Small cell carcinoma
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| Format: | Buch |
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| Sprache: | English |
| Veröffentlicht: |
Philadelphia [u.a.]
Saunders
1997
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| Schriftenreihe: | Chest surgery clinics of North America
7,1 |
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| Online-Zugang: | Inhaltsverzeichnis |
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| 245 | 1 | 0 | |a Small cell carcinoma |c Leslie J. Kohman, guest ed. |
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| 490 | 1 | |a Chest surgery clinics of North America |v 7,1 | |
| 650 | 2 | |a Carcinomes | |
| 650 | 4 | |a Carcinoma |x Lung |x Small Cell | |
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Datensatz im Suchindex
| _version_ | 1819611480360747008 |
|---|---|
| adam_text | SMALL CELL CARCINOMA
CONTENTS
Preface xi
Leslie J. Kohman
Basic Science of Small Cell Lung Cancer 1
Carol L. Williams
The unique phenotype expressed by small cell lung cancer
(SCLC) cells is responsible for the distinct clinical behavior of
SCLC. Basic research of SCLC is aimed at identifying and charac¬
terizing the unique attributes of SCLC cells that distinguish SCLC
from other forms of lung cancer and contribute to the malignant
behavior of SCLC. This article summarizes recent scientific ad¬
vances in this area. Specific issues which are addressed include
our current understanding of how SCLC arises, the origin and
consequences of the neuroendocrine phenotype expressed by
SCLC cells, and the role of SCLC adhesion molecules in SCLC
metastasis.
Neuroendocrine Tumors of the Lung: Pathology
and Molecular Biology 21
Frank Vuitch, Yoshitaka Sekido, Kwun Fong, Bruce Mackay,
John D. Minna, and Adi F. Gazdar
Neuroendocrine tumors of the lung constitute a varied spectrum.
Carcinoid tumors have low grade malignant potential, atypical
carcinoid tumors show intermediate biologic aggressiveness, and
large cell neuroendocrine carcinomas and small cell lung carcino¬
mas are highly lethal. Clinical and pathologic features and molec¬
ular biology findings are reviewed. The genetic alterations associ¬
ated with small cell lung carcinomas are emphasized.
CHEST SURGERY CLINICS OF NORTH AMERICA
VOLUME 7 • NUMBER 1 • FEBRUARY 1997 V
Differential Diagnosis of Small Cell Neuroendocrine
Carcinoma of the Lung 49
William H. Warren and Victor E. Gould
The diagnosis of small cell neuroendocrine carcinoma is usually
established using minimal biopsy techniques such as transbron
chial biopsy, transbronchial brushing, or transthoracic needle as¬
piration. Although this can often establish the diagnosis, we have
become increasingly aware of the differential diagnosis, including
lower grade neuroendocrine tumors, peripheral neuroectodermal
tumors of the chest wall, and lung carcinomas coexpressing small
cell and non neuroendocrine phenotypes. The clinician must be
aware of this differential diagnosis and, when necessary, obtain
further biopsy material.
Paraneoplastic Syndromes Associated with Small Cell
Lung Cancer 65
Carmine C. Marchioli and Stephen L. Graziano
The term paraneoplastic syndrome refers to the ability of some
tumors to produce signs and symptoms at a distance from the
site of the primary tumor or its metastases. Paraneoplastic syn¬
dromes may develop before the diagnosis of carcinoma is made.
Paraneoplastic syndromes associated with small cell lung cancer
(SCLC) include endocrinologic abnormalities secondary to pep
tide hormone production, and neurologic sequelae due to autoan
tibody production. This article reviews the common paraneoplas¬
tic syndromes that may occur in patients with SCLC.
Staging of the Patient with Small Cell Lung Cancer 81
Gail E. Darling
The current staging system and rationale for its use for small cell
lung cancer is reviewed, along with current anatomic staging
techniques. Prognostic indicators and serum markers and their
clinical relevance are discussed. New staging techniques and
promising methods of investigation are described. The roles of
staging aggressiveness and stage migration are reviewed, includ¬
ing the role of surgical staging.
Surgical Treatment of Peripheral Small Cell Lung Cancer 95
John D. Urschel
Approximately 5% of small cell lung cancer (SCLC) patients pres¬
ent with an asymptomatic peripheral tumor (solitary pulmonary
nodule) on routine chest radiography. In this setting, the diag¬
nosis of SCLC is often made at thoracotomy. Complete resection,
mediastinal lymph node sampling, and postoperative chemo¬
therapy are indicated. If the diagnosis is made preoperatively,
multiorgan scanning and mediastinoscopy are required prior to
thoracotomy. Survival for pathologic stage I SCLC treated by
vi CONTENTS
surgery and postoperative chemotherapy is comparable to sur¬
vival for surgically treated stage I non SCLC.
Is There a Place for Surgery in Central Small Cell
Lung Cancer? 105
Leslie J. Kohman
Only two randomized studies have compared surgical resection
to nonsurgical treatment in the small cell lung cancer patient.
Neither study found any advantage to surgery. Advocates of
surgery recommend the use of TNM staging for these patients,
and several subgroups may indeed benefit from the selective
inclusion of resection in the overall treatment plan.
The Role of Chemotherapy in the Treatment of Small
Cell Lung Cancer 113
Frances A. Shepherd
Because small cell lung cancer (SCLC) is a systemic malignancy,
chemotherapy is the mainstay treatment for patients with all
stages of this tumor. Many chemotherapeutic agents have activity
against SCLC, and when combined in three or four drug regi¬
mens, they produce a response in 75% to 90% of patients. Median
survival times for patients with limited disease range from 14 to
16 months, and a small proportion may be cured. For extensive
stage patients, median survival is usually less than 1 year; 2 year
disease free survival is uncommon. Current research is focusing
on ways to increase the dose intensity of chemotherapy delivery.
Role of Radiotherapy in the Treatment of Small Cell Lung
Carcinoma 135
Todd E. Williams and Andrew T. Turrisi III
Radiotherapy is an important component in the treatment of
limited stage small cell carcinoma of the lung. It improves both
local control and survival. This article reviews the scientific and
clinical data that have led to combined therapy being considered
the current standard for care of limited stage disease. Questions
of radiation dose, treatment volume, fractionation, and integra¬
tion with chemotherapy are discussed. New avenues of investiga¬
tion to reduce toxicity and optimize treatment efficacy are also
discussed.
Prophylactic Cranial Irradiation for Patients with Small
Cell Lung Cancer: An Enduring Controversy 151
Henry Wagner, Jr
Small cell lung cancer (SCLC) is a systemic disease that usually
presents with locally bulky disease in the lung and mediastinal
nodes, with either subclinical (limited stage) or detectable (exten
CONTENTS vii
sive stage) extrathoracic metastases. Treatment with local modal¬
ities alone leads almost invariably to systemic relapse, and treat¬
ment with only systemic therapy usually results in recurrence
at sites of initially demonstrated disease. Although prophylactic
cranial radiation is far from an ideal solution to the problem of
CNS metastases in patients with SCLC, it presently seems prefera¬
ble to the alternative of observation and generally ineffective
palliative treatment at time of relapse in the CNS.
Practical Issues in the Management of the Patient with
Small Cell Lung Cancer 167
Ramaswamy Govindan and Daniel C. Ihde
Small cell lung cancer (SCLC) accounts for 20% of all lung can¬
cers. More than two thirds of patients with SCLC present with
clinically evident distant metastases. Patients with limited stage
disease are treated with a combination of chemotherapy and
chest radiation. Patients with extensive stage disease and good
performance status are candidates for combination chemother¬
apy. Almost all patients relapse after an initial response. This
article focuses on the common sense approach to the management
of SCLC.
Future Directions in the Therapy of Small Cell Lung Cancer 183
Michael C. Perry
Current therapy for small cell lung cancer seems to have reached
a plateau. To rise off this plateau it will be necessary to improve
local control through radiation therapy, and control of distant
metastases with new chemotherapy strategies. It will also be
necessary to treat pharmacologic sanctuaries, reduce treatment
related toxicities, and prevent second malignancies.
Index 195
Subscription Information Inside back cover
Viii CONTENTS
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| illustrated | Illustrated |
| indexdate | 2024-12-23T14:26:15Z |
| institution | BVB |
| language | English |
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| physical | VIII, 198 S. Ill., graph. Darst. |
| publishDate | 1997 |
| publishDateSearch | 1997 |
| publishDateSort | 1997 |
| publisher | Saunders |
| record_format | marc |
| series | Chest surgery clinics of North America |
| series2 | Chest surgery clinics of North America |
| spellingShingle | Small cell carcinoma Chest surgery clinics of North America Carcinomes Carcinoma Lung Small Cell Kleinzelliges Bronchialkarzinom (DE-588)4212979-5 gnd |
| subject_GND | (DE-588)4212979-5 (DE-588)4143413-4 |
| title | Small cell carcinoma |
| title_auth | Small cell carcinoma |
| title_exact_search | Small cell carcinoma |
| title_full | Small cell carcinoma Leslie J. Kohman, guest ed. |
| title_fullStr | Small cell carcinoma Leslie J. Kohman, guest ed. |
| title_full_unstemmed | Small cell carcinoma Leslie J. Kohman, guest ed. |
| title_short | Small cell carcinoma |
| title_sort | small cell carcinoma |
| topic | Carcinomes Carcinoma Lung Small Cell Kleinzelliges Bronchialkarzinom (DE-588)4212979-5 gnd |
| topic_facet | Carcinomes Carcinoma Lung Small Cell Kleinzelliges Bronchialkarzinom Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007508189&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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| work_keys_str_mv | AT kohmanlesliej smallcellcarcinoma |