The post-imperative negative variation in schizophrenic patients and healthy subjects

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1. Verfasser: Klein, Christoph (VerfasserIn)
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Sprache:German
Veröffentlicht: Frankfurt am Main [u.a] Lang 1997
Schriftenreihe:Psychophysiologie in Labor und Feld 3
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Datensatz im Suchindex

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adam_text CONTENTS CHAPTER 1 INTRODUCTION INTO SCHIZOPHRENIA - THE DSM-III-R DIAGNOSTIC CONCEPT . 17 CHAPTER 2 NEUROETIOLOGICAL FACTS AND THEORIES ABOUT SCHIZOPHRENIA . 21 2.1 T HE N EUROPSYCHOLOGICAL T HEORY OF S CHIZOPHRENIA BY F RITH (1992) . 22 2.1.1 SCHIZOPHRENIA AS A DISORDER OF WILLED ACTION . 22 2.1.2 SCHIZOPHRENIA AS A DISORDER OF SELF-MONITORING . 23 2.13 SCHIZOPHRENIA AS A DISORDER OF THE MONITORING OF THE INTENTIONS OF OTHERS . 25 2.1.4 SCHIZOPHRENIA AS A DISORDER OF META-REPRESENTATIONS . 26 2.1.5 DISCUSSION OF THE THEORY OF FRITH (1992) . 27 2.2 S TRUCTURAL AND P HYSIOLOGICAL B RAIN F INDINGS IN S CHIZOPHRENIA . 29 22.1 STRUCTURAL FINDINGS IN THE PREFRONTAL CORTEX . 29 22.2 PHYSIOLOGICAL FINDINGS IN THE PREFRONTAL CORTEX . 29 223 STRUCTURAL FINDINGS IN THE TEMPORO-LIMBIC SYSTEM . 31 22.4 PHYSIOLOGICAL FINDINGS IN THE TEMPORO-LIMBIC SYSTEM . 31 2.23 FINDINGS IN SUBCORTICAL STRUCTURES . 32 22.6 INTEGRATING THE DIVERSITY OF BRAIN FINDINGS - THE NEURO-DEVELOPMENTAL THEORY OF SCHIZOPHRENIA BY WEINBERGER (1991) . 33 22.7 DISCUSSION OF THE NEURO-DEVELOPMENTAL THEORY OF SCHIZOPHRENIA BY WEINBERGER (1991) . 36 CHAPTER 3 EVENT-RELATED POTENTIALS IN SCHIZOPHRENIA . 39 3.1 S OME T HEORETICAL AND M ETHODOLOGICAL A SPECTS OF ERP R ESEARCH . 40 3.2 C ONTINGENT N EGATIVE V ARIATION (CNV) . 41 3.3 C ONTINGENT N EGATIVE V ARIATION IN S CHIZOPHRENIC P ATIENTS . 46 3.4 P OST -I MPERATIVE N EGATIVE V ARIATION (PINV) . 49 3.5 PINV IN S CHIZOPHRENIC P ATIENTS . 49 3.6 DOES THE PREHMXITAL CORTEX CONTRIBUTE TO THE OCCURENCE OF THE PINV? . 54 3.7 P300 . 55 3.8 M ODELS OF THE P300 . 56 3.9 P300 IN SCHIZOPHRENIC PATIENTS . 57 12 CONTENT CHAPTER 4 THE BASIC EXPERIMENTAL DESIGN AND METHODOLOGICAL COMMONALITIES OF THE REPORTED EXPERIMENTS . 61 4.1 T HE B ASIC E XPERIMENTAL P ROCEDURES . 61 4.2 T HE L ABORATORIES . 62 4.3 T HE R ECRUTIMENT OF E XPERIMENTAL S UBJECTS . 63 43.1 SCHIZOPHRENIC PATIENTS . 63 4.3.2 HEALTHY CONTROL SUBJECTS . 63 4.4 THE ASSESSMENT OF THE PSYCHOPATHOLOGICAL STATE IN SCHIZOPHRENIC PATIENTS. 63 4.5 T HE T ESTING P ROCEDURE . 64 43.1 HAVING THE SUBJECTS BECOME ACQUAINTED WITH THE LABORATORY, ELECTRODE APPLICATION, AND SOME QUESTIONNAIRE DATA . 64 43.2 RECORDING OF DEFINED EYE MOVEMENTS OF LARGE AMPLITUDE . 66 43.3 THE EXPERIMENTAL INSTRUCTION . 66 43.4 PRACTICE TRIALS . 68 433 EXPERIMENTAL TRIALS . 68 43.6 FINAL STEPS . 68 4.6 P RESENTATION OF E XPERIMENTAL S TIMULI AND P HYSIOLOQCAL R ECORDINGS . 69 4.6.1 AMPLIFIER SETTINGS . 69 4.7 D ATA R EDUCTION AND S TATISTICAL A NALYSIS . 69 4.7.1 CORRECTION OF DC SHIFTS . 69 4.7.2 FURTHER DATA PROCESSING STEPS WITH THE KN-PROGRAMS . 70 4.73 CORRECTION OF ARTIFACTS . 74 4.7.4 STATISTICAL PROCEDURES . 75 CHAPTER 5 COGNITIVE DETERMINANTS OF THE PINV . 81 5.1 T HE T HEORETICAL B ACKGROUND OF E XPERIMENT A . 81 5.2 H YPOTHESES . 90 5.3 T HE L ABORATORY . 92 5.4 R ECRUITMENT OF S UBJECTS AND A SSESSMENT OF P SYCHOPATHOLOGICAL V ARIABLES IN S CHIZOPHRENIC P ATIENTS . 92 5.5 T HE T ESTING P ROCEDURE . 93 5.6 T HE T ASK P RESENTATION . 94 5.7 A PPARATUS AND PHYSIOLOGICAL R ECORDINGS . 94 5.8 D ATA R EDUCTION AND D ATA A NALYSIS . 95 5.9 R ESULTS OF E XPERIMENT A . 98 5.9.1 REACTION TIMES (RT) . 98 5.9.2 EVENT-RELATED POTENTIALS . 98 5.9.2.1 GRAND AVERAGES OF THE PATIENT AND THE CONTROL GROUPS . 98 5.9.2.2 INITIAL AND TERMINAL CONTINGENT NEGATIVE VARIATION (ICNV, TCNV) . 99 CONTENT 13 5.9.2.3 POST-IMPERATIVE NEGATIVE VARIATION (PINV) . 103 5.9.2.4 LATE POSITIVE COMPLEXES (LPC) . 112 5.10 D ISCUSSION OF R ESULTS . 119 5.10.1 REACTION TIMES . 119 5.102 INITIAL AND TERMINAL CNV . 120 5.103 WS-LPC AND IS-LPC . 121 5.10.4 PINV . 122 CHAPTER 6 THE IMPACT OF THE MOTOR RESPONSE ON THE PINV . 127 6.1 T HE T HEORETICAL B ACKGROUND OF E XPERIMENT B . 127 6.2 H YPOTHESES . 130 6.3 T HE L ABORATORY . 133 6.4 R ECRUITMENT OF S UBJECTS AND A SSESSMENT OF C LINICAL V ARIABLES IN THE P ATIENT G ROUP . 133 6.5 T ESTING P ROCEDURE . 134 6.6 T HE T ASK P RESENTATION . 134 6.7 A PPARATUS AND P HYSIOLOGICAL R ECORDINGS . 135 6.8 D ATA R EDUCTION AND DATA A NALYSIS . 136 6.9 R ESULTS OF E XPERIMENT B . 138 6.9.1 REACTION TIMES (RT) . 138 6.9.2 EVENT RELATED POTENTIALS . 138 6.9.2.1 GRAND AVERAGES OF THE PATIENT AND THE CONTROL GROUP . 138 6.9.2.2 TERMINAL CONTINGENT NEGATIVE VARIATION (TCNV) . 139 6.9.3.2 POST-IMPERATIVE NEGATIVE VARIATION (PINV) . 143 6.9.3.3 LATE POSITIVE COMPLEX (LPC) . 152 6.10 D ISCUSSION . 155 6.10.1 REACTION TIMES (RT) . 155 6.10.2 TERMINAL CONTINGENT NEGATIVE VARIATION (TCNV) . 155 6.103 LATE POSITIVE COMPLEX (LPC) . 156 6.10.4 POST-IMPERATIVE NEGATIVE VARIATION (PINV). 157 CHAPTER 7 DOES THE PINV REFLECT FACILITATION OR DYSFACILITATION ? . 165 7.1 T HEORETICAL BACKGROUND OF THE I NVESTIGATION OF A COUSTICAL P ROBE -EP IN E XPERIMENTS A AND B . 165 7.1.1 BRAIN STRUCTURES INVOLVED IN ERP GENERATION . 167 7.12 CORTICAL FACILITATION AND DYSFACILITATION . 170 7.13 RESEARCH QUESTIONS . 172 7.2 H YPOTHESES . 174 14 CONTENT 7.3 E XPERIMENTAL DATA A NALYZED IN C HAPTER 7 . 175 7.4 P RESENTATION OF P ROBE S TIMULI IN E XPERIMENTS A AND B . 175 7.5 D ATA R EDUCTION AND S TATISTICAL A NALYSIS OF THE P ROBE EP . 176 7.6 R ESULTS OF EXPERIMENT A . 178 7.7 R ESULTS OF E XPERIMENT B . 181 7.8 D ISCUSSION . 186 CHAPTER 8 TOPOGRAPHY OF THE PINV IN SCHIZOPHRENIC PATIENTS AND IN GROUPS OF HEALTHY SUBJECTS . 191 8.1 T HE T HEORETICAL B ACKGROUND OF EXPERIMENTS C AND D . 193 8.2 B IOPHYSICAL P RINCIPLES OF EEG R ECORDING . 195 82.1 CORTICAL ARCHITECTURE . 195 8.2.2 BIOPHYSICAL PROCESSES IN HOMOGENEOUS MEDIA . 196 8.2.3 BIOPHYSICAL PROCESSES IN INHOMOGENEOUS MEDIA . 198 8.2.4 REFERENCE DEPENDENCE AND EEG RECORDINGS . 200 8.3 H YPOTHESES . 203 8.4 T HE L ABORATORY . 205 8.5 R ECRUITMENT OF S UBJECTS AND ASSESSMENT OF P SYCHOPATHOLOGICAL V ARIABLES IN S CHIZOPHRENIC P ATIENTS . 205 85.1 SUBJECT GROUPS IN EXPERIMENT C . 205 85.2 SUBJECT GROUPS IN EXPERIMENT D . 206 8.6 T HE T ESTING P ROCEDURE . 207 8.7 T HE T ASK P RESENTATION . 207 8.8 A PPARATUS AND P HYSIOLOGICAL RECORDINGS . 207 8.9 D ATA R EDUCTION AND D ATA A NALYSIS . 209 8.10 R ESULTS OF E XPERIMENT C: PINV T OPOGRAPHY IN S CHIZOPHRENIC . 211 P ATIENTS AND H EALTHY C ONTROL S UBJECTS . 211 8.10.1 GRAND AVERAGES . 212 8.102 SCALP AMPLITUDE MAPS . 214 8.10.3 CORTEX AMPLITUDE MAPS . 218 8.10.4 SCALP LAPLACIAN MAPS . 222 8.11 R ESULTS OF E XPERIMENT D: PINV T OPOGRAPHY IN S UBJECTS S CORING H IGH V ERSUS L OW ON A S CHIZOTYPAL P ERSONALITY D IMENSION . 225 8.11.1 GRAND AVERAGES . 225 8.112 SCALP AMPLITUDES MAPS . 227 8.11.3 CORTEX AMPLITUDE MAPS . 230 8.11.4 SCALP LAPLACIAN MAPS . 233 8.12 C ONTINGENT N EGATIVE V ARIATION AND P OST -I MPERATIVE N EGATIVE . 235 V ARIATION . 235 8.12.1 COMPARATIVE TOPOGRAPHY OFICNV, TCNV, AND PINV IN SCHIZOPHRENIC CONTENT 15 PATIENTS AND HEALTHY CONTROLS . 235 8.12.2 TOPOGRAPHICAL CHANGES AFTER IS PRESENTATION - PINV WITH THE TCNV BASELINE. 238 8.13 C ONTROL OF E YE MOVEMENT A RTIFACTS . 244 8.14 S TATISTICAL A NALYSIS OF THE M AP D ATA . 246 8.14.1 SCHIZOPHRENIC PATIENTS VERSUS HEALTHY CONTROLS . 247 8.14.2 LOW-SCORING VERSUS HIGH-SCORING SUBJECTS . 252 8.15 G ENERAL D ISCUSSION . 261 8.15.1 COMPARING THE DIFFERENT TYPES OF MAPS . 261 8.15.2 THE TOPOGRAPHY OF THE PINV IN SCHIZOPHRENIC PATIENTS AND HEALTHY CONTROLS . 262 CHAPTER 9 RESULT INTEGRATION AND GENERAL DISCUSSION . 263 9.1 R EACTION T IMES . 263 9.2 C ONTINGENT N EGATIVE V ARIATION (CNV) . 263 9.3 P OST -I MPERATIVE N EGATIVE V ARIATION (PINV) . 265 93.1 PINV IN HEALTHY SUBJECTS . 265 93.2 TOPOGRAPHY OF THE PINV - AVERAGED OVER THE EXPERIMENTAL CONDITIONS . 270 9.3.2.1 LATERALIZATION OF THE PINV . 270 9.3.2.2 ANTERIOR-POSTERIOR DISTRIBUTION OF THE PINV . 270 9.3.2.3 TEMPORAL COURSE OF THE LATERALIZATION OF THE PINV . 278 933 FUNCTIONAL SIGNIFICANCE OF THE PINV . 280 93.4 THE AMBIGUITY EFFECT . 280 933 THE PROVISIONAL MEMORY EFFECT . 283 93.6 THE NOGO EFFECT . 286 SUMMARY . 289 REFERENCES . 293 APPENDIX A ADDITIONAL STATISTICAL RESULTS NOT LISTED IN THE TEXT . 357 A PPENDIX A . 1 M ULTIVARIATE A NALYSIS OF V ARIANCE (MANOVA) R ESULTS O F THE S LOW N EGATIVE P OTENTIAL S HIFTS OF E XPERIMENT A . 357 A PPENDIX A.2 ANOVA R ESULTS FOR THE DATA OF EXPERIMENT A U SING D IFFERENT B ASELINES . 359 A PPENDIX A.3 ANOVA R ESULTS FOR THE DATA OF E XPERIMENT B U SING THE P RETRIAL B ASELINE . 362 A PPENDIX A.4 ANOVA R ESULTS FOR THE D ATA OF E XPERIMENT D E XCLUDING TWO L EFT -H ANDED S UBJECTS IN THE H IGH -S CORING G ROUP . 363 16 CONTENT APPENDIX B SCALP AMPLITUDE AND SCALP LAPLACIAN MAPS OF EXPERIMENTS C AND D NOT PRESENTED IN CHAPTER 8 . 365 A PPENDIX B. 1 M APS OF E XPERIMENT C . 365 A PPENDIX B.2 M APS OF E XPERIMENT D . 373 APPENDIX C THE GERMAN TRANSLATION OF THE SCHIZOTYPAL PERSONALITY QUESTIONNAIRE (SPQ; RAINE, 1991) . 381 M ETHODS . 381 RESULTS & D ISCUSSION . 381 C ONCLUSIONS . 386
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spelling Klein, Christoph Verfasser aut
The post-imperative negative variation in schizophrenic patients and healthy subjects Christoph Klein
Frankfurt am Main [u.a] Lang 1997
386 S. Ill., graph. Darst.
txt rdacontent
n rdamedia
nc rdacarrier
Psychophysiologie in Labor und Feld 3
Zugl.: Konstanz, Univ., Diss., 1995
Diagnostic and statistical manual of mental disorders 1987 (DE-588)4233017-8 gnd rswk-swf
Contingent Negative Variation physiology
Evoked potentials (Electrophysiology)
Schizophrenia Physiological aspects
Schizophrenia physiopathology
Slow potentials (Electrophysiology)
Psychophysiologische Diagnostik (DE-588)4176252-6 gnd rswk-swf
Negative Schizophrenie (DE-588)4296787-9 gnd rswk-swf
(DE-588)4113937-9 Hochschulschrift gnd-content
Negative Schizophrenie (DE-588)4296787-9 s
Diagnostic and statistical manual of mental disorders 1987 (DE-588)4233017-8 u
Psychophysiologische Diagnostik (DE-588)4176252-6 s
DE-604
Psychophysiologie in Labor und Feld 3 (DE-604)BV011077664 3
DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007424067&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle Klein, Christoph
The post-imperative negative variation in schizophrenic patients and healthy subjects
Psychophysiologie in Labor und Feld
Diagnostic and statistical manual of mental disorders 1987 (DE-588)4233017-8 gnd
Contingent Negative Variation physiology
Evoked potentials (Electrophysiology)
Schizophrenia Physiological aspects
Schizophrenia physiopathology
Slow potentials (Electrophysiology)
Psychophysiologische Diagnostik (DE-588)4176252-6 gnd
Negative Schizophrenie (DE-588)4296787-9 gnd
subject_GND (DE-588)4233017-8
(DE-588)4176252-6
(DE-588)4296787-9
(DE-588)4113937-9
title The post-imperative negative variation in schizophrenic patients and healthy subjects
title_auth The post-imperative negative variation in schizophrenic patients and healthy subjects
title_exact_search The post-imperative negative variation in schizophrenic patients and healthy subjects
title_full The post-imperative negative variation in schizophrenic patients and healthy subjects Christoph Klein
title_fullStr The post-imperative negative variation in schizophrenic patients and healthy subjects Christoph Klein
title_full_unstemmed The post-imperative negative variation in schizophrenic patients and healthy subjects Christoph Klein
title_short The post-imperative negative variation in schizophrenic patients and healthy subjects
title_sort the post imperative negative variation in schizophrenic patients and healthy subjects
topic Diagnostic and statistical manual of mental disorders 1987 (DE-588)4233017-8 gnd
Contingent Negative Variation physiology
Evoked potentials (Electrophysiology)
Schizophrenia Physiological aspects
Schizophrenia physiopathology
Slow potentials (Electrophysiology)
Psychophysiologische Diagnostik (DE-588)4176252-6 gnd
Negative Schizophrenie (DE-588)4296787-9 gnd
topic_facet Diagnostic and statistical manual of mental disorders 1987
Contingent Negative Variation physiology
Evoked potentials (Electrophysiology)
Schizophrenia Physiological aspects
Schizophrenia physiopathology
Slow potentials (Electrophysiology)
Psychophysiologische Diagnostik
Negative Schizophrenie
Hochschulschrift
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volume_link (DE-604)BV011077664
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