. DURATION OF STUDY
381 2.9. MEASUREMENT OF PERCUTANEOUS ABSORPTION 382 2.10. EXPRESSION OF
DATA 382 CONTENTS XXI 3. APPLICATION OF MODEL TO SKIN ABSORPTION AND
METABOLISM MEASUREMENTS 382 4. COMPARISON OF MODEL TO OTHER METHODS 385
REFERENCES 385 CHAPTER 21 ISOLATED PERFUSED PORCINE SKIN FLAP SYSTEMS
JIM E. RIVIERE 1. INTRODUCTION 387 2. METHODS 388 2.1. SURGERY 388 2.2.
ISOLATED PERFUSION TECHNIQUE 390 2.3. ASSESSMENT OF VIABILITY 390 2.4.
DESIGN OF PERCUTANEOUS ABSORPTION AND TRANSDERMAL DRUG DELIVERY STUDIES
391 2.5. DATA ANALYSIS 392 2.6. PHARMACOKINETIC MODELING AND IN VITRO
AND IN VIVO EXTRAPOLATION 395 3. APPLICATIONS 398 3.1. PASSIVE
PERCUTANEOUS ABSORPTION AND BIOTRANSFORMATION OF PESTICIDES 398 3.2.
IONTOPHORESIS 402 4. ADVANTAGES AND DISADVANTAGES OF THE IPPSF 404
REFERENCES 405 CHAPTER 22 VAGINAL EPITHELIAL MODELS SY-JUEN WU AND
JOSEPH R. ROBINSON 1. INTRODUCTION 409 2. TISSUE PERMEABILITY 409 2.1.
MATERIALS 411 2.2. IN VITRO MODEL 411 2.3. IN SITU MODEL 414 2.4. IN
VIVO MODEL 418 2.5. OVARIECTOMIZED RAT MODEL 419 2.6. METABOLIC ENZYME
ACTIVITY STUDY 420 3. APPLICATIONS 421 4. ADVANTAGES AND DISADVANTAGES
422 REFERENCES 423 XXII CONTENT S CHAPTER 23 OCULAR EPITHELIAL MODELS
VINCENT H. L. LEE 1. INTRODUCTION 425 2. CHOICE OF ANIMAL MODELS 426 3.
TYPES OF EXPERIMENTAL MODELS 427 3.1. IN VITRO MODELS 427 3.2. IN VIVO
MODELS 428 4. CONCLUSIONS 432 REFERENCES 433 INDEX 437
|
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV011308472 |
| illustrated | Illustrated |
| indexdate | 2024-12-23T14:29:14Z |
| institution | BVB |
| isbn | 030645243X |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007596001 |
| oclc_num | 35086114 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | XXII, 444 S. Ill., graph. Darst. |
| publishDate | 1996 |
| publishDateSearch | 1996 |
| publishDateSort | 1996 |
| publisher | Plenum Press |
| record_format | marc |
| series | Pharmaceutical biotechnology |
| series2 | Pharmaceutical biotechnology |
| spellingShingle | Models for assessing drug absorption and metabolism Pharmaceutical biotechnology Drugs Metabolism Research Methodology Models, Biological Pharmaceutical Preparations metabolism Pharmacokinetics Pharmacokinetics Research Methodology Resorption (DE-588)4140438-5 gnd Arzneimittel (DE-588)4003115-9 gnd Pharmakokinetik (DE-588)4115557-9 gnd |
| subject_GND | (DE-588)4140438-5 (DE-588)4003115-9 (DE-588)4115557-9 (DE-588)4143413-4 |
| title | Models for assessing drug absorption and metabolism |
| title_auth | Models for assessing drug absorption and metabolism |
| title_exact_search | Models for assessing drug absorption and metabolism |
| title_full | Models for assessing drug absorption and metabolism ed. by Ronald T. Borchardt ... |
| title_fullStr | Models for assessing drug absorption and metabolism ed. by Ronald T. Borchardt ... |
| title_full_unstemmed | Models for assessing drug absorption and metabolism ed. by Ronald T. Borchardt ... |
| title_short | Models for assessing drug absorption and metabolism |
| title_sort | models for assessing drug absorption and metabolism |
| topic | Drugs Metabolism Research Methodology Models, Biological Pharmaceutical Preparations metabolism Pharmacokinetics Pharmacokinetics Research Methodology Resorption (DE-588)4140438-5 gnd Arzneimittel (DE-588)4003115-9 gnd Pharmakokinetik (DE-588)4115557-9 gnd |
| topic_facet | Drugs Metabolism Research Methodology Models, Biological Pharmaceutical Preparations metabolism Pharmacokinetics Pharmacokinetics Research Methodology Resorption Arzneimittel Pharmakokinetik Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007596001&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV007730074 |
| work_keys_str_mv | AT borchardtronaldt modelsforassessingdrugabsorptionandmetabolism |