Frontiers in bioprocessing II proceedings of Frontiers in Biochemistry II, Boulder, Colorado, June 17 - 21, 1990
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| 245 | 1 | 0 | |a Frontiers in bioprocessing II |b proceedings of Frontiers in Biochemistry II, Boulder, Colorado, June 17 - 21, 1990 |c ed. by Paul Todd ... American Chemical Society |
| 264 | 1 | |a Washington, DC |c 1992 | |
| 300 | |a XX, 425 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
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| 650 | 0 | 7 | |a Biotechnologie |0 (DE-588)4069491-4 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)1071861417 |a Konferenzschrift |y 1990 |z Boulder Colo. |2 gnd-content | |
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Datensatz im Suchindex
| DE-BY-TUM_call_number | 1001 76.2004 A 2199 |
|---|---|
| DE-BY-TUM_katkey | 1469312 |
| DE-BY-TUM_location | Mag |
| DE-BY-TUM_media_number | 040050232901 |
| _version_ | 1820890172208709632 |
| adam_text | Contents
Preface
..................................................................................................................................... xix
Frontiers in Bioprocessing: An Assessment
................................................................................. 1
Ahn S.
Michaels
The First Frontier. Synthesis of Biological Products
.............................................................................. 1
The Second Frontier: Characterization and Control of Biopolymer Structure
................................ 3
The Third Frontier: Biosensors and
Bioprocess
Control Strategies
.................................................... 4
The Fourth Frontier: Separation and Purification of Bioproducts
..................................................... 4
A Look into the Future: Whither Bioprocessing?
.................................................................................. 7
PART I: PROTEIN AND ENZYME ENGINEERING
The Role of Protein Crystals in Biotechnology and Industry
............................................. 10
Alexander McPherson
The New Polymer Chemistry
......................................................................................................................... 10
The New Pharmacology
.................................................................................................................................. 11
The Role of Protein Crystals
......................................................................................................................... 12
Center for Advanced Research in Biotechnology: A Multidisciplinary
Approach to Protein Engineering
...................................................................................................... 16
G. L. Gilliland, B. Veerapandian, J. Dill, O.
Herzberg,
С.
Chiu,
G.
Kapadia,
J.
Moult,
D.
Bacon,
M.
Toner,
K. Fidelis, F.
Schwarz,
P.
Ready,
К. МсКеппеу,
M.
Kantorów,
J.
Moore,
J.
Hoskins,
W.
J.
Stevens,
D.
Garnier,
E.
Eisenstein,
К.
Fisher, P. Bryan,
P. Alexander, S. L. Edwards, M.
Mauro,
К.
Darwish,
К
Choudhury,
H.
Li,
R.
Raag,
and
T. L. Poulos
CARB:
Organization and Activities
........................................................................................................... 17
Protein Engineering
Research
Studies
........................................................................................................ 19
Molecular Modeling
Research
...................................................................................................................... 27
Cell-Free Protein Synthesis Bioreactor
.......................................................................................... 31
Alexander S. Spirin
Flow-Through Bioreactors for Cell-Free Protein Synthesis
................................................................... 32
Characteristics and Peculiarities of the Flow-Through Cell-Free Systems
.......................................... 37
Direct Gene Expression in Preparative Cell-Free Systems
..................................................................... 38
xi
Recombination in Replicating RNAs
................................................................................................ 44
Alexander B. Chetverin, Leonid A. Voronin, Alexander V. Munishkin,
Larisa
A. Bondareva, Helena V. Chetverina, and Victor I. Ugarov
Synopsis of Methods
.......................................................................................................................................
45
Recombinant RNA
Sequences
...................................................................................................................... 45
Enantioselective Enzymatic Synthesis of Prostaglandin-Synthons
in Multiphase Reaction Media
............................................................................................................ 50
S.
Schapöhler,
T.
Scheper,
K
Schügerí,
and E.-R. Barenschee
Multiphase Reaction Media
.......................................................................................................................... 50
Prostaglandin-Synthons
................................................................................................................................. 51
Materials and Methods
................................................................................................................................... 51
Principles of Liquid Membrane Emulsion Systems
.................................................................................. 51
Experimental Setup and Results
.................................................................................................................. 52
Principles of the Organic Solvent Systems
................................................................................................. 55
Experimental Setup and Results
.................................................................................................................. 57
Design and Synthesis of
a
Peptide
Having Chymotrypsin-Like
Catalytic Activity
......................................................................................................................................... 63
John M. Stewart, Karl W.
Hahn,
Wiesław
A. Klis,
John
R.
Conn,
and Michael Corey
Design
................................................................................................................................................................. 64
Synthesis and Purification
.............................................................................................................................. 65
Properties of Chymohelizyme-l
.................................................................................................................... 67
PARTII:
BIOSENSORS AND IN SITU
MEASUREMENT SYSTEMS
Fiber-Optic Sensors Using Raman and Surface-Enhanced
Raman Spectroscopy
................................................................................................................................ 72
5.
M. Angel, M. L. Myrvck, and F. P. Milanovich
Raman Spectroscopy and
SERS
................................................................................................................... 72
Fiber-Optic Sensor Designs
........................................................................................................................... 74
Applications of Remote Raman Spectroscopy
.......................................................................................... 78
SERS
Using Diode Lasers
............................................................................................................................. 86
Non-Invasive
Spectroscopie
Monitoring of
a Bioprocess
....................................................... 90
Anna G. Cavinato, David M.
Mayes,
Zhihong Ge,
and James B. Callis
Materials and Methods
................................................................................................................................. 91
Results and Discussion
............................................................................,............................... 93
xii
In Situ On-Line Optical Fiber Sensor for Fluorescence Monitoring
in Bioreactors
............................................................................................................................................... 99
John].
Horváth
and Christopher
J
. Spangler
Experimental Methods
.................................................................................................................................... 100
Flow-Through Cuvette: Results
.................................................................................................................. 104
Optical Fiber/Rod Measurements: Results
............................................................................................... 107
Flow-Through Cuvette: Discussion
............................................................................................................
Ill
Optical Fiber/Rod: Discussion
..................................................................................................................... 113
Fiber-Optic Biosensors Incorporating Sustained Release of Reagents
.......................... 116
Tony Alex, Henrik
Pedersen, and George H. Sigel, Jr.
Design of OTHER Fiber-Optic Biosensors
............................................................................................... 117
Instrumentation
................................................................................................................................................ 118
Peroxide Sensor
................................................................................................................................................ 118
pH
Shift Sensor
................................................................................................................................................ 118
Mathematical Modeling.
................................................................................................................................. 120
Sustained Release of Intermediates
............................................................................................................. 122
Whole Cell Biosensors: A Brief Overview and Presentation of a Novel
Neuron-Based Approach
......................................................................................................................... 126
Devdatt L.
Kurdikar,
Rodney S. Skeen, Bernard
/.
Van
Wie,
Charles D. Barnes, and Simon J. Fung
Whole Cell Biosensors: A Brief Review
.................................................................................................... 126
Temperature Sensitivity of
Neuronal
Response to
Neurotransmitters
................................................ 130
Investigation of Immobilized-Cell Energetics and Metabolism Using
NMR Spectroscopy
................................................................................................................ 138
Catherine A. Briasco and Channing R. Robertson
Materials and Methods
................................................................................................................................... 140
35S Autoradiography: Results and Discussion
......................................................................................... 143
31P NMR Spectroscopy: Results and Discussion
..................................................................................... 143
PART
Ш:
CELL-CULTURE SYSTEMS
The Formation of /J-Lactamase Inclusion Bodies in Escherichia
coli
and Comparison with In Vitro Studies
........................................................................................... 152
Gregory A. Bowden, Pascal Valax, and George Georgiou
Materials and Methods
................................................................................................................................... 153
/J-Lactamase Aggregation in Escherichia
coli:
Results
............................................................................ 153
Folding and Aggregation of
/ì-Lactamase In
Vitro: Results
................................................................. 160
xxn
Secretion of Heterologous Proteins and Peptides by Pichta
pastoris
................................ 162
Robert S.
Siegel
General Characteristics of the P.
pastoris
Expression System
................................................................ 162
Expression of Secreted Proteins by P.
pastoris
.......................................................................................... 163
Glycosylation by P.
pastoris
............................................................................................................................
!63
Proteolysis of Secreted Peptides
................................................................................................................... 164
Pilot Plant Production of
Recombinant
Human Epidermal Growth Factor
..................................... 165
Streptomyces Bioprocessing: From Secondary Metabolites
to Heterologous Proteins
........................................................................................................................ 168
Kimberlee K, Wallace, Gregory F. Payne, and Marilyn
К
Speedie
Characterizing Secondary Metabolism in Terms of the Extracellular Environment
......................... 168
Characterizing Secondary Metabolism in Terms of the Intracellular Environment
.......................... 171
The Future: Genetic Engineering for Secondary Metabolism
.............................................................. 175
Streptomyces for Heterologous Protein Production
.................................................................................. 175
Strategy for the Production and Stabilization of
Lignin Peroxidase
from Phanerochaete chrysosporium in Air-Lift and Stirred
Tank Bioreactors
........................................................................................................................................ 181
Austin H. C. Chen, Carlos G. Dosoretz, and Hans E. Grethlein
Materials and Methods
................................................................................................................................... 182
Discussion and Conclusions
.......................................................................................................................... 185
Bioprocessing of Higher Plant-Cell Cultures
.............................................................................. 188
Henrik Pedersen,
Sang Yo Byun, and Chee-Kok Chin
Bioprocessing Techniques and Options
...................................................................................................... 188
Cell Directed Bioprocessing
.......................................................................................................................... 190
Reactor Directed Bioprocessing
................................................................................................................... 195
Advanced Bioprocessing
................................................................................................................................. 196
The Oligosaccharides of Glycoproteins: Factors Affecting Their
Synthesis and Their Influence on Glycoprotein Properties
................................................. 199
Charles F. Goochee, Michael J.
Gramer, Dana C.
Andersen,
Jennifer
B. Bahr,
and James R.
Rasmussen
Factors Affecting the Synthesis of Glycoprotein Oligosaccharides
....................................................... 199
Glycoprotein Oligosaccharide Conformation
............................................................................................ 215
Effects of Oligosaccharides on Glycoprotein Properties
......................................................................... 217
Modeling the Regulation of Antibody Synthesis and Assembly
in
a Murine
Hybridoma.......................................................................................................................... 241
M. C.
Flickinger and T. Bibila
Materials and Methods
................................................................................................................................... 243
Levels of Total Cellular
RNA
and Heavy and Light Chain mRNAs
During Exponential and Stationary Phase: Results
............................................................................ 247
Heavy and Light Chain mRNA Half-Lives: Results
............................................................................... 247
An Initial Structured Kinetic Model
...................................................................................................... 250
Model Simulations
......................................................................................................................... 252
Xiv
PART IV: BIOREACTOR ENGINEERING AND CONTROL
Modeling of Immobilized Microbial Cells: Influence of Substrate
or Product Inhibition on Activity and Biomass Spatial Profiles
....................................... 260
David
F. Ollis
and Gregory D. Sayles
Product Inhibition: Model
........................................................................................................................... 261
Product Inhibition: Results and Discussion
............................................................................................. 263
Product Inhibition: Reactor Design
.......................................................................................................... 265
Substrate Inhibition: Model
........................................................................................................................ 267
Substrate Inhibition: Model Results and Discussion
............................................................................. 270
Substrate Utilization: Reactor Design
...................................................................................................... 273
Micromixing in Fermentation—The Response of Microorganisms
to Hydrodynamic Forces
........................................................................................................................ 277
Eric H. Dunlop
The Basic Problem
.......................................................................................................................................... 277
Microscales in Fermentation
........................................................................................................................ 279
Gas-Liquid Oxygen Transfer in Perfluorochemical-in-Water
Dispersions
................................................................................................................................................... 286
James D. McMillan and Daniel I. C. Wang
History of Perfluorochemical
Oxygénation
............................................................................................... 286
Background
....................................................................................................................................................... 287
Approach
.......................................................................................................................................................... 287
Materials and Methods
.................................................................................................................................. 288
Experimental Results
..................................................................................................................................... 289
Mechanism of Enhancement
........................................................................................................................ 293
Length and Time Scales
................................................................................................................................. 294
Unsteady State Modeling
.............................................................................................................................. 295
Modeling Results
............................................................................................................................................ 298
PART V:
BIOSEPARATIONS SCALEUP
Strategies To Minimize Fouling in the Membrane Processing
ofBiofluids
.................................................................................................................................................... 304
Anthony G. Fane, K. J. Kim, P. H. Hodgson, G. Leslie,
C. J. D.
Fell,
А. С.
M.
Franken,
V. Chen, and
К. Я
Liew
The Various Forms of Fouling
.................................................................................................................... 304
Retentive
Ultrafilters
..................................................................................................................................... 305
Retentive
Microfilters
—
Biomass
................................................................................................................. 309
Solute-Permeable Membranes
—
Protein Transport
................................................................................. 313
Membrane
Pretreatment
................................................................................................................................ 316
xv
Role of Functionalized Membrane Separation Technology
in Downstream Processing of Biotechnology-Derived Proteins
......................................... 321
Vipin
К
Garg, Stephen E.
Zale,
Abdul R. M. Azad,
and O. Dile
Holton
Functionalized Membrane Technology
...................................................................................................... 321
MAb Purification
............................................................................................................................................ 323
Scaleup and Process Development Considerations
................................................................................. 324
Other Applications
......................................................................................................................................... 326
Extraction of Lipases in Aqueous Two-Phase Systems: The Strategy
for an Optimization
.................................................................................................................................. 331
U.
Menge
Material and Methods
.................................................................................................................................... 331
Results: Optimization Methodology for Phase Partitioning Experiments
........................................ 332
Optimization of Phase Extractions of
Lipase
from Mucor miehei
........................................................ 334
Influence of the Phase Volume on the Purification Factor
.................................................................. 335
Combination of Two-Phase Extractions
.................................................................................................... 337
Comparison of the Phase Partitioning of Three Lipases
....................................................................... 337
Salt-Polyethylene
Glycol
Two-Phase Aqueous Systems To Purify
Proteins and Nucleic Acid Mixtures
................................................................................................ 340
Kenneth D. Cole
Materials and Methods
.................................................................................................................................. 341
Results
............................................................................................................................................................... 343
A Polyethylene
Glycol-
Sodium Chloride Multiphase System
for Extraction of Acid Hydrolysates
................................................................................................. 352
Robin M. Stewart and Paul Todd
Materials and Methods
.................................................................................................................................. 352
Results and Discussion
.................................................................................................................................. 353
PART VI: EMERGING TECHNOLOGIES
IN BIOSEPARATIONS
An Expert System for Selection and Synthesis of Protein Purification
Processes
.......................................................................................................................................................
35g
X A. Asenjo and F. Maugeri
Selection of Separation Sequence
............................................................................................................... 359
Process Design
............................................................................................................................................... 362
Development of an Expert System
........................................................................,]...........
ISSIZZ.........
367
xvi
Thermodynamics of Aqueous Mixtures of Salts and Polymers
......................................... 380
Heriberto
Cabezas,
Jr., Mostafa Kabiri-Badr, Steven M. Snyder,
and David C.
Szlag
Chemical Potential Model
............................................................................................................................ 380
Model Parameters
........................................................................................................................................... 385
Phase Behavior of Polymer-Polymer Systems
.......................................................................................... 385
Phase Behavior of Salt-Polymer Systems
.................................................................................................. 387
Membrane Affinity Technology for
Biomolecule
Purification
and Diagnostics
.......................................................................................................................................... 392
Fook
Hai
Lee, Kent Murphy, Paul
Lin, Sara Vasan,
DaranyAn,
Suzanne
DeMarco,
Vincent Forte, and Dennis Pietronigro
Technical Data and Product Performance
................................................................................................. 392
Discussion
......................................................................................................................................................... 396
Recycling Free-Flow Focusing: Apparatus and Applications
............................................. 399
James
A. Ostrem,
Glen Ward,
Leon Barstow, Rodolfo
Marquez,
Thomas
R.
Van Oosbree, Buck A. Rhodes, and Catherine
С
Wasmann
Instrument Design and Operation
.............................................................................................................. 399
Applications
..................................................................................................................................................... 402
INDEX
Index
................................................................................................................................................................ 414
XVII
|
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| genre | (DE-588)1071861417 Konferenzschrift 1990 Boulder Colo. gnd-content |
| genre_facet | Konferenzschrift 1990 Boulder Colo. |
| id | DE-604.BV005583850 |
| illustrated | Illustrated |
| indexdate | 2024-12-23T11:40:16Z |
| institution | BVB |
| isbn | 0841221812 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-003496411 |
| oclc_num | 311630672 |
| open_access_boolean | |
| owner | DE-12 DE-M49 DE-BY-TUM DE-634 DE-11 |
| owner_facet | DE-12 DE-M49 DE-BY-TUM DE-634 DE-11 |
| physical | XX, 425 S. Ill., graph. Darst. |
| publishDate | 1992 |
| publishDateSearch | 1992 |
| publishDateSort | 1992 |
| record_format | marc |
| series2 | Conference proceedings series |
| spellingShingle | Frontiers in bioprocessing II proceedings of Frontiers in Biochemistry II, Boulder, Colorado, June 17 - 21, 1990 Biotechnologie (DE-588)4069491-4 gnd |
| subject_GND | (DE-588)4069491-4 (DE-588)1071861417 |
| title | Frontiers in bioprocessing II proceedings of Frontiers in Biochemistry II, Boulder, Colorado, June 17 - 21, 1990 |
| title_auth | Frontiers in bioprocessing II proceedings of Frontiers in Biochemistry II, Boulder, Colorado, June 17 - 21, 1990 |
| title_exact_search | Frontiers in bioprocessing II proceedings of Frontiers in Biochemistry II, Boulder, Colorado, June 17 - 21, 1990 |
| title_full | Frontiers in bioprocessing II proceedings of Frontiers in Biochemistry II, Boulder, Colorado, June 17 - 21, 1990 ed. by Paul Todd ... American Chemical Society |
| title_fullStr | Frontiers in bioprocessing II proceedings of Frontiers in Biochemistry II, Boulder, Colorado, June 17 - 21, 1990 ed. by Paul Todd ... American Chemical Society |
| title_full_unstemmed | Frontiers in bioprocessing II proceedings of Frontiers in Biochemistry II, Boulder, Colorado, June 17 - 21, 1990 ed. by Paul Todd ... American Chemical Society |
| title_short | Frontiers in bioprocessing II |
| title_sort | frontiers in bioprocessing ii proceedings of frontiers in biochemistry ii boulder colorado june 17 21 1990 |
| title_sub | proceedings of Frontiers in Biochemistry II, Boulder, Colorado, June 17 - 21, 1990 |
| topic | Biotechnologie (DE-588)4069491-4 gnd |
| topic_facet | Biotechnologie Konferenzschrift 1990 Boulder Colo. |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=003496411&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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