Immunopharmacology of free radical species
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| Sprache: | English |
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London [u.a.]
Acad. Press
1995
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| Schriftenreihe: | The handbook of immunopharmacology
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| 245 | 1 | 0 | |a Immunopharmacology of free radical species |c ed. by David Blake ... |
| 264 | 1 | |a London [u.a.] |b Acad. Press |c 1995 | |
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| 650 | 4 | |a PROSTI RADIKALI | |
| 650 | 4 | |a REAKTIVNE OBLIKE KISIKA | |
| 650 | 4 | |a ANTIOXIDANTS | |
| 650 | 4 | |a FREE RADICALS | |
| 650 | 4 | |a OXIDANTS |x adverse effects | |
| 650 | 4 | |a REACTIVE OXYGEN SPECIES | |
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Datensatz im Suchindex
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| adam_text | 21 3C- IMMUNOPHAVMACOBPJJ F FREE RADICAL SPECIES EDITED BY DAVID BLAKE
AND PAUL G. WINYARD THE LONDON HOSPITAL MEDICAL COLLEGE, LONDON, UK
ACADEMIC PRESS HARCOURT BRACE AND COMPANY, PUBLISHERS LONDON SAN DIEGO
NEW YORK BOSTON SYDNEY TOKYO TORONTO CONTENTS CONTRIBUTORS XI SERIES
PREFACE XV PREFACE XVII 1. METHODS FOR THE DETECTION AND MEASUREMENT OF
BEACTIVE RADICAL SPECIES IN VIVO AND IN VITRO 1 MARTIN GROOTVELD AND
CHRISTOPHER J. RHODES 1. INTRODUCTION 1 2. DIRECT OBSERVATION OF
FREE-RADICAL SPECIES IN BIOLOGICAL SAMPLES BY ELECTRON SPIN RESONANCE 7.
SPECTROSCOPY 2 3. DETECTION OF PROTEIN DAMAGE ARISING FROM THE ACTION OF
OXYGEN-DERIVED RADICAL SPECIES 3 8. 4. DNA DAMAGE 4 9. 5. OXIDATIVE
DAMAGE TO CARBOHYDRATES 5 10. 6. ANALYSIS OF PRODUCTS ARISING FROM THE
INTERACTIONS OF REACTIVE OXYGEN SPECIES WITH FURTHER BIOMOLECULES OF LOW
MOLECULAR MASS 7 2. LIPID PEROXIDATION AND CARDIOVASCULAR DISEASE 23
VICTOR M. DARLEY-USMAR, RONALD P. MASON, WAKE CHAMULITRAT, NEIL HOGG AND
BALARAMAN KALYANARAMAN 6.1 AROMATIC HYDROXYLATION 7 6.2 HIGH-RESOLUTION
H-NMR SPECTROSCOPY 8 DETECTION OF PRODUCTS ARISING FROM THE
RADICAL-MEDIATED PEROXIDATION OF POLYUNSATURATED FATTY ACIDS 13
CONCLUSIONS 18 ACKNOWLEDGEMENTS 18 REFERENCES 18 1. INTRODUCTION 23 2.
MECHANISMS OF LIPID PEROXIDATION 24 2.1 GENERAL PRINCIPLES OF INITIATION
AND PROPAGATION IN LIPID PEROXIDATION 24 2.2 INITIATION REACTIONS 24
2.2.1 ENZYMATIC PEROXIDATION CATALYSED BY LIPOXYGENASES 25 2.2.2 HAEM
PROTEINS AND LIPID PEROXIDATION 26 2.2.3 SUPEROXIDE, NITRIC OXIDE AND
PEROXYNITRITE 26 2.3 PROPAGATION REACTIONS 27 2.4 INTERACTIONS BETWEEN
LIPID HYDROPEROXIDES AND TRANSITION METALS 27 2.5 CHAIN-BREAKING
ANTIOXIDANTS 27 2.5.1 THE ANTIOXIDANT AND PRO-OXIDANT REACTIONS OF
A-TOCOPHEROL 28 3. 4. 5. 2.5.2 THE ANTIOXIDANT REACTIONS OF NITRIC OXIDE
29 2.5.3 SYNERGISTIC INTERACTIONS BETWEEN ANTIOXIDANTS 29 2.6
LIPOXYGENASE, SEEDING PEROXIDES AND LDL OXIDATION 30 2.6.1
OXIDIZABILITY AND THE POTENCY OF CHAIN-BREAKING ANTIOXIDANTS IN LDL 31
CELL CULTURE MODELS OF LIPOPROTEIN OXIDATION 32 3.1 ENDOTHELIAL CELLS 32
3.2 MACROPHAGES 32 3.3 INTRACELLULAR ANTIOXIDANTS AND ATHEROSCLEROSIS 33
SUMMARY 34 REFERENCES 34 VI CONTENTS 3. FREE RADICALS AND ANTIOXIDANTS
IN ATHEROSCLEROSIS 39 CATHERINE RICE-EVANS 1. INTRODUCTION 39 2. THE
POSSIBLE MECHANISMS OF THE OXIDATION OF LDL IN THE PRODUCTION OF LIPID
HYDROPEROXIDES 40 3. ANTIOXIDANTS AND THEIR ACTIONS 42 4. THE
INVOLVEMENT OF FREE RADICALS IN THE PATHOGENESIS OF ATHEROSCLEROSIS 44
4.1 CELL-INDUCED MODIFICATION 44 4.2 CO-INCUBATION WITH TRANSITION
METALS, OR HAEM PROTEINS AND RUPTURED ERYTHROCYTES AND MYOCYTES 45 5.
OXIDIZED LDL - IS IT A REALITY? 48 6. ACKNOWLEDGEMENTS 49 7. REFERENCES
49 4. OXIDANT STRESS AND THE HEART: MODULATION OF ION TRANSPORT
MECHANISMS DURING ISCHAEMIA AND BEPERFUSION 53 MICHAEL J. SHATTOCK AND
PETER S. HADDOCK 1. REPERFUSION OF THE HEART AND OXIDANT STRESS 54 4.
1.1 BACKGROUND 54 1.2 ARE FREE RADICALS PRODUCED DURING EARLY
REPERFUSION IN THE HEART? 54 1.3 FREE RADICALS AND REPERFUSION
ARRHYTHMIAS 54 1.4 FREE RADICALS AND CONTRACTILE DYSFUNCTION 56 2. HOW
THE HEART COPES WITH OXIDANT STRESS 56 2.1 ANTIOXIDANTS AND FREE-RADICAL
SCAVENGERS IN THE HEART 56 2.2 OXIDANT STRESS-INDUCED ALTERATIONS IN
MYOCARDIAL GLUTATHIONE STATUS 57 3. MEMBRANE CONSEQUENCES OF OXIDANT
STRESS 57 3.1 EFFECTS OF OXIDANT STRESS ON THE ACTION POTENTIAL 57 3.2
EFFECTS OF OXIDANT STRESS ON MEMBRANE CURRENTS 57 3.2.1 CALCIUM AND
SODIUM INWARD CURRENTS 58 3.2.2 STEADY-STATE BACKGROUND CURRENTS 58
3.2.3 TRANSIENT INWARD CURRENT 59 3.3 OXIDANT STRESS AND CALCIUM
OVERLOAD 59 3.3.1 REDISTRIBUTION OF INTRACELLULAR CALCIUM STORES? 60 5.
3.3.2 INCREASED CELLULAR CALCIUM INFLUX? 60 6. 3.3.3 DECREASED CELLULAR
CALCIUM 7. EFFLUX? 61 8. 3.3.4 NA/K PUMP ACTIVITY AND ITS ROLE IN
CELLULAR CALCIUM HOMEOSTASIS 61 OXIDANT STRESS, REDOX STATE AND PROTEIN
FUNCTION 62 4.1 THIOL STATUS AND PROTEIN ACTIVITY 62 4.1.2 INFLUENCE OF
GLUTATHIONE STATUS ON SARCOLEMMAL PROTEIN FUNCTION 62 4.2 OXIDANT STRESS
AND NA/K PUMP FUNCTION 63 4.2.1 NA/K PUMP STRUCTURE AND REGULATORY ROLE
OF SULPHYDRYL GROUPS 63 4.2.2 FREE RADICALS AND NA/K PUMP FUNCTION 63
4.3 GLUTATHIONE AND NA/K PUMP FUNCTION 63 4.3.1 ISOLATED NA/K ATPASE
STUDIES 64 4.3.2 CYTOCHEMICAL ANALYSIS OF NA/K PUMP FUNCTION IN
LANGENDORFF- PERFUSED ISOLATED HEARTS: EFFECT OF GLUTATHIONE 65 4.3.3
BIOCHEMICAL ANALYSIS OF NA/ K ATPASE ACTIVITY IN SARCOLEMMAL
PREPARATIONS 66 4.3.4 WHOLE-CELL VOLTAGE-CLAMP RECORDINGS OF NA/K PUMP
CURRENT: EFFECTS OF CELLULAR GLUTATHIONE MANIPULATION 67 MOLECULAR
MECHANISM OF OXIDANT STRESS-INDUCED MODIFICATIONS OF PROTEIN FUNCTION 68
SUMMARY AND CONCLUSIONS 68 ACKNOWLEDGEMENT 69 REFERENCES 69 5. FREE
BADICALS IN CENTRAL NERVOUS SYSTEM DISEASES 73 JAMES A. CLEMENS AND JILL
A. PANETTA 1. EVIDENCE FOR THE EXISTENCE OF FREE RADICALS IN THE BRAIN
73 2. SOURCES OF FREE RADICALS 75 2.1 RADICAL PRODUCTION DURING NORMAL
METABOLISM 75 2.2 CATECHOLAMINES 75 CONTENTS VII 2.3 TRANSITION METALS
AND FREE-RADICAL FORMATION 75 2.4 GENERATION OF OXYGEN RADICALS FROM
LIPIDS 76 2.5 FREE RADICAL GENERATION BY PHAGOCYTIC CELLS 77 DEFENCES
AGAINST FREE RADICAL ATTACK 77 EVIDENCE FOR A ROLE FOR FREE RADICALS IN
CNS DISEASES 77 4.1 CEREBRAL ISCHAEMIA 77 4.2 PARKINSON S DISEASE 78 4.3
FREE RADICALS AND ALZHEIMER S DISEASE AND DOWN S SYNDROME 78 4.4
AMYOTROPHIC LATERAL SCLEROSIS 79 4.5 FREE RADICALS AND NORMAL AGEING 79
5. PROTECTIVE EFFECTS OF ANTIOXIDANTS 79 6. SUMMARY 80 7. REFERENCES 80
6. BENAL TRANSPLANTATION AND ISCHAEMIA*BEPERFUSION INJURY 85 COLIN J.
GREEN 1. THE CLINICAL PROBLEM 85 2. RENAL ISCHAEMIA 85 3. CURRENT
METHODS OF RENAL PRESERVATION 4. PRESUMED MECHANISMS OF ISCHAEMIC DAMAGE
86 5. OXIDATIVE STRESS 87 86 6. DELOCALIZATION OF IRON 88 7. LOSS OF
CALCIUM HOMEOSTASIS 89 8. SECOND MESSENGERS 91 9. RESPIRATORY CHAIN
DYSFUNCTION 92 10. CONCLUSIONS 92 11. REFERENCES 93 7. A VASCULAR BASIS
FOR FREE BADICAL INVOLVEMENT IN INFLAMMATORY JOINT DISEASE 97 MICHELE L.
KUS, KEVIN FAIRBURN, DAVID BLAKE AND PAUL G. WINYARD 1. INTRODUCTION 98
2. MECHANISMS, ANTIOXIDANT DEFENCES AND CONSEQUENCES OF FREE-RADICAL
PRODUCTION IN THE RHEUMATOID JOINT 98 2.1 MECHANISMS OF FREE-RADICAL
FORMATION IN THE RHEUMATOID JOINT 98 3. 2.1.1 PHAGOCYTOSIS 98 2.1.2
FORMATION OF NITRIC OXIDE 99 2.1.3 HYPOXIC*REPERFUSION INJURY 99 2.2
ANTIOXIDANT DEFENCES AGAINST FREE- RADICAL DAMAGE IN THE HUMAN JOINT 100
2.2.1 ENZYMIC ANTIOXIDANTS 100 2.2.1.1 SUPEROXIDE DISMUTASES 100 4.
2.2.1.2 CATALASE 100 2.2.1.3 GLUTATHIONE AND GLUTATHIONE PEROXIDASE 101
2.2.2 LOW MOLECULAR WEIGHT ANTIOXIDANTS 101 2.2.2.1 A-TOCOPHEROL 101
2.2.2.2 0-CAROTENE 101 5. 2.2.2.3 ASCORBATE 101 2.2.2.4 URATE 101 2.2.3
TRANSITION-METAL CHELATORS 102 2.2.3.1 TRANSFERRIN AND LACTOFERRIN 102
2.2.3.2 CAERULOPLASMIN 102 2.3 SOME BIOLOGICAL CONSEQUENCES OF ROM IN 6.
THE RHEUMATOID JOINT 102 2.3.1 LIPID PEROXIDATION AND THE OXIDATIVE
MODIFICATION OF LDL 102 7. 2.3.2 IGG DENATURATION 103 2.3.3 2.3.4 2.3.5
103 2.3.6 3.2 3.3 INACTIVATION OF AI-ANTITRYPSIN DNA DAMAGE 104
FRAGMENTATION OF HYALURONIC ACID 104 NF-XB ACTIVATION 104 LIPID
ABNORMALITIES IN INFLAMMATORY JOINT DISEASE 105 3.1
HYPERCHOLESTEROLAEMIA AND INFLAMMATORY ARTHRITIS 105 LIPOPROTEIN (A) AND
RHEUMATOID ARTHRITIS 105 DEPLETION OF LIPID-ASSOCIATED ANTIOXIDANTS IN
THE RHEUMATOID JOINT 105 FORMATION OF OX-LDL IN THE INFLAMED HUMAN JOINT
106 4.1 POSSIBLE MECHANISMS OF LDL OXIDATION IN THE RA JOINT 106 4.1.1
15-LIPOXYGENASE AND PHOSPHOLIPASE A 2 106 4.1.2 DEGRADATION OF
CAERULOPLASMIN 106 POTENTIAL PRO-INFLAMMATORY INFLUENCES OF OX- LDL IN
RA 107 5.1 CYTOKINE EXPRESSION 107 EXPRESSION OF ADHESION MOLECULES 107
CYTOTOXICITY 107 ANTI-LIPOPROTEIN ANTIBODIES IN RA 107 FOAM-CELL
FORMATION 108 CHAIN-BREAKING ANTIOXIDANTS AS THERAPEUTIC INTERVENTIONS
IN HUMAN INFLAMMATORY DISEASES - A CAUTIONARY NOTE 108 REFERENCES 109
5.2 5.3 5.4 5.5 VIII CONTENTS 8. BEACTIVE OXYGEN SPECKS IN SKIN
INFLAMMATION 113 CHRISTOPHER J. MORRIS, CHARLES W. TRENAM AND JOHN R.
EARL 1. INTRODUCTION 113 2. ANTIOXIDANT DEFENCE MECHANISMS ,114 3.
CATALYTIC IRON AND ITS SOURCES 116 4. ULTRAVIOLET-INDUCED SKIN
INFLAMMATION 117 4.1 ROLE OF PHAGOCYTES 118 5. LIPID PEROXIDATION 118 6.
XANTHINE OXIDASE 119 7. NITRIC OXIDE 119 8. REFERENCES 120 9. FREE
RADICALS, INFLAMMATION AND EYE DISEASES 127 M. GOSS-SAMPSON, A.J. VIVIAN
AND F.J. KELLY 1. INTRODUCTION 127 2. CORNEA 128 3. AQUEOUS HUMOUR 129
4. LENS 130 5. VITREOUS HUMOUR 133 6. RETINA 134 6.1 RETINOPATHY OF
PREMATURITY 7. UVEITIS 138 8. ACKNOWLEDGEMENT 139 9. REFERENCES 139 136
A COLOUR PLATE SECTION APPEARS BETWEEN PAGES 142*143. 10. FREE RADICALS
IN GASTROINTESTINAL AND HEPATIC DISEASE 143 NICOLA J. SIMMONDS 1.
INTRODUCTION 143 2. INVOLVEMENT OF FREE RADICALS IN THE INFLAMMATORY
RESPONSE 144 2.1 STOMACH AND DUODENUM 144 2.1.1 2.1.2 2.1.3 2.1.4 2.2
SMALL 2.2.1 2.2.2 2.2.3 2.3 COLON 2.3.1 2.3.2 2.3.3 INCREASED PRODUCTION
OF FREE RADICALS 144 PRODUCTION OF MUCOSAL DAMAGE 145 EFFECTS OF
ANTIOXIDANTS 145 CONCLUSIONS 146 BOWEL 146 ISCHAEMIA-REPERFUSION 146
NECROTIZING ENTEROCOLITIS 147 RADIATION ENTERITIS 147 147 INFLAMMATORY
BOWEL DISEASE 147 ISCHAEMIC COLITIS 152 BEHCET S DISEASE 152 2.4
PANCREAS 152 2.4.1 2.4.2 2.4.3 INCREASED PRODUCTION OF FREE RADICALS 152
PRODUCTION OF CELL DAMAGE 153 EFFECTS OF ANTIOXIDANTS 153 2.4.4 2.5
LIVER 2.5.1 2.5.2 2.5.3 2.5.4 2.5.5 2.5.6 2.5.7 2.5.8 CONCLUSIONS 153
153 ALCOHOLIC LIVER DISEASE 154 PARACETAMOL-INDUCED LIVER DAMAGE 156
IMMUNE-MEDIATED LIVER DAMAGE 156 CHOLESTATIC LIVER DISEASE 156 IRON
OVERLOAD (HAEMOCHROMATBSIS) 157 ISCHAEMIA-REPERFUSION INJURY AND LIVER
TRANSPLANTATION 157 XENOBIOTIC LIVER INJURY 158 NITRIC OXIDE IN LIVER
DISEASE 15! 3. FREE RADICALS AND CARCINOGENESIS IN THE GASTROINTESTINAL
TRACT 159 3.1 GASTRIC 3.2 COLON : CANCER 159 CANCER 159 3.3
HEPATOCELLULAR CANCER 160 4. CONCLUSION! 5. REFERENCES I 160 160 11.
FREE RADICALS, MUSCLE FATIGUE AND DAMAGE 175 M.J. JACKSON, A. MCARDLE
AND S. O FARRELL 1. INTRODUCTION 175 2. EXERCISE 175 3. FREE RADICALS
AND MUSCLE FATIGUE 176 4. FREE RADICALS AND EXERCISE-INDUCED MUSCLE
DAMAGE 178 5. ISCHAEMIA/REPERFUSION DAMAGE TO MUSCLE 6. MUSCLE DISEASES
180 7. REFERENCES 180 180 CONTENTS IX 12. FREE BADICALS, OXIDATIVE
STRESS AND DIABETES MELLITUS 183 ALAN J. SINCLAIR AND JOSEPH LUNEC 1.
INTRODUCTION 183 1.1 THE VASCULAR LESION IN DIABETES 183 2. FREE
RADICALS AND DIABETES MELLITUS 184 3. FREE RADICALS AND ISLET CELLS IN
DIABETES 187 4. CRITERIA FOR A ROLE OF FREE RADICALS IN DIABETIC
VASCULAR DISEASE 188 5. MECHANISMS OF FREE-RADICAL DAMAGE IN DIABETES
189 5.1 NON-ENZYMATIC GLYCOSYLATION OF PROTEIN 189 6. 7. 8. 5.2 SORBITOL
(POLYOL) PATHWAY 190 5.3 FREE RADICALS AND ATHEROSCLEROSIS 191 5.4 OTHER
MECHANISMS OF TISSUE DAMAGE IN DIABETES INVOLVING FREE RADICALS 193
STRATEGIES TO MODULATE FREE-RADICAL ACTIVITY IN DIABETIC VASCULAR
DISEASE 193 FUTURE STUDIES 194 REFERENCES 195 13. DNA DAMAGE BY FREE
BADICALS: CARCINOGENIC IMPLICATIONS 199 OKEZIE I. ARUOMA AND BARRY
HALLIWELL 1. INTRODUCTION 199 2. DNA AS A TARGET OF FREE-RADICAL DAMAGE
200 3. POSSIBLE MECHANISMS OF DNA DAMAGE INDUCED BY OXIDATIVE STRESS 201
4. THE PHYSIOLOGICAL IMPORTANCE OF DNA DAMAGE INDUCED BY OXIDATIVE
STRESS: CARCINOGENIC IMPLICATIONS 202 5. PROBING THE MECHANISM OF DNA
DAMAGE IN CELLS EXPOSED TO OXIDATIVE STRESS: CURRENT STATUS 203 6.
MEASUREMENT OF 8-HYDROXYGUANINE AND 8- HYDROXYDEOXYGUANOSINE 205 6.1
HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY 205 8. 9. 6.2 GAS
CHROMATOGRAPHY*MASS SPECTROMETRY 206 6.3 COMPARISON OF THE HPLC AND
GC-MS METHODS 207 6.3.1 SOME COMMENTS ON THE DISCREPANCY 207 6.3.2 CAN
HPLC UNDERESTIMATE 8-OH-DGUA? 209 6.3.3 ARTEFACTS IN GC-MS TECHNIQUES?
209 ANTIOXIDANT THERAPY: POINTS FOR CONSIDERATION 209 ACKNOWLEDGEMENTS
210 REFERENCES 210 14. FREE BADICALS IN LUNG INFLAMMATION AND
ENVIRONMENTAL EXPOSURE TO POLLUTANTS 215 M. YEADON INTRODUCTION 215
ENDOGENOUS SOURCES OF ROS IN THE LUNG 216 EXOGENOUS SOURCES OF ROS IN
THE LUNG 217 ANTIOXIDANT DEFENCE SYSTEMS IN THE LUNG 218 PULMONARY
TARGETS OF ROS 218 LUNG EPITHELIUM AND AIRWAY REACTIVITY 219 8. OXIDANT
STRESS AND LIPID MEDIATORS 9. ROS AND AIRWAY MUCUS 225 10. ROS IN HUMAN
LUNG DISEASES AND THERAPEUTICS 225 11. CONCLUDING REMARKS 227 12.
REFERENCES 227 223 15. FREE BADICALS AND LIVER INJURY 233 KEVIN H.
CHEESEMAN 1. INTRODUCTION 233 2. LIVER STRUCTURE AND FUNCTION 233 3.
FREE RADICALS IN EXPERIMENTAL AND CLINICAL LIVER INJURY 234 3.1 CARBON
TETRACHLORIDE-INDUCED LIVER INJURY 234 3.2 ETHANOL-INDUCED LIVER INJURY
237 3.3 IRON OVERLOAD AND LIVER INJURY 238 3.4 POLYHALOGENATED AROMATIC
CHEMICALS, IRON AND HEPATIC PORPHYRIA 239 3.5 PEROXISOME PROLIFERATORS
240 3.6 PARACETAMOL-INDUCED LIVER INJURY 240 3.7 QUINONES,
HYDROPEROXIDASES AND RELATED EXPERIMENTAL AGENTS 241 X CONTENTS 3.8
COMMON THREADS AND DISCREPANCIES 241 3.9 REPERFUSION INJURY IN LIVER
ALLOGRAFTS 241 3.10 ISCHAEMIC HEPATITIS 243 4. CONCLUDING REMARKS 243 5.
DEDICATION 243 6. REFERENCES 243 16. THE CONIOSES: ORGANOTYPIC
INFLAMMATORY OXIDATIVE BESPONSES TO ENVIRONMENTAL PANICULATE POLLUTANTS
247 PETER H. EVANS 1. INTRODUCTION 247 2. THE CONIOSES: ORGANOTYPIC
RESPONSES TO PARTICULATE-INDUCED INJURY 248 2.1 LUNG 248 DIRECT
FREE-RADICAL PANICULATE REACTIONS 248 PHAGOCYTE-DERIVED FREE RADICALS
249 OXIDATIVE EFFECTS 250 MODULATORY ACTIONS 250 2.1.1 2.1.2 2.1.3 2.1.4
251 2.2 2.1.5 CO-CARCINOGENESIS GUT 251 2.2.1 CANCER 251 2.2.2
INFLAMMATORY BOWEL DISEASE 251 2.2.3 PARTICLE MIGRATION 251 2.3 SKIN 251
2.4 JOINTS 252 2.5 BRAIN 252 2.5.1 CANCER 252 2.5.2 ALZHEIMER S DISEASE
252 3. ANTIOXIDANT DEFENCE MECHANISMS AND THERAPY 254 3.1 PHYSIOLOGICAL
254 3.2 NUTRITIONAL 254 3.3 PHARMACOLOGICAL 254 4. CONCLUSION 255 5.
ACKNOWLEDGEMENTS 256 6. REFERENCES 256 17. BEACTIVE OXYGEN: BECENT
THERAPEUTIC INTERVENTION STRATEGIES 263 JILL A. PANETTA AND JOHN M.
MCCALL 1. INTRODUCTION 263 2. ENZYME-RELATED THERAPEUTIC APPROACHES 265
2.1 NITRIC OXIDE SYNTHASE 266 3. ENDOGENOUS ANTIOXIDANTS/DERIVATIVES 267
4. EXOGENOUS ANTIOXIDANTS 268 4.1 STEROIDS 268 4.2 PHENOLS 269 5. 6. 7.
4.3 SPIN TRAPS 270 4.4 ANTIOXIDANT HETEROCYCLES 271 4.5 IRON REDOX CYCLE
MODIFIERS 272 INFLAMMATORY CASCADE 273 CONCLUSION 273 REFERENCES 274
GLOSSARY 279 KEY TO ILLUSTRATIONS 289 INDEX 295
|
| any_adam_object | 1 |
| building | Verbundindex |
| bvnumber | BV010570350 |
| classification_rvk | XI 6600 |
| ctrlnum | (OCoLC)438656451 (DE-599)BVBBV010570350 |
| discipline | Medizin |
| format | Book |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV010570350 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T17:55:12Z |
| institution | BVB |
| isbn | 0121035204 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007045716 |
| oclc_num | 438656451 |
| open_access_boolean | |
| owner | DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-578 |
| owner_facet | DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-578 |
| physical | XIII, 301 S. Ill., graph. Darst. |
| publishDate | 1995 |
| publishDateSearch | 1995 |
| publishDateSort | 1995 |
| publisher | Acad. Press |
| record_format | marc |
| series2 | The handbook of immunopharmacology |
| spelling | Immunopharmacology of free radical species ed. by David Blake ... London [u.a.] Acad. Press 1995 XIII, 301 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier The handbook of immunopharmacology ANTIOKSIDANTI OKSIDANTI - škodljivi učinki PROSTI RADIKALI REAKTIVNE OBLIKE KISIKA ANTIOXIDANTS FREE RADICALS OXIDANTS adverse effects REACTIVE OXYGEN SPECIES Immunpharmakologie (DE-588)4026639-4 gnd rswk-swf Freies Radikal (DE-588)4137149-5 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Freies Radikal (DE-588)4137149-5 s Immunpharmakologie (DE-588)4026639-4 s DE-604 Blake, David Sonstige oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007045716&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Immunopharmacology of free radical species ANTIOKSIDANTI OKSIDANTI - škodljivi učinki PROSTI RADIKALI REAKTIVNE OBLIKE KISIKA ANTIOXIDANTS FREE RADICALS OXIDANTS adverse effects REACTIVE OXYGEN SPECIES Immunpharmakologie (DE-588)4026639-4 gnd Freies Radikal (DE-588)4137149-5 gnd |
| subject_GND | (DE-588)4026639-4 (DE-588)4137149-5 (DE-588)4143413-4 |
| title | Immunopharmacology of free radical species |
| title_auth | Immunopharmacology of free radical species |
| title_exact_search | Immunopharmacology of free radical species |
| title_full | Immunopharmacology of free radical species ed. by David Blake ... |
| title_fullStr | Immunopharmacology of free radical species ed. by David Blake ... |
| title_full_unstemmed | Immunopharmacology of free radical species ed. by David Blake ... |
| title_short | Immunopharmacology of free radical species |
| title_sort | immunopharmacology of free radical species |
| topic | ANTIOKSIDANTI OKSIDANTI - škodljivi učinki PROSTI RADIKALI REAKTIVNE OBLIKE KISIKA ANTIOXIDANTS FREE RADICALS OXIDANTS adverse effects REACTIVE OXYGEN SPECIES Immunpharmakologie (DE-588)4026639-4 gnd Freies Radikal (DE-588)4137149-5 gnd |
| topic_facet | ANTIOKSIDANTI OKSIDANTI - škodljivi učinki PROSTI RADIKALI REAKTIVNE OBLIKE KISIKA ANTIOXIDANTS FREE RADICALS OXIDANTS adverse effects REACTIVE OXYGEN SPECIES Immunpharmakologie Freies Radikal Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007045716&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT blakedavid immunopharmacologyoffreeradicalspecies |