Toxicology in transition proceedings of the 1994 Eurotox Congress, meeting held in Basel, Switzerland, August 21-24, 1994 ; with 59 tables

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adam_text 2733-9-59 TOXICOLOGY IN TRANSITION PROCEEDINGS OF THE 1994 EUROTOX CONGRESS MEETING HELD IN BASEL, SWITZERLAND, AUGUST 21-24, 1994 EDITED BY THE PUBLICATION COMMITTEE G.H. DEGEN, J.R SEILER AND P BENTLEY WITH 104 FIGURES AND 59 TABLES SPRINGER CONTENTS GENETICALLY MODIFIED CELLS AND ANIMALS IN TOXICOLOGICAL RESEARCH CONCEPTS, POTENTIALS, METHODS FOR CONSTRUCTING TRANSGENIC CELLS AND ANIMALS - INTRODUCTION K.BURKI 3 USE OF RECOMBINANT CELLS IN METABOLIC AND MECHANISTIC STUDIES (ANALYSIS OF PATHWAYS) W. A. SCHMALIX AND J. DOHMER 8 APPLICATIONS FOR TRANSGENIC ANIMALS IN TOXICOLOGY D.BRUSICK . 23 THE BENCHMARK DOSE CONCEPT PRINCIPLES, BENEFITS AND LIMITATIONS OF THE NOEL APPROACH DJ.ESDAILE 37 COMPARISON OF BENCHMARK DOSES (BMD) WITH NO-OBSERVED-ADVERSE- EFFECT-LEVELS (NOAEL) AND LOW-OBSERVED-ADVERSE-EFFECT-LEVELS (LOAEL) FOR SUBCHRONIC STUDIES R. S. NAIR, M. W. STEVENS, M. A. MARTENS, ANDJ. EKUTA 44 BIOINDICATORS IN ECOTOXICOLOGY BIOINDICATORS IN ECOTOXICOLOGY: AN OVERVIEW J.LOPEZ-BAREA 5 7 USE OF CYTOCHROME P450 1A IN FISH AS A BIOMARKER OF AQUATIC POLLUTION A.GOKS0YR 80 RECEPTOR-MEDIATED TOXICITY CELLULAR AND MOLECULAR BIOLOGY OF ARYL HYDROCARBON (AH) RECEPTOR-MEDIATED GENE EXPRESSION S. SAFE AND V. KRISHNAN 99 INHIBITORS OF THE SODIUM PUMP: TOXINS, THEN DRUGS, AND NOW HORMONES J.-D. HORISBERGER 116 RODENT RESPONSES TO PEROXISOME PROLIFERATORS - A RECEPTOR-MEDIATED PHENOMENON ? J. D. TUGWOOD 125 VI ROLE OF SECOND MESSENGERS IN MINERAL PARTICLE-INDUCED PRODUCTION OF REACTIVE OXYGENS SPECIES BY PHAGOCYTES K. SAVOLAINEN ANDM. RUOTSALAINEN 134 ESTROGENIC EFFECTS OF SOME XENOBIOTICS M. VARGOVD, M. GAJDOVD.J. JAKUBOVSKY, ANDL. WSDLOVD 148 IN VITRO TESTS IN REGULATORY TOXICOLOGY IN VITRO METHODS IN REGULATORY TOXICOLOGY: THE CRUCIAL SIGNIFICANCE OF VALIDATION M.BALIS 155 SCIENTIFIC, ETHICAL AND LEGAL ASPECTS OF THE ACCEPTANCE OF IN VITRO METHODS IN REGULATORY TOXICOLOGY E.WALUM 163 THE VALIDATION AND USE OF IN VITRO TERATOGENICITY TESTS R. BECHTER 170 IN VITRO METHODS IN REGULATORY TOXICOLOGY R.BASS 192 IN VITRO TESTS IN REGULATORY TOXICOLOGY: SYMPOSIUM CHAIRMAN S SUMMING-UP M. BALLS 205 EX VIVO AND IN VITRO MODELS IN ACETAMINOPHEN HEPATOTOXICITY STUDIES. RELATIONSHIP BETWEEN GLUTATHIONE DEPLETION, OXIDATIVE STRESS AND DISTURBANCES IN CALCIUM HOMEOSTASIS AND ENERGY METABOLISM S. ELLOUK-ACHARD, V. LEVESSE, C. MARTIN, C. PHAM-HUY, H. DUTERTRE- CATELLA, M. THEVENIN, J.-M. WARNET, AND J. R. CLAUDE 209 RABBIT RENAL PROXIMAL TUBULE SUSPENSIONS AS A MODEL FOR NEPHROTOXICITY EVALUATION OF NATIVE OR IN SITU METABOLIZED B-LACTAM ANTIBIOTICS H. DUTERTRE-CATELLA, C. MARTIN, M. DEBRAY, C. PHAM-HUY, M. THEVENIN, J.M.WARNET,R. A. PODEVIN, AND J.R.CLAUDE 215 NEUROBEHAVIORAL ABNORMALITIES INDUCED BY SUBSTANCE ABUSE NEUROBEHAVIORAL ABNORMALITIES INDUCED BY PRENATAL EXPOSURE TO SUBSTANCES OF ABUSE - STATING THE PROBLEM J.EISNER 221 PRENATAL EXPOSURE TO MARIHUANA AND TOBACCO DURING INFANCY, EARLY AND MIDDLE CHILDHOOD: EFFECTS AND AN ATTEMPT AT SYNTHESIS. P. A. FRIED 233 DELAYED DEVELOPMENTAL NEURO- AND IMMUNOTOXICITY OF BENZODIAZEPINES M. SCHLUMPF., R. PARMER, E. E. BUTIKOFER, S. INDERBITZIN, A. R. SALILI,A..A. SCHREIBER, H. R. RAMSEIER, H. VAN LOVEREN, AND W. LICHTENSTEIGER 261 VII CHANGES OF EEG OF FREELY-MOVING RATS CAUSED BY THREE GENERATION ORGANOPHOSPHATE TREATMENT L. NAGYMAIJTINYI 288 DEVELOPMENTAL NEUROTOXICITY OF CARBON MONOXIDE M. R. CARRATU, R. CAGIANO, M. A. DE SALVIA, L. TRABACE, AND V. CUOMO.......... 295 SAFETY ASSESSMENT OF OVER THE COUNTER (OTC) PRODUCTS THE SAFETY ASSESSMENT OF OVER THE COUNTER (OTC) PRODUCTS B.SCHMID 305 OTC PHARMACEUTICALS AND GENOTOXICITY TESTING: THE PARACETAMOL, ANTHRAQUINONE, AND GRISEOFULVIN CASES L.MULLER 312 SAFETY ASSESSMENT OF OTC PRODUCTS: DOXYLAMINE SUCCINATE J.A.SKARE .* 326 SAFETY ASSESSMENT OF OTC PRODUCTS: A REGULATORY VIEW P.SJOBERG 341 DRUG TOXICITY FINDINGS AND NO ACTION TAKEN F. W. WOLFF. 346 SPECIES SPECIFICITY OF ORGAN TOXICITY SPECIES SPECIFICITY OF ORGAN TOXICITY W.BUTLER 351 SPECIES SPECIFICITY AT THE MOLECULAR LEVEL: THE CASE OF NITRIC OXIDE SYNTHASE E.FELLEY-BOSCO .. 357 MECHANISMS UNDERLYING SPECIES-SPECIFICITY IN TARGET ORGAN SPECIFICITY E. A. LOCK 367 SPECIES SPECIFICITY OF ORGAN TOXICITY: BEHAVIORAL DIFFERENCES G. BIGNAMI, G. DELL OMO, ANDE. ALLEVA 375 TERRESTRIAL ECOTOXICITY OF CHEMICAL SUBSTANCES DEVELOPMENT OF OECD TEST GUIDELINES AND HAZARD ASSESSMENT PROCEDURES FOR TERRESTRIAL EFFECTS N.GRANDY 397 DEVELOPMENT OF GUIDANCE FOR TERRESTRIAL EFFECTS ASSESSMENT L. SAMS0E-PETERSEN ANDF. PEDERSEN 406 VIII APPLICATION OF QUICK AND SIMPLE PLANT BIOASSAYS TO ASSESS THE GENOTOXICITY OF ENVIRONMENTAL POLLUTANTS - DETECTION OF POTENTIAL HEALTH HAZARDS OF AIR, WATER AND SOIL CONTAMINANTS T.-H.MA 420 COMPARISON OF SUSCEPTIBILITY TO CHEMICALS (PESTICIDES) OF SPECIES USED FOR HUMAN AND ENVIRONMENTAL EFFECT ASSESSMENT W. PFLUGER 434 TOXICOLOGICAL EVALUATION OF POLLUTANTS IN SOIL - CONCEPT OF THE AGU AND ASSESSMENT OF TOLERABLE CONCENTRATIONS FOR METALS B. LIEBL, U. SCHWEGLER, E. ROSCHER, AND G. KERSCHER 446 IMMUNODEFICIENT MOUSE SYSTEMS THE SCID (SEVERE COMBINED IMMNODEFICIENCY) MOUSE - ITS BIOLOGY AND USE IN IMMUNOTOXICOLOGICAL RESEARCH M.L0VIK ; 455 THE SCID MOUSE AS A TOOL TO BRIDGE THE GAP BETWEEN ANIMAL AND HUMAN RESPONSES H. VAN LOVEREN ANDC. DEHEER 468 THE SCID MOUSE AND ITS USE IN IMMUNOPHARMACOLOGICAL AND IMMUNOTOXICOLOGICAL INVESTIGATIONS C. H. LADEL, H. PILSCHNER, AND U. BAMBERGER 472 STEREOCHEMICAL EFFECTS CHIRALITY - FROM MOLECULES TO ORGANISMS /. P. SELLER 491 INTERACTIONS BETWEEN THE IN VITRO METABOLISM OF XENOBIOTICS AND FATTY ACIDS. THE CASE OF IBUPROFEN AND OTHER CHIRAL PROFENS. J.M. MAYER, B. TESTA, M.ROY-DEVOS, C. AUDERGON, ANDJ.C. ETTER 499 SIDE EFFECTS AND TOXIC REACTIONS OF CHIRAL DRUGS: A CLINICAL PERSPECTIVE M. EICHELBAUM 514 ANALYSIS OF (S)- AND (R)-PROPANOLOL IN HUMAN PLASMA AND URINE BY A SPECIFIC IMMUNOENZYMTIC ASSAY VERSUS HPLC C. PHAM-HUY, A. SAHUI-GNASSI, F. MASSICOT, H. GALONS, H. DUTERTRE- CATELLA,B.RADENEN.JM. WARNET,H.T.DUE, AND J.R.CLAUDE 522 BIOLOGICAL BEHAVIOR OF PRESTAGES OF CANCER CELLS BIOLOGICAL BEHAVIOR OF PRESTAGES OF CANCER CELLS: AN INTRODUCTION R. SCHULTE-HERMANN 531 IX PRENEOPLASTIC LESIONS IN KIDNEY AND CARCINOGENESIS BY NON-GENOTOXIC COMPOUNDS D.R. DIETRICH ANDT.RASONYI 536 EARLY CELLULAR ALTERATIONS IN CHEMICAL LIVER CARCINOGENESIS AS ASSESSED BY IMMUNOHISTOCHEMICAL AND MOLECULAR BIOLOGICAL TECHNIQUES H. S. HUITFELDT 547 LATE MANUSCRIPTS THE UK APPROACH TO THE REGULATION AND EVALUATION OF NOVEL FOODS PRODUCED BY BIOTECHNOLOGY D.A.JONAS 557 YOUNG SCIENTISTS POSTER AWARD MOLECULAR MIMIKRY OF CF3CO-LYSINE BY LIPOIC ACID I: THE DEHYDROLIPOAMIDE ACETYLTRANSFERASE SUBUNIT OF THE HUMAN PYRUVATE DEHYDROGENASE AS AUTOANTIGEN IN HALOTHANE HEPATITIS U. CHRISTEN ANDJ. GUT 565 MOLECULAR MIMIKRY OF CF3CO-LYSINE BY LIPOIC ACID II: LIPOIC ACID BEARING PROTEINS AS AUTOANTIGEN IN HALOTHANE HEPATITIS N. FREY, V. KOCH, ANDJ. GUT 566 SUBJECT INDEX 567
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spelling Toxicology in transition proceedings of the 1994 Eurotox Congress, meeting held in Basel, Switzerland, August 21-24, 1994 ; with 59 tables ed. by G. H. Degen ...
Berlin u.a. Springer 1995
IX, 569 S. graph. Darst.
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spellingShingle Toxicology in transition proceedings of the 1994 Eurotox Congress, meeting held in Basel, Switzerland, August 21-24, 1994 ; with 59 tables
Toxikologie (DE-588)4060538-3 gnd
subject_GND (DE-588)4060538-3
(DE-588)1071861417
title Toxicology in transition proceedings of the 1994 Eurotox Congress, meeting held in Basel, Switzerland, August 21-24, 1994 ; with 59 tables
title_auth Toxicology in transition proceedings of the 1994 Eurotox Congress, meeting held in Basel, Switzerland, August 21-24, 1994 ; with 59 tables
title_exact_search Toxicology in transition proceedings of the 1994 Eurotox Congress, meeting held in Basel, Switzerland, August 21-24, 1994 ; with 59 tables
title_full Toxicology in transition proceedings of the 1994 Eurotox Congress, meeting held in Basel, Switzerland, August 21-24, 1994 ; with 59 tables ed. by G. H. Degen ...
title_fullStr Toxicology in transition proceedings of the 1994 Eurotox Congress, meeting held in Basel, Switzerland, August 21-24, 1994 ; with 59 tables ed. by G. H. Degen ...
title_full_unstemmed Toxicology in transition proceedings of the 1994 Eurotox Congress, meeting held in Basel, Switzerland, August 21-24, 1994 ; with 59 tables ed. by G. H. Degen ...
title_short Toxicology in transition
title_sort toxicology in transition proceedings of the 1994 eurotox congress meeting held in basel switzerland august 21 24 1994 with 59 tables
title_sub proceedings of the 1994 Eurotox Congress, meeting held in Basel, Switzerland, August 21-24, 1994 ; with 59 tables
topic Toxikologie (DE-588)4060538-3 gnd
topic_facet Toxikologie
Konferenzschrift 1994 Basel
url http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006613742&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
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