Neonatal gastroenterology

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Sprache:English
Veröffentlicht: Philadelphia [u.a.] Saunders 1996
Schriftenreihe:Clinics in perinatology 23,2
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Datensatz im Suchindex

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adam_text NEONATAL GASTROENTEROLOGY CONTENTS Foreword ix Philip Sunshine Preface xiii Josef Neu Oral Motor Function in the Neonate 161 Chantal Lau and Richard J. Schanler Oral feeding success in neonates primarily depends upon the proper coordination of sucking, swallowing, and respiration. Consideration of specific external factors, however, may enhance the infant s performance. For instance, premature infants can successfully oral feed despite an immature sucking pattern and such achievement is further facilitated by regulating milk flow. In addition, awareness is growing that proper development of maternal behavior can positively affect the infant s ability to feed. Gastrointestinal Motility in the Neonate 179 Carol Lynn Berseth Motor function in the stomach and intestine is responsible for the forward propulsion of nutrients. The regulation of motor function is multifaceted in the adult and many of the aspects of regulation are immature in the preterm infant. Thus, gastric emptying and intestinal transit are delayed in the preterm infant compared to the term infant and the adult. Manometry has been used to identify better feeding strategies for preterm infants and to iden¬ tify those infants at risk for developing feeding intolerance. CLINICS IN PERINATOLOGY VOLUME 23 • NUMBER 2 • JUNE 1996 V Digestion in the Newborn 191 Margit Hamosh This article discusses the enzymes active in the digestion of the major nutrients. Activity levels of digestive enzymes are com¬ pared between infant and adult. Emphasis is placed on specific compensatory mechanisms that operate during the physiologic pancreatic insufficiency of the newborn (such as fat digestion in the stomach by gastric lipase, and the role of milk bile salt dependent lipase and amylase in the digestion of fat and carbohy¬ drate). Digestion, Absorption, and Fermentation of Carbohydrates in the Newborn 211 C. Lawrence Kien In the newborn, sugars present in human milk and formulas are assimilated by both small intestinal digestion and, especially in the case of lactose, by colonic bacterial fermentation. Colonic fermentation of carbohydrate serves three major functions: con¬ servation of a fraction of the metabolizable energy of dietary carbohydrate that is not absorbed in the small intestine, preven¬ tion of osmotic diarrhea, and production of short chain fatty acids that stimulate sodium and water absorption, serve as fuel for coloncytes, and stimulate cell replication in colon and small intes¬ tine. Nutrient Absorption in the Preterm Neonate 229 Josef Neu and Otakar Koldovsky The capability of the gastrointestinal tract to absorb various nutri¬ ents depends on its maturity. This article summarizes several aspects of intestinal nutrient absorption as they relate to matura¬ tion of the gastrointestinal tract, and integrates the process of membrane digestion and absorption with other reviews of lume nal digestion included in this issue. Intestinal physiology and development are discussed as they pertain to absorption of carbo¬ hydrates, protein, lipids, and minerals, and how this information might be used in clinical practice. Neonatal Intestinal Metabolism 245 Robert E. Kimura In the presence of glutamine, glucose, and 3 hydroxybutyrate, glutamine is the preferred oxidative substrate in enterocytes of suckling and weaned rats. The oxidation of substrates that enter the citric acid cycle in the form of acetyl CoA such as glucose, fatty acid, and lipids is low during the suckling period and increases after weaning. The control of the citric acid cycle ap¬ pears to be the intramitochondrial [NADH]/[NAD+] ratio which is high during the suckling period and low in the intestine of vi CONTENTS weaned rats. The changes in substrate oxidation during weaning is not controlled by the endogenous steroid burst that occurs at 16 days of age. Substrate oxidation only changes after weaning suggesting that a change in diet is a significant factor in intestinal substrate oxidation. Trophic Factors for the Gastrointestinal Tract 265 Jane D. Carver and Lewis A. Barness Trophic factors influence the coordinated pre and postnatal growth and the development of the gastrointestinal (GI) tract. Systemically as well as enterally administered trophic factors have effects upon the GI tract, several have the potential to be used therapeutically to enhance GI maturation and repair follow¬ ing injury. Gastrointestinal trophic factors in human milk play an important role in regulating the adaptive functional changes which accompany the transition to postnatal enteral feedings. Neonatal Gastrointestinal Mucosal Immunity 287 Elizabeth Mannick and John N. Udall, Jr The gastrointestinal mucosal immune system is immature early in life. This puts the newborn infant at risk for infectious and allergic diseases. Breast milk contains cells, immunoglobulins, and antimicrobial substances which may be important for host defense. With age and proper nutrition the gastrointestinal muco¬ sal immune system matures and becomes important in host de¬ fense. Gastroesophageal Reflux in the Preterm Infant 305 Donald A. Novak Gastroesophageal reflux is a problem familiar to most pediatri¬ cians. The focus of this article is to provide a synopsis of the current state of knowledge regarding gastroesophageal reflux in the premature population, as well as to provide the practitioner with a rational basis upon which to diagnose and treat gastro¬ esophageal reflux in this population. Neonatal Hepatobiliary Disorders 321 Joel M. Andres Neonatal hepatobiliary disorders are now better understood due primarily to new discoveries in molecular genetics, virology, and immunology. Because they are almost always pathologic and require early intervention, the neonatologist must recognize in¬ fants with these hepatocellular and ductal cholestatic problems occurring in the first few weeks of life. This article focuses mainly on new developments regarding neonatal metabolic disorders and their potential for gene therapy; perinatal infections, espe¬ cially those caused by hepatitis B virus, hepatitis C virus, and CONTENTS Vli human immunodeficiency virus; and recent concepts of neonatal hepatitis and biliary atresia, including a review of predictors that influence outcome for infants undergoing Kasai portoenterostomy and liver transplantation. Surgical Conditions of the Neonatal Intestinal Tract 353 David W. Kays Surgical conditions affecting the neonatal intestine, including du¬ odenal atresia, jejunoileal atresia, meconium ileus, midgut volvu¬ lus, Hirschsprung s disease, and necrotizing enterocolitis, are cov¬ ered. Emphasis is on the practical issues of resuscitation and systematic evaluation. Detailed information on the surgical ap¬ proach is then provided, to aid the surgeon in training, and the non surgeon alike in understanding the management issues that arise in the operating room. Finally, long term issues that arise in the follow up of these children are addressed. Short Bowel Syndrome 377 Jon A. Vanderhoof This article discusses the management of short bowel syndrome during the neonatal period. It includes information regarding etiology and pathophysiology and parenteral and enteral nutri¬ tion therapy. Finally, a discussion of the role of intestinal trans¬ plantation in the treatment of short bowel syndrome is included. Neonatal Gastrointestinal Imaging 387 William A. Cumming and Jonathan L. Williams As an aid to practicing neonatologists, the many gastrointestinal anomalies and diseases found in neonates are discussed with regard to choosing the most efficient and appropriate imaging modalities in each. The discussion is organized under anatomical headings: esophagus, stomach, small bowel, colon, liver, and miscellaneous. Nine representative images are included as illus¬ trations. There is a brief discussion of umbilical arterial and venous catheters. Index 409 Subscription Information Inside back cover Viii CONTENTS
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publishDate 1996
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publisher Saunders
record_format marc
series Clinics in perinatology
series2 Clinics in perinatology
spellingShingle Neonatal gastroenterology
Clinics in perinatology
Maagdarmstelsel gtt
Maladies gastro-intestinales - Enfant
Néonatalogie
Pasgeborenen gtt
Child
Gastrointestinal Diseases
Infant
Neonatal gastroenterology
Neonatology
Gastrointestinale Krankheit (DE-588)4114483-1 gnd
Neugeborenes (DE-588)4041781-5 gnd
Verdauungskanal (DE-588)4078786-2 gnd
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(DE-588)4143413-4
title Neonatal gastroenterology
title_auth Neonatal gastroenterology
title_exact_search Neonatal gastroenterology
title_full Neonatal gastroenterology Josef Neu, guest ed.
title_fullStr Neonatal gastroenterology Josef Neu, guest ed.
title_full_unstemmed Neonatal gastroenterology Josef Neu, guest ed.
title_short Neonatal gastroenterology
title_sort neonatal gastroenterology
topic Maagdarmstelsel gtt
Maladies gastro-intestinales - Enfant
Néonatalogie
Pasgeborenen gtt
Child
Gastrointestinal Diseases
Infant
Neonatal gastroenterology
Neonatology
Gastrointestinale Krankheit (DE-588)4114483-1 gnd
Neugeborenes (DE-588)4041781-5 gnd
Verdauungskanal (DE-588)4078786-2 gnd
Physiologie (DE-588)4045981-0 gnd
Krankheit (DE-588)4032844-2 gnd
topic_facet Maagdarmstelsel
Maladies gastro-intestinales - Enfant
Néonatalogie
Pasgeborenen
Child
Gastrointestinal Diseases
Infant
Neonatal gastroenterology
Neonatology
Gastrointestinale Krankheit
Neugeborenes
Verdauungskanal
Physiologie
Krankheit
Aufsatzsammlung
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