Understanding experimental design and interpretation in pharmaceutics

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Hauptverfasser: Armstrong, N. A. (VerfasserIn), James, Kenneth C. (VerfasserIn)
Format: Buch
Sprache:English
Veröffentlicht: New York u.a. Horwood 1990
Ausgabe:1. publ.
Schriftenreihe:Ellis Horwood series in pharmaceutical technology
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adam_text UNDERSTANDING EXPERIMENTAL DESIGN AND INTERPRETATION IN PHARMACEUTICS N. A. ARMSTRONG B.PHARM.,PH.D.,F.R.PHARM.S.,MCPP K. C. JAMES M.PHARM., PH.D., D.SC.,FRSC, F.R.PHARM.S., C.CHEM. WELSH SCHOOL OF PHARMACY DIVISION OF PHARMACEUTICS, UNIVERSITY OF WALES, COLLEGE OF CARDIFF ELLIS HORWOOD NEW YORK LONDON TORONTO SYDNEY TOKYO SINGAPORE TABLE OF CONTENTS 1. INTRODUCTION TO EXPERIMENTAL DESIGN 7 2. COMPARISON OF MEAN VALUES 9 COMPARISON OF TWO MEANS WHEN THE VARIANCE OF THE WHOLE POPULATION IS KNOWN 10 COMPARISON OF TWO MEANS WHEN THE VARIANCE OF THE WHOLE POPULATION IS NOT KNOWN 11 COMPARISON OF MEANS AMONG MORE THAN TWO GROUPS OF DATA 12 ANALYSIS OF VARIANCE 13 LEAST SIGNIFICANT DIFFERENCE 16 TWO-WAY ANALYSIS OF VARIANCE 17 3. NON-PARAMETRIC TREATMENTS 21 NON-PARAMETRIC TESTS FOR PAIRED DATA 21 THE SIGN TEST 21 THE WILCOXON SIGNED RANK TEST 23 NON-PARAMETRIC TESTS FOR UNPAIRED DATA 24 THE WILCOXON TWO-SAMPLE TEST 24 4. FACTORIAL DESIGN OF EXPERIMENTS 27 TWO-LEVEL, TWO-FACTOR EXPERIMENTAL DESIGNS 27 NOTATION IN FACTORIALLY DESIGNED EXPERIMENTS 27 FACTORIAL DESIGNS WITH INTERACTION BETWEEN FACTORS 30 FACTORIAL DESIGNS WITH THREE FACTORS 34 FACTORIAL DESIGNS WITH MORE THAN THREE FACTORS 39 FACTORIAL DESIGNS WITH THREE FACTORIAL LEVELS 45 THREE-FACTOR, THREE-LEVEL DESIGNS 49 GENERAL COMMENTS ON FACTORIAL DESIGN 54 6 TABLE OF CONTENTS 5. CORRELATION AND REGRESSION 56 LINEAR REGRESSION 56 MULTIPLE LINEAR REGRESSION 63 STEPWISE REGRESSION 67 NON-LINEAR REGRESSION 67 FITTING CURVES TO MODELS 73 CURVE FITTING WITHOUT MODELS 75 FREE-WILSON ANALYSIS 77 6. MULTIVARIATE ANALYSIS 81 INTRODUCTION TO MULTIVARIATE ANALYSIS 81 DISTANCE MATRIX 82 COVARIANCE MATRIX 84 CORRELATION MATRIX 86 DETERMINANTS 87 EIGENVALUES AND EIGENVECTORS 91 CLUSTER ANALYSIS 97 DENDROGRAMS 100 DISCRIMINATION 108 PRINCIPAL COMPONENTS ANALYSIS 114 FACTOR ANALYSIS 119 ROTATION 125 COMPUTERIZED ROTATION 132 7. OPTIMIZATION 136 MODEL-DEPENDENT OPTIMIZATION 136 ANOVA WITH RESPONSE SURFACE METHODOLOGY 144 OPTIMIZATION WHEN INTERACTION OCCURS BETWEEN THE INDEPENDENT VARIABLES . 145 USE OF CODED DATA 147 SECOND-ORDER RELATIONSHIPS BETWEEN INDEPENDENT AND DEPENDENT VARIABLES 148 COMPUTER SOFTWARE PACKAGES FOR OPTIMIZATION 154 8. MODEL-INDEPENDENT OPTIMIZATION 15 7 OPTIMIZATION BY SIMPLEX SEARCH 157 APPENDIX 1: COMPUTER PROGRAMS IN BASIC AND MINITAB COMMANDS . . . . .163 APPENDIX 2: MATHEMATICAL TABLES . . . . 179 INDEX 182
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James, Kenneth C.
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series2 Ellis Horwood series in pharmaceutical technology
spellingShingle Armstrong, N. A.
James, Kenneth C.
Understanding experimental design and interpretation in pharmaceutics
Data Interpretation, Statistical
Drug Design
Drugs Design
Experimental design
Technology, Pharmaceutical
Pharmazie (DE-588)4045705-9 gnd
Forschungsplanung (DE-588)4155051-1 gnd
subject_GND (DE-588)4045705-9
(DE-588)4155051-1
title Understanding experimental design and interpretation in pharmaceutics
title_auth Understanding experimental design and interpretation in pharmaceutics
title_exact_search Understanding experimental design and interpretation in pharmaceutics
title_full Understanding experimental design and interpretation in pharmaceutics N. A. Armstrong ; K. C. James
title_fullStr Understanding experimental design and interpretation in pharmaceutics N. A. Armstrong ; K. C. James
title_full_unstemmed Understanding experimental design and interpretation in pharmaceutics N. A. Armstrong ; K. C. James
title_short Understanding experimental design and interpretation in pharmaceutics
title_sort understanding experimental design and interpretation in pharmaceutics
topic Data Interpretation, Statistical
Drug Design
Drugs Design
Experimental design
Technology, Pharmaceutical
Pharmazie (DE-588)4045705-9 gnd
Forschungsplanung (DE-588)4155051-1 gnd
topic_facet Data Interpretation, Statistical
Drug Design
Drugs Design
Experimental design
Technology, Pharmaceutical
Pharmazie
Forschungsplanung
url http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002875450&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
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