Antipsychotic drugs and their side effects

Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly changing fields in the life sciences. Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiol...

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Veröffentlicht: London u.a. Acad. Press 1993
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520 |a Over the past 40 years, the effectiveness of conventional neuroleptic agents for psychotic illness has been offset by a wide range of adverse side-effects, including movement disorders like parkinsonism and akathisia; although, in many cases, these can be minimised by titration to the minimum effective dose 
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Datensatz im Suchindex

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adam_text ANTIPSYCHOTIC DRUGS AND THEIR SIDE-EFFECTS EDITED BY THOMAS R.E. BARNES DEPARTMENT OF PSYCNIATRY, CHARING CROSS AND WESTMINSTER MEDICAL SCHOOL, LONDON, UK ACADEMIC PRESS HARCOURT BRACE & COMPANY, PUBLISHERS LONDON SAN DIEGO NEW YORK BOSTON SYDNEY TOKYO TORONTO CONTENTS CONTRIBUTORS XI SERIES PREFACE XIII NEUROSCIENCE EDITORIAL ADVISORY BOARD XV PREFACE XVI PART I: BASIC SCIENCE 1 1 THE PHARMACOLOGY OF THE PHENOTHIAZINES, BUTYROPHENONES, 3 THIOXANTHINES AND DIPHENYLBUTYLPIPERIDINES B.E. LEONARD 1.1 INTRODUCTION 3 1.2 EFFECTS OF NEUROLEPTICS ON DOPAMINERGIC AND OTHER NEUROTRANSMITTER SYSTEMS 5 1.3 HETEROGENEITY OF DOPAMINERGIC NEURONS IN THE MESOCORTICAL SYSTEM 8 1.4 INTERACTION OF NEUROLEPTICS WITH NON-DOPAMINERGIC RECEPTORS 11 1.5 ACTION OF NEUROLEPTICS ON DIFFERENT TYPES OF NEUROTRANSMITTER RECEPTOR 12 1.6 STRUCTURE-ACTIVITY RELATIONSHIPS AND PHARMACOKINETIC ASPECTS 13 1.7 BEHAVIOURAL AND PHARMACOLOGICAL PROPERTIES OF THE NEUROLEPTICS 17 1.8 CLINICAL PHARMACOLOGY OF THE NEUROLEPTICS 21 1.9 HORMONAL CHANGES RESULTING FROM NEUROLEPTIC TREATMENT 22 1.10 CONCLUSION 23 2 THE PHARMACOLOGY OF DOZAPINE-LIKE ATYPICAL ANTIPSYCHOTICS 27 DM. COWARD 2.1 INTRODUCTION 27 CONTENTS 2.2 NEUROLEPTIC-LIKE PROPERTIES IN ANIMAL STUDIES 30 2.3 ATYPICAL PROPERTIES OF CLOZAPINE 31 2.4 NEUROTRANSMITTER INTERACTIONS OF CLOZAPINE AND RELATED AGENTS 33 2.5 MECHANISMS UNDERLYING CLOZAPINE S ATYPICALITY 35 2.6 CONCLUSIONS 41 2.7 SUMMARY 41 PHARMACOLOGY AND CLINICAL PROPERTIES OF SELECTIVE DOPAMINE 45 ANTAGONISTS WITH FOCUS ON SUBSTITUTED BENZAMIDES JES GERLACH 3.1 INTRODUCTION 45 3.2 ANTAGONISM OF DOPAMINE RECEPTORS 47 3.3 CONCLUSION AND FUTURE TRENDS 59 PRE- AND POSTSYNAPTIC D, TO D 5 DOPAMINE RECEPTOR MECHANISMS 65 IN RELATION TO ANTIPSYCHOTIC ACTIVITY JOHN L. WADDINGTON 4.1 PHARMACOLOGICAL CHARACTERISTICS OF DOPAMINE RECEPTOR SUBTYPES 66 4.2 DJ RECEPTOR ANTAGONISTS AS PUTATIVE ANTIPSYCHOTIC AGENTS 69 4.3 SELECTIVE D 2 AUTORECEPTOR AGONISTS, ANTAGONISTS AND PARTIAL AGONISTS AS PUTATIVE ANTIPSYCHOTIC AGENTS 76 4.4 *- IMPLICATIONS FOR THE DOPAMINE HYPOTHESIS OF SCHIZOPHRENIA 81 PREDICTION OF ANTIPSYCHOTIC ACTIVITY 87 NADIA M.J. RUPNIAK AND SUSAN D. IVERSEN 5.1 INTRODUCTION 87 5.2 PRECLINICAL SCREENS FOR ANTIPSYCHOTIC DRUGS 88 5.3 DESIRABLE PRECLINICAL PROFILE USING DOPAMINE ANTAGONIST SCREENS 89 5.4 PRECLINICAL PROFILES OF NOVEL AGENTS SUGGESTING ANTIPSYCHOTIC ACTIVITY 90 5.5 DISCUSSION AND TARGETS FOR FUTURE RESEARCH 94 EFFECTS OF NEUROLEPTICS ON NEURONAL AND SYNAPTIC STRUCTURE 99 P.]. HARRISON 6.1 NEUROLEPTIC EFFECTS ON NEURONS 100 6.2 NEUROLEPTIC EFFECTS ON SYNAPSES 104 VI CONTENTS 6.3 NEUROLEPTIC EFFECTS IN HUMAN BRAIN 106 6.4 NEUROLEPTICS AND GENE EXPRESSION 108 BRAIN IMAGING AND ANTIPSYCHOTIC DRUGS 111 P.F. LIDDLE 7.1 INTRODUCTION 112 7.2 BRAIN-IMAGING TECHNIQUES . 113 7.2 BRAIN-IMAGING TECHNIQUES 7.3 EFFECTS OF ANTIPSYCHOTIC DRUGS ON BRAIN ACTIVITY 7.4 OCCUPATION OF NEURORECEPTORS BY ANTIPSYCHOTIC DRUGS 7.5 CONCLUSIONS REGARDING ANTIPSYCHOTIC DRUG ACTION 122 124 PHARMACOKINETICS OF ANTIPSYCHOTIC DRUGS 127 S.H. CURRY 8.1 INTRODUCTION 127 8.2 ANALYTICAL METHODS 128 8.3 NEUROLEPTIC DRUG METABOLITES 130 8.4 PRESYSTEMIC ELIMINATION (FIRST-PASS EFFECT) 131 8.5 ENZYME INDUCTION 133 8.6 BINDING TO PLASMA PROTEIN 133 8.7 PH-DEPENDENT PHENOMENA 134 8.8 ELIMINATION HALF-LIFE 134 8.9 U-SHAPED CLINICAL-CHEMICAL RELATIONSHIPS 135 8.10 CHANGEOVER FROM ORAL MEDICATION TO DEPOT NEUROLEPTICS 138 -8.11 PROLACTIN 139 8.12 THERAPEUTIC MONITORING 139 -8.13 CONCLUSION 141 PART II: CLINICAL ISSUES 145 9 THE ASSESSMENT OF ANTIPSYCHOTIC MEDICATION IN CLINICAL TRIALS 147 S.R. HIRSCH 9.1 INTRODUCTION 147 9.2 PHASE I STUDIES 148 9.3 PHASE II STUDIES 148 9.4 PHASE III STUDIES 150 9.5 PHASE IV STUDIES 150 9.6 FIXED- VERSUS FLEXIBLE-DOSE STUDIES 150 9.7 PATIENT SELECTION 151 9.8 STATISTICAL ASPECTS 152 9.9 RATING INSTRUMENTS . 153 CONTENTS 9.10 CLINICAL DESIGNS FOR SPECIFIC PURPOSES 153 9.11 OTHER MEASURES OF PHARMACOLOGICAL EFFICACY 155 9.12 CONCLUSION 155 10 INDICATIONS FOR ANTIPSYCHOTIC DRUGS 157 R.G. MCCREADIE 157 163 163 164 164 165 11 ACUTE TREATMENT 169 10.1 10.2 10.3 10.4 10.5 10.6 ACUTE J.M. 11.1 11.2 11.3 11.4 11.5 11.6 11.7 11.8 SCHIZOPHRENIA MANIA DELUSIONAL DEPRESSION FUNCTIONAL PSYCHOSIS DEMENTIA MISCELLANEOUS INDICATIONS TREATMENT KANE INTRODUCTION INDICATIONS CHOICE OF DRUG DOSAGE ANTIPSYCHOTIC DRUG DOSAGE EQUIVALENCIES STRATEGIES FOR TREATING NON-RESPONSIVE PATIENTS CLOZAPINE CONCLUSIONS 169 171 171 174 176 177 178 180 12 MAINTENANCE ANTIPSYCHOTIC MEDICATION 183 J.M. DAVIS, P.G. JANICAK, A. SINGLA AND R.P. SHARMA 12.1 INTRODUCTION 183 12.2 TIME-COURSE OF RELAPSE 186 12.3 INDICATIONS FOR MAINTENANCE 190 12.4 TARGETED TREATMENT 191 12.5 DOSAGE OF MEDICATION 193 12.6 CHOICE OF MEDICATION 194 12.7 EFFECT OF ANTIPSYCHOTIC DRUGS ON THE COURSE OF SCHIZOPHRENIA 195 12.8 MAINTENANCE DRUGS AND PSYCHOSOCIAL TREATMENT 197 12.9 POSTPSYCHOTIC DEPRESSION 198 12.10 SUPERSENSITIVITY 199 - 12.11 CONCLUSION 201 CONTENTS 13 DEPOT NEUROLEPTICS 205 D.A.W. JOHNSON 13.1 INTRODUCTION 205 13.2 COMPLIANCE 207 13.3 DELIVERY SERVICE 208 13.4 RISK OF SIDE-EFFECTS 209 13.5 CONCLUSIONS 211 14 THE SIDE-EFFECTS OF ANTIPSYCHOTIC DRUGS. I. CNS AND NEUROMUSCULAR EFFECTS 213 T.R.E. BARNES AND J.G. EDWARDS 14.1 NEUROPSYCHIATRIC EFFECTS 214 14.2 NEUROMUSCULAR EFFECTS 217 14.3 AUTONOMIC EFFECTS 239 15 THE SIDE-EFFECTS OF ANTIPSYCHOTIC DRUGS. II. EFFECTS ON OTHER 249 PHYSIOLOGICAL SYSTEMS J.G. EDWARDS AND T.R.E. BARNES 15.1 ENDOCRINE AND METABOLIC DISORDERS 250 15.2 IMMUNOLOGICAL REACTIONS 253 15.3 CUTANEOUS REACTIONS 253 15.4 OPHTHALMOLOGICAL REACTIONS 255 15.5 HAEMATOLOGICAL REACTIONS 256 15.6 CARDIAC EFFECTS 258 15.7 RESPIRATORY REACTIONS 260 15.8 GASTROINTESTINAL REACTIONS 260 15.9 HEPATIC REACTIONS 261 15.10 SEXUAL DYSFUNCTION 262 15.11 EFFECTS ON THE EMBRYO AND NEWBORN 265 15.12 DRUG INTERACTIONS 267 - 15.13 CONCLUSIONS 270 INDEX 277
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spellingShingle Antipsychotic drugs and their side effects
Antipsicóticos (aplicações terapêuticas) larpcal
Antipsicóticos (farmacologia) larpcal
Antipsychotische geneesmiddelen gtt
Bijwerkingen gtt
Drogas de abuso (complicações) larpcal
Drogas de abuso (efeitos) larpcal
Antipsychotic Agents adverse effects
Antipsychotic Agents pharmacology
Antipsychotic Agents therapeutic use
Psychotropic drugs Complications
Psychotropic drugs Side effects
Psychopharmakon (DE-588)4047729-0 gnd
Arzneimittelnebenwirkung (DE-588)4003134-2 gnd
subject_GND (DE-588)4047729-0
(DE-588)4003134-2
title Antipsychotic drugs and their side effects
title_auth Antipsychotic drugs and their side effects
title_exact_search Antipsychotic drugs and their side effects
title_full Antipsychotic drugs and their side effects ed. by Thomas R. E. Barnes
title_fullStr Antipsychotic drugs and their side effects ed. by Thomas R. E. Barnes
title_full_unstemmed Antipsychotic drugs and their side effects ed. by Thomas R. E. Barnes
title_short Antipsychotic drugs and their side effects
title_sort antipsychotic drugs and their side effects
topic Antipsicóticos (aplicações terapêuticas) larpcal
Antipsicóticos (farmacologia) larpcal
Antipsychotische geneesmiddelen gtt
Bijwerkingen gtt
Drogas de abuso (complicações) larpcal
Drogas de abuso (efeitos) larpcal
Antipsychotic Agents adverse effects
Antipsychotic Agents pharmacology
Antipsychotic Agents therapeutic use
Psychotropic drugs Complications
Psychotropic drugs Side effects
Psychopharmakon (DE-588)4047729-0 gnd
Arzneimittelnebenwirkung (DE-588)4003134-2 gnd
topic_facet Antipsicóticos (aplicações terapêuticas)
Antipsicóticos (farmacologia)
Antipsychotische geneesmiddelen
Bijwerkingen
Drogas de abuso (complicações)
Drogas de abuso (efeitos)
Antipsychotic Agents adverse effects
Antipsychotic Agents pharmacology
Antipsychotic Agents therapeutic use
Psychotropic drugs Complications
Psychotropic drugs Side effects
Psychopharmakon
Arzneimittelnebenwirkung
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