The imidazoline receptor pharmacology, functions, ligands, and relevance to biology and medicine ; [this volume is the result of a conference entitled II International Symposium on Imidazoline Receptors held in New York, New York on July 19 - 20, 1994]
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| adam_text | ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Volume 763
July 12, 1995
THE IMIDAZOLINE RECEPTOR:
PHARMACOLOGY, FUNCTIONS,
LIGANDS, AND RELEVANCE TO BIOLOGY
AND MEDICINE a
Editors
Donald J. Reis, Pascal Bousquet, and Angelo Parini
Conference Organizer
Donald J. Reis
Advisory Committee
D. J. Reis (USA), Chairman
D. Atlas (Israel) A. Parini (France)
P. Bousquet (France) J. L. Reid (UK)
D. B. Bylund (USA) R. R. Ruffolo, Jr. (USA)
J. P. Chalmers (Australia) S. Schafer (Germany)
J. A. Garcia Sevilla (Spain) P. M. Vanhoutte (France)
M. Gothert (Germany) J. E. Wikberg (Sweden)
J. H. Laragh (USA)
CONTENTS Preface. By Donald J. Reis, Pascal Bousquet, and Angelo
Parini xv
Part I. Imidazoline and Alpha 2 Adrenergic Receptors
Pharmacological Characteristics of Alpha 2 Adrenergic Receptor
Subtypes. By David B. Bylund 1
Possible Structural and Functional Relationships between
Imidazoline Receptors and a2 Adrenoceptors. By J. Paul
Hieble and Robert R. Ruffolo, Jr 8
This volume is the result of a conference entitled II International Symposium on Imidazoline
Receptors held in New York, New York on July 19 20, 1994.
Ij Imidazoline Receptors. Definition, Characterization, Distribution,
and Transmembrane Signaling. By Paul Ernsberger,
Marilyn E. Graves, Lynette M. Graff, Nasser Zakieh,
Phong Nguyen, Laura A. Collins, Kelly L. Westbrooks,
and Guintvere G. Johnson 22
Dynamic Properties of ^ Receptors. By Jarl E. S. Wikberg 43
Imidazoline Receptors, Subclassification, and Drug Induced
Regulation. By C. A. Hamilton 57
Nonadrenergic Binding of [3H]Atipamezole in Rat Lung. A Novel
Imidazole Binding Site? By Birgitta Sjoholm, Juha Matti
Savola, and Mika Scheinin 66
Adrenergic and Imidazoline Receptor Mediated Responses to UK
14,304 18 (Brimonidine) in Rabbits and Monkeys. A Species
Difference. By James Burke, Alex Kharlamb, Tanveer
Shan, Eileen Runde, Edwin Padillo, Cynthia Manlapaz,
and Larry Wheeler 78
2,6 Dimethyl Clonidine: a2 Adrenoceptor or Ij Imidazoline
Receptor Agonist? By P. Ernsberger, P. Li, and D. D. Smyth 96
Part II. Imidazoline Receptors: Structure, Pharmacology, and
Regulation
Imidazoline Binding Sites. Pharmacological and Molecular
Characteristics. By Angelo Parini 100
Use of High Affinity, Radioiodinated Probes for Identification of
Imidazoline/Guanidinium Receptive Sites. By Stephen M.
Lanier, Bujana Lanier, Venkatesalu Bakthavachalam,
Christopher R. McGrath, and John L. Neumeyer 106
[3H]Cirazoline as a Tool for the Characterization of Imidazoline
Sites. By I. Angel, M. Le Rouzic, C. Pimoule, D. Graham,
and S. Arbilla 112
Functional Studies of Specific Imidazoline 2 Receptor Ligands. By
D. J. Nutt, N. French, S. Handley, A. Hudson, S.
Husbands, H. Jackson, S. Jordan, M. D. Lalies, J. Lewis,
L. Lione, N. Mallard, and J. Pratt 125
Antiidiotypic Antibodies as Tools to Study Imidazoline Receptors.
By Fatima Bennai, Hugues Greney, Annick Molines,
Pascal Bousquet, and Monique Dontenwill 140
Structure Affinity Relationship of Cirazoline Derivatives for
Idazoxan Imidazoline Specific Sites in the Human Cerebral
Cortex and the Rabbit Kidney. By L. Brasili, M. Pigini,
J. D. Ehrhardt, A. Molines, H. Greney, P. Bousquet, and
M. Dontenwill 149
Pancreatic B Cells Express an Imidazoline Binding Site That Is
Distinct from Ij and I2 Sites. By Susan L. F. Chan, Colin A.
Brown, Kay E. Scarpello, and Noel G. Morgan 153
Imidazoline Binding Sites on PC 12 Cells and Bovine Chromaffin
Cells. By G. Steffen, A. Dendorfer, and P. Dominiak 157
Optimization of Radioligand Binding Assays for I] Imidazoline
Sites. By Paul Ernsberger, John E. Piletz, Lynette M.
Graff, and Marilyn E. Graves 163
Pharmacological and Immunological Characterization of Solubilized
130 140 and 66 kD Imidazoline Receptors jn the Rat Brain.
By Pablo V. Escriba, Andres Ozaita, Antonio Miralles,
Donald J. Reis, and Jesus A. Garcia Sevilla 169
[3H]Idazoxan Binds to Mitochondrial I2 Imidazoline Binding Sites
in Isolated Cells from Rabbit Kidney Proximal Tubule. By
C. Gargalidis Moudanos and A. Parini 172
Castration of Rats Upregulates the Imidazoline Receptor in
Prostate. By Y. Nassir, S. Regunathan, D. J. Reis, E. D.
Vaughan, Jr., and D. Felsen 174
Part HI. Imidazoline Receptor Distribution
I2 Imidazoline Receptors in the Healthy and Pathologic Human
Brain. By Jesus A. Garcia Sevilla, Antonio Miralles,
Magdalena Sastre, Pablo V. Escriba, Gabriel Olmos, and
J. Javier Meana 178
Distribution of Nonadrenergic [3H]Rilmenidine Binding in Rat
Brain and Kidney. By P. R. King, S. Suzuki, W. J. Louis, and
A. L. Gundlach 194
Distribution of Imidazoline Receptor Binding Protein in the Central
Nervous System. By David A. Ruggiero, Soundararajan
Regunathan, Hong Wang, Teresa A. Milner, and Donald
J. Reis 208
In Situ Hybridization. A Complementary Method to Radioligand
Mediated Autoradiography for Localizing Adrenergic, Alpha 2
Receptor Prpducing Cells. By Anthony P. Nicholas, Vincent
PlERIBONE, AKE DAGERLIND, BjORN MEISTER, ROBERT ElDE,
and Tomas Hokfelt 222
Part IV. Signal Transaction
Potassium Channels, Imidazolines, and Insulin Secreting Cells. By
Mark J. Dunne, Elizabeth A. Harding, Jonathan H.
Jaggar, Paul E. Squires, Rtxin Liang, Charlotte Kane,
Roger F. L. James, and Nicholas J. M. London 243
A New Therapeutic Approach for Sickle Cell Disease. Blockade of
the Red Cell Ca2+ Activated K+ Channel by Clotrimazole. By
Carlo Brugnara, Lucia de Franceschi, Carrie C. Armsby,
Nacera Saadane, Marie Trudel, Yves Beuzard, Ann
Rtttenhouse, Nader Rifai, Orah Platt, and Seth L. Alper . 262
Clonidine and Cirazoline Inhibit Activation of Nicotinic Channels
in PC 12 Cells. By I. F. Musgrave, D. Krautwurst,
J. Hescheler, and G. Schultz 272
Calcium Channel Dependent and I] Imidazoline Receptor Binding
Properties of 2 (4 Isothiocyanatobenzyl) Imidazoline Analogs
in Vascular and Brain Tissues. By L. Lei, M. Slavica,
P. Ernsberger, M. E. Graves, P. Patil, D. Miller, and
D. Feller 283
Inhibition of Red Cell Ca2+ Activated K+ Transport by Clotrimazole
Does Not Take Place via Imidazoline Binding Sites. By
I. Coupry, C. C. Armsby, S. Alper, A. Parini, and C.
Brugnara 287
Effects of Rilmenidine on Signal Transduction Mechanisms
Associated with a2 Adrenergic and Imidazoline Receptors in
Brain. By Soundararajan Regunathan, Sonja Bramwell,
and Donald J. Reis 290
Part V. Endogenous Ligands
Endogenous Ligands of Imidazoline Receptors: Classic and
Immunoreactive Clonidine Displacing Substance and
Agmatine. By Donald J. Reis, Gen Li, and Soundararajan
Regunathan 295
Molecular and Physiological Properties of Clonidine Displacing
Substance. By Daphne Atlas 314
Agmatine Is Synthesized by a Mitochondrial Arginine
Decarboxylase in Rat Brain. By Gen Li, Soundararajan
Regunathan, and Donald J. Reis 325
Agmatine Is Widely and Unequally Distributed in Rat Organs. By
Walter Raasch, Soundararajan Regunathan, Gen Li, and
Donald J. Reis 330
Immunopurification of a Vasopressive Substance from Human
Serum with an Anti Clonidine Antibody. By M. Dontenwill,
A. Molines, F. Bennai, J. Feldman, G. Bricca,
A. Belcourt, and P. Bousquet 335
Part VI. Cellular Actions: Kidney, Pancreas, Adipocytes, Trachea
Imidazoline Receptors and Sodium Excretion in the Rat Kidney. By
Donald D. Smyth, Francis K. Darkwa, and S. Brian
Penner 340
Rilmenidine Alters Renal Function When Administered
Intracerebroventricularly or Intrarenally. By S. Brian Penner
and Donald D. Smyth 353
a2 Adrenoceptor and Imidazoline Preferring Binding Sites in the
Dog Kidney. By Roger G. Evans and John M. Haynes 357
Characterization of the Imidazoline Binding Site Involved in
Regulation of Insulin Secretion. By Noel G. Morgan, Susan
L. F. Chan, Colin A. Brown, and Efthymia Tsoli 361
Imidazolines Stimulate Release of Insulin from RIN 5AH Cells
Independently from Ir and I2 Imidazoline Receptors. By
Gabriel Olmos, Rohit N. Kulkarni, Munirul Haque, and
John MacDermot 374
Influence of Clonidine on Alloxan Induced Diabetes in Rats. By
Mihai Nechifor, Cristiana Filip, Elena Teslariu, Bogdan
I. Neughebauer, Marcel Costuleanu, and Adriana Negru. . 377
Nonadrenergic Imidazoline Binding Sites and Amine Oxidase
Activities in Fat Cells. By Christian Carpene, Luc Marti,
Alan Hudson, and Max Lafontan 380
Evidence for a Role for Imidazoline i! Binding Site in Rat Brown
Adipocytes. By G. Mory, F. Tesson, M. Combes George,
M. Nechad, and A. Parini 398
Regulation of Electrolyte Transport in Rabbit Tracheal Epithelial
Cells by the I f Imidazoline Agonist Moxonidine. By Carole
M. Liedtke and Paul Ernsberger 401
Part VII. Cellular Actions: CNS and Autonomic Nervous System
a2 Adrenoceptor Independent Inhibition by Imidazolines and
Guanidines of Noradrenaline Release from Peripheral, but Not
Central Noradrenergic Neurons. By M. Gothert, G. J.
Molderings, K. Fink, and E. Schlicker 405
No Relationship of It and ^ Imidazoline Binding Sites to
Inhibitory Effects of Imidazolines on Ligand Gated Ion
Channels. An Investigation in the Adrenal Medulla and in
Neuroblastoma Cells. By G. J. Molderings, K. Ruppert,
H. Bonisch, and M. Gothert 420
Moxonidine Decreases Gastric Secretion and Gastric Mucosal
Injury in Rats. By G. B. Glavin and D. D. Smyth 433
Role of the Epithelium in the Release of Contractile Agents from
the Rat Vas Deferens by Clonidine. By Afonso Caricati
Neto, Andre S. Pupo, Almir G. Wanderley, Manuel
Nunez Vergara, Ivan Ho Jun Koh, Neide H. Jurkiewicz,
and Aron Jurkiewicz 436
Coexpression of Imidazoline Receptors and Agmatine in Rat
Carotid Body. By Charlotte Youngson, Soundararajan
Regunathan, Hong Wang, Gen Li, and Donald J. Reis 440
Effect of 11 Imidazoline Receptor Activation on Responses of
Hypoglossal and Phrenic Nerve to Chemical Stimulation. By
M. A. Haxhiu, I. A. Dreshaj, B. Erokwu, L. A. Collins, and
P. Ernsberger 445
Centrally Mediated Ocular Hypotension: Potential Role of
Imidazoline Receptors. By W. Richard Campbell and David
E. Potter 463
Chronic Imidazoline Drug Treatment Increases the
Immunoreactivity of Glial Fibrillary Acidic Protein in Rat
Brain. LSL 60101 as a Novel and Selective Ligand for I2
Imidazoline Receptors. By Jesus A. Garcia Sevilla, Regina
Alemany, Gabriel Olmos, Angel Menargues, and Rosend
Obach 486
In Vivo Modulation of Norepinephrine and Glutamate Release
through Imidazoline Receptors in the Rat Central Nervous
System. By J. J. Meana, M. Herrera Marschitz, and
M. Goiny 490
Effects of the I2 Imidazoline Receptor Ligand LSL 60101 on
Various Models of Anorexia in Rats. By Angel Menargues,
Mar Cedo, Olga Artiga, Rossend Obach, and Jesus A.
Garcia Sevilla 494
Spinal Imidazoline Receptors Do Not Mediate the Antinociceptive
Action of Intrathecal Clonidine in the Rat. By Philip J.
Monroe, Deborah L. Smith, and David J. Smith 497
The Stimulatory Effect of Clonidine on Locus Coeruleus
Noradrenergic Neurons through Imidazoline Receptors Is
Modulated by Excitatory Amino Acids. By Joseba Pineda,
J. Angel Ruiz Ortega, Luisa Ugedo, and Jesus A.
Garcia Sevilla 501
Chronic Treatment with Phenelzine and Other Irreversible
Monoamine Oxidase Inhibitors Downregulates I2 Imidazoline
Receptors in the Brain and Liver. By Regina Alemany,
Gabriel Olmos, and Jesus A. Garcia Sevilla 506
Involvement of IrImidazoline Receptors in Mood Disorders. By
John E. Piletz and Angelos Halaris 510
Decreased Number and Immunoreactivity of I2 Imidazoline
Receptors in the Frontal Cortex of Suicide Victims. By
Magdalena Sastre, Pablo V. Escriba, Donald J. Reis, and
Jesus A. Garcia Sevilla 520
Human Cerebral Imidazoline Binding Sites. Further Biochemical
Investigations. By H. Greney, M. Dontenwill, G. Bricca,
A. Belcourt, and P. Bousquet 523
Part VIII. Cardiovascular System and Hypertension
Imidazoline Receptors and Cardiovascular Regulations. A
Statement. By Pascal Bousquet, Hugues Greney, Fatima
Bennai, Josiane Feldman, Jeanne Stutzmann, Alain
Belcourt, and Monique Dontenwill 526
Importance of Imidazoline Receptors in the Cardiovascular Actions
of Centrally Acting Antihypertensive Agents. By Geoffrey
A. Head 531
Alpha 2 Adrenergic Receptors. Immunohistochemical Localization
and Role in Mediating Inhibition of Adrenergic RVLM
Presympathetic Neurons by Catecholamines and Clonidine. By
R. L. Stornetta, D. Huangfu, D. L. Rosin, K. R. Lynch,
and P. G. Guyenet 541
Mechanism of Sympathoinhibition by Imidazolines. By Bela Szabo
and Rolf Urban 552
a Adrenoceptors and GABA Receptors in the Hypertensive and
Hypotensive Actions of Noradrenaline Intrathecally Injected in
Anesthetized Rats. By M. C. Garcia and S. M. Celuch 566
Imidazoline and Adrenoceptor Involvement in Cardiovascular
Responses to Clonidine in Sham and Sinoaortic Denervated
Rats. By D. Ricci and C. A. Taira 570
Influence of Imidazolines on Catecholamine Release in Pithed
Spontaneously Hypertensive Rats. By W. Hauser, J. Gutting,
Th. Nguyen, and P. Dominiak 573
Imidazoline Receptors in Vascular Smooth Muscle and Endothelial
Cells. By Soundararajan Regunathan, Charlotte
Youngson, Hong Wang, and Donald J. Reis 580
The Relationship between the Adrenoceptor and Nonadrenoceptor
Mediated Effects of Imidazoline and Imidazole Containing
Compounds. By J. C. McGrath, C. M. Brown, C. J. Daly,
D. Kendall, A. MacKinnon, D. J. Miller, M. Nagadeh,
A. O Dowd, J. J. O Dowd, D. Pinthong, G. Singh,
A. G. B. Templeton, and V. G. Wilson 591
Effect of the Imidazoline Receptor Ligand Moxonidine on Human
Platelet Aggregation. By Sally A. Wiest and Mitchell
I. Steinberg 606
Role of Imidazoline Receptors in Halothane Epinephrine
Arrhythmias. By Yukio Hayashi, Takahiko Kamibayashi,
Atsushi Yamatodani, Masakazu Kuro, and Ikuto Yoshiya . 610
Antiarrhythmic Effect of the Selective I Imidazoline Receptor
Modulator Moxonidine on Ouabain Induced Cardiac
Arrhythmia in Guinea Pigs. By H. J. Mest, P. Thomsen, and
A. Raap 620
Rilmenidine and the High Risk Hypertensive Patient. By John H.
Laragh 634
Ii Agents: A New Approach to the Treatment of Hypertension. By
M. Dubar and G. Pillion 642
Why Imidazoline Receptor Modulator in the Treatment of
Hypertension? By S. G. Schafer, E. C. Kaan, M. O.
Christen, A. Low Kroger, H. J. Mest, and G. J.
MOLDERINGS 659
Clinical Pharmacology of Drugs Acting on Imidazoline and
Adrenergic Receptors. Studies with Clonidine, Moxonidine,
Rilmenidine, and Atenolol. By John L. Reid, Vsevolod
Panfilov, Graham MacPhee, and Henry L. Elliott 673
Central Nervous System Norepinephrine Turnover in Essential
Hypertension. By Gavin W. Lambert, Claudia Ferrier,
David M. Kaye, Garry L. Jennings, Victor Kalff, Michael
J. Kelly, Helen S. Cox, Andrea G. Turner, and Murray D.
Esler 679
*****
Subject Index 695
Index of Contributors 705
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| genre | (DE-588)1071861417 Konferenzschrift 1994 New York, NY gnd-content |
| genre_facet | Konferenzschrift 1994 New York, NY |
| id | DE-604.BV010437298 |
| illustrated | Illustrated |
| indexdate | 2024-12-23T13:58:59Z |
| institution | BVB |
| institution_GND | (DE-588)5161436-4 |
| isbn | 0897669355 0897669363 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-006955625 |
| oclc_num | 645754879 |
| open_access_boolean | |
| owner | DE-12 DE-355 DE-BY-UBR DE-20 DE-188 |
| owner_facet | DE-12 DE-355 DE-BY-UBR DE-20 DE-188 |
| physical | XVI, 707 S. Ill., zahlr. graph. Darst. |
| publishDate | 1995 |
| publishDateSearch | 1995 |
| publishDateSort | 1995 |
| publisher | New York Acad. of Sciences |
| record_format | marc |
| series | Annals of the New York Academy of Sciences |
| series2 | Annals of the New York Academy of Sciences |
| spellingShingle | The imidazoline receptor pharmacology, functions, ligands, and relevance to biology and medicine ; [this volume is the result of a conference entitled II International Symposium on Imidazoline Receptors held in New York, New York on July 19 - 20, 1994] Annals of the New York Academy of Sciences Imidazoline (DE-588)4161313-2 gnd Rezeptor (DE-588)4049722-7 gnd |
| subject_GND | (DE-588)4161313-2 (DE-588)4049722-7 (DE-588)1071861417 |
| title | The imidazoline receptor pharmacology, functions, ligands, and relevance to biology and medicine ; [this volume is the result of a conference entitled II International Symposium on Imidazoline Receptors held in New York, New York on July 19 - 20, 1994] |
| title_auth | The imidazoline receptor pharmacology, functions, ligands, and relevance to biology and medicine ; [this volume is the result of a conference entitled II International Symposium on Imidazoline Receptors held in New York, New York on July 19 - 20, 1994] |
| title_exact_search | The imidazoline receptor pharmacology, functions, ligands, and relevance to biology and medicine ; [this volume is the result of a conference entitled II International Symposium on Imidazoline Receptors held in New York, New York on July 19 - 20, 1994] |
| title_full | The imidazoline receptor pharmacology, functions, ligands, and relevance to biology and medicine ; [this volume is the result of a conference entitled II International Symposium on Imidazoline Receptors held in New York, New York on July 19 - 20, 1994] ed. by Donald J. Reis ... |
| title_fullStr | The imidazoline receptor pharmacology, functions, ligands, and relevance to biology and medicine ; [this volume is the result of a conference entitled II International Symposium on Imidazoline Receptors held in New York, New York on July 19 - 20, 1994] ed. by Donald J. Reis ... |
| title_full_unstemmed | The imidazoline receptor pharmacology, functions, ligands, and relevance to biology and medicine ; [this volume is the result of a conference entitled II International Symposium on Imidazoline Receptors held in New York, New York on July 19 - 20, 1994] ed. by Donald J. Reis ... |
| title_short | The imidazoline receptor |
| title_sort | the imidazoline receptor pharmacology functions ligands and relevance to biology and medicine this volume is the result of a conference entitled ii international symposium on imidazoline receptors held in new york new york on july 19 20 1994 |
| title_sub | pharmacology, functions, ligands, and relevance to biology and medicine ; [this volume is the result of a conference entitled II International Symposium on Imidazoline Receptors held in New York, New York on July 19 - 20, 1994] |
| topic | Imidazoline (DE-588)4161313-2 gnd Rezeptor (DE-588)4049722-7 gnd |
| topic_facet | Imidazoline Rezeptor Konferenzschrift 1994 New York, NY |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006955625&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002532608 |
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